{"id":"https://openalex.org/W89173908","doi":null,"title":"A randomized comparison of one single dose of vaginal 50 microg misoprostol with 3 mg dinoprostone in pre-induction cervical ripening.","display_name":"A randomized comparison of one single dose of vaginal 50 microg misoprostol with 3 mg dinoprostone in pre-induction cervical ripening.","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W89173908","mag":"89173908","pmid":"https://pubmed.ncbi.nlm.nih.gov/11075969"},"language":"en","primary_location":{"id":"pmid:11075969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11075969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044341951","display_name":"S Charoenkul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800913826","display_name":"Bangkok Metropolitan Administration","ror":"https://ror.org/04g5xjh29","country_code":"TH","type":"government","lineage":["https://openalex.org/I2800913826"]},{"id":"https://openalex.org/I2801262096","display_name":"Vajira Hospital","ror":"https://ror.org/04evmpa20","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I2801262096"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"S Charoenkul","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Thailand","institution_ids":["https://openalex.org/I2800913826","https://openalex.org/I2801262096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035447212","display_name":"Manit Sripramote","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sripramote","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.00947298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"83","issue":"9","first_page":"1026","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10600","display_name":"Reproductive Health and Contraception","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/misoprostol","display_name":"misoprostol","score":0.9559999704360962},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cervical-ripening","display_name":"cervical ripening","score":0.9300000071525574},{"id":"https://openalex.org/keywords/labor-induction","display_name":"labor induction","score":0.9449999928474426},{"id":"https://openalex.org/keywords/bishop-score","display_name":"Bishop score","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hyperstimulation-syndrome","display_name":"hyperstimulation syndrome","score":0.7739999890327454},{"id":"https://openalex.org/keywords/oxytocin-augmentation","display_name":"oxytocin augmentation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vaginal-delivery","display_name":"vaginal delivery","score":0.6679999828338623},{"id":"https://openalex.org/keywords/term-pregnancy","display_name":"term pregnancy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/parity","display_name":"parity","score":0.5320000052452087},{"id":"https://openalex.org/keywords/uterine-contraction","display_name":"uterine contraction","score":0.5920000076293945},{"id":"https://openalex.org/keywords/drug-safety-and-efficacy-comparison","display_name":"drug safety and efficacy comparison","score":0.5370000004768372},{"id":"https://openalex.org/keywords/single-dose-administration","display_name":"single-dose administration","score":0.5099999904632568},{"id":"https://openalex.org/keywords/preterm-birth-prevention","display_name":"preterm birth prevention","score":0.3930000066757202},{"id":"https://openalex.org/keywords/neonatal-outcomes","display_name":"neonatal outcomes","score":0.35499998927116394},{"id":"https://openalex.org/keywords/maternal-outcomes","display_name":"maternal outcomes","score":0.42800000309944153},{"id":"https://openalex.org/keywords/neonatal-morbidity","display_name":"neonatal morbidity","score":0.4449999928474426},{"id":"https://openalex.org/keywords/neonatal-mortality","display_name":"neonatal mortality","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9490723609924316},{"id":"https://openalex.org/C2779199973","wikidata":"https://www.wikidata.org/wiki/Q416025","display_name":"Misoprostol","level":4,"score":0.9222376346588135},{"id":"https://openalex.org/C2779418813","wikidata":"https://www.wikidata.org/wiki/Q866320","display_name":"Bishop score","level":4,"score":0.8703060746192932},{"id":"https://openalex.org/C2910976051","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Dinoprostone","level":3,"score":0.7839207649230957},{"id":"https://openalex.org/C2780802667","wikidata":"https://www.wikidata.org/wiki/Q1497276","display_name":"Labor induction","level":3,"score":0.7034740447998047},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5774381160736084},{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.5273096561431885},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5226504802703857},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5036751627922058},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.49172165989875793},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4843808114528656},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.48405665159225464},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4101558327674866},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.3448255658149719},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3293219804763794},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.27516603469848633},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17117047309875488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11391916871070862},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.09317344427108765},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007751","descriptor_name":"Labor, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010120","descriptor_name":"Oxytocics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11075969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11075969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Medical Association of Thailand = Chotmaihet thangphaet","raw_type":"Clinical Trial"},{"id":"mag:89173908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11075969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408545619","https://openalex.org/W1830516124","https://openalex.org/W7097780678","https://openalex.org/W1508676443","https://openalex.org/W2266540596","https://openalex.org/W53518156","https://openalex.org/W2908377311","https://openalex.org/W7100470122","https://openalex.org/W7219969684","https://openalex.org/W2185052286"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"compare":[2],"the":[3,157,160,167,181,243,256,271,276,355,363,370,382,387],"efficacy":[4,332],"and":[5,55,63,105,166,180,273,292,314,327],"safety":[6],"of":[7,11,19,37,68,74,81,89,122,149,156,162,169,197,231,239,252,278,318,322,333,339,378],"one":[8,16,203],"single":[9,17,120,335],"dose":[10,18,121,338],"50":[12,123,336],"pg":[13],"misoprostol":[14,125,244,272,313,383],"to":[15,103,117,140,225,324,347,361,386],"3":[20,127,348],"mg":[21,128,349],"dinoprostone":[22,274,315,350,388],"administered":[23,130,341],"vaginally":[24,340],"for":[25,35,79,93],"pre-induction":[26],"cervical":[27,253,352],"ripening":[28],"in":[29,110,192,206,242,316,351,365,381,393],"term-pregnant":[30],"women,":[31],"who":[32,76],"had":[33,77,85],"indications":[34,78],"induction":[36],"labor":[38,94],"with":[39,210,219],"unripe":[40],"cervices.":[41],"STUDY":[42],"DESIGN:":[43],"A":[44],"randomized":[45],"double-blind":[46],"controlled":[47],"trial.":[48],"SETTING:":[49],"Bangkok":[50],"Metropolitan":[51],"Administration":[52],"Medical":[53],"College":[54],"Vajira":[56],"Hospital,":[57],"Bangkok,":[58],"Thailand.":[59],"SUBJECTS:":[60],"One":[61],"hundred":[62],"forty-three":[64],"singleton":[65],"pregnant":[66],"women":[67],">":[69],"or":[70,126],"=":[71],"37":[72],"weeks":[73],"gestation,":[75],"termination":[80],"pregnancy.":[82],"All":[83],"patients":[84,208,212,395],"a":[86,119,236,334,375],"Bishop":[87,147,183],"score":[88,148,184,186,198,215],"0-6,":[90],"without":[91],"contraindications":[92],"induction.":[95],"INTERVENTION:":[96],"The":[97,108,146,177,195,331],"subjects":[98,109],"were":[99,113,190,283,296,310],"stratified":[100],"by":[101,115],"parity":[102],"nullipara":[104],"multipara":[106],"group.":[107,389],"each":[111],"stratum":[112],"allocated":[114],"randomization":[116],"receive":[118],"microg":[124,337],"dinoprostone,":[129],"vaginally.":[131],"Twenty-four":[132],"hours":[133,153,201,251,282,295],"after":[134,154],"medication,":[135],"oxytocin":[136],"augmentation":[137],"was":[138,202,229,235,258,264,357,374],"given":[139],"both":[141,193],"groups.":[142,194],"MAIN":[143],"OUTCOME":[144],"MEASURE:":[145],"cervix":[150],"at":[151,199],"24":[152,200,281],"insertion":[155],"studied":[158],"drugs,":[159],"occurrence":[161],"abnormal":[163,366],"uterine":[164,367],"contraction,":[165],"number":[168],"vaginal":[170,268,325],"deliveries":[171,269],"within":[172,280,293],"24,":[173],"48":[174,294],"hours.":[175],"RESULTS:":[176],"demographic":[178],"data":[179],"initial":[182],"(median":[185],"3.5":[187],"versus":[188,217,287,300],"4.0)":[189],"comparable":[191],"change":[196,214],"unit":[204],"higher":[205,237,376],"misoprostol-treated":[207,394],"compared":[209,385],"dinoprostone-treated":[211],"(mean":[213],"6.5":[216],"5.5,":[218],"95":[220],"per":[221,285,289,298,302],"cent":[222,286,290,299,303],"CI":[223],"0.04":[224],"2.1,":[226],"p=0.042)":[227],"but":[228],"not":[230,259,344,358],"clinical":[232],"importance.":[233],"There":[234],"frequency":[238,377],"hyperstimulation":[240,379],"syndrome":[241,380],"group":[245,384],"(6.9%":[246],"vs":[247],"0%)":[248],"during":[249],"8":[250],"ripening.":[254,353],"Although":[255,354],"difference":[257],"statistically":[260],"significant":[261,308],"(p=0.058),":[262],"it":[263],"clinically":[265,345],"important.":[266],"Comparing":[267],"between":[270,312,369],"groups,":[275,372],"frequencies":[277],"delivery":[279,326],"46.3":[284],"35.7":[288],"(p=0.350),":[291],"88.9":[297],"89.3":[301],"(p>0.05),":[304],"non-significantly":[305],"different.":[306],"No":[307],"differences":[309,364],"noted":[311],"terms":[317],"interval":[319],"from":[320],"start":[321],"medication":[323],"neonatal":[328],"outcomes.":[329],"CONCLUSION:":[330],"misoprostol,":[342],"is":[343,396],"different":[346],"study":[356],"sufficiently":[359],"large":[360],"detect":[362],"contractions":[368],"two":[371],"there":[373],"Close":[390],"utero-fetal":[391],"monitoring":[392],"needed.":[397]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}