{"id":"https://openalex.org/W89396678","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","title":"Abstract 4016: Does Prasugrel Provide a Clinically Important Treatment Benefit Compared with Clopidogrel? A Bayesian Analysis of TRITON-TIMI 38","display_name":"Abstract 4016: Does Prasugrel Provide a Clinically Important Treatment Benefit Compared with Clopidogrel? A Bayesian Analysis of TRITON-TIMI 38","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W89396678","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","mag":"89396678"},"language":"en","primary_location":{"id":"doi:10.1161/circ.118.suppl_18.s_819-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031087237","display_name":"Sanjay Kaul","orcid":"https://orcid.org/0000-0001-9640-4146","observed_orcids":["https://orcid.org/0000-0001-9640-4146"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjay Kaul","raw_affiliation_strings":["Cedars-Sinai Med Cntr, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003094687","display_name":"Prediman K. Shah","orcid":"https://orcid.org/0000-0002-6351-8291","observed_orcids":["https://orcid.org/0000-0002-6351-8291"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prediman K Shah","raw_affiliation_strings":["Cedars-Sinai Med Cntr, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108285896","display_name":"George A. Diamond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George A Diamond","raw_affiliation_strings":["Cedars-Sinai Med Cntr, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai Med Cntr, Los Angeles, CA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"suppl_18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prasugrel","display_name":"prasugrel","score":1.0},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":1.0},{"id":"https://openalex.org/keywords/triton-timi-38","display_name":"TRITON-TIMI 38","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8930000066757202},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/bayesian-analysis","display_name":"Bayesian analysis","score":0.621999979019165},{"id":"https://openalex.org/keywords/minimal-clinically-important-difference","display_name":"minimal clinically important difference","score":0.7950000166893005},{"id":"https://openalex.org/keywords/net-clinical-benefit","display_name":"net clinical benefit","score":0.906000018119812},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ischemic-events","display_name":"ischemic events","score":0.5049999952316284},{"id":"https://openalex.org/keywords/posterior-probability","display_name":"posterior probability","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777028646","wikidata":"https://www.wikidata.org/wiki/Q416232","display_name":"Prasugrel","level":4,"score":0.8742799758911133},{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.865997314453125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8440821170806885},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.7014291286468506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5904194712638855},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5288889408111572},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4774751663208008},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4082756042480469},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.36942794919013977},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31014853715896606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.118.suppl_18.s_819-a","doi":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.118.suppl_18.s_819-a","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W28360546","https://openalex.org/W2168703994","https://openalex.org/W2775525525","https://openalex.org/W2167681297","https://openalex.org/W2022237719","https://openalex.org/W2128324735","https://openalex.org/W2080589301","https://openalex.org/W2159545665","https://openalex.org/W2093709628","https://openalex.org/W2886778197"],"abstract_inverted_index":{"Background:":[0],"In":[1],"contrast":[2],"to":[3,14,82,141],"the":[4,8,41,63,74,115,121,129,131,137,178,192,210,266,269],"conventional":[5,251],"frequentist":[6],"analysis,":[7],"Bayesian":[9,88,254,288],"method":[10],"is":[11,71,143,195,200,208,219,244],"ideally":[12],"suited":[13],"provide":[15],"a":[16,20,87,257],"quantitative":[17],"estimate":[18],"of":[19,23,40,212,233,268,290],"given":[21],"magnitude":[22],"treatment":[24,240,286],"benefit":[25,68,194,199,215,236,278],"or":[26,93,160,279],"harm.":[27],"Objective:":[28],"A":[29],"reappraisal,":[30],"with":[31,50,150,216,238],"emphasis":[32],"on":[33],"both":[34],"statistical":[35,252],"significance":[36],"and":[37,69,104,117,126,168,184,197,226,285],"clinical":[38,79,190,214],"importance,":[39],"recently":[42],"reported":[43],"TRITON-TIMI":[44,108,242,291],"38":[45,243,292],"trial":[46],"that":[47,62,136,248],"compared":[48],"prasugrel":[49,217,239],"clopidogrel":[51],"in":[52,67,120,241,260],"ACS":[53],"patients":[54],"scheduled":[55],"for":[56,78,224,228],"PCI.":[57],"Methods:":[58],"Posterior":[59],"probabilities":[60],"(Pr)":[61],"relative":[64],"difference":[65,119],"(d)":[66],"risk":[70],"greater":[72],"than":[73,247],"putative":[75],"threshold":[76],"value":[77],"importance":[80],"(d>0%":[81],"20%)":[83],"were":[84],"derived":[85],"from":[86,107],"analysis":[89,255],"using":[90],"an":[91],"uninformative":[92],"\u201cagnostic\u201d":[94],"prior":[95],"(log":[96],"mean":[97],"RR,":[98],"=":[99,102],"0,":[100],"SD":[101],"2)":[103],"empirical":[105],"evidence":[106],"38.":[109],"Results":[110],"(Table":[111],")":[112],":":[113],"Although":[114],"Pr(d>0%)":[116],"Pr(d>10%)":[118,154,193],"primary":[122],"endpoint":[123],"are":[124,148],"100%":[125],"97.5%,":[127],"respectively,":[128],"Pr(d>20%),":[130],"\u201cminimum":[132],"clinically":[133,234,262],"important":[134,235],"difference\u201d":[135],"study":[138],"was":[139],"powered":[140],"detect,":[142],"only":[144],"40%.":[145],"Similar":[146],"patterns":[147],"observed":[149],"all-cause":[151],"death/MI/CVA.":[152],"The":[153,174,231],"harm":[155,171,176,280],"(for":[156],"either":[157],"TIMI":[158,161,185,203],"major":[159,162,186,204],"plus":[163,205],"minor":[164,206],"bleeding)":[165],"exceeds":[166,172,177],"90%,":[167],"Pr":[169],"(d>20%)":[170],"65%.":[173],"Pr(d>20%)":[175,179,198],"benefit.":[180],"Combining":[181],"ischemic":[182],"endpoints":[183],"bleeding":[187,207],"into":[188],"net":[189,213],"benefit,":[191],"<80%":[196],"<5%.":[201],"If":[202],"included,":[209],"probability":[211,232],"therapy":[218],"reduced":[220],"even":[221],"further":[222],"(<5%":[223],"d>10%":[225],"<1%":[227],"d>20%).":[229],"Conclusions:":[230],"associated":[237],"far":[245],"less":[246],"implied":[249],"by":[250],"significance.":[253],"provides":[256],"useful":[258],"tool":[259],"quantifying":[261],"meaningful":[263],"difference.":[264],"Ultimately,":[265],"clarity":[267],"balance":[270],"between":[271],"\u201cclinically":[272],"important\u201d,":[273],"not":[274],"just":[275],"\u201cstatistically":[276],"significant\u201d,":[277],"should":[281],"influence":[282],"guideline":[283],"recommendations":[284],"decisions.":[287],"Analysis":[289],"Trial":[293]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}