{"id":"https://openalex.org/W89638032","doi":null,"title":"Hypertonic saline resuscitation.","display_name":"Hypertonic saline resuscitation.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W89638032","mag":"89638032","pmid":"https://pubmed.ncbi.nlm.nih.gov/9816702"},"language":"en","primary_location":{"id":"pmid:9816702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090166605","display_name":"Michel Rocha Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"M Rocha e Silva","raw_affiliation_strings":["Research Division, Faculty of Medicine, University of S\u00e3o Paulo, Brazil. mrsilva@incor.usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Faculty of Medicine, University of S\u00e3o Paulo, Brazil. mrsilva@incor.usp.br","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090166605"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":1.4748,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.79635095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"58","issue":"4","first_page":"393","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertonic-saline","display_name":"hypertonic saline","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hemorrhagic-shock","display_name":"hemorrhagic shock","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/volume-expansion","display_name":"volume expansion","score":0.640999972820282},{"id":"https://openalex.org/keywords/hypernatremia","display_name":"hypernatremia","score":0.718999981880188},{"id":"https://openalex.org/keywords/hyperosmolarity","display_name":"hyperosmolarity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.5600000023841858},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6515304446220398},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6135916113853455},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5573253631591797},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5553304553031921},{"id":"https://openalex.org/C3017567848","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Hypertonic saline","level":2,"score":0.5495405197143555},{"id":"https://openalex.org/C2781309813","wikidata":"https://www.wikidata.org/wiki/Q1320276","display_name":"Hypovolemia","level":2,"score":0.5222204923629761},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.5177313685417175},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5078802704811096},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4976394474506378},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.497456818819046},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4915238320827484},{"id":"https://openalex.org/C2993864201","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen transport","level":3,"score":0.4653972089290619},{"id":"https://openalex.org/C117277713","wikidata":"https://www.wikidata.org/wiki/Q925744","display_name":"Tonicity","level":2,"score":0.45730334520339966},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.44302898645401},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.4305069148540497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4208727180957794},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.40027284622192383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18417510390281677},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010952","descriptor_name":"Plasma Substitutes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012462","descriptor_name":"Saline Solution, Hypertonic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9816702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"Journal Article"},{"id":"mag:89638032","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1497763706","https://openalex.org/W1518199423","https://openalex.org/W1582679003","https://openalex.org/W1902960727","https://openalex.org/W1965737875","https://openalex.org/W1979447888","https://openalex.org/W1980570225","https://openalex.org/W1983028895","https://openalex.org/W2057172189","https://openalex.org/W2072214664","https://openalex.org/W2117966002","https://openalex.org/W2124805870","https://openalex.org/W4320300849"],"related_works":["https://openalex.org/W52887516","https://openalex.org/W2164586945","https://openalex.org/W2249514431","https://openalex.org/W2464560133","https://openalex.org/W2308243015","https://openalex.org/W2386584569","https://openalex.org/W3120555281","https://openalex.org/W2049222172","https://openalex.org/W2431363703","https://openalex.org/W2135175115"],"abstract_inverted_index":{"Treatment":[0],"of":[1,17,49,74,85,91,113,154,159,185,187,201,212,220,251],"severe":[2,11],"hemorrhage":[3],"offers":[4],"few":[5],"theoretical":[6],"problems,":[7],"but":[8,38],"in":[9,20,58,127,240,266],"practice,":[10],"blood":[12,176,242],"loss":[13,90],"usually":[14],"occurs":[15],"out":[16],"hospital,":[18],"often":[19],"more":[21],"or":[22,214],"less":[23],"inaccessible":[24],"scenarios.":[25],"Controversy":[26],"rages":[27],"over":[28],"ideal":[29,31],"fluid,":[30,170],"volume,":[32],"and":[33,67,83,102,110,116,174,227,244,271],"minimum":[34],"O2":[35],"carrying":[36],"capacity,":[37],"all":[39],"agree":[40],"that":[41,63,223],"pre-hospital,":[42],"isotonic":[43],"resuscitation":[44],"is":[45,157],"unfeasible.":[46],"The":[47,72,182],"effects":[48,200,211],"highly":[50],"hypertonic":[51,202],"7.5%":[52],"NaCl":[53],"(HS)":[54],"was":[55],"first":[56,218],"described":[57],"1980,":[59],"when":[60,123],"we":[61],"showed":[62],"it":[64],"induced":[65],"immediate":[66],"long":[68,198],"lasting":[69,199],"hemodynamic":[70,92],"restoration.":[71],"addition":[73],"6%":[75],"dextran-70":[76],"to":[77,125,255,258],"(HSD)":[78],"significantly":[79],"enhances":[80],"the":[81,160,162,167,190,197,210],"duration":[82],"intensity":[84],"volume":[86,135,156,164],"expansion,":[87,136],"with":[88,120,189],"no":[89],"effects.":[93,232],"HS/HSD":[94],"restores":[95],"cardiac":[96,141,263,268],"output,":[97],"arterial":[98,241],"pressure,":[99],"base":[100],"excess":[101],"oxygen":[103],"availability,":[104],"induce":[105],"pre-capillary":[106],"vasodialtion,":[107],"moderate":[108],"hyperosmolarity":[109],"hypernatremia,":[111],"reversal":[112],"high":[114],"glucose":[115],"lactate.":[117],"It":[118],"interferes":[119],"endocrine":[121],"secretions":[122],"administered":[124],"animals":[126],"hemorrhagic":[128],"hypotension.":[129],"HS":[130],"acts":[131],"through":[132,145],"transient":[133],"plasma":[134],"positive":[137],"inotropic":[138],"effect":[139],"on":[140,149,209],"contractility,":[142],"precapillary":[143],"vasodilation":[144],"a":[146,245],"direct":[147],"action":[148],"vascular":[150],"smooth":[151],"muscle.":[152],"Expansion":[153],"circulating":[155],"part":[158],"mechanism,":[161],"extra":[163],"coming":[165],"from":[166,172,229],"intracellular":[168],"compartment":[169],"especially":[171],"endothelial":[173],"red":[175],"cells,":[177],"which":[178],"facilitate":[179],"microcirculatory":[180],"flow.":[181],"new":[183],"field":[184],"interactions":[186],"hypertonicity":[188],"immune":[191],"mechanisms":[192],"may":[193],"provide":[194],"insight":[195],"into":[196],"solutions.":[203],"Randomized":[204],"double":[205],"blind":[206],"prospective":[207],"studies":[208,234],"HS,":[213],"HSD,":[215],"used":[216],"as":[217,276,278],"treatment":[219],"shock":[221],"show":[222,235],"both":[224],"are":[225],"safe":[226],"free":[228],"collateral,":[230],"toxic":[231],"These":[233],"an":[236],"early":[237],"significant":[238],"rise":[239],"pressure":[243],"non-significant":[246],"trend":[247],"towards":[248],"higher":[249,267],"levels":[250],"survival.":[252],"HSD":[253],"administration":[254],"patients":[256],"about":[257],"undergo":[259],"cardiopulmonary":[260,274],"bypass":[261],"for":[262],"surgery":[264],"results":[265],"output":[269],"before,":[270],"immediately":[272],"following":[273],"bypass,":[275],"well":[277],"zero":[279],"fluid":[280],"balance.":[281]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}