{"id":"https://openalex.org/W89492054","doi":null,"title":"Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.","display_name":"Analysis of whole genomic expression profiles and screening of the key signaling pathways associated with pancreatic cancer.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W89492054","mag":"89492054","pmid":"https://pubmed.ncbi.nlm.nih.gov/22949936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3430114"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2437166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3430114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3430114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078180611","display_name":"Chengzhi He","orcid":"https://orcid.org/0000-0001-5013-0207","observed_orcids":["https://orcid.org/0000-0001-5013-0207"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengzhi He","raw_affiliation_strings":["Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440606","display_name":"Hua Jiang","orcid":"https://orcid.org/0009-0001-7606-273X","observed_orcids":["https://orcid.org/0009-0001-7606-273X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054999062","display_name":"Shasha Geng","orcid":"https://orcid.org/0000-0002-7443-1618","observed_orcids":["https://orcid.org/0000-0002-7443-1618"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shasha Geng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102754378","display_name":"Haihui Sheng","orcid":"https://orcid.org/0000-0003-1350-3769","observed_orcids":["https://orcid.org/0000-0003-1350-3769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haihui Sheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052768263","display_name":"Xiaoying Shen","orcid":"https://orcid.org/0000-0002-8387-3952","observed_orcids":["https://orcid.org/0000-0002-8387-3952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoying Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaoyan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyan Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062603099","display_name":"Shizhang Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shizhang Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102901476","display_name":"Xi-Mei Chen","orcid":"https://orcid.org/0009-0004-8883-2086","observed_orcids":["https://orcid.org/0009-0004-8883-2086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ximei Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033351279","display_name":"Changqing Yang","orcid":"https://orcid.org/0000-0002-9761-6850","observed_orcids":["https://orcid.org/0000-0002-9761-6850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changqing Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078703807","display_name":"Hengjun Gao","orcid":"https://orcid.org/0000-0003-1310-0986","observed_orcids":["https://orcid.org/0000-0003-1310-0986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hengjun Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8181,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72021388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"6","first_page":"537","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":1.0},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.8820000290870667},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.6539999842643738},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/early-detection-biomarkers","display_name":"early diagnosis biomarkers","score":0.7490000128746033},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.9207974672317505},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6735094785690308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.56728196144104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5617989897727966},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5523444414138794},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5447472333908081},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5083746314048767},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.47517603635787964},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44058889150619507},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4244821071624756},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4115754961967468},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.4106713533401489},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.397481769323349},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38960686326026917},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25084003806114197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24931424856185913}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2437166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3430114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22949936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22949936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3430114","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3430114/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:89492054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22949936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2437166","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3430114","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1514861465","https://openalex.org/W1555435626","https://openalex.org/W1656339735","https://openalex.org/W1967002030","https://openalex.org/W1977024334","https://openalex.org/W1981616764","https://openalex.org/W1983950902","https://openalex.org/W1994296775","https://openalex.org/W2000635259","https://openalex.org/W2006723371","https://openalex.org/W2007174756","https://openalex.org/W2013453542","https://openalex.org/W2014877570","https://openalex.org/W2024792479","https://openalex.org/W2034893372","https://openalex.org/W2043730386","https://openalex.org/W2057486197","https://openalex.org/W2066317700","https://openalex.org/W2066355249","https://openalex.org/W2073897377","https://openalex.org/W2076150416","https://openalex.org/W2081600712","https://openalex.org/W2089228305","https://openalex.org/W2095483969","https://openalex.org/W2103382943","https://openalex.org/W2103459879","https://openalex.org/W2118795194","https://openalex.org/W2141983633","https://openalex.org/W2145181332","https://openalex.org/W2158472843","https://openalex.org/W2158528663","https://openalex.org/W2162947777","https://openalex.org/W2165389801","https://openalex.org/W2169675397","https://openalex.org/W3131496819","https://openalex.org/W4297752814"],"related_works":["https://openalex.org/W3028951999","https://openalex.org/W3032036520","https://openalex.org/W2138162864","https://openalex.org/W2765762897","https://openalex.org/W2161342739","https://openalex.org/W2298027736","https://openalex.org/W1974749747","https://openalex.org/W3148513700","https://openalex.org/W2388217716","https://openalex.org/W2383678540"],"abstract_inverted_index":{"The":[0,115],"tumorigenesis":[1],"of":[2,13,17,31,122,143],"pancreatic":[3,18,41,72,99,112,123,136],"cancer":[4,19,42,73,113,124,137],"is":[5,33],"thought":[6],"to":[7,37,45,140],"be":[8],"a":[9,34],"complex":[10],"process.":[11],"Investigation":[12],"the":[14,22,120,144],"molecular":[15],"mechanism":[16],"and":[20,28,39,44,76,83,106,148],"exploring":[21],"specific":[23,29],"markers":[24],"for":[25],"early":[26],"diagnosis":[27],"targets":[30],"therapy":[32],"key":[35],"point":[36],"prevent":[38],"treat":[40],"effectively":[43],"improve":[46],"their":[47],"prognosis.":[48],"In":[49,130],"this":[50],"study,":[51],"expression":[52],"profiles":[53],"experiment":[54],"was":[55,125,138],"performed":[56],"using":[57],"Agilent":[58],"human":[59],"whole":[60],"genomic":[61],"oligonucleotide":[62],"microarrays":[63],"with":[64,71,98],"41,000":[65],"genes.":[66],"Differentially":[67],"expressed":[68,95],"genes":[69,96,102],"related":[70,139],"were":[74,92,103,108],"screened,":[75],"analyzed":[77],"further":[78],"by":[79],"GO":[80],"term":[81],"analysis":[82],"KEGG":[84],"Pathway":[85],"analysis.":[86],"Our":[87],"results":[88],"showed":[89],"that":[90,119,135],"there":[91],"1276":[93],"differentially":[94],"associated":[97],"cancer.":[100],"691":[101],"up":[104],"regulated":[105,110],"585":[107],"down":[109],"in":[111,127],"group.":[114],"present":[116],"study":[117,133],"confirmed":[118],"occurrence":[121],"involved":[126],"multiple-gene":[128],"interaction.":[129],"addition,":[131],"our":[132],"found":[134],"an":[141],"activation":[142],"mTOR":[145],"signaling":[146],"pathway":[147],"renal":[149],"cell":[150],"carcinoma":[151],"pathway.":[152]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}