{"id":"https://openalex.org/W90233174","doi":null,"title":"Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C.","display_name":"Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C.","publication_year":2005,"publication_date":"2005-03-01","ids":{"openalex":"https://openalex.org/W90233174","mag":"90233174","pmid":"https://pubmed.ncbi.nlm.nih.gov/15816478"},"language":"en","primary_location":{"id":"pmid:15816478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Fumiaki Kimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286968","display_name":"Tamano Hospital","ror":"https://ror.org/03q4pc925","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405262307","https://openalex.org/I4405286968"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiaki Kimura","raw_affiliation_strings":["Department of Internal Medicine, Tamano-Municipal Hospital, Tamano City, Okayama, Japan. f-kimura@po1.oninet.ne.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tamano-Municipal Hospital, Tamano City, Okayama, Japan. f-kimura@po1.oninet.ne.jp","institution_ids":["https://openalex.org/I4405286968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084410022","display_name":"Hisao Hayashi","orcid":"https://orcid.org/0000-0002-4934-2656","observed_orcids":["https://orcid.org/0000-0002-4934-2656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisao Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017158756","display_name":"Motoyoshi Yano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motoyoshi Yano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kentaro Yoshioka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kentaro Yoshioka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058170028","display_name":"Tadashi Matsumura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadashi Matsumura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056020393","display_name":"Tomoko Fukuda","orcid":"https://orcid.org/0009-0002-8260-1098","observed_orcids":["https://orcid.org/0009-0002-8260-1098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoko Fukuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077226376","display_name":"Nobuyuki Shigeto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuyuki Shigeto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848874","display_name":"Shigehiro Yamahara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigehiro Yamahara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071191278","display_name":"Fukada Koushi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fukada Koushi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuo Mishima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuo Mishima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108362129","display_name":"Tadashi Yoshino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadashi Yoshino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977970","display_name":"Mitsune Tanimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitsune Tanimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100921971","display_name":"Ikuro Kimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikuro Kimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9694,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76242865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"52","issue":"62","first_page":"563","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.7896000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.17499999701976776,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.996999979019165},{"id":"https://openalex.org/keywords/phlebotomy","display_name":"phlebotomy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/low-iron-diet","display_name":"low-iron diet","score":0.925000011920929},{"id":"https://openalex.org/keywords/iron-induced-oxidative-stress","display_name":"iron-induced oxidative stress","score":0.7059999704360962},{"id":"https://openalex.org/keywords/serum-ferritin","display_name":"serum ferritin","score":0.9079999923706055},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/iron-intake","display_name":"iron intake","score":0.8989999890327454},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2777357209","wikidata":"https://www.wikidata.org/wiki/Q3595842","display_name":"Phlebotomy","level":2,"score":0.9916561841964722},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6993785500526428},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.5349916815757751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5188837647438049},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.46415767073631287},{"id":"https://openalex.org/C2779875672","wikidata":"https://www.wikidata.org/wiki/Q2537479","display_name":"Serum iron","level":3,"score":0.4545605778694153},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.43635040521621704},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4067080318927765},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.35954946279525757},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2647022008895874},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07919743657112122}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018962","descriptor_name":"Phlebotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019266","descriptor_name":"Iron, Dietary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15816478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepato-gastroenterology","raw_type":"Clinical Trial"},{"id":"mag:90233174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15816478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987797969","https://openalex.org/W25378787","https://openalex.org/W2416441627","https://openalex.org/W2145445855","https://openalex.org/W2031430809","https://openalex.org/W2170760996","https://openalex.org/W2320253548","https://openalex.org/W2062658684","https://openalex.org/W2010543223","https://openalex.org/W2088877812"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Iron-induced":[1],"oxidative":[2,244],"stress":[3,245],"plays":[4],"an":[5,252],"important":[6],"role":[7],"in":[8,42,62,83,128,178,190,201,222,255],"the":[9,32,45,48,79,214],"pathogenesis":[10],"of":[11,51,81,142,155,213],"chronic":[12,92,260],"hepatitis":[13,93,261],"C.":[14,262],"Both":[15],"phlebotomy":[16,52,82,100,114,237],"for":[17,26,149,259],"removing":[18],"body":[19],"iron":[20,24,29,55,75,84,112,138,156,220,249,256],"stores":[21],"and":[22,53,131,181,246],"low":[23,54,74,111,137,248],"diet":[25,56,76,139,160,250],"minimizing":[27],"portal":[28],"supply":[30],"to":[31,37,70,172,184,229],"liver":[33],"have":[34,57],"been":[35,60],"shown":[36],"improve":[38,78],"serum":[39,122],"transaminase":[40],"levels":[41,124,166,195],"patients":[43,89,96,106],"with":[44,91,99,109],"disease.":[46],"However,":[47],"cooperative":[49],"effects":[50],"not":[58,240],"yet":[59],"elucidated":[61],"detail.":[63],"METHODOLOGY:":[64],"A":[65,130,180,203],"pilot":[66],"study":[67],"was":[68,118,147,225],"undertaken":[69],"investigate":[71],"whether":[72],"a":[73,110,136,209,247],"could":[77],"efficacy":[80],"reduction":[85,257],"therapy.":[86],"Of":[87],"21":[88],"diagnosed":[90],"C,":[94],"10":[95,126],"were":[97,107,167,198],"treated":[98,108],"alone":[101,238],"(group":[102,115],"A)":[103],"while":[104],"11":[105],"plus":[113],"B).":[116],"Phlebotomy":[117],"repeated":[119],"biweekly":[120],"until":[121],"ferritin":[123],"reached":[125],"ng/mL":[127],"both":[129],"B":[132,224],"groups.":[133],"In":[134],"addition,":[135],"(iron":[140],"intake":[141,157,221],"8":[143],"mg/day":[144],"or":[145],"less)":[146],"recommended":[148],"group":[150,179,191,202,223],"B,":[151],"followed":[152],"by":[153],"estimation":[154],"from":[158,170,182,227],"daily":[159],"records.":[161],"RESULTS:":[162],"Serum":[163],"alanine":[164],"aminotransferase":[165],"significantly":[168,199],"improved":[169],"106+/-30":[171],"68+/-22":[173],"IU/L":[174,186],"(p<0.005,":[175],"paired":[176,188],"t-test)":[177,189],"100+/-33":[183],"46+/-10":[185],"(p<0.002,":[187],"B.":[192],"The":[193,217],"enzyme":[194,215],"after":[196],"treatment":[197],"higher":[200,210],"(p<0.02,":[204],"non-paired":[205],"t-test),":[206],"which":[207],"showed":[208],"upward":[211],"distribution":[212],"activity.":[216],"estimated":[218],"dietary":[219],"reduced":[226],"17.6+/-6.1":[228],"8.2+/-3.7":[230],"mg/day.":[231],"CONCLUSIONS:":[232],"These":[233],"findings":[234],"suggest":[235],"that":[236],"does":[239],"completely":[241],"remove":[242],"iron-induced":[243],"induces":[251],"additional":[253],"effect":[254],"therapy":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}