{"id":"https://openalex.org/W901049929","doi":"https://doi.org/10.1371/journal.pone.0133219","title":"Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer","display_name":"Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer","publication_year":2015,"publication_date":"2015-07-16","ids":{"openalex":"https://openalex.org/W901049929","doi":"https://doi.org/10.1371/journal.pone.0133219","mag":"901049929","pmid":"https://pubmed.ncbi.nlm.nih.gov/26181325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4504492"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0133219","doi":"https://doi.org/10.1371/journal.pone.0133219","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133219","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133219&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133219&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038157510","display_name":"James E. Korkola","orcid":"https://orcid.org/0000-0002-0030-6216","observed_orcids":["https://orcid.org/0000-0002-0030-6216"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Korkola","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035793503","display_name":"Eric Andrew Collisson","orcid":"https://orcid.org/0000-0001-8037-9388","observed_orcids":["https://orcid.org/0000-0001-8037-9388","https://orcid.org/0000-0002-2829-355X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Collisson","raw_affiliation_strings":["University of California San Francisco, Division of Heme/Onc, San Francisco, California, United States of America","Univ. of California San Francisco, San Francisco, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, Division of Heme/Onc, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Univ. of California San Francisco, San Francisco, CA (United States)","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084824340","display_name":"Laura M. Heiser","orcid":"https://orcid.org/0000-0003-3330-0950","observed_orcids":["https://orcid.org/0000-0003-3330-0950"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Heiser","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078786746","display_name":"Chris J. Oates","orcid":"https://orcid.org/0000-0002-4444-8603","observed_orcids":["https://orcid.org/0000-0002-4444-8603"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]},{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Chris Oates","raw_affiliation_strings":["Netherlands Cancer Institute, Division of Biochemistry, Amsterdam, The Netherlands; University of Warwick, Centre for Complexity Science, Coventry, United Kingdom","Netherlands Cancer Institute, Amsterdam (The Netherlands)","Univ. of Warwick, Coventry (United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Cancer Institute, Division of Biochemistry, Amsterdam, The Netherlands; University of Warwick, Centre for Complexity Science, Coventry, United Kingdom","institution_ids":["https://openalex.org/I2898336195","https://openalex.org/I39555362"]},{"raw_affiliation_string":"Netherlands Cancer Institute, Amsterdam (The Netherlands)","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Univ. of Warwick, Coventry (United Kingdom)","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601122","display_name":"Nora Bayani","orcid":"https://orcid.org/0009-0008-7809-7822","observed_orcids":["https://orcid.org/0009-0008-7809-7822"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora Bayani","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112008118","display_name":"Sleiman M. Itani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sleiman Itani","raw_affiliation_strings":["University of California, Berkeley, Department of Electrical Engineering and Computer Sciences, Berkeley, California, United States of America","Univ. of California, Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Berkeley, Department of Electrical Engineering and Computer Sciences, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Univ. of California, Berkeley, CA (United States)","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087541423","display_name":"Amanda M. Esch","orcid":"https://orcid.org/0000-0002-4355-7162","observed_orcids":["https://orcid.org/0000-0002-4355-7162"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Esch","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042879883","display_name":"Wallace Thompson","orcid":"https://orcid.org/0000-0002-5179-6307","observed_orcids":["https://orcid.org/0000-0002-5179-6307"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wallace Thompson","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001076376","display_name":"Obi L. Griffith","orcid":"https://orcid.org/0000-0002-0843-4271","observed_orcids":["https://orcid.org/0000-0002-0843-4271","https://orcid.org/0000-0002-6388-446X"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Obi L. Griffith","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115591111","display_name":"Nicholas J. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Wang","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109962841","display_name":"Wen Lin Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Lin Kuo","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Cooper","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065418957","display_name":"Jessica I. Billig","orcid":"https://orcid.org/0000-0002-7586-6306","observed_orcids":["https://orcid.org/0000-0002-7586-6306"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Billig","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082653095","display_name":"Safiyyah Ziyad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Safiyyah Ziyad","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004609947","display_name":"Jenny L. Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny L. Hung","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063399929","display_name":"Lakshmi R. Jakkula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshmi Jakkula","raw_affiliation_strings":["Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032383367","display_name":"Heidi S. Feiler","orcid":"https://orcid.org/0000-0002-6580-3547","observed_orcids":["https://orcid.org/0000-0002-6580-3547"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Feiler","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America; Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America; Lawrence Berkeley National Laboratories, Life Sciences Division, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I165690674"]},{"raw_affiliation_string":"Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020581776","display_name":"Yiling Lu","orcid":"https://orcid.org/0000-0002-3662-2106","observed_orcids":["https://orcid.org/0000-0002-3662-2106"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiling Lu","raw_affiliation_strings":["MD Anderson Cancer Center, Department of Systems Biology, Houston, Texas, United States of America","MD Anderson Cancer Center, Houston, TX (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Department of Systems Biology, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX (United States)","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["MD Anderson Cancer Center, Department of Systems Biology, Houston, Texas, United States of America","MD Anderson Cancer Center, Houston, TX (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anderson Cancer Center, Department of Systems Biology, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"MD Anderson Cancer Center, Houston, TX (United States)","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044658654","display_name":"Paul T. Spellman","orcid":"https://orcid.org/0000-0002-4810-0022","observed_orcids":["https://orcid.org/0000-0002-4810-0022"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul T. Spellman","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045155646","display_name":"Claire Jennifer Tomlin","orcid":"https://orcid.org/0000-0003-3192-3185","observed_orcids":["https://orcid.org/0000-0003-3192-3185"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Tomlin","raw_affiliation_strings":["University of California, Berkeley, Department of Electrical Engineering and Computer Sciences, Berkeley, California, United States of America","Univ. of California, Berkeley, CA (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Berkeley, Department of Electrical Engineering and Computer Sciences, Berkeley, California, United States of America","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Univ. of California, Berkeley, CA (United States)","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112866063","display_name":"Sach Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Sach Mukherjee","raw_affiliation_strings":["Netherlands Cancer Institute, Division of Biochemistry, Amsterdam, The Netherlands","German Center for Neurodegenerative Diseases, Bonn (Germany)","Netherlands Cancer Institute, Amsterdam (The Netherlands)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Netherlands Cancer Institute, Division of Biochemistry, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, Bonn (Germany)","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Netherlands Cancer Institute, Amsterdam (The Netherlands)","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028899187","display_name":"Joe W. Gray","orcid":"https://orcid.org/0000-0001-9225-6756","observed_orcids":["https://orcid.org/0000-0001-9225-6756"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joe W. Gray","raw_affiliation_strings":["Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","Oregon Health Sciences Univ., Portland, OR (United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health Sciences University, Department of Biomedical Engineering, Portland, Oregon, United States of America","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Oregon Health Sciences Univ., Portland, OR (United States)","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5028899187"],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.1647,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.7555161,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"7","first_page":"e0133219","last_page":"e0133219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.8820000290870667},{"id":"https://openalex.org/keywords/akt-inhibitors","display_name":"AKT inhibitors","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gsk690693","display_name":"GSK690693","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/ribosomal-protein-s6-phosphorylation","display_name":"S6 phosphorylation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/her3-phosphorylation","display_name":"HER3 phosphorylation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/compensatory-signaling","display_name":"compensatory signaling","score":0.7059999704360962},{"id":"https://openalex.org/keywords/signaling-network-modeling","display_name":"signaling network modeling","score":0.5149999856948853},{"id":"https://openalex.org/keywords/skbr-3-cells","display_name":"SK-BR-3 cells","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7002202272415161},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4619380235671997},{"id":"https://openalex.org/C205606062","wikidata":"https://www.wikidata.org/wiki/Q5249645","display_name":"Decoupling (probability)","level":2,"score":0.4247910678386688},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4243677258491516},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4158819615840912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41149765253067017},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4097242057323456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3870874047279358},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.348505437374115},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33589017391204834},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08281385898590088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06888765096664429},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077341","descriptor_name":"Lapatinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003959","descriptor_name":"Diamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038601","descriptor_name":"Ribosomal Protein S6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038601","descriptor_name":"Ribosomal Protein S6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042361","descriptor_name":"Mammary Glands, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1371/journal.pone.0133219","doi":"https://doi.org/10.1371/journal.pone.0133219","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133219","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133219&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:26181325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26181325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4504492","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4504492/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:osti.gov:1212476","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1212476","pdf_url":"https://www.osti.gov/servlets/purl/1212476","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.8233","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.8233","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e9/a1/pone.0133219.PMC4504492.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:01e6b6cfbd714bc98c36f3440a8d060c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/01e6b6cfbd714bc98c36f3440a8d060c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 7, p e0133219 (2015)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt2c4652pn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2c4652pn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1485909","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Decoupling_of_the_PI3K_Pathway_via_Mutation_Necessitates_Combinatorial_Treatment_in_HER2_Breast_Cancer_/1485909","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:opus.lib.uts.edu.au:10453/117302","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10453/117302","pdf_url":null,"source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:pub.dzne.de:141393","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/search?p=id:%22DZNE-2020-07715%22","pdf_url":null,"source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE 10(7), e0133219 (2015). doi:10.1371/journal.pone.0133219","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:qt2c4652pn","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/2c4652pn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Collisson, Eric; Korkola, JE; Collisson, EA; Heiser, L; Oates, C; Bayani, N; \u00c2\u00a0et al.(2015). Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2c4652pn","raw_type":"article"},{"id":"doi:10.25405/ncl.34311402","doi":"https://doi.org/10.25405/ncl.34311402","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34311402","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34311402.v1","doi":"https://doi.org/10.25405/ncl.34311402.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34311402.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0133219","doi":"https://doi.org/10.1371/journal.pone.0133219","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0133219","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0133219&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3601695324","display_name":"Intratumor heterogeneity underlying treatment resistance in HER2+ breast tumors","funder_award_id":"U01CA195469","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4014392549","display_name":"Integrative signaling models to decipher complex cancer phenotypes","funder_award_id":"U01CA164720","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5241188568","display_name":"Targeted and global proteomic strategies for early breast cancer detection","funder_award_id":"U24CA126477","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5760277475","display_name":"Systems Biology of Collective Cell Decisions","funder_award_id":"P50GM107615","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7644078643","display_name":null,"funder_award_id":"SAC110012","funder_id":"https://openalex.org/F4320306141","funder_display_name":"Susan G. Komen for the Cure"},{"id":"https://openalex.org/G9000919045","display_name":"OHSU Knight Cancer Institute","funder_award_id":"P30CA069533","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G945509937","display_name":"Model-based predictions of responses RTK Pathway therapies","funder_award_id":"U54CA112970","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306141","display_name":"Susan G. Komen for the Cure","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320309233","display_name":"Oregon Health and Science University","ror":"https://ror.org/009avj582"},{"id":"https://openalex.org/F4320316999","display_name":"Prospect Creek Foundation","ror":"https://ror.org/05pnphj78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334223","display_name":"Knight Cancer Institute, Oregon Health and Science University","ror":"https://ror.org/002shna07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W901049929.pdf","grobid_xml":"https://content.openalex.org/works/W901049929.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W155933052","https://openalex.org/W235121939","https://openalex.org/W1579152647","https://openalex.org/W1797430954","https://openalex.org/W1989024286","https://openalex.org/W1991166678","https://openalex.org/W1997056190","https://openalex.org/W1999070116","https://openalex.org/W2017081079","https://openalex.org/W2020372547","https://openalex.org/W2050875658","https://openalex.org/W2060616543","https://openalex.org/W2061061337","https://openalex.org/W2069526613","https://openalex.org/W2089288294","https://openalex.org/W2093345318","https://openalex.org/W2097698108","https://openalex.org/W2101824720","https://openalex.org/W2106036365","https://openalex.org/W2109170986","https://openalex.org/W2109189228","https://openalex.org/W2110444464","https://openalex.org/W2126983941","https://openalex.org/W2137018685","https://openalex.org/W2139444209","https://openalex.org/W2142739240","https://openalex.org/W2142799999","https://openalex.org/W2149106642","https://openalex.org/W2149908785","https://openalex.org/W2150926065","https://openalex.org/W2151672555","https://openalex.org/W2155228605","https://openalex.org/W2160697532","https://openalex.org/W2162946128","https://openalex.org/W2318605753","https://openalex.org/W4301159569"],"related_works":["https://openalex.org/W7098905973","https://openalex.org/W1995130202","https://openalex.org/W2158936191","https://openalex.org/W3112290174","https://openalex.org/W2003043489","https://openalex.org/W2592536550","https://openalex.org/W2056427943","https://openalex.org/W2328450128","https://openalex.org/W3192884023","https://openalex.org/W2125235596"],"abstract_inverted_index":{"We":[0,24,59,79,141,190],"report":[1],"here":[2],"on":[3,101],"experimental":[4],"and":[5,18,30,35,41,124,150,219],"theoretical":[6],"efforts":[7],"to":[8,12,33,98,121,132,177,198],"determine":[9],"how":[10],"best":[11],"combine":[13],"drugs":[14],"that":[15,61,108,125,144,145,202,211,220],"inhibit":[16],"HER2":[17],"AKT":[19,37,210,217],"in":[20,43,69,75,82,85,117,135,154,180,186,244],"HER2(+)":[21,48,164],"breast":[22,49],"cancers.":[23],"accomplished":[25],"this":[26],"by":[27,115,229],"measuring":[28],"cellular":[29],"molecular":[31],"responses":[32],"lapatinib":[34,64,95,116,126,139,158,213,231,243],"the":[36,102,200,221],"inhibitors":[38],"(AKTi)":[39],"GSK690693":[40],"GSK2141795":[42],"a":[44,192],"panel":[45],"of":[46,63,148,163,209,215,223],"22":[47],"cancer":[50],"cell":[51,71,77,87,182,188],"lines":[52,72,88,183],"carrying":[53,170],"wild":[54],"type":[55],"or":[56,94,172],"mutant":[57],"PIK3CA.":[58],"observed":[60,179],"combinations":[62],"plus":[65],"AKTi":[66,93,97,128,160],"were":[67,111,175],"synergistic":[68],"HER2(+)/PIK3CA(mut)":[70,118,181],"but":[73,184],"not":[74,185,238],"HER2(+)/PIK3CA(wt)":[76,136,187],"lines.":[78,189],"measured":[80],"changes":[81],"phospho-protein":[83],"levels":[84,110,131],"15":[86],"after":[89],"treatment":[90],"with":[91,138,168,232],"lapatinib,":[92],"+":[96,127,159],"shed":[99],"light":[100],"underlying":[103],"signaling":[104,218],"dynamics.":[105],"This":[106,235],"revealed":[107],"p-S6RP":[109,130],"less":[112],"well":[113],"attenuated":[114],"cells":[119,123,137,156,166],"compared":[120],"HER2(+)/PIK3CAwt":[122],"reduced":[129],"those":[133,178],"achieved":[134],"alone.":[140],"also":[142],"found":[143],"compensatory":[146],"up-regulation":[147],"p-HER3":[149],"p-HER2":[151],"is":[152],"blunted":[153],"PIK3CA(mut)":[155],"following":[157],"treatment.":[161],"Responses":[162],"SKBR3":[165],"transfected":[167],"lentiviruses":[169],"control":[171],"PIK3CA(mut":[173],")sequences":[174],"similar":[176],"used":[191],"nonlinear":[193],"ordinary":[194],"differential":[195],"equation":[196],"model":[197],"support":[199],"idea":[201],"PIK3CA":[203,224],"mutations":[204,225],"act":[205],"as":[206],"downstream":[207,216],"activators":[208],"blunt":[212],"inhibition":[214],"effects":[222],"can":[226],"be":[227],"countered":[228],"combining":[230],"an":[233],"AKTi.":[234],"combination":[236],"does":[237],"confer":[239],"substantial":[240],"benefit":[241],"beyond":[242],"HER2+/PIK3CA(wt)":[245],"cells.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
