{"id":"https://openalex.org/W891009167","doi":null,"title":"Molekulare Wirkmechanismen von Tyrosinkinase-Inhibitoren in der Therapie der chronischen myeloischen Leuk\u00e4mie","display_name":"Molekulare Wirkmechanismen von Tyrosinkinase-Inhibitoren in der Therapie der chronischen myeloischen Leuk\u00e4mie","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W891009167","mag":"891009167"},"language":"de","primary_location":{"id":"pmh:oai:docserv.uni-duesseldorf.de:15466","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15466","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058818082","display_name":"Daniela Br\u00fcnnert","orcid":"https://orcid.org/0000-0003-0870-9578","observed_orcids":["https://orcid.org/0000-0003-0870-9578"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniela Br\u00fcnnert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0870-9578","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058818082"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.8479999899864197},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-drug-action","display_name":"molecular mechanisms of drug action","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cd34-hematopoietic-stem-cells","display_name":"CD34+ hematopoietic stem cells","score":0.8510000109672546},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7979999780654907},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cell-adhesion-genes","display_name":"cell adhesion genes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.5849999785423279},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.5320000052452087},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.5189999938011169},{"id":"https://openalex.org/keywords/bcr-abl-mutations","display_name":"BCR-ABL mutations","score":0.40400001406669617},{"id":"https://openalex.org/keywords/bcr-abl2","display_name":"BCR-ABL2","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6647966504096985},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43910321593284607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.344206839799881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32781916856765747}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:docserv.uni-duesseldorf.de:15466","doi":null,"is_oa":false,"landing_page_url":"https://docserv.uni-duesseldorf.de/servlets/DocumentServlet?id=15466","pdf_url":null,"source":{"id":"https://openalex.org/S4406922359","display_name":"Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:891009167","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Daniela_Bruennert/publication/44842234_Molekulare_Wirkmechanismen_von_Tyrosinkinase-Inhibitoren_in_der_Therapie_der_chronischen_myeloischen_Leukmie/links/0fcfd5058922931986000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":185,"referenced_works":["https://openalex.org/W18208397","https://openalex.org/W85529956","https://openalex.org/W126539919","https://openalex.org/W130020229","https://openalex.org/W139593588","https://openalex.org/W326932590","https://openalex.org/W1490860457","https://openalex.org/W1497974883","https://openalex.org/W1509669696","https://openalex.org/W1510546584","https://openalex.org/W1513007231","https://openalex.org/W1521832405","https://openalex.org/W1529003705","https://openalex.org/W1536062643","https://openalex.org/W1550698494","https://openalex.org/W1561506007","https://openalex.org/W1574829782","https://openalex.org/W1581614904","https://openalex.org/W1583472519","https://openalex.org/W1708068686","https://openalex.org/W1810683183","https://openalex.org/W1820233248","https://openalex.org/W1842775090","https://openalex.org/W1908340894","https://openalex.org/W1928548710","https://openalex.org/W1934425437","https://openalex.org/W1963769227","https://openalex.org/W1964445294","https://openalex.org/W1967607619","https://openalex.org/W1968631842","https://openalex.org/W1969530308","https://openalex.org/W1969675752","https://openalex.org/W1969969746","https://openalex.org/W1970778316","https://openalex.org/W1970930330","https://openalex.org/W1971335269","https://openalex.org/W1971657539","https://openalex.org/W1973720500","https://openalex.org/W1974825648","https://openalex.org/W1978777017","https://openalex.org/W1979300538","https://openalex.org/W1981740211","https://openalex.org/W1982661171","https://openalex.org/W1983075214","https://openalex.org/W1985177017","https://openalex.org/W1985870989","https://openalex.org/W1986058924","https://openalex.org/W1986139301","https://openalex.org/W1987925274","https://openalex.org/W1988652789","https://openalex.org/W1988762859","https://openalex.org/W1989123817","https://openalex.org/W1990452038","https://openalex.org/W1991428150","https://openalex.org/W1991795177","https://openalex.org/W1992456066","https://openalex.org/W1992940526","https://openalex.org/W1994045067","https://openalex.org/W1998593414","https://openalex.org/W1998799043","https://openalex.org/W1999489919","https://openalex.org/W2000098166","https://openalex.org/W2001590374","https://openalex.org/W2002904896","https://openalex.org/W2003282728","https://openalex.org/W2006917576","https://openalex.org/W2007689676","https://openalex.org/W2008188428","https://openalex.org/W2008629475","https://openalex.org/W2008952509","https://openalex.org/W2009157674","https://openalex.org/W2010083101","https://openalex.org/W2010440856","https://openalex.org/W2011133292","https://openalex.org/W2012348415","https://openalex.org/W2013346022","https://openalex.org/W2015408128","https://openalex.org/W2015700471","https://openalex.org/W2016086822","https://openalex.org/W2016656445","https://openalex.org/W2017021967","https://openalex.org/W2017728128","https://openalex.org/W2020092689","https://openalex.org/W2024021544","https://openalex.org/W2025173384","https://openalex.org/W2025708651","https://openalex.org/W2026359801","https://openalex.org/W2026542427","https://openalex.org/W2028468783","https://openalex.org/W2029987300","https://openalex.org/W2031255542","https://openalex.org/W2032379319","https://openalex.org/W2032592101","https://openalex.org/W2033452367","https://openalex.org/W2033755897","https://openalex.org/W2036103078","https://openalex.org/W2037498487","https://openalex.org/W2037798465","https://openalex.org/W2038588592","https://openalex.org/W2039755155","https://openalex.org/W2039978091","https://openalex.org/W2040323503","https://openalex.org/W2041004587","https://openalex.org/W2042779695","https://openalex.org/W2048476437","https://openalex.org/W2048782984","https://openalex.org/W2049611823","https://openalex.org/W2051593267","https://openalex.org/W2057718276","https://openalex.org/W2057944226","https://openalex.org/W2058576674","https://openalex.org/W2061305437","https://openalex.org/W2063968553","https://openalex.org/W2064698668","https://openalex.org/W2065633879","https://openalex.org/W2068057137","https://openalex.org/W2070124503","https://openalex.org/W2070862399","https://openalex.org/W2072900979","https://openalex.org/W2075091190","https://openalex.org/W2075110532","https://openalex.org/W2075706560","https://openalex.org/W2076372887","https://openalex.org/W2076401083","https://openalex.org/W2080977505","https://openalex.org/W2082174166","https://openalex.org/W2082580993","https://openalex.org/W2083353096","https://openalex.org/W2083399846","https://openalex.org/W2084437888","https://openalex.org/W2088981780","https://openalex.org/W2090786449","https://openalex.org/W2095067362","https://openalex.org/W2095570221","https://openalex.org/W2096791952","https://openalex.org/W2097946794","https://openalex.org/W2102610315","https://openalex.org/W2102752109","https://openalex.org/W2102752941","https://openalex.org/W2102807711","https://openalex.org/W2107268345","https://openalex.org/W2115676808","https://openalex.org/W2117710149","https://openalex.org/W2120365943","https://openalex.org/W2120921046","https://openalex.org/W2121777852","https://openalex.org/W2123339281","https://openalex.org/W2124196948","https://openalex.org/W2126476276","https://openalex.org/W2131171876","https://openalex.org/W2131174104","https://openalex.org/W2132411546","https://openalex.org/W2134094496","https://openalex.org/W2134512113","https://openalex.org/W2134566943","https://openalex.org/W2134709252","https://openalex.org/W2137723669","https://openalex.org/W2139462813","https://openalex.org/W2139553721","https://openalex.org/W2140472738","https://openalex.org/W2141769989","https://openalex.org/W2142323135","https://openalex.org/W2145738273","https://openalex.org/W2151486690","https://openalex.org/W2151504205","https://openalex.org/W2152648806","https://openalex.org/W2153521785","https://openalex.org/W2161223414","https://openalex.org/W2163287785","https://openalex.org/W2165848530","https://openalex.org/W2170839629","https://openalex.org/W2274550965","https://openalex.org/W2312804644","https://openalex.org/W2313524135","https://openalex.org/W2313786846","https://openalex.org/W2314938037","https://openalex.org/W2324425957","https://openalex.org/W2327432287","https://openalex.org/W2329648702","https://openalex.org/W2331901447","https://openalex.org/W2411908043","https://openalex.org/W2424287322","https://openalex.org/W2477393059","https://openalex.org/W2564723484","https://openalex.org/W2585360546"],"related_works":["https://openalex.org/W1496076106","https://openalex.org/W1563862124","https://openalex.org/W7034595718","https://openalex.org/W7057865158","https://openalex.org/W803872598","https://openalex.org/W2970362842","https://openalex.org/W2499312253","https://openalex.org/W2380352856","https://openalex.org/W2796422908","https://openalex.org/W1873391081"],"abstract_inverted_index":{"Bei":[0],"der":[1,19,43,47,49,138,142,178,186,218,236,241,307],"chronischen":[2],"myeloischen":[3],"Leukamie":[4],"(CML)":[5],"handelt":[6],"es":[7],"sich":[8,129,171,221],"um":[9],"eine":[10,16,36,39,92,174,204],"maligne":[11],"Stammzellerkrankung,":[12],"deren":[13],"charakteristisches":[14],"Merkmal":[15],"reziproke":[17],"Translokation":[18],"Chromosomen":[20],"9":[21],"und":[22,56,84,158,197,208,294],"22":[23],"(Philadelpia-Chromosom)":[24],"ist,":[25],"die":[26,71,166,227,265,300,312,328],"zur":[27],"Bildung":[28],"des":[29,229,290],"BCR-ABL":[30,291],"Onkoproteins":[31],"fuhrt.":[32],"Dieses":[33],"spielt":[34],"durch":[35,72,264,267],"gesteigerte":[37],"Tyrosinkinaseaktivitat":[38],"essentielle":[40],"Rolle":[41],"in":[42,137,283,299,306,327],"leukamischen":[44],"Zelltransformation.":[45],"In":[46,61],"Therapie":[48,83],"CML":[50,308],"werden":[51,64],"seit":[52],"2000":[53],"hoch":[54,124,149],"potente":[55],"nebenwirkungsarme":[57],"Tyrosinkinase-Inhibitoren":[58],"eingesetzt.\r":[59],"dieser":[62],"Arbeit":[63,219],"fruhe":[65],"transkriptionelle":[66],"Veranderungen":[67],"bei":[68,80],"Patienten":[69],"aufgezeigt,":[70],"Imatinib-Therapie":[73,88,147],"induziert":[74],"werden.":[75,320],"Eine":[76],"hierarchische":[77],"Clusteranalyse":[78],"zeigte":[79],"den":[81,99,183],"vor":[82],"nach":[85,144,212],"7":[86,145],"Tagen":[87,146],"gewonnenen":[89],"CD34+":[90,180],"Stammzellen":[91,211],"klare":[93],"Differenzierung":[94],"zwischen":[95],"beiden":[96],"Gruppen.":[97],"Von":[98],"etwa":[100],"14.500":[101],"auf":[102],"dem":[103],"Genchip":[104],"gespotteten":[105],"Genen":[106],"waren":[107,136,288],"183":[108],"Gene":[109,122,127,148,153,160,272,289,298],"mit":[110,188,222,244,253],"einem":[111,189],"Lower":[112],"Confidence":[113],"Bound":[114],"von":[115,243,331],"mindestens":[116],"1,2-fach":[117],"signifikant":[118,123],"herunter":[119,161],"sowie":[120,296,317],"120":[121],"reguliert.":[125],"Die":[126,321],"liesen":[128],"dabei":[130],"verschiedenen":[131,184],"funktionellen":[132],"Gruppen":[133],"zuordnen.":[134],"Dabei":[135,287],"pathophysiologisch":[139],"relevante":[140],"Gruppe":[141],"Adhasion":[143,177],"reguliert,":[150],"wahrend":[151],"Zellzyklus-assoziierte":[152],"ebenso":[154],"wie":[155,305],"DNA":[156,195],"Replikations-":[157],"Reparaturassoziierte":[159],"reguliert":[162],"waren.":[163,275],"Betrachtet":[164],"man":[165],"differenziell":[167,273,303],"exprimierten":[168],"Gene,":[169],"lasst":[170],"schlussfolgern,":[172],"dass":[173,263],"initiale":[175],"bessere":[176],"Ph+":[179],"Zellen":[181,252,261],"an":[182],"Komponenten":[185],"Knochenmarkmatrix":[187],"verminderten":[190,194],"Zellzyklus":[191,295,318],"inklusive":[192],"einer":[193],"Replikation":[196],"mitotischer":[198],"Aktivitat":[199],"einhergeht.":[200],"Dies":[201],"wiederum":[202],"zieht":[203],"verminderte":[205],"Proliferation,":[206,315],"Expansion":[207],"Produktion":[209],"leukamischer":[210],"sich.\r":[213],"Der":[215,239],"zweite":[216],"Teil":[217],"beschaftigte":[220],"Untersuchungen":[223],"zu":[224],"Ursachen":[225],"fur":[226,314],"Uberlegenheit":[228],"TKIs":[230],"Nilotinib":[231,256,268,332],"gegenuber":[232,333],"Imatinib":[233,247,284],"am":[234],"Modell":[235],"K562":[237,251,260],"Zelllinie.":[238],"Vergleich":[240],"Genexpressionsprofile":[242],"0,5":[245],"\u00b5M":[246,255],"versus":[248,257],"DMSO":[249,258],"behandelten":[250,259,285],"0,05":[254],"zeigte,":[262],"Behandlung":[266],"2,18-mal":[269],"so":[270],"viele":[271],"exprimiert":[274,304],"Auch":[276],"ihr":[277],"differenzieller":[278],"Expressionsgrad":[279],"war":[280],"starker":[281],"als":[282],"Zellen.":[286],"Signalings,":[292],"Proliferation":[293],"Resistenzassoziierte":[297],"gegensatzliche":[301],"Richtung":[302],"Pathologie.":[309],"Funktionell":[310],"konnten":[311],"Genexpressionsdaten":[313],"Apoptose":[316],"validiert":[319],"Untersuchungsergebnisse":[322],"geben":[323],"einen":[324],"molekularen":[325],"Einblick":[326],"starkere":[329],"Effizienz":[330],"Imatinib.":[334]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
