{"id":"https://openalex.org/W89532013","doi":null,"title":"Enhanced production of gamma-interferon by thyroid-derived T cell clones from patients with Hashimoto's thyroiditis.","display_name":"Enhanced production of gamma-interferon by thyroid-derived T cell clones from patients with Hashimoto's thyroiditis.","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W89532013","mag":"89532013","pmid":"https://pubmed.ncbi.nlm.nih.gov/3115656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1542409"},"language":"en","primary_location":{"id":"pmid:3115656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3115656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542409/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019182116","display_name":"G. Prete","orcid":"https://orcid.org/0000-0001-6659-5607","observed_orcids":["https://orcid.org/0000-0001-6659-5607"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G F Del Prete","raw_affiliation_strings":["Cattedra di Allergologia e Immunologia Clinica, University of Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cattedra di Allergologia e Immunologia Clinica, University of Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034765164","display_name":"Antonio Tiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Tiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012861031","display_name":"Stefano Mariotti","orcid":"https://orcid.org/0000-0002-1208-7057","observed_orcids":["https://orcid.org/0000-0002-1208-7057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Mariotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014279456","display_name":"Aldo Pinchera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pinchera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063250044","display_name":"M Ricci","orcid":"https://orcid.org/0009-0001-9982-0441","observed_orcids":["https://orcid.org/0009-0001-9982-0441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ricci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110061228","display_name":"Sergio Romagnani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Romagnani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9583,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.93857518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"69","issue":"2","first_page":"323","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.17599999904632568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hashimoto-s-thyroiditis","display_name":"Hashimoto's thyroiditis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/t-cell-clones","display_name":"T cell clones","score":0.8550000190734863},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/thyroid-autoimmunity","display_name":"thyroid autoimmunity","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6784663200378418},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6060584187507629},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.5828732252120972},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5738059878349304},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.5648114681243896},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5274401307106018},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.44222456216812134},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4308927655220032},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.42725950479507446},{"id":"https://openalex.org/C2776180460","wikidata":"https://www.wikidata.org/wiki/Q6046491","display_name":"Interferon type II","level":4,"score":0.41356760263442993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3964834213256836},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39291563630104065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38064631819725037},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3721495270729065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3510279357433319},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2842794358730316},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1607443392276764},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.12176051735877991},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12017425894737244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:3115656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3115656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1542409","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542409/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmh:oai:flore.unifi.it:2158/344568","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/344568","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unica.it:11584/36561","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11584/36561","pdf_url":null,"source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:89532013","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3115656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1542409","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1542409/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W155421318","https://openalex.org/W194427280","https://openalex.org/W1498199553","https://openalex.org/W1930066950","https://openalex.org/W1979560589","https://openalex.org/W1981028029","https://openalex.org/W1982125977","https://openalex.org/W1982643652","https://openalex.org/W2005588999","https://openalex.org/W2021847833","https://openalex.org/W2027274130","https://openalex.org/W2028064181","https://openalex.org/W2032948393","https://openalex.org/W2039272795","https://openalex.org/W2046401733","https://openalex.org/W2056440486","https://openalex.org/W2059168808","https://openalex.org/W2083324894","https://openalex.org/W2155803319","https://openalex.org/W2398147021","https://openalex.org/W2418570547"],"related_works":["https://openalex.org/W839657109","https://openalex.org/W2145721468","https://openalex.org/W6991600076","https://openalex.org/W2237515560","https://openalex.org/W2007743654","https://openalex.org/W1976723934","https://openalex.org/W7018858766","https://openalex.org/W2002283128","https://openalex.org/W165601482","https://openalex.org/W2127568995"],"abstract_inverted_index":{"T":[0,34,68,139,273],"lymphocytes":[1,274],"from":[2,37,44,72,88,100,142,182,212],"thyroid":[3,101,143,168,222,237],"infiltrate":[4],"and":[5,29,43,96,133,144],"peripheral":[6],"blood":[7],"(PB)":[8],"of":[9,39,46,65,84,94,108,112,119,146,153,178,201,243,248,258,277,282],"four":[10,40],"patients":[11,113,215],"with":[12,114,156],"Hashimoto's":[13],"thyroiditis":[14],"(HT)":[15],"were":[16,50,205],"analysed":[17],"at":[18],"clonal":[19],"level":[20],"for":[21],"their":[22],"ability":[23],"to":[24,60,228,241,253,261,267],"secrete":[25],"interleukin":[26],"2":[27],"(IL-2)":[28],"gamma-interferon":[30],"(gamma-IFN).":[31],"As":[32],"controls,":[33],"cell":[35,69,140],"clones":[36,70,86,99,111,141,155,181,196,204,211,224,238],"PB":[38,145,184],"normal":[41,89,172],"donors":[42],"spleen":[45,173],"two":[47],"trauma":[48],"victims":[49],"used.":[51],"While":[52],"no":[53],"abnormality":[54],"was":[55,75,160,185,239],"found":[56],"in":[57,138,167,171,197,255,279],"the":[58,63,151,199,213,217,249,256,264,280],"capacity":[59],"produce":[61,229],"IL-2,":[62],"proportion":[64,107,177],"gamma-IFN-producing":[66],"(IFN-P)":[67],"derived":[71,87],"HT":[73,147],"infiltrates":[74,169],"significantly":[76,187],"higher":[77,117,162],"(P":[78,163,189],"less":[79,164,190],"than":[80,82,121,165,170,191],"0.0005)":[81,166],"that":[83,242],"IFN-P":[85,98,154,179,202,209],"or":[90,174],"patient":[91,183],"PB.":[92,175],"Most":[93],"CD4+":[95,109,218],"CD8+":[97],"infiltrates,":[102],"as":[103,105],"well":[104],"a":[106],"PB-derived":[110,208],"HT,":[115],"released":[116],"amounts":[118],"gamma-IFN":[120,131,233,254,268],"control":[122,244],"clones.":[123,245],"A":[124],"relationship":[125],"could":[126,225],"be":[127,226,276],"demonstrated":[128],"between":[129],"high":[130],"production":[132],"natural":[134],"killer":[135],"(NK)":[136],"activity":[137],"patients.":[148],"In":[149,246],"fact,":[150],"percentage":[152],"NK":[157],"potential":[158,266],"(NK+)":[159],"remarkably":[161],"The":[176],"NK+":[180,203,210,223],"also":[186],"increased":[188],"0.02)":[192],"but,":[193],"unlike":[194],"thyroid-derived":[195],"which":[198],"majority":[200],"CD8+,":[206],"most":[207],"same":[214],"expressed":[216],"phenotype.":[219],"Almost":[220],"all":[221],"triggered":[227],"more":[230],"gamma-IFN,":[231],"while":[232],"synthesis":[234],"by":[235,271],"NK-negative":[236],"comparable":[240],"view":[247],"multiple":[250],"effects":[251],"ascribed":[252],"cascade":[257],"events":[259],"leading":[260],"immune":[262],"responses,":[263],"abnormal":[265],"secretion":[269],"shown":[270],"intrathyroidal":[272],"may":[275],"importance":[278],"pathogenesis":[281],"autoimmune":[283],"thyroiditis.":[284]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
