{"id":"https://openalex.org/W896726668","doi":"https://doi.org/10.1038/srep06501","title":"Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage","display_name":"Establishment of an experimental ferret ocular hypertension model for the analysis of central visual pathway damage","publication_year":2014,"publication_date":"2014-10-13","ids":{"openalex":"https://openalex.org/W896726668","doi":"https://doi.org/10.1038/srep06501","mag":"896726668","pmid":"https://pubmed.ncbi.nlm.nih.gov/25308730","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4194439"},"language":"en","primary_location":{"id":"doi:10.1038/srep06501","doi":"https://doi.org/10.1038/srep06501","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep06501","pdf_url":"https://www.nature.com/articles/srep06501.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep06501.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108450953","display_name":"Takashi Fujishiro","orcid":"https://orcid.org/0000-0003-2016-3264","observed_orcids":["https://orcid.org/0000-0003-2016-3264"]},"institutions":[{"id":"https://openalex.org/I4210149740","display_name":"Saitama Red Cross Hospital","ror":"https://ror.org/05j40pq70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210149740"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Fujishiro","raw_affiliation_strings":["Saitama Red Cross Hospital, Saitama, Japan","Ophthalmology, Saitama Red Cross Hospital, Chuoku kamiochiai 8-3-33, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama Red Cross Hospital, Saitama, Japan","institution_ids":["https://openalex.org/I4210149740"]},{"raw_affiliation_string":"Ophthalmology, Saitama Red Cross Hospital, Chuoku kamiochiai 8-3-33, Japan","institution_ids":["https://openalex.org/I4210149740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009861886","display_name":"Hiroshi Kawasaki","orcid":"https://orcid.org/0000-0002-2514-1497","observed_orcids":["https://orcid.org/0000-0002-2514-1497"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kawasaki","raw_affiliation_strings":["Kanazawa University, Kanazawa, Japan","Ophthalmology, Koritsu Showa Hospital, tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanazawa University, Kanazawa, Japan","institution_ids":["https://openalex.org/I10091056"]},{"raw_affiliation_string":"Ophthalmology, Koritsu Showa Hospital, tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053803582","display_name":"Makoto Aihara","orcid":"https://orcid.org/0000-0001-6810-0583","observed_orcids":["https://orcid.org/0000-0001-6810-0583"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Aihara","raw_affiliation_strings":["Shirato Eye Clinic, Tokyo, Japan","Ophthalmology, Univ of Tokyo, School of Medicine, Bunkyo\u2013Ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shirato Eye Clinic, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Ophthalmology, Univ of Tokyo, School of Medicine, Bunkyo\u2013Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077335496","display_name":"Tadashiro Saeki","orcid":"https://orcid.org/0009-0001-5641-0020","observed_orcids":["https://orcid.org/0009-0001-5641-0020"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashiro Saeki","raw_affiliation_strings":["Koritsu Showa Hospital, Tokyo, Japan","Molecular and Systems Neurobiology, University of Tokyo Graduate School of Medicine, tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koritsu Showa Hospital, Tokyo, Japan","institution_ids":[]},{"raw_affiliation_string":"Molecular and Systems Neurobiology, University of Tokyo Graduate School of Medicine, tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Reiko Ymagishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Ymagishi","raw_affiliation_strings":["University of Tokyo School of Medicine, Tokyo, Japan","Ophthalmology, Univ of Tokyo, School of Medicine, Bunkyo\u2013Ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tokyo School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Ophthalmology, Univ of Tokyo, School of Medicine, Bunkyo\u2013Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takuya Atarashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Atarashi","raw_affiliation_strings":["University of Tokyo School of Medicine, Tokyo, Japan","Department of Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-Ku, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tokyo School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-Ku, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069416560","display_name":"Chihiro Mayama","orcid":"https://orcid.org/0000-0002-4138-3568","observed_orcids":["https://orcid.org/0000-0002-4138-3568"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chihiro Mayama","raw_affiliation_strings":["University of Tokyo School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tokyo School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074724972","display_name":"Makoto Araie","orcid":"https://orcid.org/0000-0001-9025-3973","observed_orcids":["https://orcid.org/0000-0001-9025-3973"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Makoto Araie","raw_affiliation_strings":["Kanto Chuo Hospital, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanto Chuo Hospital, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074724972"],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.4383,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.7917079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"4","issue":"1","first_page":"6501","last_page":"6501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":0.734000027179718},{"id":"https://openalex.org/keywords/ferrets","display_name":"ferrets","score":0.7329999804496765},{"id":"https://openalex.org/keywords/lateral-geniculate-nucleus","display_name":"lateral geniculate nucleus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.9259999990463257},{"id":"https://openalex.org/keywords/aqueous-outflow-obstruction","display_name":"aqueous outflow obstruction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/elevated-intraocular-pressure","display_name":"intraocular pressure elevation","score":0.796999990940094},{"id":"https://openalex.org/keywords/optic-nerve-head-cupping","display_name":"optic nerve head cupping","score":0.9089999794960022},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.6859354972839355},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.47959983348846436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4262327551841736},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32931190729141235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22702118754386902},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.08740121126174927}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005829","descriptor_name":"Geniculate Bodies","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012165","descriptor_name":"Retinal Ganglion Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014795","descriptor_name":"Visual Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014855","descriptor_name":"Wallerian Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015348","descriptor_name":"Vision, Binocular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/srep06501","doi":"https://doi.org/10.1038/srep06501","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep06501","pdf_url":"https://www.nature.com/articles/srep06501.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3171088","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4194439","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4194439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4194439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:25308730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25308730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01288:0000258685","doi":null,"is_oa":true,"landing_page_url":"https://kanazawa-u.repo.nii.ac.jp/records/14336","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports","raw_type":"journal article"},{"id":"pmh:oai:kanazawa-u.repo.nii.ac.jp:00014336","doi":null,"is_oa":true,"landing_page_url":"https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=14336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400882","display_name":"Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I10091056","host_organization_name":"Kanazawa University","host_organization_lineage":["https://openalex.org/I10091056"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/srep06501","doi":"https://doi.org/10.1038/srep06501","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep06501","pdf_url":"https://www.nature.com/articles/srep06501.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7251035891","display_name":"Mechanisms of brain formation regulated by birth","funder_award_id":"25640032","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8792456652","display_name":"Mechanisms of brain formation in higher mammals","funder_award_id":"25290013","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W896726668.pdf","grobid_xml":"https://content.openalex.org/works/W896726668.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W823176817","https://openalex.org/W1486289153","https://openalex.org/W1574402411","https://openalex.org/W1596967638","https://openalex.org/W1664668314","https://openalex.org/W1964207930","https://openalex.org/W1968324173","https://openalex.org/W1970476186","https://openalex.org/W1973239499","https://openalex.org/W1979417655","https://openalex.org/W1981476685","https://openalex.org/W1987421719","https://openalex.org/W1987469308","https://openalex.org/W1990948719","https://openalex.org/W1995714700","https://openalex.org/W1999364724","https://openalex.org/W2013148589","https://openalex.org/W2020198518","https://openalex.org/W2021384712","https://openalex.org/W2023194277","https://openalex.org/W2025582291","https://openalex.org/W2032370326","https://openalex.org/W2036683334","https://openalex.org/W2046809027","https://openalex.org/W2051204481","https://openalex.org/W2052831082","https://openalex.org/W2068726997","https://openalex.org/W2077086374","https://openalex.org/W2078684091","https://openalex.org/W2079224601","https://openalex.org/W2085097624","https://openalex.org/W2091181665","https://openalex.org/W2091212002","https://openalex.org/W2095006109","https://openalex.org/W2111763193","https://openalex.org/W2130255482","https://openalex.org/W2135930638","https://openalex.org/W2154670208","https://openalex.org/W2161893149","https://openalex.org/W2166924457","https://openalex.org/W2170295734","https://openalex.org/W2172089648","https://openalex.org/W2395825980","https://openalex.org/W4210575144"],"related_works":["https://openalex.org/W3005553059","https://openalex.org/W2910951682","https://openalex.org/W2125959545","https://openalex.org/W820684139","https://openalex.org/W1968324173","https://openalex.org/W2025582291","https://openalex.org/W2069213374","https://openalex.org/W4246000436","https://openalex.org/W4229787811","https://openalex.org/W1486289153"],"abstract_inverted_index":{"Glaucoma":[0],"optic":[1,157],"neuropathy":[2],"(GON)":[3],"is":[4,86],"a":[5,107,187],"condition":[6],"where":[7],"pathogenic":[8],"intraocular":[9],"pressure":[10],"(IOP)":[11],"results":[12,24],"in":[13,25],"axonal":[14],"damage":[15,27,59,163],"following":[16],"retinal":[17],"ganglion":[18],"cell":[19],"(RGC)":[20],"death,":[21],"and":[22,44,49,54,66,137,161],"further":[23],"secondary":[26,193],"of":[28,52,57,79,115,149,156,164,195],"the":[29,42,47,55,120,135,147,150,168,183],"lateral":[30],"geniculate":[31],"nucleus":[32],"(LGN).":[33],"Therapeutic":[34],"targets":[35],"for":[36,102,141],"glaucoma":[37],"thus":[38],"focus":[39],"on":[40,99],"both":[41],"LGN":[43,58,165],"RGC.":[45],"However,":[46],"temporal":[48],"spatial":[50],"patterns":[51],"degeneration":[53,194],"mechanism":[56],"have":[60],"not":[61],"been":[62],"fully":[63],"elucidated.":[64],"Suitable":[65],"convenient":[67],"ocular":[68],"hypertension":[69],"(OH)":[70],"animal":[71],"models":[72],"with":[73,90,177],"binocular":[74,91],"vision":[75,92],"comparable":[76],"to":[77,110,123,133,191],"that":[78],"monkeys":[80],"are":[81],"strongly":[82],"needed.":[83],"The":[84],"ferret":[85,184],"relatively":[87],"small":[88],"mammal":[89],"like":[93],"humans":[94],"-":[95],"here":[96],"we":[97],"report":[98],"its":[100],"suitability":[101],"investigating":[103],"LGN.":[104,200],"We":[105,181],"developed":[106],"new":[108],"method":[109],"elevate":[111],"IOP":[112,138],"by":[113,174],"injection":[114],"cultured":[116,128],"conjunctival":[117,129],"cells":[118,130],"into":[119],"anterior":[121],"chamber":[122],"obstruct":[124],"aqueous":[125],"outflow.":[126],"Histologically,":[127],"successfully":[131],"proliferated":[132],"occlude":[134],"angle,":[136],"was":[139],"elevated":[140],"13":[142],"weeks":[143],"after":[144],"injection.":[145],"Macroscopically,":[146],"size":[148],"eye":[151,170],"gradually":[152],"expanded.":[153],"Subsequent":[154],"enlargement":[155],"nerve":[158],"head":[159],"cupping":[160],"atrophic":[162],"projected":[166],"from":[167],"OH":[169,189],"were":[171],"clearly":[172],"observed":[173],"anterograde":[175],"staining":[176],"cholera":[178],"toxin":[179],"B.":[180],"believe":[182],"may":[185],"be":[186],"promising":[188],"model":[190],"investigate":[192],"central":[196],"nervous":[197],"system":[198],"including":[199]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
