{"id":"https://openalex.org/W90353322","doi":null,"title":"Congenital diethylstilbestrol-associated vaginal/cervical adenosis (DES babies).","display_name":"Congenital diethylstilbestrol-associated vaginal/cervical adenosis (DES babies).","publication_year":1979,"publication_date":"1979-05-01","ids":{"openalex":"https://openalex.org/W90353322","mag":"90353322","pmid":"https://pubmed.ncbi.nlm.nih.gov/156173"},"language":"en","primary_location":{"id":"pmid:156173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/156173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Arkansas Medical Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075396657","display_name":"Barclay Dl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D L Barclay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075396657"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.00908403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"75","issue":"12","first_page":"451","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diethylstilbestrol","display_name":"diethylstilbestrol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vaginal-adenosis","display_name":"vaginal adenosis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/clear-cell-adenocarcinoma","display_name":"clear cell adenocarcinoma","score":0.953000009059906},{"id":"https://openalex.org/keywords/vaginal-adenocarcinoma","display_name":"vaginal adenocarcinoma","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cervical-adenocarcinoma","display_name":"cervical adenocarcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/columnar-epithelium","display_name":"columnar epithelium","score":0.7519999742507935},{"id":"https://openalex.org/keywords/uterine-abnormalities","display_name":"uterine abnormalities","score":0.6449999809265137},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.4699999988079071},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5699999928474426},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8264702558517456},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.7901995778083801},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.7790404558181763},{"id":"https://openalex.org/C2781397067","wikidata":"https://www.wikidata.org/wiki/Q423989","display_name":"Diethylstilbestrol","level":3,"score":0.7045620679855347},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5854502320289612},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5736123919487},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5557519197463989},{"id":"https://openalex.org/C2778592230","wikidata":"https://www.wikidata.org/wiki/Q1807522","display_name":"Vaginal cancer","level":4,"score":0.5315171480178833},{"id":"https://openalex.org/C2778293109","wikidata":"https://www.wikidata.org/wiki/Q5130800","display_name":"Clear-cell adenocarcinoma","level":4,"score":0.5294392108917236},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4404403567314148},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4300463795661926},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.398731529712677},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.272533655166626},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20141056180000305},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13975465297698975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11808273196220398},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.09383219480514526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002578","descriptor_name":"Uterine Cervical Dysplasia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002584","descriptor_name":"Cervix Uteri","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004054","descriptor_name":"Diethylstilbestrol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008431","descriptor_name":"Maternal-Fetal Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014625","descriptor_name":"Vaginal Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:156173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/156173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Arkansas Medical Society","raw_type":"Journal Article"},{"id":"mag:90353322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/156173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2278460937","https://openalex.org/W2409178525","https://openalex.org/W1862992063","https://openalex.org/W1517029702","https://openalex.org/W1438802058","https://openalex.org/W161737752","https://openalex.org/W2113625426","https://openalex.org/W172536849","https://openalex.org/W2017783643","https://openalex.org/W2411106399"],"abstract_inverted_index":{"An":[0],"epidemiologic":[1],"study":[2],"of":[3,21,32,36,73,76,83,94,124,131,148,162,191,247,251,267,283,300],"clear":[4],"cell":[5],"vaginal":[6,168,231,268],"adenocarcinoma":[7,75,257,271,282],"in":[8,40,89,156,193,200,210],"young":[9,284],"women":[10,126],"(15-22":[11],"years":[12,98],"old)":[13],"showed":[14],"an":[15,111],"apparent":[16],"association":[17],"with":[18,99,197,264],"maternal":[19],"ingestion":[20],"diethylstilbestrol":[22],"(DES)":[23],"during":[24,63,158],"1st":[25],"trimester":[26],"pregnancy.":[27,64],"In":[28],"1971,":[29],"a":[30,68,129,188,214,236,289],"Registry":[31],"Clear":[33],"Cell":[34],"Adenocarcinoma":[35],"the":[37,48,77,92,132,144,159,176,181,194,201,248,252,265,298,301],"Genital":[38],"Tract":[39],"Young":[41],"Females":[42],"was":[43],"established,":[44],"and":[45,50,56,96,114,135,240,294],"shortly":[46],"thereafter":[47],"Food":[49],"Drug":[51],"Administration":[52],"warned":[53],"that":[54,108,115],"DES":[55,109,155,208],"chemically":[57],"related":[58],"nonsteroidal":[59],"estrogens":[60],"were":[61,152],"contraindicated":[62],"DES-exposed":[65,125],"females":[66],"have":[67,128,139,167,172,213,235],"0.14":[69],"to":[70,119,154,269,291],"1.4/1000":[71],"risk":[72],"developing":[74],"cervix/vagina":[78],"by":[79,222],"age":[80,93,103,223],"24.":[81],"Diagnoses":[82],"these":[84],"cancers":[85],"usually":[86],"are":[87],"made":[88],"girls":[90,205,227],"between":[91],"14":[95,224],"23":[97],"peak":[100],"incidence":[101,190],"at":[102,219,261],"19;":[104],"data":[105],"further":[106],"shows":[107],"is":[110,276,287],"incomplete":[112],"carcinogen":[113],"additional":[116],"factors":[117],"contribute":[118],"its":[120],"carcinogenesis.":[121],"About":[122],"20%":[123],"will":[127,138,166,171],"deformity":[130],"upper":[133,202],"vagina/cervix,":[134],"approximately":[136],"95%":[137],"abnormal":[140,230],"columnar":[141],"epithelium":[142],"on":[143,288,297],"cervix/upper":[145],"vagina.":[146],"75%":[147],"patients":[149],"whose":[150],"mothers":[151],"exposed":[153],"utero":[157],"8th":[160],"week":[161],"gestation":[163],"or":[164,221],"earlier":[165],"adenosis;":[169],"7%":[170],"this":[173],"finding":[174],"if":[175],"mother's":[177],"exposure":[178,209],"occurred":[179],"after":[180],"17th":[182],"week.":[183],"Recent":[184],"reports":[185],"also":[186,234],"indicate":[187],"high":[189],"abnormalities":[192],"uterus/oviducts":[195],"associated":[196],"gross":[198],"changes":[199],"vagina/cervix.":[203,253],"Asymptomatic":[204],"who":[206,228],"had":[207],"uteru":[211],"should":[212,233],"complete":[215],"annual":[216],"pelvic":[217],"examination":[218,239],"menarche":[220],"years.":[225],"Younger":[226],"develop":[229],"bleeding/discharge":[232],"periodic":[237],"thorough":[238],"Pap":[241],"smear,":[242],"as":[243,245],"well":[244],"palpation":[246],"entire":[249],"length":[250],"So":[254],"far,":[255],"cervical/vaginal":[256],"has":[258],"been":[259],"diagnosed":[260],"initial":[262],"examination,":[263],"ratio":[266],"cervical":[270],"being":[272],"almost":[273],"2:1.":[274],"There":[275],"no":[277],"standard":[278],"therapy":[279],"yet":[280],"for":[281],"women.":[285],"Treatment":[286],"case":[290,292],"basis,":[293],"prognosis":[295],"depends":[296],"stage":[299],"disease":[302],"when":[303],"diagnosed.":[304]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}