{"id":"https://openalex.org/W89140879","doi":null,"title":"Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.","display_name":"Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis.","publication_year":2005,"publication_date":"2005-10-01","ids":{"openalex":"https://openalex.org/W89140879","mag":"89140879","pmid":"https://pubmed.ncbi.nlm.nih.gov/16435988"},"language":"en","primary_location":{"id":"pmid:16435988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16435988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049348918","display_name":"Akira Murakami","orcid":"https://orcid.org/0000-0002-5694-2828","observed_orcids":["https://orcid.org/0000-0002-5694-2828"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Murakami","raw_affiliation_strings":["Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. cancer@kais.kyoto-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. cancer@kais.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hisashi Ishida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hisashi Ishida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041348423","display_name":"Kimie Kobo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimie Kobo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113642667","display_name":"Ikuyo Furukawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikuyo Furukawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091277575","display_name":"Yasutaka Ikeda","orcid":"https://orcid.org/0000-0002-9128-279X","observed_orcids":["https://orcid.org/0000-0002-9128-279X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasutaka Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022299248","display_name":"Megumi Yonaha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megumi Yonaha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001105345","display_name":"Yohko Aniya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yohko Aniya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108283782","display_name":"Hajime Ohigashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Ohigashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6813,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.62458869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"437","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.753000020980835},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8159999847412109},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anti-oxidative-activity","display_name":"anti-oxidative activity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/inflammation-associated-carcinogenesis","display_name":"inflammation-associated carcinogenesis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.7559999823570251},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.9700000286102295},{"id":"https://openalex.org/keywords/sugarcane","display_name":"sugarcane","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chebulagic-acid","display_name":"chebulagic acid","score":0.9890000224113464},{"id":"https://openalex.org/keywords/resveratrol-derivatives","display_name":"resveratrol derivatives","score":0.871999979019165},{"id":"https://openalex.org/keywords/sesquiterpenes","display_name":"sesquiterpenes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.6320000290870667},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6508925557136536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6112251281738281},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6052320599555969},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5105270147323608},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5088615417480469},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.505228579044342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47847530245780945},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4523301422595978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2589837908744812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25525957345962524},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010945","descriptor_name":"Plants, Edible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018514","descriptor_name":"Plant Structures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042381","descriptor_name":"Granulocyte Precursor Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042381","descriptor_name":"Granulocyte Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16435988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16435988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"mag:89140879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16435988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1531940878","https://openalex.org/W1556885607","https://openalex.org/W1565012681","https://openalex.org/W1588425240","https://openalex.org/W1589976196","https://openalex.org/W1597643123","https://openalex.org/W1670312687","https://openalex.org/W1929698897","https://openalex.org/W1966400620","https://openalex.org/W1973266162","https://openalex.org/W1973645248","https://openalex.org/W1974764350","https://openalex.org/W1990362555","https://openalex.org/W1991709988","https://openalex.org/W1999382806","https://openalex.org/W2001078312","https://openalex.org/W2008508671","https://openalex.org/W2009267289","https://openalex.org/W2010757088","https://openalex.org/W2011752799","https://openalex.org/W2011812683","https://openalex.org/W2011855358","https://openalex.org/W2021189672","https://openalex.org/W2023847300","https://openalex.org/W2025876684","https://openalex.org/W2028296755","https://openalex.org/W2028535996","https://openalex.org/W2031055677","https://openalex.org/W2034209850","https://openalex.org/W2041784704","https://openalex.org/W2045656328","https://openalex.org/W2051672316","https://openalex.org/W2053076890","https://openalex.org/W2053209378","https://openalex.org/W2059215353","https://openalex.org/W2060488177","https://openalex.org/W2060922482","https://openalex.org/W2076169439","https://openalex.org/W2079826117","https://openalex.org/W2081608638","https://openalex.org/W2083406069","https://openalex.org/W2085115067","https://openalex.org/W2085205603","https://openalex.org/W2088031490","https://openalex.org/W2094412730","https://openalex.org/W2113347787","https://openalex.org/W2118277939","https://openalex.org/W2133381153","https://openalex.org/W2133926249","https://openalex.org/W2140820328","https://openalex.org/W2143204694","https://openalex.org/W2149125209","https://openalex.org/W2158006041","https://openalex.org/W2158758214","https://openalex.org/W2161114383","https://openalex.org/W2162102323","https://openalex.org/W2163560321","https://openalex.org/W2163651437","https://openalex.org/W2197166772","https://openalex.org/W2332570628","https://openalex.org/W2417890903","https://openalex.org/W2476345168"],"related_works":["https://openalex.org/W2028296755","https://openalex.org/W2077596335","https://openalex.org/W2431236692","https://openalex.org/W2055377214","https://openalex.org/W2071705097","https://openalex.org/W7099776799","https://openalex.org/W2506025182","https://openalex.org/W131328411","https://openalex.org/W2103952995","https://openalex.org/W226997802"],"abstract_inverted_index":{"Okinawa":[0,112,127,241],"prefecture":[1],"in":[2,24,39,96,116,126,173,239,251],"Japan":[3],"is":[4,28],"a":[5,135,189,225],"distinct":[6],"area":[7,242],"characterized":[8],"by":[9,72],"unique":[10,110],"traditional":[11],"food":[12,70,104,236],"habits":[13],"and":[14,34,55,65,90,113,128,194,202,213,228],"longevity.":[15],"Prolonged":[16],"exposure":[17],"to":[18,30,32,37,111,175,206],"activated":[19],"leukocytes,":[20],"playing":[21],"pivotal":[22],"roles":[23],"chronic":[25],"inflammation-associated":[26],"carcinogenesis,":[27],"known":[29],"lead":[31],"oxidative":[33],"nitrosative":[35],"damage":[36],"macromolecules":[38],"the":[40,117,143,157,166,179,220,240],"body":[41],"since":[42],"they":[43],"are":[44],"primary":[45],"sources":[46],"of":[47,68,102,107,137,142,150,156,165,178,191,219],"free":[48],"radicals,":[49],"such":[50],"as":[51],"superoxide":[52],"anion":[53],"(O(2)(-))":[54],"nitric":[56],"oxide":[57],"(NO).":[58],"In":[59,161,216],"this":[60],"study,":[61],"we":[62],"estimated":[63],"anti-oxidative":[64,212],"anti-nitrosative":[66,214],"activities":[67],"Okinawan":[69],"items":[71,210,237],"employing":[73],"two":[74],"cellular":[75],"experimental":[76],"systems:":[77],"(1)":[78],"phorbol":[79],"ester-induced":[80],"O(2)(-)":[81,151],"generation":[82,95,152,171],"from":[83],"differentiated":[84],"HL-60":[85],"human":[86],"promyelocytic":[87],"leukemia":[88],"cells;":[89],"(2)":[91],"lipopolysaccharide":[92],"(LPS)-induced":[93],"NO":[94,170],"RAW264.7":[97],"murine":[98],"macrophages.":[99],"A":[100],"total":[101],"138":[103],"items,":[105],"consisting":[106],"42":[108],"samples":[109],"96":[114],"common":[115,250],"Japanese":[118],"main":[119],"island,":[120],"were":[121,185,204,230],"purchased":[122],"at":[123,134,188],"local":[124],"markets":[125],"extracted":[129],"with":[130,211],"chloroform.":[131],"When":[132],"tested":[133,187],"concentration":[136,190],"100":[138],"microg/ml,":[139],"38%":[140],"(16/42)":[141],"former":[144,167],"showed":[145,168],"70%":[146],"or":[147],"more":[148],"inhibition":[149],"while":[153],"21%":[154],"(20/96)":[155],"latter":[158,180],"did":[159],"so.":[160],"parallel,":[162],"64%":[163],"(27/42)":[164],"significant":[169],"suppression":[172],"contrast":[174],"48%":[176],"(46/96)":[177],".":[181],"Twenty-one":[182],"active":[183,221],"species":[184],"further":[186],"20":[192],"mug/ml,":[193],"eleven":[195],"species,":[196],"including":[197],"sugar":[198],"cane,":[199],"wild":[200],"turmeric,":[201],"zedoary,":[203],"indicated":[205],"be":[207],"most":[208],"promising":[209],"properties.":[215],"addition,":[217],"some":[218],"constituents":[222],"(chebulagic":[223],"acid,":[224],"resveratrol":[226],"derivative,":[227],"sesquiterpenoids)":[229],"identified.":[231],"Our":[232],"results":[233],"suggest":[234],"that":[235],"typical":[238],"have":[243],"higher":[244],"cancer":[245],"preventive":[246],"potential":[247],"than":[248],"those":[249],"Japan.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
