{"id":"https://openalex.org/W89354874","doi":"https://doi.org/10.14712/fb2010056040158","title":"Advanced Rai Stage in Patients with Chronic Lymphocytic Leukaemia Correlates with Simultaneous Hypermethylation of Plural Tumour Suppressor Genes","display_name":"Advanced Rai Stage in Patients with Chronic Lymphocytic Leukaemia Correlates with Simultaneous Hypermethylation of Plural Tumour Suppressor Genes","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W89354874","doi":"https://doi.org/10.14712/fb2010056040158","mag":"89354874","pmid":"https://pubmed.ncbi.nlm.nih.gov/20974048"},"language":"en","primary_location":{"id":"doi:10.14712/fb2010056040158","doi":"https://doi.org/10.14712/fb2010056040158","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2010056040158","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2010056040158.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2010056040158.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028558550","display_name":"Kristina Forsterov\u00e1","orcid":"https://orcid.org/0000-0002-9119-081X","observed_orcids":["https://orcid.org/0000-0002-9119-081X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Kristina Forsterov\u00e1","raw_affiliation_strings":["Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine and General University Hospital, Prague, Czech Republic. kfors@lf1.cuni.cz","Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine and General University Hospital, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine and General University Hospital, Prague, Czech Republic. kfors@lf1.cuni.cz","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine and General University Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045750194","display_name":"Hana Votavov\u00e1","orcid":"https://orcid.org/0000-0002-2990-579X","observed_orcids":["https://orcid.org/0000-0002-2990-579X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"H. Votavov\u00e1","raw_affiliation_strings":["Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111843172","display_name":"J Schwarz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J. Schwarz","raw_affiliation_strings":["Institute of Haematology and Blood Transfusion, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Haematology and Blood Transfusion, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049988038","display_name":"Josef Karban","orcid":"https://orcid.org/0000-0003-4199-6476","observed_orcids":["https://orcid.org/0000-0003-4199-6476"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"J. Karban","raw_affiliation_strings":["Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070769214","display_name":"\u010cestm\u00edr \u0160tuka","orcid":"https://orcid.org/0000-0003-2493-6375","observed_orcids":["https://orcid.org/0000-0003-2493-6375"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"\u010c. \u0160tuka","raw_affiliation_strings":["Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088476247","display_name":"Marek Trn\u011bn\u00fd","orcid":"https://orcid.org/0000-0002-6952-6073","observed_orcids":["https://orcid.org/0000-0002-6952-6073"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210096318","display_name":"Institute of Haematology and Blood Transfusion","ror":"https://ror.org/00n6rde07","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210096318"]},{"id":"https://openalex.org/I4210162037","display_name":"General University Hospital in Prague","ror":"https://ror.org/04yg23125","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210162037"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"M. Trn\u011bn\u00fd","raw_affiliation_strings":["Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic","Institute of Haematology and Blood Transfusion, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Charles University in Prague, First Faculty of Medicine, 1st Department of Medicine \u2013 Clinical Department of Haematology of the First Faculty of Medicine and General University Hospital, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210162037"]},{"raw_affiliation_string":"Institute of Haematology and Blood Transfusion, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210096318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3923,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64676153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"56","issue":"4","first_page":"158","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rai-stage","display_name":"Rai stage","score":0.7020000219345093},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cpg-island-methylation","display_name":"CpG island methylation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dlc1","display_name":"DLC1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/shp-1","display_name":"SHP-1","score":0.9440000057220459},{"id":"https://openalex.org/keywords/p15","display_name":"p15","score":0.925000011920929},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lamin-a-c","display_name":"lamin A/C","score":0.9449999928474426},{"id":"https://openalex.org/keywords/methylation-patterns","display_name":"methylation patterns","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.7898718118667603},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6538775563240051},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5492338538169861},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4942662715911865},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.48096123337745667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4618697464466095},{"id":"https://openalex.org/C2779835924","wikidata":"https://www.wikidata.org/wiki/Q146786","display_name":"Plural","level":2,"score":0.45672091841697693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4362291693687439},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.42222076654434204},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37807130813598633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32337576150894165},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.22002804279327393},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.21524199843406677},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050762","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p15","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053824","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.14712/fb2010056040158","doi":"https://doi.org/10.14712/fb2010056040158","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2010056040158","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2010056040158.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},{"id":"pmid:20974048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20974048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia biologica","raw_type":"Journal Article"},{"id":"mag:2189266680","doi":null,"is_oa":false,"landing_page_url":"https://fb.cuni.cz/data/files/folia_biologica/volume_56_2010_4/fb2010a0022.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.14712/fb2010056040158","doi":"https://doi.org/10.14712/fb2010056040158","is_oa":true,"landing_page_url":"https://doi.org/10.14712/fb2010056040158","pdf_url":"https://foliabiologica.lf1.cuni.cz/media/pdf/fb_2010056040158.pdf","source":{"id":"https://openalex.org/S72738211","display_name":"Folia Biologica","issn_l":"0015-5500","issn":["0015-5500","2533-7602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310314351","host_organization_name":"First Faculty of Medicine, Charles University","host_organization_lineage":["https://openalex.org/P4310314351","https://openalex.org/P4310314207"],"host_organization_lineage_names":["First Faculty of Medicine, Charles University","Charles University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Biologica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2266430997","display_name":null,"funder_award_id":"MSM 0021620808","funder_id":"https://openalex.org/F4320321005","funder_display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy"}],"funders":[{"id":"https://openalex.org/F4320321005","display_name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","ror":"https://ror.org/037n8p820"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W89354874.pdf","grobid_xml":"https://content.openalex.org/works/W89354874.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W60865865","https://openalex.org/W154103547","https://openalex.org/W1243376384","https://openalex.org/W1429374962","https://openalex.org/W1527161131","https://openalex.org/W1530031862","https://openalex.org/W1564039428","https://openalex.org/W1640016724","https://openalex.org/W1661110056","https://openalex.org/W1965350712","https://openalex.org/W1965851569","https://openalex.org/W1966171454","https://openalex.org/W1966248949","https://openalex.org/W1974533942","https://openalex.org/W1979787390","https://openalex.org/W1983348452","https://openalex.org/W1990595543","https://openalex.org/W1994063413","https://openalex.org/W1994465394","https://openalex.org/W1996467876","https://openalex.org/W1996641742","https://openalex.org/W1997073961","https://openalex.org/W2013837480","https://openalex.org/W2024473839","https://openalex.org/W2031192472","https://openalex.org/W2035882662","https://openalex.org/W2040257851","https://openalex.org/W2041835558","https://openalex.org/W2045917022","https://openalex.org/W2047329830","https://openalex.org/W2054823635","https://openalex.org/W2058922488","https://openalex.org/W2062629274","https://openalex.org/W2063825367","https://openalex.org/W2063936314","https://openalex.org/W2064084870","https://openalex.org/W2067795112","https://openalex.org/W2068874359","https://openalex.org/W2071918743","https://openalex.org/W2072308003","https://openalex.org/W2073509406","https://openalex.org/W2076333931","https://openalex.org/W2078673385","https://openalex.org/W2079523816","https://openalex.org/W2080411938","https://openalex.org/W2080951919","https://openalex.org/W2086637735","https://openalex.org/W2091414779","https://openalex.org/W2099348990","https://openalex.org/W2101073455","https://openalex.org/W2101844301","https://openalex.org/W2102606444","https://openalex.org/W2103163028","https://openalex.org/W2114832764","https://openalex.org/W2118094114","https://openalex.org/W2119125180","https://openalex.org/W2119932131","https://openalex.org/W2130198345","https://openalex.org/W2139545242","https://openalex.org/W2145367294","https://openalex.org/W2145669281","https://openalex.org/W2148646651","https://openalex.org/W2150696691","https://openalex.org/W2151022113","https://openalex.org/W2152369601","https://openalex.org/W2153778988","https://openalex.org/W2156169904","https://openalex.org/W2164674592","https://openalex.org/W2318933236","https://openalex.org/W2470517880","https://openalex.org/W3188542113","https://openalex.org/W4210997484"],"related_works":["https://openalex.org/W2189266680","https://openalex.org/W2771701567","https://openalex.org/W2079523816","https://openalex.org/W2538802494","https://openalex.org/W2676063604","https://openalex.org/W2751012782","https://openalex.org/W1988707779","https://openalex.org/W2587158546","https://openalex.org/W2992056366","https://openalex.org/W1965350712"],"abstract_inverted_index":{"Hypermethylation":[0,77],"of":[1,9,12,19,33,47,65,78,88,92],"CpG":[2],"islands":[3],"within":[4],"gene":[5,13,82],"promoters":[6],"is":[7],"one":[8,81],"various":[10],"mechanisms":[11],"silencing":[14],"involved":[15],"in":[16,38,55,73,85],"the":[17,75],"pathogenesis":[18],"human":[20],"cancer.":[21],"By":[22],"using":[23],"methylation-specific":[24],"polymerase":[25],"chain":[26],"reaction":[27],"we":[28],"explored":[29],"aberrant":[30],"promoter":[31],"methylation":[32,46,91],"five":[34],"tumour":[35],"suppressor":[36],"genes":[37,96],"29":[39],"patients":[40,66],"with":[41,98],"chronic":[42],"lymphocytic":[43],"leukaemia.":[44],"Aberrant":[45],"DLC1,":[48],"SHP1,":[49],"p15":[50],"and":[51,62],"p16":[52],"occurred,":[53],"respectively,":[54],"89.7":[56],"%,":[57,59],"70":[58],"62.1":[60],"%":[61,64,87],"31":[63],"at":[67,79,101],"diagnosis.":[68,102],"Lamin":[69],"A/C":[70],"was":[71,83],"unmethylated":[72],"all":[74],"samples.":[76],"least":[80],"detected":[84],"96.6":[86],"patients.":[89],"Concurrent":[90],"two":[93],"or":[94],"more":[95],"correlated":[97],"Rai":[99],"stage":[100]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}