{"id":"https://openalex.org/W89255894","doi":"https://doi.org/10.1007/978-1-60761-974-1_10","title":"Engineering BAC Reporter Gene Constructs for Mouse Transgenesis","display_name":"Engineering BAC Reporter Gene Constructs for Mouse Transgenesis","publication_year":2010,"publication_date":"2010-10-04","ids":{"openalex":"https://openalex.org/W89255894","doi":"https://doi.org/10.1007/978-1-60761-974-1_10","mag":"89255894","pmid":"https://pubmed.ncbi.nlm.nih.gov/21080280","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5647146"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-974-1_10","doi":"https://doi.org/10.1007/978-1-60761-974-1_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-974-1_10","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1503659850","display_name":"Transgenic Mouse Methods and Protocols"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5647146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073373032","display_name":"Yu Fu","orcid":"https://orcid.org/0000-0001-9849-7841","observed_orcids":["https://orcid.org/0000-0001-9849-7841"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Fu","raw_affiliation_strings":["Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025491098","display_name":"Peter F. Maye","orcid":"https://orcid.org/0000-0003-0098-4399","observed_orcids":["https://orcid.org/0000-0003-0098-4399"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Maye","raw_affiliation_strings":["Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I75929689"],"apc_list":null,"apc_paid":null,"fwci":2.1461,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.86271871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"693","issue":null,"first_page":"163","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-artificial-chromosome","display_name":"bacterial artificial chromosome","score":0.8840000033378601},{"id":"https://openalex.org/keywords/reporter-gene-constructs","display_name":"reporter gene constructs","score":0.8669999837875366},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8169999718666077},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fluorescent-reporter-proteins","display_name":"fluorescent protein reporter","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mcherry","display_name":"mCherry","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tenascin-c","display_name":"tenascin-C","score":0.9430000185966492},{"id":"https://openalex.org/keywords/skeletal-biology","display_name":"skeletal biology","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C182901222","wikidata":"https://www.wikidata.org/wiki/Q419061","display_name":"Bacterial artificial chromosome","level":4,"score":0.8662903308868408},{"id":"https://openalex.org/C2779260011","wikidata":"https://www.wikidata.org/wiki/Q412287","display_name":"mCherry","level":4,"score":0.7732961177825928},{"id":"https://openalex.org/C73247094","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Transgenesis","level":5,"score":0.7381834983825684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6346426010131836},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6146104335784912},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5847605466842651},{"id":"https://openalex.org/C70239388","wikidata":"https://www.wikidata.org/wiki/Q920203","display_name":"Recombineering","level":4,"score":0.5437347888946533},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5409520268440247},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.5398650765419006},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5296993851661682},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5205332040786743},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4688464403152466},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4510469138622284},{"id":"https://openalex.org/C132144397","wikidata":"https://www.wikidata.org/wiki/Q2966744","display_name":"Human artificial chromosome","level":4,"score":0.4485081434249878},{"id":"https://openalex.org/C13575015","wikidata":"https://www.wikidata.org/wiki/Q1562492","display_name":"Genomic library","level":4,"score":0.4426463842391968},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.41105547547340393},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.27654188871383667},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.2639811336994171},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1500672698020935},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11299654841423035},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C519853106","wikidata":"https://www.wikidata.org/wiki/Q3640158","display_name":"Reproductive biology","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022202","descriptor_name":"Chromosomes, Artificial, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-60761-974-1_10","doi":"https://doi.org/10.1007/978-1-60761-974-1_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-974-1_10","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:21080280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21080280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5647146","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5647146","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Methods Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5647146","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5647146","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Methods Mol Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3986572963","display_name":"Creating Multi-Gene Reporter Mice Via \"Recombineering\"","funder_award_id":"R21RR021707","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1970913937","https://openalex.org/W1992277099","https://openalex.org/W1995696614","https://openalex.org/W2017400430","https://openalex.org/W2030674934","https://openalex.org/W2050558334","https://openalex.org/W2096525273","https://openalex.org/W2121098824","https://openalex.org/W2126969864","https://openalex.org/W2128016314","https://openalex.org/W2151214732","https://openalex.org/W2151464048","https://openalex.org/W4241827326"],"related_works":["https://openalex.org/W2412073464","https://openalex.org/W2089129609","https://openalex.org/W1992277099","https://openalex.org/W140877168","https://openalex.org/W2085303526","https://openalex.org/W1970913937","https://openalex.org/W2915513689","https://openalex.org/W7101048970","https://openalex.org/W2017342413","https://openalex.org/W1524109526"],"abstract_inverted_index":{"A":[0],"culmination":[1],"of":[2,13,40,47,59,64,69,80,150,163,173],"large-scale":[3],"ideas":[4],"and":[5,44,57,106,196],"efforts":[6,94],"has":[7],"truly":[8],"allowed":[9,32],"for":[10,25,53,76,123],"the":[11,38,45,54,77,143,164,186,232,238],"use":[12],"large":[14],"genomic":[15,126],"DNA":[16,127,218],"clones":[17,61,128],"housed":[18],"in":[19,92],"Bacterial":[20],"Artificial":[21],"Chromosome":[22],"(BAC)":[23],"vectors":[24],"biological":[26],"research.":[27],"Fundamental":[28],"advances":[29,102],"that":[30,145,190,207],"have":[31,98,176],"this":[33,202],"to":[34,71,110,117,129,185,200,204,215,220,236],"happen":[35],"include":[36],"(1)":[37],"completion":[39],"genome":[41],"sequencing":[42],"projects":[43],"establishment":[46],"highly":[48],"annotated":[49],"web-accessible":[50],"databases":[51],"allowing":[52,75],"rapid":[55,78],"identity":[56],"purchase":[58],"BAC":[60,125,182,224],"containing":[62],"genes":[63],"interest.":[65],"(2)":[66],"The":[67,121],"generation":[68],"methodologies":[70],"modify":[72],"BACs":[73,105,193],"genetically,":[74],"creation":[79],"gene":[81,87,132],"targeting":[82],"constructs":[83,88,133,219],"or":[84],"transgenic":[85,115,217,239],"reporter":[86,114,131,240],"using":[89,104,124,210],"homologous":[90],"recombination":[91,108],"bacteria.Recent":[93],"on":[95,100,136],"our":[96],"part":[97],"capitalized":[99],"these":[101],"by":[103],"bacterial":[107],"methods":[109,214],"generate":[111,237],"fluorescent":[112],"protein":[113],"mice":[116],"study":[118],"skeletal":[119],"biology.":[120],"rationale":[122],"engineer":[130,216],"is":[134,194],"based":[135],"their":[137],"much":[138],"larger":[139],"size,":[140],"thus":[141],"increasing":[142],"likelihood":[144],"most,":[146],"if":[147],"not":[148],"all,":[149],"a":[151,160,169],"gene's":[152,166],"respective":[153],"cis":[154],"regulator":[155],"elements":[156],"are":[157,208],"present,":[158],"giving":[159],"truer":[161],"representation":[162],"endogenous":[165],"expression.":[167],"In":[168],"relatively":[170],"short":[171],"amount":[172],"time,":[174],"we":[175,198,229,234],"become":[177],"extremely":[178],"proficient":[179],"at":[180],"generating":[181],"reporters.":[183],"Contrary":[184],"widely":[187],"perceived":[188],"notion":[189],"working":[191],"with":[192],"complex":[195],"difficult,":[197],"decided":[199],"write":[201],"chapter":[203],"encourage":[205],"laboratories":[206],"currently":[209],"traditional":[211],"molecular":[212],"cloning":[213],"strongly":[221],"consider":[222],"learning":[223],"methodologies.":[225],"As":[226],"an":[227],"example,":[228],"walk":[230],"through":[231],"steps":[233],"took":[235],"mouse":[241],"line,":[242],"Tenascin":[243],"C":[244],"(TNC)-mCherry.":[245]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
