{"id":"https://openalex.org/W8960120","doi":"https://doi.org/10.1096/fasebj.20.4.a168-a","title":"Obesity\u2010associated increases in acute phase protein expression and additive effects of leptin","display_name":"Obesity\u2010associated increases in acute phase protein expression and additive effects of leptin","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W8960120","doi":"https://doi.org/10.1096/fasebj.20.4.a168-a","mag":"8960120"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.20.4.a168-a","doi":"https://doi.org/10.1096/fasebj.20.4.a168-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a168-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075390136","display_name":"Natalie Stein","orcid":"https://orcid.org/0000-0003-1438-6875","observed_orcids":["https://orcid.org/0000-0003-1438-6875"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Jill Stein","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674930","display_name":"Hyojung Kim","orcid":"https://orcid.org/0000-0002-0827-6576","observed_orcids":["https://orcid.org/0000-0002-0827-6576"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyojung Kim","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074213441","display_name":"Kathleen Ann Hoag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Hoag","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 322 N. Kedzie Hall East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 322 N. Kedzie Hall East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074385583","display_name":"Janette M. Harkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janette Harkins","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 10 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 10 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007854905","display_name":"Nicholas Shroeder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Shroeder","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080431806","display_name":"Zahid Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahid Islam","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 227 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 227 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060677752","display_name":"James J. Pestka","orcid":"https://orcid.org/0000-0003-4689-2756","observed_orcids":["https://orcid.org/0000-0003-4689-2756"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Pestka","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 234a Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 234a Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034720305","display_name":"Gerd Bobe","orcid":"https://orcid.org/0000-0002-3129-5628","observed_orcids":["https://orcid.org/0000-0002-3129-5628"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerd Bobe","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 309 Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009516018","display_name":"Kate Claycombe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Claycombe","raw_affiliation_strings":["Food Science and Human Nutrition Michigan State University 302a Trout Building East Lansing Michigan 48824"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Michigan State University 302a Trout Building East Lansing Michigan 48824","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I87216513"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00113196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.8799999952316284},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.671999990940094},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.8629999756813049},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8669999837875366},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9298524856567383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8726948499679565},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8540918231010437},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.7323505878448486},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.5542277693748474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5479998588562012},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.533049464225769},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5178658962249756},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4951404631137848},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4453936219215393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29766032099723816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.20.4.a168-a","doi":"https://doi.org/10.1096/fasebj.20.4.a168-a","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.20.4.a168-a","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001293285","https://openalex.org/W2006584817","https://openalex.org/W2081445536","https://openalex.org/W2182158982","https://openalex.org/W2165626579","https://openalex.org/W2053591203","https://openalex.org/W2102993471","https://openalex.org/W2019361383","https://openalex.org/W2146797036","https://openalex.org/W2152640194"],"abstract_inverted_index":{"Inflammation":[0],"is":[1],"key":[2],"in":[3,39,69,122,165],"obesity\u2010associated":[4,37],"cardiovascular":[5],"disease":[6],"(CVD)":[7],"development.":[8],"The":[9],"obese":[10,50,80],"have":[11],"higher":[12],"serum":[13,27,64,102,139],"leptin":[14,40,68,78,91,111,145,152,158],"(an":[15],"inflammatory":[16],"factor)":[17],"and":[18,26,44,55,67,86,89,104,119,141,143,157,175],"the":[19,132],"acute":[20],"phase":[21],"factors":[22],"C\u2010reactive":[23],"protein":[24],"(CRP)":[25],"amyloid":[28],"A":[29],"(SAA)":[30],"than":[31,71],"lean":[32,56,72,109],"counterparts.":[33],"We":[34,61],"hypothesized":[35],"that":[36],"increases":[38],"levels":[41],"increase":[42,148],"CRP":[43,85,103,118,174],"SAA":[45,87,105,120,176],"expression":[46],"by":[47,170,177],"using":[48],"diet\u2010induced":[49],"(DIO;":[51],"60%":[52],"fat":[53,58],"diet)":[54,59],"(10%":[57],"mice.":[60,73],"found":[62,144],"increased":[63,84,93,101,117,153],"CRP,":[65,155],"SAA,":[66,156],"DIO":[70],"Next,":[74],"we":[75,137],"tested":[76],"whether":[77,90],"deficient":[79],"(ob/ob)":[81],"mice":[82,99,115,124,128],"had":[83,100],"levels,":[88,150],"further":[92,116],"concentrations":[94,106,121],"of":[95,134,173],"these":[96,149],"proteins.":[97],"Ob/ob":[98],"compared":[107],"to":[108,113],"mice;":[110],"administration":[112],"ob/ob":[114,123,127],"over":[125],"saline\u2010injected":[126],"(P<0.05).":[129],"To":[130],"find":[131],"mechanism":[133],"CRP/SAA":[135],"increases,":[136],"measured":[138],"IL\u20101B":[140],"IL\u20106":[142],"does":[146],"not":[147],"but":[151],"hepatic":[154],"signaling":[159],"intermediates":[160],"(JAK\u20102).":[161],"Increased":[162],"CVD":[163],"risk":[164],"obesity":[166],"may":[167],"be":[168],"mediated":[169],"direct":[171],"upregulation":[172],"leptin.":[178]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}