{"id":"https://openalex.org/W89146506","doi":null,"title":"Functional alteration of brain dopaminergic system in isolated aggressive mice.","display_name":"Functional alteration of brain dopaminergic system in isolated aggressive mice.","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W89146506","mag":"89146506","pmid":"https://pubmed.ncbi.nlm.nih.gov/11769459"},"language":"en","primary_location":{"id":"pmid:11769459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11769459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Matsuda","raw_affiliation_strings":["Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871 Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109048602","display_name":"Morito Sakaue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Sakaue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003799324","display_name":"Yukio Ago","orcid":"https://orcid.org/0000-0001-7562-4000","observed_orcids":["https://orcid.org/0000-0001-7562-4000"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ago","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109374170","display_name":"Yoshimasa Sakamoto","orcid":"https://orcid.org/0009-0000-4274-1307","observed_orcids":["https://orcid.org/0009-0000-4274-1307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sakamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091267274","display_name":"Yutaka K\u014dyama","orcid":"https://orcid.org/0000-0002-6508-0094","observed_orcids":["https://orcid.org/0000-0002-6508-0094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Koyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040297057","display_name":"Atsushi Baba","orcid":"https://orcid.org/0000-0002-6871-7249","observed_orcids":["https://orcid.org/0000-0002-6871-7249"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Baba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4214,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.48905054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"3","first_page":"71","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/social-isolation","display_name":"social isolation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dopamine-receptors","display_name":"dopamine receptors","score":0.8309999704360962},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.8569999933242798},{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/isolation-stress","display_name":"isolation stress","score":0.753000020980835},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dopamine-serotonin-interaction","display_name":"serotonin-dopamine interaction","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.7968683838844299},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7232073545455933},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7214444875717163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6296629905700684},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6201726198196411},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5363807082176208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5259566307067871},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5213550329208374},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4929466247558594},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4202108383178711},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36537617444992065},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.3465802073478699},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30425482988357544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19871681928634644}],"mesh":[{"descriptor_ui":"D000374","descriptor_name":"Aggression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000374","descriptor_name":"Aggression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004146","descriptor_name":"Dioxanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004149","descriptor_name":"Dioxoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005625","descriptor_name":"Frontal Lobe","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012934","descriptor_name":"Social Isolation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11769459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11769459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","raw_type":"Journal Article"},{"id":"mag:89146506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11769459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1564008432","https://openalex.org/W2666015618","https://openalex.org/W1991033273","https://openalex.org/W3101967367","https://openalex.org/W2047661943","https://openalex.org/W2093579916","https://openalex.org/W2076031799","https://openalex.org/W2013547168","https://openalex.org/W2071681001","https://openalex.org/W1969016546"],"abstract_inverted_index":{"The":[0,78,117],"present":[1],"study":[2,23],"examined":[3],"the":[4,24,36,47,68,73,85,103,138,146,153,156],"effects":[5],"of":[6,27,35,81,119,155],"social":[7],"isolation":[8,139],"on":[9,17,121],"cortical":[10,28,60,104,142],"dopamine":[11],"(DA)":[12],"release":[13,62,106,144],"in":[14,31,55,63,65,84,90,94,102,110,114,127,131],"vivo":[15,64],"and":[16,46,67,98,145,151,163],"brain":[18,147],"DA":[19,29,48,61,83,105,143,148],"receptor":[20,39,49,75,149,161],"functions":[21],"to":[22,159],"possible":[25],"involvement":[26],"neurons":[30],"an":[32],"antiaggressive":[33],"effect":[34,69,118],"serotonin":[37],"(5-HT)1A":[38],"agonist":[40,50],"(S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]":[41],"propoxy]-1,3-benzodioxole":[42],"HCl":[43],"(MKC-242).":[44],"MKC-242":[45,58],"apomorphine":[51,120],"reduced":[52],"aggressive":[53],"behavior":[54],"isolated":[56,91,111,128],"mice.":[57,96,116,133],"increased":[59],"mice,":[66],"was":[70,88,124],"antagonized":[71],"by":[72],"5-HT1A":[74,160],"antagonist":[76],"N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide.":[77],"basal":[79],"level":[80],"extracellular":[82],"frontal":[86],"cortex":[87],"higher":[89],"mice":[92,112,129],"than":[93,113,130],"grouped":[95,115,132],"MKC-242-induced":[97],"high":[99,164],"K(+)-induced":[100,165],"increases":[101],"were":[107],"less":[108],"pronounced":[109,126],"locomotor":[122],"activity":[123],"more":[125],"These":[134],"findings":[135],"suggest":[136],"that":[137],"stress":[140],"enhances":[141],"function":[150],"reduces":[152],"responses":[154],"dopaminergic":[157],"terminals":[158],"stimulation":[162],"depolarization.":[166]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
