{"id":"https://openalex.org/W890153107","doi":null,"title":"Assessing Differential Genetic Effects Of Gene Variants On Choroidal Neovascularization And Geographic Atrophy","display_name":"Assessing Differential Genetic Effects Of Gene Variants On Choroidal Neovascularization And Geographic Atrophy","publication_year":2011,"publication_date":"2011-04-22","ids":{"openalex":"https://openalex.org/W890153107","mag":"890153107"},"language":"en","primary_location":{"id":"mag:890153107","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2357841","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101528897","display_name":"Clara Lee","orcid":"https://orcid.org/0000-0002-9785-9211","observed_orcids":["https://orcid.org/0000-0002-9785-9211"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Lee","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0002-9785-9211","affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091888632","display_name":"Guy Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Hughes","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423455","display_name":"Ye Wang","orcid":"https://orcid.org/0000-0002-5423-6196","observed_orcids":["https://orcid.org/0000-0002-5423-6196"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ye Wang","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0002-5423-6196","affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014366714","display_name":"Maureen E. Crocker","orcid":"https://orcid.org/0000-0002-5150-7229","observed_orcids":["https://orcid.org/0000-0002-5150-7229"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen Crocker","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0002-5150-7229","affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111644286","display_name":"Seanna Grob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seanna Grob","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084220023","display_name":"Mark H. Nelson","orcid":"https://orcid.org/0000-0001-5894-5427","observed_orcids":["https://orcid.org/0000-0001-5894-5427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Nelson","raw_affiliation_strings":["RetinaNet Corporation, Winston Salem, North Carolina"],"raw_orcid":"https://orcid.org/0000-0001-5894-5427","affiliations":[{"raw_affiliation_string":"RetinaNet Corporation, Winston Salem, North Carolina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076490467","display_name":"Michael H. Goldbaum","orcid":"https://orcid.org/0000-0002-7721-2736","observed_orcids":["https://orcid.org/0000-0002-7721-2736"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Goldbaum","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0002-7721-2736","affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045570324","display_name":"Paul E. Tornambe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311914864","display_name":"Scripps Health","ror":"https://ror.org/05bhsww40","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul E. Tornambe","raw_affiliation_strings":["Ophthalmology, Scripps Health, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology, Scripps Health, La Jolla, California","institution_ids":["https://openalex.org/I1311914864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100457607","display_name":"Yuhong Chen","orcid":"https://orcid.org/0000-0001-6131-7595","observed_orcids":["https://orcid.org/0000-0001-6131-7595","https://orcid.org/0009-0003-8280-6218"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Yuhong Chen","raw_affiliation_strings":["Department of Ophthalmology & Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China","Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California"],"raw_orcid":"https://orcid.org/0000-0001-6131-7595","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology & Vision Science, Eye and ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210112065"]},{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100432232","display_name":"Kang Zhang","orcid":"https://orcid.org/0000-0002-4549-1697","observed_orcids":["https://orcid.org/0000-0002-4549-1697","https://orcid.org/0000-0002-5737-4084"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Zhang","raw_affiliation_strings":["Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","Department of Ophthalmology & Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah"],"raw_orcid":"https://orcid.org/0000-0002-4549-1697","affiliations":[{"raw_affiliation_string":"Ophthalmology, Institute for Genomic Medicine and Shiley Eye Center, University of California San Diego, La Jolla, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Ophthalmology & Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05358967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":"14","first_page":"5230","last_page":"5230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9900000095367432},{"id":"https://openalex.org/keywords/geographic-atrophy","display_name":"geographic atrophy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.8939999938011169},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.6869999766349792},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.7782669067382812},{"id":"https://openalex.org/C2991880128","wikidata":"https://www.wikidata.org/wiki/Q47200750","display_name":"Geographic atrophy","level":3,"score":0.740242600440979},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6445297002792358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.534500777721405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45289722084999084},{"id":"https://openalex.org/C93226319","wikidata":"https://www.wikidata.org/wiki/Q193137","display_name":"Differential (mechanical device)","level":2,"score":0.45037803053855896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4257075786590576},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.40404075384140015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38103917241096497},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.25894004106521606},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:890153107","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2357841","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8245000243186951}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1220327175","https://openalex.org/W2737205464","https://openalex.org/W2740260390","https://openalex.org/W3185025539","https://openalex.org/W3021709075","https://openalex.org/W866142200","https://openalex.org/W2992044260","https://openalex.org/W967342276","https://openalex.org/W1422807987","https://openalex.org/W1448169403"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}