{"id":"https://openalex.org/W89875415","doi":null,"title":"Determination of the in vitro antidiabetic potential of a polyherbal commercial tea","display_name":"Determination of the in vitro antidiabetic potential of a polyherbal commercial tea","publication_year":2014,"publication_date":"2014-12-12","ids":{"openalex":"https://openalex.org/W89875415","mag":"89875415"},"language":"en","primary_location":{"id":"pmh:oai:repository.up.ac.za:2263/43216","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2263/43216","pdf_url":"http://hdl.handle.net/2263/43216","source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2263/43216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087153496","display_name":"V. Paddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"V. Paddy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087153496"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/antidiabetic-herbal-extract","display_name":"antidiabetic herbal extract","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hypoglycemic-activity","display_name":"hypoglycemic activity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/polyphenol-content","display_name":"polyphenol content","score":0.7300000190734863},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/yarrow","display_name":"yarrow","score":0.8560000061988831},{"id":"https://openalex.org/keywords/agathosma-betulina","display_name":"Agathosma betulina","score":0.9580000042915344},{"id":"https://openalex.org/keywords/salvia-officinalis","display_name":"Salvia officinalis","score":0.996999979019165},{"id":"https://openalex.org/keywords/taraxacum-officinale","display_name":"Taraxacum officinale","score":0.9919999837875366},{"id":"https://openalex.org/keywords/thyme","display_name":"thyme","score":1.0},{"id":"https://openalex.org/keywords/fenugreek","display_name":"fenugreek","score":0.996999979019165},{"id":"https://openalex.org/keywords/urtica-urens","display_name":"Urtica urens","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ea-hy926-cells","display_name":"EA.hy926 cells","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7811875343322754},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43920066952705383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36912673711776733},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3619638681411743},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3356427550315857},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32202839851379395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28590497374534607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1310136616230011}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.up.ac.za:2263/43216","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2263/43216","pdf_url":"http://hdl.handle.net/2263/43216","source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:89875415","doi":null,"is_oa":false,"landing_page_url":"https://repository.up.ac.za/handle/2263/43216","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.up.ac.za:2263/43216","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2263/43216","pdf_url":"http://hdl.handle.net/2263/43216","source":{"id":"https://openalex.org/S4306401870","display_name":"UpSpace Institutional Repository (University of Pretoria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I69552723","host_organization_name":"University of Pretoria","host_organization_lineage":["https://openalex.org/I69552723"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W89875415.pdf","grobid_xml":"https://content.openalex.org/works/W89875415.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W24971894","https://openalex.org/W32239657","https://openalex.org/W33937063","https://openalex.org/W145557346","https://openalex.org/W177352898","https://openalex.org/W199500174","https://openalex.org/W238746270","https://openalex.org/W255295199","https://openalex.org/W1500360861","https://openalex.org/W1535207151","https://openalex.org/W1540831188","https://openalex.org/W1557827154","https://openalex.org/W1570803478","https://openalex.org/W1602419707","https://openalex.org/W1620646435","https://openalex.org/W1659912652","https://openalex.org/W1764216613","https://openalex.org/W1771148581","https://openalex.org/W1941039829","https://openalex.org/W1963557257","https://openalex.org/W1963967729","https://openalex.org/W1964101504","https://openalex.org/W1964485476","https://openalex.org/W1964574198","https://openalex.org/W1965163005","https://openalex.org/W1965992526","https://openalex.org/W1966442649","https://openalex.org/W1966621383","https://openalex.org/W1968378561","https://openalex.org/W1973501052","https://openalex.org/W1974029411","https://openalex.org/W1975962913","https://openalex.org/W1978990715","https://openalex.org/W1979059320","https://openalex.org/W1979755400","https://openalex.org/W1980722911","https://openalex.org/W1981563855","https://openalex.org/W1983748529","https://openalex.org/W1986450451","https://openalex.org/W1986767591","https://openalex.org/W1986853688","https://openalex.org/W1987908785","https://openalex.org/W1989015885","https://openalex.org/W1990275174","https://openalex.org/W1990857181","https://openalex.org/W1991349795","https://openalex.org/W1993570389","https://openalex.org/W1994768802","https://openalex.org/W1997371591","https://openalex.org/W1998936301","https://openalex.org/W2001091071","https://openalex.org/W2001897889","https://openalex.org/W2001906066","https://openalex.org/W2003927233","https://openalex.org/W2005165301","https://openalex.org/W2009218598","https://openalex.org/W2010591549","https://openalex.org/W2011040053","https://openalex.org/W2012393267","https://openalex.org/W2012647565","https://openalex.org/W2012991711","https://openalex.org/W2013221532","https://openalex.org/W2014367025","https://openalex.org/W2015055160","https://openalex.org/W2015384877","https://openalex.org/W2017280433","https://openalex.org/W2018588779","https://openalex.org/W2019971469","https://openalex.org/W2020117101","https://openalex.org/W2020621217","https://openalex.org/W2021010709","https://openalex.org/W2022072520","https://openalex.org/W2027059985","https://openalex.org/W2027542963","https://openalex.org/W2028248571","https://openalex.org/W2029274443","https://openalex.org/W2033129984","https://openalex.org/W2034613428","https://openalex.org/W2036783743","https://openalex.org/W2037256135","https://openalex.org/W2037740057","https://openalex.org/W2039683651","https://openalex.org/W2041134161","https://openalex.org/W2042542708","https://openalex.org/W2042684610","https://openalex.org/W2044437167","https://openalex.org/W2044491937","https://openalex.org/W2045471667","https://openalex.org/W2046229036","https://openalex.org/W2047563190","https://openalex.org/W2048553024","https://openalex.org/W2052283577","https://openalex.org/W2052478159","https://openalex.org/W2053107720","https://openalex.org/W2054986712","https://openalex.org/W2055759795","https://openalex.org/W2056025726","https://openalex.org/W2064087129","https://openalex.org/W2064240173","https://openalex.org/W2066481661","https://openalex.org/W2067027699","https://openalex.org/W2067154070","https://openalex.org/W2067894486","https://openalex.org/W2070032192","https://openalex.org/W2071343451","https://openalex.org/W2071866695","https://openalex.org/W2072379206","https://openalex.org/W2073169399","https://openalex.org/W2074802228","https://openalex.org/W2077041474","https://openalex.org/W2078601501","https://openalex.org/W2080218238","https://openalex.org/W2081274536","https://openalex.org/W2083308882","https://openalex.org/W2083405476","https://openalex.org/W2084561741","https://openalex.org/W2086390170","https://openalex.org/W2088869790","https://openalex.org/W2090553974","https://openalex.org/W2092978093","https://openalex.org/W2094819420","https://openalex.org/W2095535884","https://openalex.org/W2097555085","https://openalex.org/W2097739170","https://openalex.org/W2101837743","https://openalex.org/W2103969285","https://openalex.org/W2105023135","https://openalex.org/W2105093768","https://openalex.org/W2106219777","https://openalex.org/W2109276468","https://openalex.org/W2109688740","https://openalex.org/W2110840270","https://openalex.org/W2111876001","https://openalex.org/W2113128881","https://openalex.org/W2115821311","https://openalex.org/W2123744385","https://openalex.org/W2126638108","https://openalex.org/W2126997806","https://openalex.org/W2130948593","https://openalex.org/W2131247432","https://openalex.org/W2133812072","https://openalex.org/W2138211788","https://openalex.org/W2145836790","https://openalex.org/W2147993882","https://openalex.org/W2150909814","https://openalex.org/W2152748192","https://openalex.org/W2154682611","https://openalex.org/W2155491243","https://openalex.org/W2157768596","https://openalex.org/W2158545474","https://openalex.org/W2158726425","https://openalex.org/W2159205789","https://openalex.org/W2159390865","https://openalex.org/W2162843198","https://openalex.org/W2163296198","https://openalex.org/W2163915523","https://openalex.org/W2165292984","https://openalex.org/W2171070739","https://openalex.org/W2182248926","https://openalex.org/W2182561175","https://openalex.org/W2185931545","https://openalex.org/W2218369502","https://openalex.org/W2386544756","https://openalex.org/W2414425146","https://openalex.org/W2468004658","https://openalex.org/W2474548418","https://openalex.org/W2514438731","https://openalex.org/W2592256582","https://openalex.org/W2607483098","https://openalex.org/W3202887155","https://openalex.org/W4253134632","https://openalex.org/W4365388753"],"related_works":["https://openalex.org/W2083761776","https://openalex.org/W3043660905","https://openalex.org/W3185898010","https://openalex.org/W7214446510","https://openalex.org/W1996526777","https://openalex.org/W4377985735","https://openalex.org/W2996834170","https://openalex.org/W2051929452","https://openalex.org/W1988217950","https://openalex.org/W3212687312"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"mellitus":[3],"(T2DM)":[4],"is":[5,19,32,658],"an":[6,13,706],"increasing":[7],"global":[8],"health":[9],"concern,":[10],"currently":[11],"affecting":[12],"estimated":[14],"382":[15],"million":[16],"individuals.":[17],"There":[18],"no":[20],"cure":[21],"for":[22,27,619],"T2DM":[23],"and":[24,29,81,91,121,138,153,167,208,227,234,259,275,294,305,348,370,451,592,598,626,634,641,709],"the":[25,70,151,189,200,249,267,279,357,363,375,383,392,403,410,414,439,444,449,490,543,546,565,583,620,646,652,701,714,721],"search":[26],"new":[28],"improved":[30],"treatments":[31],"ongoing.":[33],"Presently,":[34],"various":[35],"pharmacological":[36],"regimens":[37],"are":[38,51],"available":[39],"to":[40,54,68,353,438,564,636],"treat":[41,55],"T2DM,":[42,56],"but":[43,57],"with":[44,327],"varied":[45],"success.":[46],"Thousands":[47],"of":[48,64,84,145,180,196,202,240,282,284,291,331,362,374,418,425,454,473,492,545,553,567,586,595,623,631,638,648,655,673,703,713],"traditional":[49,683],"herbs":[50,127,665],"also":[52,315,488,510,572,601,659],"used":[53],"mainly":[58],"without":[59],"scientific":[60],"validation.":[61],"The":[62,141,157,171,194,218,238,288,323,341,406,470,550,678],"aim":[63],"this":[65,668,696],"study":[66,616,669,697],"was":[67,148,161,175,212,223,246,264,351,436,498,536,556,562],"assess":[69],"polyphenolic":[71,143,349,371],"content,":[72],"antioxidant":[73,159,173,303,329,346,368,632],"capacity,":[74],"as":[75,77,130,255,681,705],"well":[76],"in":[78,185,219,399,416,431,464,517,609,629,667,674],"vitro":[79,220,675,693],"toxicity":[80],"hypoglycaemic":[82,221,526],"activity":[83,160,174,222,229,263,304,347,369,430,483,513,544,566],"a":[85,335,396,432,458,477,518,574,603,660,682,688],"commercial":[86,445],"\u2018antidiabetic\u2019":[87],"tea":[88],"mixture":[89],"(Diabetea)":[90],"its":[92],"individual":[93,715],"constituents:":[94],"Achillea":[95],"millefolium":[96],"L.":[97,107,111,115,119,124],"(Yarrow),":[98],"Agathosma":[99],"betulina":[100,555],"Bartl.":[101],"&":[102],"Wendl.":[103],"(Buchu),":[104],"Salvia":[105],"officinalis":[106,110,277,296,507,600],"(Sage),":[108],"Taraxacum":[109],"(Dandelion),":[112],"Thymus":[113],"vulgaris":[114,274,293,475,625],"(Thyme),":[116],"Trigonella":[117],"foenum-graecum":[118,597],"(Fenugreek)":[120],"Urtica":[122],"urens":[123,313,427,456,657],"(Nettle).":[125],"\\nAll":[126],"were":[128,409],"tested":[129,385,666],"crude":[131],"extracts,":[132],"prepared":[133],"using":[134,150,163,188,214,230,248,266],"hot":[135],"water":[136],"(HW)":[137,314],"dichloromethane":[139],"(DCM).":[140],"total":[142],"content":[144,350],"each":[146,197],"extract":[147,198,424,472,523,552,571],"determined":[149,213,247],"Folin-Ciocalteau":[152],"aluminium":[154],"trichloride":[155],"methods.":[156,170],"non-cellular":[158],"assessed":[162,224],"2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic":[164],"acid":[165,232],"(ABTS)":[166],"1,1-diphenyl-2-picrylhydrazyl":[168],"(DPPH)":[169],"cell-based":[172,306,317],"measured":[176,265],"against":[177,225,484,558],"p-chloranil-induced":[178],"generation":[179,319],"reactive":[181],"oxygen":[182],"species":[183],"(ROS)":[184],"Ea.hy926":[186,205,339,407],"cells,":[187],"fluorescent":[190,271],"dye,":[191],"2',7'-dichlorfluorescein-diacetate":[192],"(DCFH-DA).":[193],"effect":[195,337],"on":[199,243,338,356],"viability":[201],"C2C12":[203,468,495,533,613],"myotubes,":[204,496,534],"endothelial":[206],"cells":[207,408],"human":[209],"lymphocytes":[210],"(HL)":[211],"sulforhodamine":[215],"B":[216],"(SRB).":[217],"\u03b1-amylase":[226,429,662],"\u03b1-glucosidase":[228,485,512,559],"3,5-dinitrosalicylic":[231],"(DNSA)":[233],"p-nitrophenyl-\u03b1-D-glucopyranoside":[235],"(p-NPG),":[236],"respectively.":[237],"type":[239,359],"inhibition":[241,441],"exerted":[242,442,670],"these":[244],"enzymes":[245],"Michaelis-Menten":[250],"enzyme":[251],"kinetics":[252],"model,":[253],"expressed":[254],"mixed,":[256],"competitive,":[257],"non-competitive":[258],"uncompetitive.":[260],"Glucose":[261],"uptake":[262,466,491,531,580,611],"2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)":[268],"amino]-2-deoxy-D-glucose":[269],"(2-NBDG)":[270],"analogue.":[272],"\\nT.":[273],"S.":[276,295,506,627],"had":[278,334,366,476],"highest":[280],"amount":[281],"polyphenols":[283],"all":[285],"extracts":[286,290,325,365,376,394,415,453,585,594,716],"tested.":[287],"HW":[289,404,450,471,522,570,593],"T.":[292,474,587,596,599,624],"showed":[297,395,573],"significant":[298,459,478,538,575,604,689],"(p":[299,320,460,479,500,514,539,576,605],"<":[300,321,378,461,480,515,540,577,606],"0.05)":[301,462,481,516,541,578,607],"cell-free":[302],"radical":[307],"scavenging":[308],"activity.":[309,581,677],"In":[310,390,650,692],"addition,":[311,651],"U.":[312,426,455,656],"limited":[316],"ROS":[318],"0.05).":[322],"Diabetea":[324,591,679,704],"presented":[326],"poor":[328],"activities,":[330],"which":[332,435,497,535,561],"some":[333,671,712],"pro-oxidant":[336],"cells.":[340],"positive":[342,547],"linear":[343],"relationship":[344],"between":[345],"shown":[352],"be":[354],"dependent":[355],"solvent":[358],"used.":[360],"All":[361,664],"DCM":[364,393,423,452,551,584],"low":[367],"content.":[372],"\\nNone":[373],"produced":[377],"50%":[379],"cell":[380,400,420],"density":[381,401],"at":[382],"concentrations":[384],"(1.3":[386],"-":[387],"20":[388],"\u03bcg/m\u2113).":[389],"general,":[391],"greater":[397],"decrease":[398],"than":[402,504,542,720],"extracts.":[405],"least":[411],"affected":[412],"by":[413,443,528,644],"terms":[417,630],"decreased":[419],"density.":[421],"\\nThe":[422],"inhibited":[428,511],"mixed":[433,519],"manner,":[434],"comparable":[437,563],"percentage":[440],"drug,":[446],"acarbose.":[447,568],"Both":[448],"caused":[457,489,602],"increase":[463,608],"glucose":[465,493,530,579,610],"into":[467,494,532,612],"myotubes.":[469,614],"inhibitory":[482],"(mixed).":[486],"It":[487],"significantly":[499],"<0.05)":[501],"more":[502,537,718],"active":[503,557],"insulin.":[505,549,649],"(DCM":[508],"extract)":[509],"manner.":[520],"Its":[521,569],"displayed":[524],"potent":[525,661],"potential":[527,622,635],"causing":[529],"control,":[548],"A.":[554,589],"(non-competitive),":[560],"Furthermore,":[582],"officinalis,":[588],"millefolium,":[590],"\\nThis":[615],"provides":[617],"evidence":[618],"antidiabetic":[621,676,690,707],"officianlis,":[628],"capacity":[633],"prevent":[637],"post-prandial":[639],"hyperglycaemia":[640,643],"alleviate":[642],"mimicking":[645],"action":[647],"organic":[653],"preparation":[654,708],"inhibitor.":[663],"form":[672],"mixture,":[680],"preparation,":[684],"did":[685],"not":[686,699],"have":[687],"capacity.":[691],"observations":[694],"from":[695],"do":[698],"support":[700],"use":[702],"reveal":[710],"that":[711],"prove":[717],"efficacious":[719],"herb":[722],"mixture.":[723]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}