{"id":"https://openalex.org/W90275139","doi":null,"title":"Efficacy of extended pirlimycin therapy for treatment of experimentally induced Streptococcus uberis intramammary infections in lactating dairy cattle.","display_name":"Efficacy of extended pirlimycin therapy for treatment of experimentally induced Streptococcus uberis intramammary infections in lactating dairy cattle.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W90275139","mag":"90275139","pmid":"https://pubmed.ncbi.nlm.nih.gov/15136992"},"language":"en","primary_location":{"id":"pmid:15136992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15136992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103339897","display_name":"S.P. Oliver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P Oliver","raw_affiliation_strings":["Food Safety Center of Excellence, Department of Animal Science, Institute of Agriculture, The University of Tennessee, 2640 Morgan Circle, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Safety Center of Excellence, Department of Animal Science, Institute of Agriculture, The University of Tennessee, 2640 Morgan Circle, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101562480","display_name":"Raul Antonio Almeida","orcid":"https://orcid.org/0000-0003-4059-1071","observed_orcids":["https://orcid.org/0000-0003-4059-1071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul A Almeida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083792846","display_name":"Barbara Erin Gillespie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara E Gillespie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032039871","display_name":"Susan J. Ivey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan J Ivey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032138315","display_name":"Hugh Moorehead","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugh Moorehead","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083735552","display_name":"Phillip Lunn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Lunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054145829","display_name":"Henry H Dowlen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry H Dowlen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David L Johnson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022349376","display_name":"K.C. Lamar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken C Lamar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.794,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.90625821,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"3","first_page":"299","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11226","display_name":"Milk Quality and Mastitis in Dairy Cows","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-uberis","display_name":"Streptococcus uberis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bovine-mastitis","display_name":"bovine mastitis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intramammary-infection","display_name":"intramammary infection","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pirlimycin","display_name":"pirlimycin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/extended-antibiotic-therapy","display_name":"extended antibiotic therapy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/intramammary-infusion","display_name":"intramammary infusion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/antimicrobial-efficacy","display_name":"antimicrobial efficacy","score":0.6349999904632568},{"id":"https://openalex.org/keywords/experimental-infection-model","display_name":"experimental infection model","score":0.8650000095367432},{"id":"https://openalex.org/keywords/early-lactation","display_name":"early lactation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/dairy-cows","display_name":"dairy cattle","score":0.6899999976158142},{"id":"https://openalex.org/keywords/somatic-cell-count","display_name":"somatic cell count","score":0.8659999966621399},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.5},{"id":"https://openalex.org/keywords/cure-rate","display_name":"cure rate","score":0.671999990940094},{"id":"https://openalex.org/keywords/dry-period","display_name":"dry period","score":0.39399999380111694},{"id":"https://openalex.org/keywords/bovine-respiratory-disease","display_name":"bovine respiratory disease","score":0.3700000047683716},{"id":"https://openalex.org/keywords/bovine-viral-diarrhea","display_name":"bovine viral diarrhea","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C2779791424","wikidata":"https://www.wikidata.org/wiki/Q310707","display_name":"Streptococcus uberis","level":4,"score":0.9864640235900879},{"id":"https://openalex.org/C2776344049","wikidata":"https://www.wikidata.org/wiki/Q835061","display_name":"Mastitis","level":2,"score":0.7226917743682861},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.7081843614578247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6597336530685425},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.2677270174026489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19947880506515503},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.11855658888816833},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0516531765460968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002981","descriptor_name":"Clindamycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003612","descriptor_name":"Dairying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008414","descriptor_name":"Mastitis, Bovine","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008414","descriptor_name":"Mastitis, Bovine","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013290","descriptor_name":"Streptococcal Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15136992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15136992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary therapeutics : research in applied veterinary medicine","raw_type":"Clinical Trial"},{"id":"mag:90275139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15136992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6875,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1511204912","https://openalex.org/W1995770338","https://openalex.org/W2008595622","https://openalex.org/W2052587051","https://openalex.org/W2061475501","https://openalex.org/W2079238219","https://openalex.org/W2095259690","https://openalex.org/W2117303935","https://openalex.org/W2121794428","https://openalex.org/W2461958619","https://openalex.org/W2506927905","https://openalex.org/W3124310193"],"related_works":["https://openalex.org/W150579181","https://openalex.org/W2001947434","https://openalex.org/W3124310193","https://openalex.org/W111225451","https://openalex.org/W2141585085","https://openalex.org/W944716765","https://openalex.org/W3159002579","https://openalex.org/W7113410562","https://openalex.org/W4386110946","https://openalex.org/W2286338987"],"abstract_inverted_index":{"Streptococcus":[0],"uberis":[1,32,69,87,124,132,220,232,326,354],"is":[2],"an":[3,201],"important":[4],"cause":[5],"of":[6,22,48,57,65,84,100,112,187,190,218,239,277,336],"mastitis":[7,33],"in":[8,72,95,108,133,237,264,280,286,293,310,314,318],"dairy":[9,74,96,114],"cows":[10,75,115],"throughout":[11],"the":[12,16,20,49,55,82,85,216,240,245,251,257,269,321],"world,":[13],"particularly":[14],"during":[15,25,76,125,340],"dry":[17],"period,":[18],"around":[19],"time":[21,345],"calving,":[23],"and":[24,40,45,79,170,211,225,254,271,333],"early":[26,77,126,341],"lactation.":[27,127],"Strategies":[28],"for":[29,63,91,215,250,256,288],"controlling":[30],"S.":[31,68,86,123,131,219,231,295,325,353],"have":[34],"not":[35],"received":[36],"adequate":[37],"research":[38],"attention":[39],"are":[41,349],"therefore":[42],"poorly":[43],"defined":[44,199],"inadequate.":[46],"Objectives":[47],"present":[50],"study":[51],"were":[52,141,235,266],"to":[53,80,144,302,352],"evaluate":[54,81],"efficacy":[56,94,99,265,339],"extended":[58,101,305],"therapy":[59,104,285,306],"regimens":[60,105,151],"with":[61,122,130,152,209,244,307],"pirlimycin":[62,102,181,191,210,246,308],"treatment":[64,150,273,290],"experimentally":[66,137,202],"induced":[67],"intramammary":[70,103,194,233,355],"infections":[71,234],"lactating":[73],"lactation":[78,342],"usefulness":[83],"experimental":[88,120,327],"infection":[89,328],"model":[90,329],"evaluating":[92,337],"antimicrobial":[93,338],"cows.":[97],"The":[98,275,324],"was":[106,182,198,207,212,291,299,330],"investigated":[107],"103":[109],"mammary":[110,139,161,204,347],"glands":[111,140,348],"68":[113],"that":[116,206,304],"became":[117],"infected":[118,129,203,241],"following":[119,284],"challenge":[121],"Cows":[128],"one":[134],"or":[135],"both":[136],"challenged":[138],"randomly":[142],"allocated":[143],"three":[145,148],"groups,":[146,180],"representing":[147],"different":[149],"pirlimycin,":[153],"including":[154],"2-day":[155,247,270,322],"(n":[156,164,172],"=":[157,165,173],"21":[158,166],"cows,":[159,167,175],"31":[160],"quarters),":[162,169],"5-day":[163,252],"32":[168],"8-day":[171,258,272],"26":[174],"40":[176],"quarters).":[177],"For":[178],"all":[179],"administered":[183],"at":[184,221,343],"a":[185,311,331,344],"rate":[186],"50":[188],"mg":[189],"hydrochloride":[192],"via":[193],"infusion.":[195],"A":[196],"cure":[197],"as":[200],"gland":[205],"treated":[208,243],"bacteriologically":[213],"negative":[214],"presence":[217],"7,":[222],"14,":[223],"21,":[224],"28":[226],"days":[227],"after":[228],"treatment.":[229,323],"Experimental":[230],"eliminated":[236],"58.1%":[238],"quarters":[242,287],"regimen,":[248,253],"68.8%":[249],"80.0%":[255],"regimen.":[259],"Significant":[260],"differences":[261],"(P":[262],"<.05)":[263],"observed":[267],"between":[268],"regimens.":[274],"number":[276],"somatic":[278,315],"cells":[279],"milk":[281,319],"decreased":[282],"significantly":[283],"which":[289],"successful":[292],"eliminating":[294],"uberis.":[296],"However,":[297],"there":[298],"no":[300],"evidence":[301],"suggest":[303],"resulted":[309],"greater":[312],"reduction":[313],"cell":[316],"counts":[317],"than":[320],"rapid":[332],"effective":[334],"means":[335],"when":[346],"highly":[350],"susceptible":[351],"infection.":[356]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}