{"id":"https://openalex.org/W89204057","doi":null,"title":"Studies on Mouse Oocyte Meiotic Arrest and Maturation","display_name":"Studies on Mouse Oocyte Meiotic Arrest and Maturation","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W89204057","mag":"89204057"},"language":"en","primary_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6204","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/10","pdf_url":"https://opencommons.uconn.edu/dissertations/10","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://opencommons.uconn.edu/dissertations/10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018677291","display_name":"Katie M. Lowther","orcid":"https://orcid.org/0000-0001-7649-974X","observed_orcids":["https://orcid.org/0000-0001-7649-974X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katie M. Lowther","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018677291"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.7851999998092651,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.19529999792575836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gpr3","display_name":"GPR3","score":0.7860000133514404},{"id":"https://openalex.org/keywords/mouse-oocytes","display_name":"mouse oocytes","score":0.746999979019165},{"id":"https://openalex.org/keywords/meiotic-arrest","display_name":"meiotic arrest","score":0.9580000042915344},{"id":"https://openalex.org/keywords/oocyte-maturation","display_name":"oocyte maturation","score":0.921999990940094},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-desensitization","display_name":"G protein-coupled receptor desensitization","score":0.7940000295639038},{"id":"https://openalex.org/keywords/grk2","display_name":"GRK2","score":0.8019999861717224},{"id":"https://openalex.org/keywords/beta-arrestin-2","display_name":"\u03b2-arrestin2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.8050000071525574},{"id":"https://openalex.org/keywords/membrane-localization","display_name":"membrane localization","score":0.42500001192092896},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.8159999847412109}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.880594789981842},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.8243209719657898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7928858995437622},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.6244176626205444},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.538385272026062},{"id":"https://openalex.org/C117943116","wikidata":"https://www.wikidata.org/wiki/Q1135604","display_name":"Receptor-mediated endocytosis","level":4,"score":0.44657203555107117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4304896295070648},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3964396119117737},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34310203790664673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13020166754722595},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0689658522605896},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.046370089054107666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6204","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/10","pdf_url":"https://opencommons.uconn.edu/dissertations/10","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-6204","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/10","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:89204057","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/10/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:opencommons.uconn.edu:dissertations-6204","doi":null,"is_oa":true,"landing_page_url":"https://opencommons.uconn.edu/dissertations/10","pdf_url":"https://opencommons.uconn.edu/dissertations/10","source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W89204057.pdf","grobid_xml":"https://content.openalex.org/works/W89204057.grobid-xml"},"referenced_works_count":269,"referenced_works":["https://openalex.org/W85024798","https://openalex.org/W158763770","https://openalex.org/W1492038278","https://openalex.org/W1507084693","https://openalex.org/W1541025915","https://openalex.org/W1541561513","https://openalex.org/W1548284562","https://openalex.org/W1550298527","https://openalex.org/W1559767829","https://openalex.org/W1580968401","https://openalex.org/W1600955774","https://openalex.org/W1604209299","https://openalex.org/W1604407960","https://openalex.org/W1664200544","https://openalex.org/W1718009280","https://openalex.org/W1769810164","https://openalex.org/W1795151741","https://openalex.org/W1909076506","https://openalex.org/W1945187946","https://openalex.org/W1961999388","https://openalex.org/W1963701928","https://openalex.org/W1963899666","https://openalex.org/W1966135676","https://openalex.org/W1966244470","https://openalex.org/W1966263664","https://openalex.org/W1966389585","https://openalex.org/W1966434897","https://openalex.org/W1967586250","https://openalex.org/W1969030895","https://openalex.org/W1969041583","https://openalex.org/W1970318944","https://openalex.org/W1970853792","https://openalex.org/W1971022983","https://openalex.org/W1971748110","https://openalex.org/W1971908496","https://openalex.org/W1972130588","https://openalex.org/W1973197643","https://openalex.org/W1973433000","https://openalex.org/W1974560738","https://openalex.org/W1974887924","https://openalex.org/W1975180353","https://openalex.org/W1975425719","https://openalex.org/W1976377553","https://openalex.org/W1978416664","https://openalex.org/W1978570830","https://openalex.org/W1979707418","https://openalex.org/W1979815209","https://openalex.org/W1980753190","https://openalex.org/W1981236576","https://openalex.org/W1983229130","https://openalex.org/W1983604049","https://openalex.org/W1983757092","https://openalex.org/W1984212762","https://openalex.org/W1986140299","https://openalex.org/W1987720030","https://openalex.org/W1988186145","https://openalex.org/W1989445395","https://openalex.org/W1989710827","https://openalex.org/W1990522517","https://openalex.org/W1991138299","https://openalex.org/W1992335354","https://openalex.org/W1993054972","https://openalex.org/W1993937267","https://openalex.org/W1994898947","https://openalex.org/W1996193406","https://openalex.org/W1998703307","https://openalex.org/W1999470156","https://openalex.org/W1999558966","https://openalex.org/W1999767086","https://openalex.org/W2002841191","https://openalex.org/W2004674628","https://openalex.org/W2004755511","https://openalex.org/W2005682259","https://openalex.org/W2008977389","https://openalex.org/W2009821764","https://openalex.org/W2010131812","https://openalex.org/W2010782393","https://openalex.org/W2010932551","https://openalex.org/W2012641207","https://openalex.org/W2013229182","https://openalex.org/W2013967645","https://openalex.org/W2015557754","https://openalex.org/W2015893386","https://openalex.org/W2016064399","https://openalex.org/W2017214646","https://openalex.org/W2018831893","https://openalex.org/W2020137180","https://openalex.org/W2020329015","https://openalex.org/W2022750564","https://openalex.org/W2023601927","https://openalex.org/W2023724239","https://openalex.org/W2024460610","https://openalex.org/W2025472785","https://openalex.org/W2025599241","https://openalex.org/W2025976079","https://openalex.org/W2026029378","https://openalex.org/W2026439530","https://openalex.org/W2027293803","https://openalex.org/W2027872555","https://openalex.org/W2028807809","https://openalex.org/W2028971323","https://openalex.org/W2029057012","https://openalex.org/W2029709883","https://openalex.org/W2030020224","https://openalex.org/W2030869665","https://openalex.org/W2033289461","https://openalex.org/W2033388874","https://openalex.org/W2036276955","https://openalex.org/W2036530105","https://openalex.org/W2036882997","https://openalex.org/W2038594983","https://openalex.org/W2039025686","https://openalex.org/W2039144927","https://openalex.org/W2040334419","https://openalex.org/W2040392785","https://openalex.org/W2040742434","https://openalex.org/W2041435551","https://openalex.org/W2041607744","https://openalex.org/W2041654178","https://openalex.org/W2042785799","https://openalex.org/W2042819854","https://openalex.org/W2042845128","https://openalex.org/W2043890741","https://openalex.org/W2044344737","https://openalex.org/W2045033520","https://openalex.org/W2046031332","https://openalex.org/W2048340376","https://openalex.org/W2048466881","https://openalex.org/W2050426634","https://openalex.org/W2053856545","https://openalex.org/W2054167608","https://openalex.org/W2054444073","https://openalex.org/W2054447098","https://openalex.org/W2054482637","https://openalex.org/W2055267037","https://openalex.org/W2056511007","https://openalex.org/W2057302775","https://openalex.org/W2057733021","https://openalex.org/W2058050014","https://openalex.org/W2058165049","https://openalex.org/W2058954610","https://openalex.org/W2059380130","https://openalex.org/W2059822315","https://openalex.org/W2060826417","https://openalex.org/W2061098391","https://openalex.org/W2061425302","https://openalex.org/W2062753235","https://openalex.org/W2063539035","https://openalex.org/W2064297433","https://openalex.org/W2064541275","https://openalex.org/W2066675037","https://openalex.org/W2069293047","https://openalex.org/W2069329287","https://openalex.org/W2070581880","https://openalex.org/W2070777738","https://openalex.org/W2070793709","https://openalex.org/W2071551486","https://openalex.org/W2071756901","https://openalex.org/W2072283416","https://openalex.org/W2072338652","https://openalex.org/W2072840386","https://openalex.org/W2073037108","https://openalex.org/W2073504759","https://openalex.org/W2073833473","https://openalex.org/W2073864515","https://openalex.org/W2075114905","https://openalex.org/W2075947666","https://openalex.org/W2076301450","https://openalex.org/W2076440038","https://openalex.org/W2077551455","https://openalex.org/W2078054054","https://openalex.org/W2078322680","https://openalex.org/W2078762926","https://openalex.org/W2078826636","https://openalex.org/W2079302947","https://openalex.org/W2079520721","https://openalex.org/W2080630904","https://openalex.org/W2080700340","https://openalex.org/W2082055785","https://openalex.org/W2082817154","https://openalex.org/W2083334427","https://openalex.org/W2083409282","https://openalex.org/W2083618678","https://openalex.org/W2083681165","https://openalex.org/W2084529284","https://openalex.org/W2085131300","https://openalex.org/W2085505306","https://openalex.org/W2085563409","https://openalex.org/W2085593164","https://openalex.org/W2086459628","https://openalex.org/W2086490634","https://openalex.org/W2086721871","https://openalex.org/W2086889423","https://openalex.org/W2087151025","https://openalex.org/W2087456608","https://openalex.org/W2089021149","https://openalex.org/W2091073917","https://openalex.org/W2091742123","https://openalex.org/W2092532048","https://openalex.org/W2093474429","https://openalex.org/W2094633125","https://openalex.org/W2095849729","https://openalex.org/W2097184870","https://openalex.org/W2097446876","https://openalex.org/W2099048572","https://openalex.org/W2099254082","https://openalex.org/W2099957469","https://openalex.org/W2099987623","https://openalex.org/W2100729936","https://openalex.org/W2102134637","https://openalex.org/W2103750154","https://openalex.org/W2104347748","https://openalex.org/W2104707781","https://openalex.org/W2106877372","https://openalex.org/W2107034951","https://openalex.org/W2109014958","https://openalex.org/W2110048510","https://openalex.org/W2110885272","https://openalex.org/W2111155686","https://openalex.org/W2111508487","https://openalex.org/W2112032807","https://openalex.org/W2112720988","https://openalex.org/W2114500570","https://openalex.org/W2116265895","https://openalex.org/W2116558029","https://openalex.org/W2119398013","https://openalex.org/W2121826020","https://openalex.org/W2122307669","https://openalex.org/W2122459288","https://openalex.org/W2124608202","https://openalex.org/W2125692373","https://openalex.org/W2126704964","https://openalex.org/W2127372435","https://openalex.org/W2129285015","https://openalex.org/W2131077102","https://openalex.org/W2132435301","https://openalex.org/W2132820021","https://openalex.org/W2135189304","https://openalex.org/W2139360692","https://openalex.org/W2140217146","https://openalex.org/W2141999550","https://openalex.org/W2143564478","https://openalex.org/W2144760499","https://openalex.org/W2145525047","https://openalex.org/W2148351021","https://openalex.org/W2150083639","https://openalex.org/W2151273490","https://openalex.org/W2152895071","https://openalex.org/W2154138800","https://openalex.org/W2154175466","https://openalex.org/W2154560913","https://openalex.org/W2155331383","https://openalex.org/W2156128097","https://openalex.org/W2157959080","https://openalex.org/W2157963288","https://openalex.org/W2159328539","https://openalex.org/W2160536323","https://openalex.org/W2160754842","https://openalex.org/W2163174772","https://openalex.org/W2163352150","https://openalex.org/W2165423149","https://openalex.org/W2166748873","https://openalex.org/W2171389484","https://openalex.org/W2183548956","https://openalex.org/W2185479777","https://openalex.org/W2235024595","https://openalex.org/W2339812856","https://openalex.org/W2413214617","https://openalex.org/W3103727215"],"related_works":["https://openalex.org/W2030869665","https://openalex.org/W2072338652","https://openalex.org/W2093037443","https://openalex.org/W7099001790","https://openalex.org/W2013229182","https://openalex.org/W2596488727","https://openalex.org/W7096915704","https://openalex.org/W2040334419","https://openalex.org/W2104707781","https://openalex.org/W2039974488"],"abstract_inverted_index":{"Mammalian":[0],"oocytes":[1],"enter":[2],"meiosis":[3],"during":[4],"embryonic":[5],"development":[6],"and":[7,56,62,69,81,94,105,116,133,140,146,204,225,246],"arrest":[8,27],"at":[9,101,200,214],"prophase":[10],"I":[11],"until":[12],"a":[13],"preovulatory":[14],"surge":[15],"of":[16,33,118,138,150,177,193],"lutenizing":[17],"hormone":[18],"(LH)":[19],"from":[20,90],"the":[21,37,40,52,58,73,91,102,114,155,180,190,201,215],"pituitary":[22],"stimulates":[23],"meiotic":[24],"resumption.":[25],"Meiotic":[26],"is":[28,46,54,60,244],"maintained":[29],"by":[30,39,64,172,250],"high":[31],"levels":[32,80,135,186],"cAMP":[34,79,107,134,147,161,185,223],"generated":[35],"in":[36,51,124,154,179],"oocyte":[38,53],"constitutively":[41],"active":[42],"receptor,":[43],"GPR3.":[44,194],"It":[45],"unknown":[47],"how":[48],"GPR3":[49,88,98,132,145,198,226,243],"activity":[50],"regulated":[55],"whether":[57],"receptor":[59],"desensitized":[61],"endocytosed":[63],"GPCR":[65],"kinase":[66],"(GRK)-induced":[67],"phosphorylation":[68,152],"\u03b2-arrestin":[70],"recruitment.":[71],"In":[72,109],"mouse":[74],"oocyte,":[75],"endocytic":[76],"inhibition":[77,128],"increased":[78,129,160],"inhibited":[82],"spontaneous":[83],"maturation.":[84],"We":[85,195],"hypothesize":[86],"that":[87,197],"signals":[89,199],"cell":[92,103,130,143,202],"surface":[93,104],"inhibiting":[95],"endocytosis":[96],"causes":[97],"to":[99,111,164,208,230,233,240],"accumulate":[100],"increase":[106],"levels.":[108,148],"order":[110],"directly":[112],"compare":[113],"localization":[115,192],"signaling":[117],"GPR3,":[119],"we":[120],"extended":[121],"our":[122],"studies":[123,237],"HEK293":[125],"cells.":[126],"Endocytic":[127],"surface-localized":[131,144],"while":[136],"overexpression":[137],"GRK2":[139,173],"\u03b2-arrestin-2":[141],"decreased":[142],"Mutation":[149,176],"potential":[151],"sites":[153,168],"third":[156],"intracellular":[157],"loop":[158],"dramatically":[159],"production":[162,224],"compared":[163],"WT;":[165],"however,":[166],"these":[167],"are":[169,238],"not":[170,183,206,219],"targeted":[171,247],"for":[174,222,248],"desensitization.":[175],"serines":[178],"C-terminus":[181],"did":[182,188],"change":[184],"but":[187],"decrease":[189],"membrane":[191,203,217,234],"conclude":[196],"does":[205],"continue":[207],"signal":[209,231],"following":[210],"internalization,":[211],"although":[212],"placement":[213],"plasma":[216],"may":[218,227],"be":[220,228],"required":[221,239],"able":[229],"prior":[232],"insertion.":[235],"Further":[236],"determine":[241],"if":[242],"phosphorylated":[245],"regulation":[249],"other":[251],"kinases":[252],"or":[253],"G":[254],"protein-coupled":[255],"interacting":[256],"proteins.":[257]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}