{"id":"https://openalex.org/W8919293","doi":null,"title":"Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.","display_name":"Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W8919293","mag":"8919293","pmid":"https://pubmed.ncbi.nlm.nih.gov/2334455"},"language":"en","primary_location":{"id":"pmid:2334455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2334455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053123676","display_name":"Hitoshi Ikeda","orcid":"https://orcid.org/0000-0001-6081-1073","observed_orcids":["https://orcid.org/0000-0001-6081-1073"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Ikeda","raw_affiliation_strings":["Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Division, Takeda Chemical Industries, Ltd., Osaka, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736333","display_name":"Shigehisa Taketomi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Taketomi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Sugiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sugiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110402652","display_name":"Yukia Shimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072650538","display_name":"Takashi Sohda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Sohda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013275","display_name":"Kanji Meguro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Meguro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9569,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.70956535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"40","issue":"2 Pt 1","first_page":"156","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.8880000114440918},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.847000002861023},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.7979999780654907},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.45399999618530273},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8849999904632568},{"id":"https://openalex.org/keywords/insulin-action","display_name":"insulin action","score":0.6140000224113464},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.6579999923706055},{"id":"https://openalex.org/keywords/diaphragm","display_name":"diaphragm","score":0.8619999885559082},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.9440000057220459},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.9795042276382446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.9066299200057983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8924693465232849},{"id":"https://openalex.org/C2776923340","wikidata":"https://www.wikidata.org/wiki/Q1393556","display_name":"Thiazolidinedione","level":4,"score":0.7010179758071899},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6673763394355774},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6533703804016113},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.5812773108482361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45157426595687866},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4494013786315918},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4474145472049713},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4281369745731354},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.4259192943572998},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3417903780937195},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2569146752357483}],"mesh":[{"descriptor_ui":"D000077205","descriptor_name":"Pioglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008820","descriptor_name":"Mice, Obese","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2334455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2334455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Comparative Study"},{"id":"mag:8919293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2334455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W42878053","https://openalex.org/W189745669","https://openalex.org/W313836430","https://openalex.org/W771163182","https://openalex.org/W1722979865","https://openalex.org/W1964756308","https://openalex.org/W1968811610","https://openalex.org/W1969089790","https://openalex.org/W1971815588","https://openalex.org/W1976909443","https://openalex.org/W1981234599","https://openalex.org/W1981753114","https://openalex.org/W1987414520","https://openalex.org/W1997590875","https://openalex.org/W2004680930","https://openalex.org/W2008575992","https://openalex.org/W2012406948","https://openalex.org/W2016981332","https://openalex.org/W2018452063","https://openalex.org/W2021099633","https://openalex.org/W2022075088","https://openalex.org/W2022567711","https://openalex.org/W2023145582","https://openalex.org/W2023321720","https://openalex.org/W2024868697","https://openalex.org/W2025801062","https://openalex.org/W2028354316","https://openalex.org/W2034441621","https://openalex.org/W2038704879","https://openalex.org/W2040936201","https://openalex.org/W2042476054","https://openalex.org/W2045977955","https://openalex.org/W2047049678","https://openalex.org/W2055806790","https://openalex.org/W2057631155","https://openalex.org/W2060575534","https://openalex.org/W2061371877","https://openalex.org/W2064397707","https://openalex.org/W2066383596","https://openalex.org/W2082399986","https://openalex.org/W2088432899","https://openalex.org/W2090389523","https://openalex.org/W2093248761","https://openalex.org/W2094126290","https://openalex.org/W2097872484","https://openalex.org/W2098493979","https://openalex.org/W2122521015","https://openalex.org/W2180480826","https://openalex.org/W6661771366","https://openalex.org/W6694940231"],"related_works":["https://openalex.org/W2414413288","https://openalex.org/W2412747875","https://openalex.org/W2389904201","https://openalex.org/W2351735759","https://openalex.org/W2387349903","https://openalex.org/W2093762151","https://openalex.org/W4251295193","https://openalex.org/W2088214478","https://openalex.org/W1989708292","https://openalex.org/W2068495554"],"abstract_inverted_index":{"The":[0],"antidiabetic":[1],"effects":[2],"of":[3,70,88],"pioglitazone":[4,42,89,149,170],"(5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione,":[5],"AD-4833,":[6],"also":[7],"known":[8],"as":[9,52],"U-72,":[10],"107E)":[11],"were":[12],"examined":[13],"in":[14,56,64,82,107,114,129,142,176],"normal,":[15],"obese,":[16],"and/or":[17],"diabetic":[18,27],"animals.":[19,58],"When":[20],"orally":[21],"administered":[22],"to":[23,79,92,173],"genetically":[24],"obese":[25,95,178],"and":[26,33,48,67,74,94,105,111,139,155],"yellow":[28,71],"KK":[29,72],"mice":[30,73],"(2.4-24.5":[31],"mg/kg/d),":[32],"Zucker":[34,83],"fatty":[35,84],"rats":[36],"(0.1-10":[37],"mg/kg/d)":[38,91],"for":[39],"4":[40],"days,":[41],"markedly":[43],"decreased":[44,102,118],"hyperglycemia,":[45],"hyperlipidemia,":[46],"hyperinsulinemia,":[47],"glucose":[49,62,104,127,138,154],"intolerance":[50],"characterized":[51],"insulin":[53,81,100,160,164],"resistant":[54],"states":[55],"these":[57],"Pioglitazone":[59,117,133],"potentiated":[60],"insulin-mediated":[61],"metabolism":[63,157],"the":[65,76,108,125],"diaphragm":[66],"adipose":[68],"tissues":[69],"enhanced":[75],"glycemic":[77],"response":[78],"exogenous":[80],"rats.":[85,132,144],"Four-day":[86],"administration":[87],"(1":[90],"aged":[93],"beagle":[96],"dogs":[97],"with":[98,159],"moderate":[99],"resistance":[101,161],"plasma":[103,115,119,126,137],"lipids":[106,120],"fasting":[109],"state,":[110],"postprandial":[112],"rises":[113],"triglyceride.":[116],"but":[121],"did":[122,134],"not":[123,135],"alter":[124,136],"level":[128],"young":[130],"normal":[131],"lipid":[140,156],"levels":[141],"streptozocin-diabetic":[143],"These":[145],"results":[146],"indicate":[147],"that":[148],"is":[150,171],"effective":[151],"on":[152,166],"abnormal":[153],"associated":[158],"by":[162],"enhancing":[163],"action":[165],"peripheral":[167],"tissues.":[168],"Therefore,":[169],"expected":[172],"be":[174],"useful":[175],"treating":[177],"non-insulin-dependent":[179],"diabetes.":[180]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
