{"id":"https://openalex.org/W89328136","doi":null,"title":"Electrophilic Nitro-Fatty Acid Regulation of Mitochondrial Function","display_name":"Electrophilic Nitro-Fatty Acid Regulation of Mitochondrial Function","publication_year":2012,"publication_date":"2012-12-10","ids":{"openalex":"https://openalex.org/W89328136","mag":"89328136"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:16871","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","pdf_url":"http://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048202946","display_name":"Jeffrey R. Koenitzer","orcid":"https://orcid.org/0000-0002-4556-8455","observed_orcids":["https://orcid.org/0000-0002-4556-8455"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey R. Koenitzer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4556-8455","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048202946"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00998998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.19089999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitro-fatty-acids","display_name":"nitro-fatty acids","score":0.8849999904632568},{"id":"https://openalex.org/keywords/nitro-oleic-acid","display_name":"nitro-oleic acid","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitochondrial-complex-ii-inhibition","display_name":"mitochondrial complex II inhibition","score":0.796999990940094},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/nitroalkanes","display_name":"nitroalkanes","score":0.7170000076293945},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.6370000243186951},{"id":"https://openalex.org/keywords/thiol-adducts","display_name":"thiol adducts","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6697514057159424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6390682458877563},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5800825953483582},{"id":"https://openalex.org/C2779676291","wikidata":"https://www.wikidata.org/wiki/Q25325349","display_name":"Cardioprotection","level":3,"score":0.515884280204773},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4908497929573059},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4436717629432678},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.43446409702301025},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4224509000778198},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.4147789478302002},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.304887056350708},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.168337881565094},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.1287812888622284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12413209676742554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:16871","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","pdf_url":"http://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:89328136","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/16871/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:16871","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","pdf_url":"http://d-scholarship.pitt.edu/16871/1/JK_dissertation_final.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W89328136.pdf","grobid_xml":"https://content.openalex.org/works/W89328136.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W50072272","https://openalex.org/W1547005412","https://openalex.org/W1575897634","https://openalex.org/W1601241694","https://openalex.org/W1975457771","https://openalex.org/W1977922788","https://openalex.org/W1979000436","https://openalex.org/W1979209667","https://openalex.org/W1987900135","https://openalex.org/W1988995464","https://openalex.org/W1990139307","https://openalex.org/W1990185204","https://openalex.org/W1990865993","https://openalex.org/W1995828947","https://openalex.org/W1996583548","https://openalex.org/W2002120674","https://openalex.org/W2003861577","https://openalex.org/W2011892782","https://openalex.org/W2012740748","https://openalex.org/W2014697941","https://openalex.org/W2017016317","https://openalex.org/W2017133833","https://openalex.org/W2018641577","https://openalex.org/W2018966387","https://openalex.org/W2021362373","https://openalex.org/W2021907601","https://openalex.org/W2022716776","https://openalex.org/W2030969794","https://openalex.org/W2036579170","https://openalex.org/W2037199975","https://openalex.org/W2038532782","https://openalex.org/W2041893207","https://openalex.org/W2042149164","https://openalex.org/W2047730122","https://openalex.org/W2048139649","https://openalex.org/W2048467721","https://openalex.org/W2050057935","https://openalex.org/W2054739775","https://openalex.org/W2056215168","https://openalex.org/W2057315336","https://openalex.org/W2058013605","https://openalex.org/W2058137293","https://openalex.org/W2059545411","https://openalex.org/W2061676392","https://openalex.org/W2063263847","https://openalex.org/W2064096645","https://openalex.org/W2066107376","https://openalex.org/W2066449689","https://openalex.org/W2068119233","https://openalex.org/W2070770446","https://openalex.org/W2074509787","https://openalex.org/W2077103811","https://openalex.org/W2081306165","https://openalex.org/W2082179514","https://openalex.org/W2083065269","https://openalex.org/W2083134443","https://openalex.org/W2083299918","https://openalex.org/W2085895322","https://openalex.org/W2092708055","https://openalex.org/W2093687559","https://openalex.org/W2096877350","https://openalex.org/W2100405364","https://openalex.org/W2104251822","https://openalex.org/W2109123226","https://openalex.org/W2109977819","https://openalex.org/W2114305841","https://openalex.org/W2115556604","https://openalex.org/W2117140314","https://openalex.org/W2123051296","https://openalex.org/W2127710249","https://openalex.org/W2128606426","https://openalex.org/W2134172788","https://openalex.org/W2137704083","https://openalex.org/W2137962262","https://openalex.org/W2139720861","https://openalex.org/W2145047965","https://openalex.org/W2146558971","https://openalex.org/W2148182710","https://openalex.org/W2152333840","https://openalex.org/W2152746956","https://openalex.org/W2154507552","https://openalex.org/W2154768987","https://openalex.org/W2158510241","https://openalex.org/W2162919259","https://openalex.org/W2164476520","https://openalex.org/W2165518882","https://openalex.org/W2341557366","https://openalex.org/W2412606629","https://openalex.org/W2916392902"],"related_works":["https://openalex.org/W2220418356","https://openalex.org/W2164476520","https://openalex.org/W1546930292","https://openalex.org/W2407765553","https://openalex.org/W1575897634","https://openalex.org/W1598565218","https://openalex.org/W4387358338","https://openalex.org/W3085887898","https://openalex.org/W2036697787","https://openalex.org/W4409833497"],"abstract_inverted_index":{"Nitro-fatty":[0],"acids":[1],"(NO2-FA)":[2],"are":[3,17,171,251],"endogenous":[4],"mediators":[5],"generated":[6],"by":[7,21,99,115,157,253,271,275,295],"reactions":[8],"of":[9,43,108,124,128,135,142,152,186,243,306,334],"nitrogen":[10],"dioxide":[11],"with":[12,24,63,193],"unsaturated":[13],"fatty":[14],"acids.":[15],"They":[16],"electrophilic":[18,299],"and":[19,27,60,113,147,168,177,197,206,248,257,263,273,291,297,309,339],"signal":[20],"reversibly":[22],"reacting":[23],"nucleophilic":[25],"cysteine":[26],"histidine":[28],"residues":[29],"on":[30,188],"proteins,":[31],"thus":[32],"altering":[33],"protein":[34,293],"function.":[35],"NO2-FA":[36,76,250,335,341],"mediate":[37],"cardioprotection":[38],"in":[39,40,56,69,85,190,212,223,235,245,319,347],"vivo":[41],"models":[42],"ischemia-reperfusion":[44],"(IR)":[45],"through":[46,81],"not":[47,93],"fully":[48],"defined":[49],"mechanisms.":[50],"Mitochondria":[51],"play":[52],"a":[53,66,209,224],"central":[54],"role":[55],"both":[57],"IR":[58,216],"injury":[59,217],"redox":[61],"signaling,":[62],"respiratory":[64,176],"inhibition":[65,107],"common":[67],"pathway":[68],"cardioprotective":[70],"signaling.":[71],"It":[72],"was":[73,97,111,131,180,221],"hypothesized":[74],"that":[75,89,106],"induce":[77],"tissue-protective":[78,210],"metabolic":[79,342],"shifts":[80],"mitochondrial":[82,136,332],"interactions.":[83],"Respirometry":[84],"isolated":[86],"mitochondria":[87],"demonstrated":[88],"complex":[90,94,109,129],"II-linked,":[91],"but":[92],"I-linked,":[95],"respiration":[96,205],"inhibited":[98,195,204,270],"nitro-oleic":[100],"acid":[101],"(OANO2).":[102],"Activity":[103],"assays":[104],"showed":[105],"II":[110,130],"pH-dependent":[112],"reversible":[114],"the":[116,125,150,184,219,236,304,348],"low":[117],"molecular":[118],"weight":[119],"thiol":[120],"\u03b2-mercaptoethanol":[121],"(BME).":[122],"Modification":[123],"Fp":[126],"subunit":[127],"confirmed":[132],"following":[133],"electrophoresis":[134],"proteins":[137],"from":[138],"OANO2-treated":[139],"lysates:":[140],"addition":[141],"BME":[143],"displaced":[144],"protein-bound":[145],"OANO2":[146,187,194,202,244,284,289,296,317,327],"led":[148],"to":[149,182,218,259,282,326,337,345],"formation":[151,305],"BME-OANO2":[153],"adducts":[154],"as":[155,173,228],"measured":[156,172],"liquid":[158],"chromatography/mass":[159],"spectrometry":[160],"(LC/MS).":[161],"Extracellular":[162],"flux":[163],"analysis,":[164],"where":[165],"O2":[166],"consumption":[167],"media":[169],"acidification":[170],"surrogates":[174],"for":[175],"glycolytic":[178],"activity,":[179],"employed":[181],"determine":[183],"effects":[185],"bioenergetics":[189],"cardiomyoblasts.":[191],"Pre-incubation":[192],"basal":[196],"maximal":[198],"respiration,":[199],"while":[200,301],"acute":[201],"injection":[203],"promoted":[207],"glycolysis,":[208],"shift":[211],"IR.":[213],"Protection":[214],"against":[215],"heart":[220,226],"observed":[222],"Langendorff-perfused":[225],"model":[227],"improved":[229],"cardiac":[230,246],"output":[231],"recovery":[232],"during":[233],"reperfusion":[234],"presence":[237],"OANO2.":[238],"Additional":[239],"studies":[240],"monitored":[241],"metabolism":[242],"tissue":[247],"cells.":[249],"metabolized":[252],"prostaglandin":[254],"reductase-1":[255],"(PGR1)":[256],"\u03b2-oxidation":[258,311],"yield":[260],"non-electrophilic":[261,307],"nitroalkanes":[262,308],"shorter":[264],"chain":[265],"nitroalkenes,":[266],"respectively.":[267],"PGR1":[268],"is":[269],"indomethacin":[272],"\uf062-oxidation":[274],"etomoxir,":[276],"so":[277],"these":[278],"compounds":[279],"were":[280],"used":[281],"inhibit":[283],"metabolism.":[285],"Indomethacin":[286,313],"treatment":[287],"attenuated":[288],"reduction":[290],"enhanced":[292,316],"adduction":[294],"its":[298],"metabolites,":[300],"etomoxir":[302],"favored":[303],"reduced":[310],"products.":[312],"also":[314],"significantly":[315],"signaling":[318,346],"cardiomyoblasts,":[320],"elevating":[321],"heme":[322],"oxygenase-1":[323],"expression":[324],"compared":[325],"alone.":[328],"This":[329],"work":[330],"identifies":[331],"actions":[333],"relevant":[336,344],"cardioprotection,":[338],"illuminates":[340],"pathways":[343],"myocardium.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
