{"id":"https://openalex.org/W894539330","doi":null,"title":"Role of a Novel microRNA in Adult Neurogenesis.","display_name":"Role of a Novel microRNA in Adult Neurogenesis.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W894539330","mag":"894539330"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107309","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/107309","pdf_url":"https://hdl.handle.net/2027.42/107309","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/107309","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082100710","display_name":"Yao-Chang Tsan","orcid":"https://orcid.org/0000-0003-0373-1290","observed_orcids":["https://orcid.org/0000-0003-0373-1290"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yao-Chang Tsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082100710"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/subventricular-zone","display_name":"subventricular zone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/noggin","display_name":"noggin","score":0.996999979019165},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.9200000166893005},{"id":"https://openalex.org/keywords/neural-stem-cell-differentiation","display_name":"neural stem cell differentiation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/astrocyte-differentiation","display_name":"astrocyte differentiation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/elavl4","display_name":"ELAVL4","score":0.8889999985694885},{"id":"https://openalex.org/keywords/3-utr-target","display_name":"3' UTR target","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neurite-morphology","display_name":"neurite morphology","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lineage-choice","display_name":"lineage choice","score":0.5320000052452087},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8978240489959717},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6916322112083435},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35939866304397583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35710322856903076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19576776027679443},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107309","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/107309","pdf_url":"https://hdl.handle.net/2027.42/107309","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:894539330","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/2027.42/107309/1/yctsan_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107309","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/107309","pdf_url":"https://hdl.handle.net/2027.42/107309","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W894539330.pdf","grobid_xml":"https://content.openalex.org/works/W894539330.grobid-xml"},"referenced_works_count":168,"referenced_works":["https://openalex.org/W15818142","https://openalex.org/W1485371658","https://openalex.org/W1487914405","https://openalex.org/W1489898053","https://openalex.org/W1530778223","https://openalex.org/W1566823022","https://openalex.org/W1575310353","https://openalex.org/W1636022999","https://openalex.org/W1859089489","https://openalex.org/W1859730138","https://openalex.org/W1894143964","https://openalex.org/W1964457265","https://openalex.org/W1969765196","https://openalex.org/W1972931349","https://openalex.org/W1972989638","https://openalex.org/W1974203453","https://openalex.org/W1976832203","https://openalex.org/W1978143545","https://openalex.org/W1982850249","https://openalex.org/W1983440237","https://openalex.org/W1983676861","https://openalex.org/W1983725263","https://openalex.org/W1984288177","https://openalex.org/W1984455015","https://openalex.org/W1984612885","https://openalex.org/W1985679507","https://openalex.org/W1986756287","https://openalex.org/W1988425964","https://openalex.org/W1990848328","https://openalex.org/W1990938412","https://openalex.org/W1992187118","https://openalex.org/W1992466747","https://openalex.org/W1994042895","https://openalex.org/W1995373854","https://openalex.org/W1996736819","https://openalex.org/W1996907803","https://openalex.org/W2000418014","https://openalex.org/W2004429089","https://openalex.org/W2005470715","https://openalex.org/W2005558505","https://openalex.org/W2005704128","https://openalex.org/W2007060410","https://openalex.org/W2008254256","https://openalex.org/W2008715172","https://openalex.org/W2009593134","https://openalex.org/W2011580597","https://openalex.org/W2012564677","https://openalex.org/W2019113072","https://openalex.org/W2020613231","https://openalex.org/W2021154165","https://openalex.org/W2021339055","https://openalex.org/W2021442315","https://openalex.org/W2021692265","https://openalex.org/W2022491750","https://openalex.org/W2023011577","https://openalex.org/W2025201512","https://openalex.org/W2026014592","https://openalex.org/W2026598920","https://openalex.org/W2027579663","https://openalex.org/W2029351232","https://openalex.org/W2030017268","https://openalex.org/W2031407988","https://openalex.org/W2031942587","https://openalex.org/W2032246129","https://openalex.org/W2033418096","https://openalex.org/W2034423362","https://openalex.org/W2034535603","https://openalex.org/W2034616897","https://openalex.org/W2036470943","https://openalex.org/W2042206438","https://openalex.org/W2042466204","https://openalex.org/W2043364678","https://openalex.org/W2043429907","https://openalex.org/W2046157151","https://openalex.org/W2046193560","https://openalex.org/W2046597024","https://openalex.org/W2047165320","https://openalex.org/W2048815806","https://openalex.org/W2050759963","https://openalex.org/W2052610336","https://openalex.org/W2053372713","https://openalex.org/W2053726612","https://openalex.org/W2057194283","https://openalex.org/W2058980325","https://openalex.org/W2062705161","https://openalex.org/W2062714539","https://openalex.org/W2063084036","https://openalex.org/W2063452219","https://openalex.org/W2063565088","https://openalex.org/W2065017983","https://openalex.org/W2065754676","https://openalex.org/W2066090522","https://openalex.org/W2066356973","https://openalex.org/W2067161293","https://openalex.org/W2067834103","https://openalex.org/W2069426164","https://openalex.org/W2069479018","https://openalex.org/W2070439522","https://openalex.org/W2071973002","https://openalex.org/W2073255619","https://openalex.org/W2075477366","https://openalex.org/W2079509173","https://openalex.org/W2079881283","https://openalex.org/W2083255040","https://openalex.org/W2083361083","https://openalex.org/W2084300863","https://openalex.org/W2084652820","https://openalex.org/W2084711660","https://openalex.org/W2085713275","https://openalex.org/W2086371555","https://openalex.org/W2086408483","https://openalex.org/W2086948882","https://openalex.org/W2087125765","https://openalex.org/W2088301374","https://openalex.org/W2089895199","https://openalex.org/W2089970049","https://openalex.org/W2091535724","https://openalex.org/W2094587344","https://openalex.org/W2094613247","https://openalex.org/W2094842746","https://openalex.org/W2095249314","https://openalex.org/W2095490681","https://openalex.org/W2095605427","https://openalex.org/W2095783168","https://openalex.org/W2096796354","https://openalex.org/W2098792835","https://openalex.org/W2099908272","https://openalex.org/W2100010244","https://openalex.org/W2101506365","https://openalex.org/W2102523256","https://openalex.org/W2103972201","https://openalex.org/W2105336002","https://openalex.org/W2107139283","https://openalex.org/W2107836010","https://openalex.org/W2108244474","https://openalex.org/W2108639829","https://openalex.org/W2111629903","https://openalex.org/W2113249378","https://openalex.org/W2116481437","https://openalex.org/W2117802141","https://openalex.org/W2121147886","https://openalex.org/W2122878223","https://openalex.org/W2125262718","https://openalex.org/W2125920059","https://openalex.org/W2125987139","https://openalex.org/W2131282078","https://openalex.org/W2131928928","https://openalex.org/W2132898050","https://openalex.org/W2133059825","https://openalex.org/W2133619319","https://openalex.org/W2134217567","https://openalex.org/W2135046848","https://openalex.org/W2138977668","https://openalex.org/W2144324967","https://openalex.org/W2145160583","https://openalex.org/W2146997290","https://openalex.org/W2147403403","https://openalex.org/W2149754187","https://openalex.org/W2151805828","https://openalex.org/W2152709462","https://openalex.org/W2152853156","https://openalex.org/W2154909423","https://openalex.org/W2164010900","https://openalex.org/W2165867905","https://openalex.org/W2166465090","https://openalex.org/W2170375626","https://openalex.org/W2341491220","https://openalex.org/W3025274120"],"related_works":["https://openalex.org/W2490506242","https://openalex.org/W2071973002","https://openalex.org/W2117802141","https://openalex.org/W2066548509","https://openalex.org/W2079797122","https://openalex.org/W2616420888","https://openalex.org/W2170178888","https://openalex.org/W2021507577","https://openalex.org/W6913130449","https://openalex.org/W4223999356"],"abstract_inverted_index":{"Multipotent,":[0],"self-renewing":[1],"stem":[2,46,133,294],"cells":[3,114,118,134,295,300],"which":[4,71],"are":[5],"present":[6],"throughout":[7],"the":[8,17,21,28,52,59,100,104,121,129,137,148,154,158,176,199,205,232,238,247,252,275,287,303],"developing":[9,149],"nervous":[10,61,150],"system":[11],"remain":[12],"in":[13,43,58,70,78,99,128,147,153,164,185,201,207,254,274],"discrete":[14],"regions":[15],"of":[16,54,92,97,106,126,139,157,162,178,182,196,231,235,243,271,277,291,305],"adult":[18,89,130,159,292],"brain.":[19,160],"In":[20,88,193],"subventricular":[22],"zone":[23],"(SVZ)":[24],"signaling":[25,56],"molecules,":[26],"including":[27,227],"bone":[29],"morphogenetic":[30],"proteins":[31],"and":[32,102,115,171,189,204,218,298,308],"their":[33],"secreted":[34],"inhibitor,":[35],"Noggin":[36,72,93,127,212],"appear":[37],"to":[38,111,312],"play":[39],"a":[40,66,81,140,310],"critical":[41],"role":[42],"controlling":[44,302],"neural":[45,132,293],"cell":[47],"(NSC)":[48],"behavior.":[49],"To":[50],"examine":[51],"function":[53],"this":[55],"pathway":[57],"intact":[60],"system,":[62,151],"we":[63,222,262],"have":[64],"developed":[65],"transgenic":[67],"mouse":[68],"model":[69],"expression":[73,94,138,304],"can":[74],"be":[75],"induced":[76],"specifically":[77],"NSC":[79,98,107,122,186,314],"via":[80,237],"Nestin":[82],"promoter-driven":[83],"reverse":[84],"tetracycline-controlled":[85],"transactivator":[86],"(rtTA).":[87],"animals,":[90],"induction":[91],"promotes":[95],"proliferation":[96],"SVZ,":[101],"shifts":[103],"differentiation":[105,173,203,209,256,315],"from":[108],"mature":[109],"astrocytes":[110],"transit":[112],"amplifying":[113],"oligodendrocyte":[116,172],"precursor":[117],"without":[119,246],"depleting":[120],"population.":[123],"Interestingly,":[124,261],"over-expression":[125,195],"SVZ":[131,165],"also":[135,263],"inhibits":[136],"novel":[141],"microRNA-410":[142],"(miR-410).":[143],"miR-410":[144,163,183,197,236,259,266,272,285],"is":[145],"expressed":[146],"remaining":[152],"germinal":[155],"zones":[156],"Over-expression":[161,242,270],"derived":[166],"neurospheres":[167],"consistently":[168],"inhibited":[169],"neuronal":[170,188,202,255],"while":[174],"promoting":[175],"formation":[177,276],"astrocytes.":[179],"Conversely,":[180],"inhibition":[181],"activity":[184],"promoted":[187],"decreased":[190],"astroglial":[191,208],"differentiation.":[192],"addition,":[194],"rescued":[198,251],"increase":[200],"decrease":[206,253],"caused":[210,257],"by":[211,258,301],"over-expression.":[213,260],"Using":[214],"computer":[215],"prediction":[216],"algorithms":[217],"luciferase":[219],"reporter":[220],"assays,":[221],"identified":[223],"multiple":[224],"neurogenic":[225,306],"genes":[226],"Elavl4":[228,244],"as":[229],"one":[230],"downstream":[233],"targets":[234],"canonical":[239],"miRNA-3\u2019UTR":[240],"interaction.":[241],"transcripts":[245],"endogenous":[248],"3\u2019":[249],"UTR":[250],"observed":[264],"that":[265,284],"affected":[267],"neurite":[268],"morphology.":[269],"resulted":[273],"short,":[278],"unbranched":[279],"neurites.":[280],"These":[281],"results":[282],"demonstrate":[283],"controls":[286],"crucial":[288],"lineage":[289],"choice":[290],"between":[296],"neurons":[297],"glial":[299],"genes,":[307],"suggest":[309],"method":[311],"regulate":[313],"following":[316],"disease,":[317],"injury":[318],"or":[319],"aging.":[320]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}