{"id":"https://openalex.org/W89146470","doi":null,"title":"Expression profile of nuclear receptors upon Epstein -- Barr virus induced B cell transformation.","display_name":"Expression profile of nuclear receptors upon Epstein -- Barr virus induced B cell transformation.","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W89146470","mag":"89146470","pmid":"https://pubmed.ncbi.nlm.nih.gov/19550398"},"language":"en","primary_location":{"id":"pmid:19550398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19550398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental oncology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.nbuv.gov.ua/handle/123456789/135700","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048705458","display_name":"Surya Pavan Yenamandra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S P Yenamandra","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm S17177, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm S17177, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Lundin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lundin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110822556","display_name":"Velmurugesan Arulampalam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Arulampalam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069832309","display_name":"Maria Yurchenko","orcid":"https://orcid.org/0000-0002-0516-4747","observed_orcids":["https://orcid.org/0000-0002-0516-4747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yurchenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064295225","display_name":"Sven Pettersson","orcid":"https://orcid.org/0000-0001-8903-3738","observed_orcids":["https://orcid.org/0000-0001-8903-3738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Pettersson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109158685","display_name":"George Klein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Klein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088246780","display_name":"Elena Kashuba","orcid":"https://orcid.org/0000-0001-7001-4035","observed_orcids":["https://orcid.org/0000-0001-7001-4035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Kashuba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7386,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.84266203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"2","first_page":"92","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/b-cell-transformation","display_name":"B cell transformation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lymphoblastoid-cell-lines","display_name":"lymphoblastoid cell lines","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nr2f2","display_name":"NR2F2","score":0.6880000233650208},{"id":"https://openalex.org/keywords/retinoic-acid-receptor-alpha","display_name":"retinoic acid receptor alpha","score":0.890999972820282},{"id":"https://openalex.org/keywords/erb","display_name":"Erb","score":0.628000020980835},{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9160000085830688},{"id":"https://openalex.org/keywords/mrna-and-protein-expression","display_name":"mRNA and protein expression","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5972234606742859},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5789613127708435},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5783951282501221},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.5590916275978088},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4463212490081787},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43606826663017273},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4338931441307068},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41423895955085754},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33504822850227356},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31565356254577637},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23438167572021484},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2205924093723297},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19550398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19550398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental oncology","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.nbuv.gov.ua:123456789/135700","doi":null,"is_oa":true,"landing_page_url":"http://dspace.nbuv.gov.ua/handle/123456789/135700","pdf_url":"http://dspace.nbuv.gov.ua/handle/123456789/135700","source":{"id":"https://openalex.org/S4306401959","display_name":"The scientific electronic library of periodicals of the National Academy of Sciences of Ukraine (National Academy of Sciences of Ukraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149851306","host_organization_name":"National Academy of Sciences of Ukraine","host_organization_lineage":["https://openalex.org/I149851306"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"mag:89146470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19550398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.nbuv.gov.ua:123456789/135700","doi":null,"is_oa":true,"landing_page_url":"http://dspace.nbuv.gov.ua/handle/123456789/135700","pdf_url":"http://dspace.nbuv.gov.ua/handle/123456789/135700","source":{"id":"https://openalex.org/S4306401959","display_name":"The scientific electronic library of periodicals of the National Academy of Sciences of Ukraine (National Academy of Sciences of Ukraine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149851306","host_organization_name":"National Academy of Sciences of Ukraine","host_organization_lineage":["https://openalex.org/I149851306"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W89146470.pdf","grobid_xml":"https://content.openalex.org/works/W89146470.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1488614375","https://openalex.org/W1598047674","https://openalex.org/W1854924505","https://openalex.org/W1968262050","https://openalex.org/W1970172735","https://openalex.org/W1995342855","https://openalex.org/W2009205752","https://openalex.org/W2021206718","https://openalex.org/W2023459898","https://openalex.org/W2026869407","https://openalex.org/W2064331238","https://openalex.org/W2070393128","https://openalex.org/W2072786589","https://openalex.org/W2122221708","https://openalex.org/W2126464814","https://openalex.org/W2137336327","https://openalex.org/W2161053030","https://openalex.org/W2193881164","https://openalex.org/W2226175820","https://openalex.org/W2414809613","https://openalex.org/W4205204633","https://openalex.org/W4297754410"],"related_works":["https://openalex.org/W2193881164","https://openalex.org/W6950816208","https://openalex.org/W3127781681","https://openalex.org/W122534809","https://openalex.org/W2412094128","https://openalex.org/W2626058781","https://openalex.org/W2748665876","https://openalex.org/W2065433208","https://openalex.org/W2059833979","https://openalex.org/W2139115185"],"abstract_inverted_index":{"BACKGROUND:":[0],"Infection":[1],"of":[2,34,43,69,83,141,164],"human":[3],"B":[4,44,137],"cells":[5,98,138],"with":[6,152],"Epstein":[7],"-":[8],"Barr":[9],"virus":[10],"(EBV)":[11],"induces":[12],"metabolic":[13],"activation,":[14],"morphological":[15],"transformation,":[16],"cell":[17,45,171],"proliferation":[18],"and":[19,58,114,116,125,148],"eventual":[20],"immortalization.":[21],"AIM:":[22],"To":[23],"identify":[24],"the":[25,30,41,51,56,78,105],"nuclear":[26,52,71,131,142,166],"receptors,":[27],"which":[28],"are":[29],"cellular":[31],"interaction":[32],"partners":[33],"EBNAs,":[35],"that":[36],"will":[37],"help":[38],"to":[39],"elucidate":[40],"mechanism":[42],"transformation.":[46],"METHODS:":[47],"We":[48],"have":[49],"compared":[50,151],"receptor":[53,132,167],"profile":[54],"in":[55,88,96,127,168],"na\u00efve":[57],"EBV-transformed":[59,89],"B-lymphocytes,":[60],"using":[61],"TaqMan":[62],"LDA":[63],"microfluidic":[64],"card":[65],"technology.":[66],"RESULTS:":[67],"Out":[68],"48":[70],"receptor,":[72],"17":[73],"showed":[74,139],"differential":[75],"expression":[76,82,144],"at":[77,104,145],"mRNA":[79,147],"level.":[80],"The":[81,130],"5":[84],"genes":[85,93,101,109,118],"was":[86],"elevated":[87],"cells,":[90],"whereas":[91],"12":[92],"were":[94,102,110,119],"downregulated":[95],"lymphoblastoid":[97],"(LCLs).":[99],"7":[100],"studied":[103],"protein":[106,149],"level;":[107],"2":[108],"up":[111],"regulated":[112,121],"(Nr2F2":[113],"RARA)":[115],"4":[117],"down":[120],"(ERB,":[122],"NUR77,":[123],"PPARG,":[124],"VDR)":[126],"LCLs.":[128],"CONCLUSION:":[129],"profiling":[133],"on":[134,160],"EBV":[135,169],"infected":[136,154],"alterations":[140],"receptors":[143],"both":[146],"levels":[150],"non":[153],"peripheral":[155],"blood":[156],"cells.":[157],"Further":[158],"analysis":[159],"a":[161],"possible":[162],"role":[163],"each":[165],"induced":[170],"transformation":[172],"should":[173],"be":[174],"performed.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}