{"id":"https://openalex.org/W89216938","doi":"https://doi.org/10.1007/978-1-4757-4860-4_5","title":"Promises and Limitations of Transgenic and Knockout Mice in Modeling Psychiatric Symptoms","display_name":"Promises and Limitations of Transgenic and Knockout Mice in Modeling Psychiatric Symptoms","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W89216938","doi":"https://doi.org/10.1007/978-1-4757-4860-4_5","mag":"89216938"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4757-4860-4_5","doi":"https://doi.org/10.1007/978-1-4757-4860-4_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-4860-4_5","pdf_url":null,"source":{"id":"https://openalex.org/S4210240477","display_name":"Neurobiological foundation of aberrant behaviors","issn_l":"1568-2625","issn":["1568-2625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiological Foundation of Aberrant Behaviors","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W640863393","display_name":"Contemporary Issues in Modeling Psychopathology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029891285","display_name":"Andrew Holmes","orcid":"https://orcid.org/0000-0001-7308-1129","observed_orcids":["https://orcid.org/0000-0001-7308-1129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Holmes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063501456","display_name":"Jacqueline N. Crawley","orcid":"https://orcid.org/0000-0002-1224-995X","observed_orcids":["https://orcid.org/0000-0002-1224-995X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline N. Crawley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3041,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53507014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"55","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.21459999680519104,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.9900000095367432},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.8289999961853027},{"id":"https://openalex.org/keywords/animal-models-of-psychiatric-disorders","display_name":"animal models of psychiatric disorders","score":0.6800000071525574},{"id":"https://openalex.org/keywords/behavioral-phenotypes","display_name":"behavioral phenotypes","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.675906240940094},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.6645041704177856},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6555445194244385},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6301707029342651},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.595563530921936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5657371282577515},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.5551707744598389},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.506098210811615},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5044766664505005},{"id":"https://openalex.org/C2796436","wikidata":"https://www.wikidata.org/wiki/Q3109064","display_name":"Gene knockin","level":3,"score":0.4949299693107605},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4462531507015228},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31234073638916016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22367766499519348},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09918984770774841}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4757-4860-4_5","doi":"https://doi.org/10.1007/978-1-4757-4860-4_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-4860-4_5","pdf_url":null,"source":{"id":"https://openalex.org/S4210240477","display_name":"Neurobiological foundation of aberrant behaviors","issn_l":"1568-2625","issn":["1568-2625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiological Foundation of Aberrant Behaviors","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W107475310","https://openalex.org/W182023876","https://openalex.org/W198410184","https://openalex.org/W1513017963","https://openalex.org/W1528722660","https://openalex.org/W1556074533","https://openalex.org/W1570564798","https://openalex.org/W1572525448","https://openalex.org/W1602497443","https://openalex.org/W1776073507","https://openalex.org/W1795694346","https://openalex.org/W1817985333","https://openalex.org/W1892491565","https://openalex.org/W1964277437","https://openalex.org/W1965215187","https://openalex.org/W1966092598","https://openalex.org/W1966385194","https://openalex.org/W1966417924","https://openalex.org/W1967569415","https://openalex.org/W1967637902","https://openalex.org/W1969887276","https://openalex.org/W1974387854","https://openalex.org/W1975087532","https://openalex.org/W1975977959","https://openalex.org/W1976638794","https://openalex.org/W1977966461","https://openalex.org/W1978581866","https://openalex.org/W1978663763","https://openalex.org/W1979021121","https://openalex.org/W1981448374","https://openalex.org/W1982958152","https://openalex.org/W1984201943","https://openalex.org/W1985221328","https://openalex.org/W1985321201","https://openalex.org/W1986576876","https://openalex.org/W1987299915","https://openalex.org/W1987395516","https://openalex.org/W1988606200","https://openalex.org/W1989850259","https://openalex.org/W1991438019","https://openalex.org/W1991702917","https://openalex.org/W1993256085","https://openalex.org/W1993280093","https://openalex.org/W1993634951","https://openalex.org/W1994017777","https://openalex.org/W1999445315","https://openalex.org/W2001271293","https://openalex.org/W2001308670","https://openalex.org/W2002346584","https://openalex.org/W2002836739","https://openalex.org/W2006041248","https://openalex.org/W2008542931","https://openalex.org/W2008815802","https://openalex.org/W2010526028","https://openalex.org/W2013082402","https://openalex.org/W2013666305","https://openalex.org/W2014793858","https://openalex.org/W2016572676","https://openalex.org/W2017436597","https://openalex.org/W2018814167","https://openalex.org/W2020184819","https://openalex.org/W2021193054","https://openalex.org/W2021620079","https://openalex.org/W2022356586","https://openalex.org/W2023525730","https://openalex.org/W2023868265","https://openalex.org/W2024197904","https://openalex.org/W2025240453","https://openalex.org/W2027388229","https://openalex.org/W2028893665","https://openalex.org/W2029277771","https://openalex.org/W2029707852","https://openalex.org/W2032058764","https://openalex.org/W2032687148","https://openalex.org/W2034561886","https://openalex.org/W2035241965","https://openalex.org/W2035577192","https://openalex.org/W2036066867","https://openalex.org/W2036180008","https://openalex.org/W2038370141","https://openalex.org/W2040500050","https://openalex.org/W2041561931","https://openalex.org/W2042232934","https://openalex.org/W2042554229","https://openalex.org/W2042651197","https://openalex.org/W2043428969","https://openalex.org/W2046100639","https://openalex.org/W2049024975","https://openalex.org/W2049819003","https://openalex.org/W2049946106","https://openalex.org/W2052722276","https://openalex.org/W2053486952","https://openalex.org/W2056162837","https://openalex.org/W2058148588","https://openalex.org/W2060197642","https://openalex.org/W2061608999","https://openalex.org/W2064044397","https://openalex.org/W2064155078","https://openalex.org/W2064636484","https://openalex.org/W2067761581","https://openalex.org/W2068818952","https://openalex.org/W2068879317","https://openalex.org/W2068923400","https://openalex.org/W2069309932","https://openalex.org/W2070279287","https://openalex.org/W2070846125","https://openalex.org/W2071200330","https://openalex.org/W2072383213","https://openalex.org/W2072392892","https://openalex.org/W2076532454","https://openalex.org/W2078312844","https://openalex.org/W2079296458","https://openalex.org/W2079714688","https://openalex.org/W2080239815","https://openalex.org/W2080422256","https://openalex.org/W2083623577","https://openalex.org/W2084882106","https://openalex.org/W2084906880","https://openalex.org/W2085936836","https://openalex.org/W2088133485","https://openalex.org/W2088581099","https://openalex.org/W2089462977","https://openalex.org/W2093499985","https://openalex.org/W2094507548","https://openalex.org/W2094554392","https://openalex.org/W2095804141","https://openalex.org/W2100216270","https://openalex.org/W2102744221","https://openalex.org/W2105837661","https://openalex.org/W2106095564","https://openalex.org/W2109982590","https://openalex.org/W2112588374","https://openalex.org/W2113038139","https://openalex.org/W2115182798","https://openalex.org/W2119951209","https://openalex.org/W2120023340","https://openalex.org/W2120610738","https://openalex.org/W2121113124","https://openalex.org/W2124492456","https://openalex.org/W2125277337","https://openalex.org/W2126629647","https://openalex.org/W2127905906","https://openalex.org/W2132167094","https://openalex.org/W2133458388","https://openalex.org/W2137495023","https://openalex.org/W2139648092","https://openalex.org/W2140474257","https://openalex.org/W2147169944","https://openalex.org/W2158271326","https://openalex.org/W2158350175","https://openalex.org/W2159179104","https://openalex.org/W2162666247","https://openalex.org/W2166066769","https://openalex.org/W2402473691","https://openalex.org/W2911335841","https://openalex.org/W2914771261","https://openalex.org/W4240238059","https://openalex.org/W4406059090","https://openalex.org/W6777267987"],"related_works":["https://openalex.org/W581521047","https://openalex.org/W2485255891","https://openalex.org/W2137061218","https://openalex.org/W2041338165","https://openalex.org/W2209436672","https://openalex.org/W2064981193","https://openalex.org/W7071753014","https://openalex.org/W4247537074","https://openalex.org/W2402473691","https://openalex.org/W2062094778"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}
