{"id":"https://openalex.org/W894895624","doi":null,"title":"Towards a global and systemic understanding of protein production in prokaryotes","display_name":"Towards a global and systemic understanding of protein production in prokaryotes","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W894895624","mag":"894895624"},"language":"en","primary_location":{"id":"pmh:hdl:10068/1018210","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1018210","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hal.science/pastel-00924232v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059933595","display_name":"Emanuele Leoncini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"LEONCINI, Emanuele","raw_affiliation_strings":["Networks, Algorithms and Probabilities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Networks, Algorithms and Probabilities","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111510613","display_name":"Philippe Robert","orcid":"https://orcid.org/0000-0001-8122-8880","observed_orcids":["https://orcid.org/0000-0001-8122-8880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROBERT, Philippe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5059933595"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11152","display_name":"Stochastic processes and statistical mechanics","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2610","display_name":"Mathematical Physics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-production","display_name":"protein production","score":0.828000009059906},{"id":"https://openalex.org/keywords/prokaryotes","display_name":"prokaryotes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.8989999890327454},{"id":"https://openalex.org/keywords/marked-poisson-point-process","display_name":"marked Poisson point process","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-dilution","display_name":"protein dilution","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mean-field-approximation","display_name":"mean-field approximation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/protein-fluctuations","display_name":"protein fluctuations","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mathematical-modeling-of-gene-expression","display_name":"mathematical modeling of gene expression","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6803449988365173},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.5208559632301331},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.47898221015930176},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.464481920003891},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4411286413669586},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.4249994158744812},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3035565912723541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2738722264766693},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/1018210","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/1018210","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:pastel-00924232v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/pastel-00924232v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quantitative Methods [q-bio.QM]. Ecole Polytechnique X, 2013. English. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:HAL:pastel-00924232v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/pastel-00924232v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Quantitative Methods [q-bio.QM]. Ecole Polytechnique X, 2013. English. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1970625978","https://openalex.org/W1976393786","https://openalex.org/W1984429906","https://openalex.org/W1993009001","https://openalex.org/W1999777663","https://openalex.org/W2004801113","https://openalex.org/W2045443950","https://openalex.org/W2047300623","https://openalex.org/W2053460598","https://openalex.org/W2059053384","https://openalex.org/W2064483836","https://openalex.org/W2069233620","https://openalex.org/W2075251971","https://openalex.org/W2096705138","https://openalex.org/W2105057212","https://openalex.org/W2118274513","https://openalex.org/W2122121413","https://openalex.org/W2123299226","https://openalex.org/W2126466006","https://openalex.org/W2137088684","https://openalex.org/W2140937954","https://openalex.org/W2171327609","https://openalex.org/W2986086925"],"related_works":["https://openalex.org/W7147234090","https://openalex.org/W4392149677","https://openalex.org/W7020717475","https://openalex.org/W2617175464","https://openalex.org/W7147123525","https://openalex.org/W2011889394","https://openalex.org/W377671284","https://openalex.org/W71000394","https://openalex.org/W7147486153","https://openalex.org/W2047300623"],"abstract_inverted_index":{"Biochemical":[0],"reactions":[1],"underlying":[2],"the":[3,14,31,48,59,88,92,103,108,157,164,172,175,199,207,213,218,223,226,246],"functioning":[4],"of":[5,33,50,91,94,111,116,122,139,163,166,174,182,209,225,229,245],"cells":[6,52],"are":[7,27],"inherently":[8],"stochastic":[9,37,227],"processes.":[10],"As":[11],"a":[12,34,75,95,135,161,187,194,203,241],"consequence,":[13],"whole":[15],"system":[16,181],"is":[17,62,184],"noisy":[18],"and":[19,147,201],"undergoes":[20],"fluctuations":[21,211],"in":[22,30,44,47,107,198,206,236],"its":[23],"fundamental":[24],"components.":[25],"Proteins":[26],"major":[28],"players":[29],"life":[32],"cell;":[35],"their":[36],"character":[38],"manifests":[39],"itself":[40],"through":[41,126],"striking":[42],"differences":[43],"phenotypes,":[45],"even":[46],"case":[49],"cloned":[51],"exposed":[53],"to":[54,86,101,133,151,238],"identical":[55],"environmental":[56],"conditions.":[57],"Given":[58],"context,":[60],"it":[61],"crucial":[63,106],"that":[64],"models":[65,235],"embrace":[66],"realistic":[67,137,243],"assumptions.":[68],"In":[69,216],"this":[70,127],"thesis":[71,219],"we":[72],"have":[73],"introduced":[74],"new":[76,128,196,204],"mathematical":[77],"framework":[78,129],"based":[79],"on":[80,222],"Marked":[81],"Poisson":[82],"Point":[83],"Processes":[84],"(MPPP)":[85],"describe":[87],"main":[89],"steps":[90,159],"production":[93,165,183],"specific":[96],"protein.":[97],"We":[98,154],"were":[99],"able":[100],"overcome":[102],"restrictive":[104],"assumption,":[105],"classical":[109],"framework,":[110],"an":[112],"exponentially":[113],"distributed":[114],"duration":[115],"all":[117],"steps.":[118],"The":[119,180,190],"non-Markovian":[120],"description":[121,244],"gene":[123,140,230],"expression":[124],"obtained":[125],"has":[130,220],"allowed":[131],"us":[132],"propose":[134],"more":[136,242],"model":[138,192],"expression,":[141,231],"which":[142],"includes":[143],"protein":[144,148,210],"elongation":[145],"step":[146],"dilution":[149],"due":[150],"volume":[152],"growth.":[153],"also":[155],"made":[156],"first":[158],"towards":[160,240],"modeling":[162],"many":[167],"proteins,":[168],"considering":[169],"interactions":[170],"as":[171],"result":[173],"competition":[176],"for":[177],"common":[178],"resources.":[179],"studied":[185],"via":[186],"mean-field":[188],"approach.":[189],"multi-protein":[191],"brings":[193],"completely":[195],"approach":[197],"domain":[200],"marks":[202],"direction":[205],"investigation":[208],"at":[212],"cellular":[214],"level.":[215],"conclusion,":[217],"focused":[221],"study":[224],"nature":[228],"by":[232],"developing":[233],"different":[234],"order":[237],"progress":[239],"phenomena.":[247]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}