{"id":"https://openalex.org/W895265406","doi":null,"title":"The Effects of SNAP-25 Deficits and Pre-Natal Nicotine in a Mouse and ADHD Model","display_name":"The Effects of SNAP-25 Deficits and Pre-Natal Nicotine in a Mouse and ADHD Model","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W895265406","mag":"895265406"},"language":"en","primary_location":{"id":"pmh:oai:digitalrepository.unm.edu:ume-research-papers-1051","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/ume-research-papers/52","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1051&context=ume-research-papers","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Medical Student Research","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1051&context=ume-research-papers","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016576452","display_name":"Jarrod Adcock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jarrod Adcock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047266715","display_name":"Michaela Haney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Haney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047804131","display_name":"Dwight James Leonard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dwight James Leonard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026143344","display_name":"Andrea M. Allan","orcid":"https://orcid.org/0000-0002-6745-4352","observed_orcids":["https://orcid.org/0000-0002-6745-4352"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea M. Allan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6745-4352","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.7778000235557556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":0.15809999406337738,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snap-25","display_name":"SNAP-25","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prenatal-nicotine-exposure","display_name":"prenatal nicotine exposure","score":0.765999972820282},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.972000002861023},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.5059999823570251},{"id":"https://openalex.org/keywords/substance-abuse","display_name":"substance abuse","score":0.6769999861717224},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.7559999823570251},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8199999928474426},{"id":"https://openalex.org/keywords/genetic-predisposition-to-addiction","display_name":"genetic predisposition to addiction","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2779997099","wikidata":"https://www.wikidata.org/wiki/Q7547253","display_name":"Snap","level":2,"score":0.8295145630836487},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6968916058540344},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.453517347574234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3891286551952362},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3755534887313843},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3630671501159668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.335978627204895},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18605387210845947},{"id":"https://openalex.org/C121684516","wikidata":"https://www.wikidata.org/wiki/Q7600677","display_name":"Computer graphics (images)","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalrepository.unm.edu:ume-research-papers-1051","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/ume-research-papers/52","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1051&context=ume-research-papers","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Medical Student Research","raw_type":"text"},{"id":"mag:895265406","doi":null,"is_oa":false,"landing_page_url":"http://repository.unm.edu/handle/1928/9737","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalrepository.unm.edu:ume-research-papers-1051","doi":null,"is_oa":true,"landing_page_url":"https://digitalrepository.unm.edu/ume-research-papers/52","pdf_url":"https://digitalrepository.unm.edu/cgi/viewcontent.cgi?article=1051&context=ume-research-papers","source":{"id":"https://openalex.org/S4377196368","display_name":"UNM\u2019s Digital Repository (University of New Mexico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169521973","host_organization_name":"University of New Mexico","host_organization_lineage":["https://openalex.org/I169521973"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Medical Student Research","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W895265406.pdf","grobid_xml":"https://content.openalex.org/works/W895265406.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1566487806","https://openalex.org/W1730181129","https://openalex.org/W1908021040","https://openalex.org/W1919808289","https://openalex.org/W1966730781","https://openalex.org/W1985512462","https://openalex.org/W1994109896","https://openalex.org/W1994386017","https://openalex.org/W1995015234","https://openalex.org/W2006829255","https://openalex.org/W2028431671","https://openalex.org/W2037662228","https://openalex.org/W2083480808","https://openalex.org/W2098140414","https://openalex.org/W2136699448","https://openalex.org/W2156813023","https://openalex.org/W2171154298"],"related_works":["https://openalex.org/W4200514400","https://openalex.org/W2164976659","https://openalex.org/W3022384880","https://openalex.org/W7015158421","https://openalex.org/W2585893684","https://openalex.org/W2027221598","https://openalex.org/W2079013323","https://openalex.org/W2076353341","https://openalex.org/W2023085424","https://openalex.org/W2164234750"],"abstract_inverted_index":{"It":[0],"has":[1,64],"been":[2],"recognized":[3],"that":[4,66,77,94,119,208],"the":[5,21,32,55,67,82,103,141,194,199,222],"foundation":[6],"of":[7,31,60,73,196,201,228],"most,":[8],"if":[9,193],"not":[10],"all,":[11],"complex":[12],"disease":[13],"processes,":[14],"particularly":[15],"neuropsychiatric":[16,35],"disorders,":[17],"is":[18,48,71],"due":[19],"to":[20,38,81,87,102,108,127,134,162,191],"interactions":[22],"between":[23,143],"subtle":[24],"genetic":[25,61,83,89],"deficits":[26],"and":[27,44,105,110,145,158,168,217,231],"environmental":[28,45],"insults.":[29],"One":[30],"most":[33],"studied":[34],"disorders":[36],"shown":[37,65,93,118],"contribute":[39],"from":[40],"both":[41,227],"heritable-related":[42],"factors":[43,197],"stressor":[46],"sensitivity":[47],"Attention":[49],"Deficit":[50],"Hyperactivity":[51],"Disorder":[52],"(ADHD).":[53],"Of":[54],"heritable":[56],"issues":[57],"involved,":[58],"meta-analysis":[59],"linkage":[62],"studies":[63,91,116],"SNARE":[68],"protein":[69],"SNAP-25,":[70],"one":[72],"many":[74],"possible":[75],"proteins":[76],"may":[78],"provide":[79],"answers":[80],"component.":[84],"In":[85],"contrast":[86],"this":[88,173],"factor,":[90],"have":[92,117],"prenatal":[95,146,177,209],"nicotine":[96,109,128,147,160,170,178,210],"exposure":[97,126,148,161],"causes":[98],"a":[99],"direct":[100],"effect":[101],"fetus":[104],"predisposes":[106],"them":[107],"substance":[111,202,218],"abuse":[112,203,219],"behavior.":[113,220],"Finally,":[114],"preliminary":[115],"heterozygote":[120],"SNAP-25":[121,144,163,180,223],"deficient":[122],"mice":[123,156,166,182,212],"following":[124],"in-utero":[125],"are,":[129],"in":[130],"fact,":[131],"hyperactive":[132],"compared":[133,153],"their":[135,184],"wild":[136,154,164,185],"type":[137,155,165,186],"littermates.":[138],"To":[139],"study":[140,174],"relationship":[142],"with":[149,157,167,183,188],"locomotor":[150],"activity,":[151],"we":[152],"without":[159,169],"exposure.":[171],"Additionally,":[172],"also":[175],"examined":[176],"exposed":[179,211],"heterozygous":[181,224],"counterpart":[187],"intraperitoneal":[189],"cocaine":[190],"see":[192],"combination":[195],"increased":[198],"likelihood":[200],"potential.":[204],"The":[205],"results":[206],"demonstrated":[207,232],"had":[213],"greater":[214,233],"locomoter":[215],"activity":[216],"Moreover":[221],"genotype":[225],"compounded":[226],"these":[229],"affects":[230],"results.":[234]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}