{"id":"https://openalex.org/W8907427","doi":null,"title":"Effects of high-mobility group box 1 on the expression of Beclin-1 and LC3 proteins following hypoxia and reoxygenation injury in rat cardiomyocytes.","display_name":"Effects of high-mobility group box 1 on the expression of Beclin-1 and LC3 proteins following hypoxia and reoxygenation injury in rat cardiomyocytes.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W8907427","mag":"8907427","pmid":"https://pubmed.ncbi.nlm.nih.gov/25664043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4307490"},"language":"en","primary_location":{"id":"pmid:25664043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307490/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111997005","display_name":"Weipan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weipan Xu","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100709762","display_name":"Hong Jiang","orcid":"https://orcid.org/0000-0001-5099-868X","observed_orcids":["https://orcid.org/0000-0001-5099-868X"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049108761","display_name":"Xiaorong Hu","orcid":"https://orcid.org/0000-0002-9378-3715","observed_orcids":["https://orcid.org/0000-0002-9378-3715"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorong Hu","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wenwen Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenwen Fu","raw_affiliation_strings":["Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University Wuhan, China","institution_ids":["https://openalex.org/I4210140357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140357"],"apc_list":null,"apc_paid":null,"fwci":1.3237,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81394705,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"12","first_page":"5353","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-mobility-group-box-1","display_name":"high mobility group box 1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hypoxia-reoxygenation","display_name":"hypoxia/reoxygenation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.972000002861023},{"id":"https://openalex.org/keywords/ammonium-glycyrrhizinate","display_name":"ammonium glycyrrhizinate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hmgb1-inhibition","display_name":"HMGB1 inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.4099999964237213},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.7777040004730225},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7774665355682373},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.7051935195922852},{"id":"https://openalex.org/C30683889","wikidata":"https://www.wikidata.org/wiki/Q926211","display_name":"High-mobility group","level":3,"score":0.6838010549545288},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6731994152069092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6518116593360901},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.6242029070854187},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.6104654669761658},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5385763049125671},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.4605533182621002},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.42830324172973633},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.37637263536453247},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.360062837600708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3448914885520935},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34361743927001953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20733368396759033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19550588726997375},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17897635698318481},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.17279106378555298},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14821845293045044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:25664043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4307490","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307490/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},{"id":"mag:8907427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25664043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4307490","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4307490/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1523693806","https://openalex.org/W1965827991","https://openalex.org/W1969698093","https://openalex.org/W1973472942","https://openalex.org/W2003079927","https://openalex.org/W2014943313","https://openalex.org/W2016640448","https://openalex.org/W2017234408","https://openalex.org/W2020956402","https://openalex.org/W2026660662","https://openalex.org/W2033066735","https://openalex.org/W2040482760","https://openalex.org/W2041538521","https://openalex.org/W2041759782","https://openalex.org/W2048030072","https://openalex.org/W2052094075","https://openalex.org/W2059718338","https://openalex.org/W2060939028","https://openalex.org/W2077771390","https://openalex.org/W2079408014","https://openalex.org/W2094964008","https://openalex.org/W2109034822","https://openalex.org/W2114242405","https://openalex.org/W2162542267","https://openalex.org/W2162843846"],"related_works":["https://openalex.org/W2807775930","https://openalex.org/W2765661492","https://openalex.org/W2267567635","https://openalex.org/W3047000153","https://openalex.org/W2192467897","https://openalex.org/W2512590140","https://openalex.org/W3117750076","https://openalex.org/W4191688","https://openalex.org/W2914697059","https://openalex.org/W3092351898"],"abstract_inverted_index":{"The":[0,11,74],"mechanisms":[1],"underlying":[2],"autophagy":[3,25],"during":[4],"myocardial":[5,79,96],"ischemia":[6],"and":[7,24,52,56,66,87,103,113,128,151,156],"reperfusion":[8],"remain":[9],"unclear.":[10],"present":[12,141],"study":[13,142],"investigated":[14],"the":[15,117,121,137,140],"relationship":[16],"between":[17],"high-mobility":[18],"group":[19],"box":[20],"1":[21],"protein":[22,86],"(HMGB1)":[23],"in":[26,116,131,159],"hypoxia/reoxygenation":[27],"(H/R)-induced":[28],"neonatal":[29],"rat":[30,33,160],"cardiomyocytes.":[31,161],"Neonatal":[32],"cardiomyocytes":[34],"were":[35,62,69],"treated":[36],"with":[37],"recombinant":[38],"HMGB1":[39,108,124,145],"(200":[40],"ng/L)":[41],"or":[42],"ammonium":[43],"glycyrrhizinate":[44],"(100":[45],"\u03bcM)":[46],"at":[47],"appropriate":[48],"concentrations.":[49],"Cell":[50],"viabilities":[51],"lactate":[53],"dehydrogenase":[54],"(LDH)":[55],"creatine":[57],"kinase":[58],"(CK)":[59],"activity":[60],"levels":[61,83,90,100,115,153],"measured.":[63],"HMGB1,":[64],"LC3":[65,92,104,152],"Beclin-1":[67,85,102,150],"expression":[68,130],"assessed":[70],"by":[71],"Western":[72],"blot.":[73],"results":[75,138],"demonstrated":[76],"that":[77,144],"HMGB1-induced":[78],"cells":[80,97],"have":[81,98],"increased":[82,111],"of":[84,91,101,123,139],"even":[88],"higher":[89],"protein,":[93],"while":[94],"HMGB1-inhibited":[95],"decreased":[99],"proteins.":[105],"In":[106,135],"addition,":[107],"induction":[109],"significantly":[110,125],"LDH":[112,127],"CK":[114,129],"cell":[118],"culture":[119,133],"medium;":[120],"inhibition":[122],"reduced":[126],"cardiomyocyte":[132],"medium.":[134],"conclusion,":[136],"suggest":[143],"is":[146],"able":[147],"to":[148],"regulate":[149],"following":[154],"hypoxia":[155],"reoxygenation":[157],"injury":[158]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
