{"id":"https://openalex.org/W8972033","doi":null,"title":"A rational approach to antioxidant therapy and vitamin E.","display_name":"A rational approach to antioxidant therapy and vitamin E.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W8972033","mag":"8972033","pmid":"https://pubmed.ncbi.nlm.nih.gov/15712759"},"language":"en","primary_location":{"id":"pmid:15712759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15712759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027717800","display_name":"Mark A. Hyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Hyman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031297075","display_name":"Joseph E. Pizzorno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Pizzorno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002820631","display_name":"Andrew Weil","orcid":"https://orcid.org/0000-0002-0377-7822","observed_orcids":["https://orcid.org/0000-0002-0377-7822"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Weil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6813,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62428956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"11","issue":"1","first_page":"14","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9959999918937683},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.6589999794960022},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.9649999737739563},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nutrient-bioavailability","display_name":"nutrient bioavailability","score":0.8579999804496765},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5759999752044678},{"id":"https://openalex.org/keywords/evidence-synthesis","display_name":"evidence synthesis","score":0.4819999933242798},{"id":"https://openalex.org/keywords/clinical-guidelines","display_name":"clinical guidelines","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.7466826438903809},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6042057275772095},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5041154623031616},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.49115845561027527},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.47741997241973877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37464433908462524},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3328290581703186},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2809222340583801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22632643580436707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11228454113006592}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15712759","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15712759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative therapies in health and medicine","raw_type":"Journal Article"},{"id":"mag:8972033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15712759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W109974915","https://openalex.org/W1593442063","https://openalex.org/W1922087192","https://openalex.org/W1940935006","https://openalex.org/W1948203460","https://openalex.org/W1986032173","https://openalex.org/W2008406860","https://openalex.org/W2037726433","https://openalex.org/W2040923416","https://openalex.org/W2042867381","https://openalex.org/W2059985362","https://openalex.org/W2063841251","https://openalex.org/W2067171545","https://openalex.org/W2069930390","https://openalex.org/W2084102521","https://openalex.org/W2090353544","https://openalex.org/W2097867305","https://openalex.org/W2134924827","https://openalex.org/W2136992691","https://openalex.org/W2139187233","https://openalex.org/W2147853742","https://openalex.org/W2154283765","https://openalex.org/W2155178079","https://openalex.org/W2209432090","https://openalex.org/W2214291492","https://openalex.org/W2324740040","https://openalex.org/W2326200998","https://openalex.org/W2328451703","https://openalex.org/W2329711941","https://openalex.org/W2334903440","https://openalex.org/W2597267452","https://openalex.org/W2598520882"],"related_works":["https://openalex.org/W2408427265","https://openalex.org/W2168249738","https://openalex.org/W1883852413","https://openalex.org/W2162462658","https://openalex.org/W2915007435","https://openalex.org/W2168934049","https://openalex.org/W6993113436","https://openalex.org/W4295548728","https://openalex.org/W3022615917","https://openalex.org/W6922547882"],"abstract_inverted_index":{"balance":[0],"is":[1,25,125],"protective,":[2],"and":[3,52,61,73,82,97,114,155,159,174,201,249,287],"if":[4],"so,":[5],"how":[6],"can":[7,122],"we":[8,121],"best":[9,26,120,128],"achieve":[10],"that":[11,24,102,212,231,244],"goal?":[12],"Nutrients,":[13],"in":[14,48,56,198,220,270,281,295],"general,":[15],"do":[16,124],"not":[17,111,181,217],"lend":[18],"themselves":[19],"to":[20,261],"a":[21,103,168],"research":[22,93],"design":[23,200],"suited":[27],"for":[28,251],"pharmacological":[29],"interventions":[30],"because,":[31],"unlike":[32],"pharmaceuticals,":[33],"nutrients":[34],"are":[35,44,215,275],"multi-functional":[36],"substances":[37],"built":[38],"into":[39,167],"our":[40],"evolutionary":[41],"design.":[42],"There":[43],"many":[45,187,267],"confounding":[46],"factors":[47],"any":[49],"randomized":[50,95,107,157,222],"trial":[51,109],"meta-analysis.":[53],"The":[54],"vagaries":[55],"individual":[57,80,205],"diets,":[58],"habits,":[59],"pre-clinical":[60],"clinical":[62,172],"disease,":[63],"genomic":[64],"diversity":[65],"of":[66,76,79,84,89,135,165,194,203,234,266,272],"SNPs":[67],"(single":[68],"nucleotide":[69],"polymorphisms),":[70],"the":[71,85,119,127,163,195,204,210,213,225,242,282,291,296],"bioavailability":[72],"biological":[74],"specificity":[75],"different":[77],"forms":[78],"nutrients,":[81,90],"selection":[83],"most":[86],"effective":[87],"combinations":[88],"make":[91],"nutritional":[92],"through":[94],"trials":[96,140,158,223],"metaanalyses":[98],"very":[99],"problematic.":[100],"Given":[101],"methodologically":[104],"sound,":[105],"definitive":[106],"placebo-controlled":[108],"has":[110],"been":[112],"done":[113],"may":[115,236,259],"never":[116],"be":[117],"done,":[118],"currently":[123],"take":[126],"available":[129],"evidence":[130,166],"from":[131,241],"basic":[132],"science,":[133],"studies":[134,268],"redox":[136],"status,":[137],"nutrient":[138],"levels,":[139],"with":[141,152,186,278,290],"clearly":[142],"measurable":[143],"intermediate":[144],"endpoints,":[145],"relevant":[146],"biomarkers,":[147],"gene":[148],"expression":[149],"analysis,":[150],"along":[151],"observational":[153],"data":[154,279,292],"large-scale":[156],"then":[160],"synthesize":[161],"all":[162],"points":[164],"biologically":[169],"plausible":[170],"theory,":[171],"guidelines":[173],"when":[175],"justified":[176],"public":[177],"policy.":[178],"This":[179,285],"was":[180],"done.":[182],"Meta-analysis":[183],"confronts":[184],"us":[185,230],"methodological":[188],"difficulties":[189],"including":[190],"publication":[191],"bias;":[192],"heterogeneity":[193],"trials;":[196],"variations":[197],"quality,":[199],"purpose":[202],"trials,":[206],"as":[207,209,253,255],"well":[208,254],"fact":[211,243],"findings":[214],"often":[216],"borne":[218],"out":[219],"later":[221],"on":[224,298],"same":[226,283],"subject.":[227],"LeLorier":[228],"admonishes":[229],"\u201cthe":[232],"popularity":[233],"meta-analysis":[235],"at":[237,276],"least":[238],"partly":[239],"come":[240],"it":[245],"makes":[246],"life":[247],"simpler":[248],"easier":[250],"reviewers":[252],"readers.":[256],"However,":[257],"oversimplification":[258,286],"lead":[260],"inappropriate":[262],"conclusions.\u201d":[263],"Furthermore,":[264],"conclusions":[265,288],"noted":[269],"abstracts":[271],"major":[273],"journals":[274],"odds":[277],"published":[280],"paper.":[284],"inconsistent":[289],"were":[293],"evident":[294],"recent-metanalysis":[297],"vitamin":[299],"E.":[300]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
