{"id":"https://openalex.org/W90386804","doi":null,"title":"Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine.","display_name":"Transvascular flux and tissue accrual of Evans blue: effects of endotoxin and histamine.","publication_year":1988,"publication_date":"1988-02-01","ids":{"openalex":"https://openalex.org/W90386804","mag":"90386804","pmid":"https://pubmed.ncbi.nlm.nih.gov/3276800"},"language":"en","primary_location":{"id":"pmid:3276800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3276800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107994911","display_name":"Thomas P. Green","orcid":"https://orcid.org/0000-0003-0171-7129","observed_orcids":["https://orcid.org/0000-0003-0171-7129"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T P Green","raw_affiliation_strings":["Department of Pediatrics, University of Minnesota, Minneapolis 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Minnesota, Minneapolis 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051688577","display_name":"D E Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049654337","display_name":"Randal P. Marchessault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Marchessault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032926779","display_name":"Catherine W. Gatto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Gatto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3014,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.55310621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"111","issue":"2","first_page":"173","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evans-blue","display_name":"Evans blue","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.47099998593330383},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8080000281333923},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/capillary-permeability","display_name":"capillary permeability","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lung","display_name":"lung","score":0.6399999856948853},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.8220000267028809},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.9610000252723694},{"id":"https://openalex.org/keywords/guinea-pig","display_name":"guinea pig","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.9919833540916443},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.5912033319473267},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5479963421821594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.542628288269043},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5263294577598572},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.4878275692462921},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4638623595237732},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.42002588510513306},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3544723391532898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35239699482917786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3331463634967804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23858657479286194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1651780605316162},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001391","descriptor_name":"Azo Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005070","descriptor_name":"Evans Blue","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005070","descriptor_name":"Evans Blue","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3276800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3276800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:90386804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3276800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985537667","https://openalex.org/W2402835926","https://openalex.org/W2276359369","https://openalex.org/W2161877684","https://openalex.org/W2326748324","https://openalex.org/W2468285881","https://openalex.org/W2396871959","https://openalex.org/W2039413276","https://openalex.org/W2039255327","https://openalex.org/W1436502606"],"abstract_inverted_index":{"We":[0,198],"investigated":[1],"the":[2,5,15,21,36,43,69,80,94,101,113,121,166,189,201,212,238,245],"relationship":[3],"between":[4],"pharmacokinetics":[6],"of":[7,24,35,52,68,82,96,112,125,156,169,185,207,233,241,255],"exogenous":[8],"molecules":[9],"and":[10,17,20,59,73,91,105,191,215,247],"transcapillary":[11,217,256],"flux":[12,54,258],"by":[13,138],"studying":[14,231],"intravascular":[16,39,154,205],"tissue":[18,56],"content":[19,155,206],"histologic":[22,167],"distribution":[23,81,95,168],"Evans":[25,40,83,126,157,170,186,208,242],"blue":[26,41,84,127,158,171,187,209,243],"in":[27,38,71,85,103,128,133,153,162,172,188,196,204,223,230,244,259],"guinea":[28],"pigs.":[29],"Pharmacokinetic":[30],"analysis":[31],"demonstrated":[32],"that":[33,200],"87%":[34],"decline":[37,152,203,222],"during":[42],"first":[44],"3":[45],"hours":[46],"after":[47],"administration":[48],"was":[49,88,107,160,174,178,194],"a":[50,148,181,253],"result":[51],"transvascular":[53],"to":[55,93,110,120,211,216],"compartments.":[57],"Rapidly":[58],"slowly":[60,114],"equilibrating":[61,115],"compartments":[62],"were":[63,75,136,145],"identified.":[64],"Greater":[65],"than":[66,159,193],"90%":[67],"clearances":[70],"lung":[72,190,246],"heart":[74,192,248],"rapid":[76,150,183],"compartment":[77],"clearances.":[78],"Histologically,":[79],"these":[86,129],"tissues":[87,173],"predominantly":[89],"extracellular":[90],"similar":[92,109],"fluorescein-labeled":[97],"dextran.":[98],"By":[99],"contrast,":[100],"accumulation":[102],"kidney":[104],"liver":[106],"kinetically":[108],"characteristics":[111],"compartment.":[116],"This":[117],"corresponded":[118],"histologically":[119],"predominant":[122],"intracellular":[123],"uptake":[124],"tissues.":[130,261],"Generalized":[131],"increases":[132],"capillary":[134,235],"permeability":[135],"produced":[137],"endotoxin":[139,177],"or":[140],"histamine":[141],"infusion.":[142],"Both":[143],"treatments":[144],"associated":[146,179],"with":[147,180],"more":[149,182],"initial":[151,202,221,239],"found":[161],"control":[163],"animals.":[164],"Although":[165],"not":[175],"altered,":[176],"appearance":[184],"seen":[195],"controls.":[197],"conclude":[199],"corresponds":[210],"intercompartmental":[213],"clearance":[214],"macromolecular":[218,257],"flux.":[219],"The":[220],"serum":[224],"concentrations":[225],"may":[226,249],"therefore":[227],"be":[228,250],"useful":[229],"disorders":[232],"generalized":[234],"permeability.":[236],"Furthermore,":[237],"accrual":[240],"used":[251],"as":[252],"marker":[254],"those":[260]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
