{"id":"https://openalex.org/W89104684","doi":null,"title":"Serum levels, tissue expression and cellular secretion of macrophage migration inhibitory factor in limited and diffuse systemic sclerosis.","display_name":"Serum levels, tissue expression and cellular secretion of macrophage migration inhibitory factor in limited and diffuse systemic sclerosis.","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W89104684","mag":"89104684","pmid":"https://pubmed.ncbi.nlm.nih.gov/26005773"},"language":"en","primary_location":{"id":"pmid:26005773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26005773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047219651","display_name":"Claudio Corallo","orcid":"https://orcid.org/0000-0003-2826-3745","observed_orcids":["https://orcid.org/0000-0003-2826-3745"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Corallo","raw_affiliation_strings":["Department of Medicine, Surgery and Neurosciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Neurosciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017678895","display_name":"Luana Ricci Paulesu","orcid":"https://orcid.org/0000-0002-7296-308X","observed_orcids":["https://orcid.org/0000-0002-7296-308X"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luana Paulesu","raw_affiliation_strings":["Department of Life Sciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028547482","display_name":"Maurizio Cutolo","orcid":"https://orcid.org/0000-0002-5396-0932","observed_orcids":["https://orcid.org/0000-0002-5396-0932","https://orcid.org/0000-0002-4548-5334","https://orcid.org/0000-0003-3975-8938"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Cutolo","raw_affiliation_strings":["Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089235093","display_name":"Francesca Ietta","orcid":"https://orcid.org/0000-0002-2160-8790","observed_orcids":["https://orcid.org/0000-0002-2160-8790"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ietta","raw_affiliation_strings":["Department of Life Sciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055468933","display_name":"Claudio Carotenuto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Carotenuto","raw_affiliation_strings":["Department of Life Sciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049298769","display_name":"Chiara Mannelli","orcid":"https://orcid.org/0000-0001-9453-238X","observed_orcids":["https://orcid.org/0000-0001-9453-238X"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Mannelli","raw_affiliation_strings":["Department of Life Sciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014496160","display_name":"Roberta Romagnoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberta Romagnoli","raw_affiliation_strings":["Department of Life Sciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013534702","display_name":"Ranuccio Nuti","orcid":"https://orcid.org/0000-0003-2380-7432","observed_orcids":["https://orcid.org/0000-0003-2380-7432"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ranuccio Nuti","raw_affiliation_strings":["Department of Medicine, Surgery and Neurosciences, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Neurosciences, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040844392","display_name":"Nicola G. Giordano","orcid":"https://orcid.org/0000-0001-5423-437X","observed_orcids":["https://orcid.org/0000-0001-5423-437X"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Giordano","raw_affiliation_strings":["Department of Medicine, Surgery and Neurosciences, University of Siena, Italy. nicola.giordano@unisi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Neurosciences, University of Siena, Italy. nicola.giordano@unisi.it","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1544,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75916806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"33","issue":"4 Suppl 91","first_page":"S98","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/limited-cutaneous-systemic-sclerosis","display_name":"limited cutaneous systemic sclerosis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis","display_name":"diffuse cutaneous systemic sclerosis","score":1.0},{"id":"https://openalex.org/keywords/serum-mif-levels","display_name":"serum MIF levels","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cd74","display_name":"CD74","score":0.6690000295639038},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8849999904632568},{"id":"https://openalex.org/keywords/dermal-microvascular-endothelial-cells","display_name":"dermal microvascular endothelial cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bleomycin-induced-fibrosis","display_name":"bleomycin-induced fibrosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mif-mrna-expression","display_name":"MIF mRNA expression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/skin-fibrosis","display_name":"skin fibrosis","score":0.4050000011920929},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sebaceous-glands","display_name":"sebaceous glands","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.8679696917533875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8646448850631714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5240585803985596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49452897906303406},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4772215485572815},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.46783390641212463},{"id":"https://openalex.org/C2776670291","wikidata":"https://www.wikidata.org/wiki/Q1779300","display_name":"Connective tissue disease","level":4,"score":0.44822508096694946},{"id":"https://openalex.org/C2779625490","wikidata":"https://www.wikidata.org/wiki/Q5340515","display_name":"Systemic scleroderma","level":3,"score":0.4406786859035492},{"id":"https://openalex.org/C2778005187","wikidata":"https://www.wikidata.org/wiki/Q5262669","display_name":"Dermal fibroblast","level":4,"score":0.4272025525569916},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.40391674637794495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.304628849029541},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2992747724056244},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2894176244735718},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.24553489685058594},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23227307200431824},{"id":"https://openalex.org/C2778751314","wikidata":"https://www.wikidata.org/wiki/Q681160","display_name":"Dermatomyositis","level":2,"score":0.11837217211723328},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0917099118232727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07571688294410706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000944","descriptor_name":"Antigens, Differentiation, B-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045743","descriptor_name":"Scleroderma, Diffuse","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D045743","descriptor_name":"Scleroderma, Diffuse","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D045743","descriptor_name":"Scleroderma, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045743","descriptor_name":"Scleroderma, Diffuse","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045745","descriptor_name":"Scleroderma, Limited","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D045745","descriptor_name":"Scleroderma, Limited","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D045745","descriptor_name":"Scleroderma, Limited","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045745","descriptor_name":"Scleroderma, Limited","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:26005773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26005773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Comparative Study"},{"id":"pmh:oai:iris.unige.it:11567/812633","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/812633","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/980728","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/980728","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:89104684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26005773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2413110635","https://openalex.org/W7043540370","https://openalex.org/W2112781735","https://openalex.org/W7099744130","https://openalex.org/W3207032379","https://openalex.org/W2045976029","https://openalex.org/W2905038375","https://openalex.org/W2911189356","https://openalex.org/W1959638470","https://openalex.org/W2180153786"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"investigate":[2],"serum":[3,34,95,214],"levels,":[4],"tissue/cellular":[5],"expression":[6],"of":[7,70,180,273],"macrophage":[8],"migration":[9],"inhibitory":[10],"factor":[11,279],"(MIF)":[12],"in":[13,68,78,110,115,137,143,159,174,187,234,254,270],"patients":[14,53,148],"with":[15,54,92,127,212,238],"limited":[16],"(lSSc)":[17],"and":[18,28,41,58,61,77,84,96,102,114,142,177,193,196,200,204,228],"diffuse":[19],"(dSSc)":[20],"systemic":[21],"sclerosis.":[22],"METHODS:":[23],"10":[24,26,29],"lSSc-patients,":[25],"dSSc-patients":[27],"controls":[30,151],"were":[31,36,45,65,108,185],"enrolled.":[32],"MIF":[33,40,63,99,133,155,170,220,245,266],"levels":[35,64,107,222,248],"assayed":[37],"by":[38,47],"ELISA.":[39],"its":[42],"receptors":[43],"CD74/CD44":[44,188],"evaluated":[46],"immunohistochemistry":[48],"on":[49],"skin":[50,176,179],"biopsies":[51],"from":[52,165],"dSSc,":[55],"lSSc":[56,144,181],"(affected":[57],"not-affected":[59,178],"skin)":[60],"controls.":[62],"assessed":[66],"(ELISA)":[67,101],"supernatants":[69],"healthy":[71],"dermal":[72,112,117],"microvascular":[73],"endothelial":[74],"cells":[75],"(MVECs)":[76],"control":[79,94,116,175,192,235,242],"(CTR),":[80],"non-affected":[81,197],"SSc":[82,111,213,282],"(NA)":[83],"affected":[85,167,195],"(SSc)":[86],"fibroblasts":[87,113,118,201,236,256],"treated":[88,237],"for":[89],"48":[90,231,251],"h":[91,126,232,252],"10%":[93,97],"SSc-serum.":[98],"supernatant":[100,246],"mRNA":[103,221],"(quantitative":[104],"real-time":[105],"PCR)":[106],"determined":[109],"untreated":[119,259],"or":[120],"stimulated":[121,211],"at":[122,225,230],"6":[123],"h-24":[124],"h-48":[125],"bleomycin":[128,239],"(50":[129],"mU/ml).":[130],"RESULTS:":[131],"Serum":[132],"was":[134,157,172],"significantly":[135,207,223],"higher":[136],"dSSc":[138],"(18.7\u00b14.1":[139],"ng/ml,":[140,146],"p<0.001)":[141,147],"(10.4\u00b14.4":[145],"respect":[149,215,257],"to":[150,216,241,258],"(2.6\u00b11.4":[152],"ng/ml).":[153],"Enhanced":[154],"immunoreactivity":[156,171],"found":[158,173,186],"keratinocytes,":[160],"fibroblasts,":[161],"endothelium,":[162],"sebaceous/sweat":[163],"glands":[164],"lSSc/dSSc":[166],"skin.":[168,198],"Faint":[169],"patients.":[182],"No":[183],"differences":[184],"receptors'":[189],"analysis":[190],"among":[191],"dSSc/lSSc":[194],"MVECs":[199],"(CTR,":[202],"NA":[203],"SSc)":[205],"produced":[206],"more":[208],"MIF,":[209],"when":[210],"control-serum":[217],"(p<0.001).":[218],"Finally,":[219],"increased":[224,249],"6h":[226],"(p<0.001)":[227,233],"decreased":[229],"compared":[240],"untreated.":[243],"Simultaneously,":[244],"protein":[247],"after":[250],"(p<0.01)":[253],"bleomycin-treated":[255],"ones.":[260],"CONCLUSIONS:":[261],"These":[262],"results":[263],"suggest":[264],"that":[265],"could":[267],"be":[268],"implicated":[269],"the":[271,281],"pathogenesis":[272],"SSc,":[274],"probably":[275],"acting":[276],"as":[277],"protective":[278],"against":[280],"stressful":[283],"conditions.":[284]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}