{"id":"https://openalex.org/W88998572","doi":null,"title":"Study of the molecular mechanism used by the peptidic vector pep-1 to introduce proteins inside cells","display_name":"Study of the molecular mechanism used by the peptidic vector pep-1 to introduce proteins inside cells","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W88998572","mag":"88998572"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/1605","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/1605","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/1605","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051238211","display_name":"S\u00f3nia Troeira Henriques","orcid":"https://orcid.org/0000-0001-9564-9651","observed_orcids":["https://orcid.org/0000-0001-9564-9651"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S\u00f3nia Troeira Henriques","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9564-9651","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051238211"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pep-1","display_name":"Pep-1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/protein-transduction","display_name":"protein transduction","score":0.753000020980835},{"id":"https://openalex.org/keywords/membrane-binding-affinity","display_name":"membrane affinity","score":0.5590000152587891},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.8309999704360962},{"id":"https://openalex.org/keywords/peptide-membrane-interactions","display_name":"peptide-membrane interactions","score":0.5730000138282776},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.609000027179718},{"id":"https://openalex.org/keywords/supported-lipid-bilayers","display_name":"supported lipid bilayers","score":0.5400000214576721},{"id":"https://openalex.org/keywords/large-unilamellar-vesicles","display_name":"large unilamellar vesicles","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7695515751838684},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.5194087028503418},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44634342193603516},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3882743716239929},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3397602438926697},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.335574746131897},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3326134979724884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3292508125305176},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3212372660636902},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31797266006469727},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.297657310962677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22637683153152466},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11309713125228882},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.10172340273857117},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/1605","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/1605","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},{"id":"mag:88998572","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ul.pt/handle/10451/1605","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/1605","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/1605","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":380,"referenced_works":["https://openalex.org/W9553890","https://openalex.org/W35241519","https://openalex.org/W60978187","https://openalex.org/W72081156","https://openalex.org/W174150423","https://openalex.org/W178469598","https://openalex.org/W197620025","https://openalex.org/W205758415","https://openalex.org/W428907568","https://openalex.org/W627595300","https://openalex.org/W1490324405","https://openalex.org/W1501427183","https://openalex.org/W1501494207","https://openalex.org/W1503039076","https://openalex.org/W1510613202","https://openalex.org/W1516421005","https://openalex.org/W1518097944","https://openalex.org/W1521801418","https://openalex.org/W1523820502","https://openalex.org/W1558087535","https://openalex.org/W1563557632","https://openalex.org/W1564714809","https://openalex.org/W1567588704","https://openalex.org/W1568032381","https://openalex.org/W1581477304","https://openalex.org/W1583480464","https://openalex.org/W1584683177","https://openalex.org/W1591583672","https://openalex.org/W1593567129","https://openalex.org/W1597018689","https://openalex.org/W1601881612","https://openalex.org/W1609951617","https://openalex.org/W1762647466","https://openalex.org/W1857189837","https://openalex.org/W1899761045","https://openalex.org/W1923665285","https://openalex.org/W1963819255","https://openalex.org/W1964011658","https://openalex.org/W1965261376","https://openalex.org/W1965493566","https://openalex.org/W1966342087","https://openalex.org/W1966377964","https://openalex.org/W1966528366","https://openalex.org/W1967847890","https://openalex.org/W1968522669","https://openalex.org/W1969407829","https://openalex.org/W1969475775","https://openalex.org/W1969771853","https://openalex.org/W1970689030","https://openalex.org/W1970743383","https://openalex.org/W1971290197","https://openalex.org/W1972409470","https://openalex.org/W1972519777","https://openalex.org/W1972711580","https://openalex.org/W1972927780","https://openalex.org/W1973001403","https://openalex.org/W1973440457","https://openalex.org/W1973783994","https://openalex.org/W1974186613","https://openalex.org/W1976258107","https://openalex.org/W1976290510","https://openalex.org/W1976822357","https://openalex.org/W1977552065","https://openalex.org/W1978248282","https://openalex.org/W1978307760","https://openalex.org/W1978714948","https://openalex.org/W1978827571","https://openalex.org/W1980441078","https://openalex.org/W1981336176","https://openalex.org/W1982095205","https://openalex.org/W1983261693","https://openalex.org/W1984266565","https://openalex.org/W1984456841","https://openalex.org/W1985506288","https://openalex.org/W1985719826","https://openalex.org/W1986516374","https://openalex.org/W1986612218","https://openalex.org/W1987349623","https://openalex.org/W1988310407","https://openalex.org/W1988857297","https://openalex.org/W1988901585","https://openalex.org/W1989410545","https://openalex.org/W1989493412","https://openalex.org/W1989557252","https://openalex.org/W1989605828","https://openalex.org/W1989832577","https://openalex.org/W1989855380","https://openalex.org/W1990065987","https://openalex.org/W1990658611","https://openalex.org/W1991655565","https://openalex.org/W1992032029","https://openalex.org/W1992095148","https://openalex.org/W1992289979","https://openalex.org/W1992599971","https://openalex.org/W1993008641","https://openalex.org/W1993452615","https://openalex.org/W1994179804","https://openalex.org/W1994434169","https://openalex.org/W1994928619","https://openalex.org/W1996805840","https://openalex.org/W1997388514","https://openalex.org/W1997822065","https://openalex.org/W1998083723","https://openalex.org/W1998601156","https://openalex.org/W1999207629","https://openalex.org/W1999249938","https://openalex.org/W2000238072","https://openalex.org/W2000714076","https://openalex.org/W2000729091","https://openalex.org/W2001050118","https://openalex.org/W2001582257","https://openalex.org/W2001802384","https://openalex.org/W2002591579","https://openalex.org/W2002913858","https://openalex.org/W2003570686","https://openalex.org/W2004373761","https://openalex.org/W2005716887","https://openalex.org/W2005984783","https://openalex.org/W2006485575","https://openalex.org/W2007092592","https://openalex.org/W2007242005","https://openalex.org/W2007308838","https://openalex.org/W2007446604","https://openalex.org/W2008082372","https://openalex.org/W2008211173","https://openalex.org/W2008724578","https://openalex.org/W2008813620","https://openalex.org/W2009211691","https://openalex.org/W2009309713","https://openalex.org/W2009404855","https://openalex.org/W2009640317","https://openalex.org/W2009756829","https://openalex.org/W2010502236","https://openalex.org/W2010659535","https://openalex.org/W2011154488","https://openalex.org/W2011259542","https://openalex.org/W2013155837","https://openalex.org/W2013278992","https://openalex.org/W2013874961","https://openalex.org/W2015326813","https://openalex.org/W2015704490","https://openalex.org/W2015816340","https://openalex.org/W2015906064","https://openalex.org/W2016166584","https://openalex.org/W2016232320","https://openalex.org/W2017540124","https://openalex.org/W2018592823","https://openalex.org/W2019144805","https://openalex.org/W2019526697","https://openalex.org/W2019793524","https://openalex.org/W2020194096","https://openalex.org/W2020583390","https://openalex.org/W2022467870","https://openalex.org/W2022726845","https://openalex.org/W2022790636","https://openalex.org/W2024514048","https://openalex.org/W2026405782","https://openalex.org/W2027285171","https://openalex.org/W2028828598","https://openalex.org/W2028869026","https://openalex.org/W2029346749","https://openalex.org/W2029692923","https://openalex.org/W2030805123","https://openalex.org/W2032284161","https://openalex.org/W2032535360","https://openalex.org/W2033933409","https://openalex.org/W2034531716","https://openalex.org/W2034574585","https://openalex.org/W2034879954","https://openalex.org/W2035961536","https://openalex.org/W2036506143","https://openalex.org/W2036709988","https://openalex.org/W2037081137","https://openalex.org/W2038300219","https://openalex.org/W2038720675","https://openalex.org/W2039873895","https://openalex.org/W2040592660","https://openalex.org/W2040824780","https://openalex.org/W2041152056","https://openalex.org/W2041628297","https://openalex.org/W2041922085","https://openalex.org/W2042037824","https://openalex.org/W2042143995","https://openalex.org/W2045754303","https://openalex.org/W2046387562","https://openalex.org/W2046704370","https://openalex.org/W2046950900","https://openalex.org/W2047115921","https://openalex.org/W2048131740","https://openalex.org/W2048404650","https://openalex.org/W2048418045","https://openalex.org/W2050211156","https://openalex.org/W2050748316","https://openalex.org/W2050815417","https://openalex.org/W2051489500","https://openalex.org/W2051675767","https://openalex.org/W2052708078","https://openalex.org/W2053104769","https://openalex.org/W2053546096","https://openalex.org/W2053670655","https://openalex.org/W2053892220","https://openalex.org/W2054080033","https://openalex.org/W2054194653","https://openalex.org/W2054346823","https://openalex.org/W2054602599","https://openalex.org/W2054767456","https://openalex.org/W2055390338","https://openalex.org/W2055776228","https://openalex.org/W2055972190","https://openalex.org/W2056842925","https://openalex.org/W2057407100","https://openalex.org/W2058368188","https://openalex.org/W2058440919","https://openalex.org/W2059015272","https://openalex.org/W2060878281","https://openalex.org/W2062461630","https://openalex.org/W2062862315","https://openalex.org/W2063001927","https://openalex.org/W2063358226","https://openalex.org/W2063802293","https://openalex.org/W2064093490","https://openalex.org/W2064242356","https://openalex.org/W2064282122","https://openalex.org/W2065191307","https://openalex.org/W2065866429","https://openalex.org/W2066591034","https://openalex.org/W2066778206","https://openalex.org/W2067106749","https://openalex.org/W2067380641","https://openalex.org/W2067758677","https://openalex.org/W2068434462","https://openalex.org/W2068522981","https://openalex.org/W2068920850","https://openalex.org/W2069773823","https://openalex.org/W2069888185","https://openalex.org/W2070179552","https://openalex.org/W2070774983","https://openalex.org/W2072312944","https://openalex.org/W2072948240","https://openalex.org/W2073406729","https://openalex.org/W2073699804","https://openalex.org/W2073833033","https://openalex.org/W2074739298","https://openalex.org/W2075442841","https://openalex.org/W2076227275","https://openalex.org/W2077886045","https://openalex.org/W2078036461","https://openalex.org/W2079335891","https://openalex.org/W2079468421","https://openalex.org/W2080544464","https://openalex.org/W2080633604","https://openalex.org/W2081088550","https://openalex.org/W2081852339","https://openalex.org/W2082047232","https://openalex.org/W2082111171","https://openalex.org/W2082468518","https://openalex.org/W2082698296","https://openalex.org/W2082790072","https://openalex.org/W2084357980","https://openalex.org/W2085538443","https://openalex.org/W2085873658","https://openalex.org/W2086264237","https://openalex.org/W2086300393","https://openalex.org/W2087000396","https://openalex.org/W2087410257","https://openalex.org/W2088702932","https://openalex.org/W2088713107","https://openalex.org/W2088960285","https://openalex.org/W2089657872","https://openalex.org/W2090429239","https://openalex.org/W2090455072","https://openalex.org/W2090571818","https://openalex.org/W2091432022","https://openalex.org/W2091516391","https://openalex.org/W2092000721","https://openalex.org/W2092295885","https://openalex.org/W2092712897","https://openalex.org/W2093130296","https://openalex.org/W2093740895","https://openalex.org/W2093877404","https://openalex.org/W2094790773","https://openalex.org/W2094996754","https://openalex.org/W2095483357","https://openalex.org/W2099985438","https://openalex.org/W2102125805","https://openalex.org/W2102264945","https://openalex.org/W2102342643","https://openalex.org/W2103799960","https://openalex.org/W2104534420","https://openalex.org/W2104571730","https://openalex.org/W2105668301","https://openalex.org/W2105887776","https://openalex.org/W2108224709","https://openalex.org/W2108234715","https://openalex.org/W2109031983","https://openalex.org/W2110597706","https://openalex.org/W2111397476","https://openalex.org/W2111994795","https://openalex.org/W2112736312","https://openalex.org/W2113972541","https://openalex.org/W2115025939","https://openalex.org/W2115495443","https://openalex.org/W2115637042","https://openalex.org/W2117645605","https://openalex.org/W2119630077","https://openalex.org/W2121737649","https://openalex.org/W2121753059","https://openalex.org/W2121936687","https://openalex.org/W2123650819","https://openalex.org/W2124307105","https://openalex.org/W2124342403","https://openalex.org/W2125450037","https://openalex.org/W2128451674","https://openalex.org/W2129177835","https://openalex.org/W2129684296","https://openalex.org/W2129995310","https://openalex.org/W2130079515","https://openalex.org/W2130885148","https://openalex.org/W2131192673","https://openalex.org/W2131384342","https://openalex.org/W2131909172","https://openalex.org/W2133205117","https://openalex.org/W2133540162","https://openalex.org/W2133991651","https://openalex.org/W2134057677","https://openalex.org/W2134905807","https://openalex.org/W2136455205","https://openalex.org/W2136702130","https://openalex.org/W2136840366","https://openalex.org/W2137327952","https://openalex.org/W2138532798","https://openalex.org/W2138726430","https://openalex.org/W2138952800","https://openalex.org/W2139069865","https://openalex.org/W2144568772","https://openalex.org/W2145707016","https://openalex.org/W2146144253","https://openalex.org/W2146633563","https://openalex.org/W2148768461","https://openalex.org/W2149138461","https://openalex.org/W2149623513","https://openalex.org/W2149638358","https://openalex.org/W2150188405","https://openalex.org/W2152058099","https://openalex.org/W2152419135","https://openalex.org/W2153955991","https://openalex.org/W2155482026","https://openalex.org/W2157303458","https://openalex.org/W2157487352","https://openalex.org/W2158482458","https://openalex.org/W2159672669","https://openalex.org/W2160038308","https://openalex.org/W2160514373","https://openalex.org/W2160564267","https://openalex.org/W2160780417","https://openalex.org/W2160863389","https://openalex.org/W2162194950","https://openalex.org/W2162851629","https://openalex.org/W2163021896","https://openalex.org/W2164843843","https://openalex.org/W2165407914","https://openalex.org/W2166458266","https://openalex.org/W2166647667","https://openalex.org/W2166802464","https://openalex.org/W2166974541","https://openalex.org/W2167806590","https://openalex.org/W2169101094","https://openalex.org/W2169818027","https://openalex.org/W2170932434","https://openalex.org/W2171846923","https://openalex.org/W2173086864","https://openalex.org/W2173140585","https://openalex.org/W2179142653","https://openalex.org/W2291223536","https://openalex.org/W2299103077","https://openalex.org/W2338690157","https://openalex.org/W3123172076","https://openalex.org/W3148913165","https://openalex.org/W3191062208","https://openalex.org/W4256523371"],"related_works":["https://openalex.org/W199624995","https://openalex.org/W7117156411","https://openalex.org/W2246732106","https://openalex.org/W7061354199","https://openalex.org/W7052988631","https://openalex.org/W930213051","https://openalex.org/W128606543","https://openalex.org/W3152982571","https://openalex.org/W2942225367","https://openalex.org/W46830828"],"abstract_inverted_index":{"The":[0,98,132],"introduction":[1],"of":[2,23,38,54,101,163,244],"genetic":[3],"material":[4],"or":[5],"proteins":[6,129],"to":[7,44,60,89,105,113,119,127,159,185,198,202,276],"originate":[8],"a":[9,17,66,82,125,167,231,280],"defined":[10],"biochemical":[11],"effect":[12],"inside":[13,95,130],"the":[14,21,31,36,46,52,63,107,116,161,188,204,224,242,263],"cell":[15,32],"has":[16,85],"remarkable":[18],"potential":[19,237],"for":[20,35,209,241,265,271,285],"treatment":[22],"Human":[24],"diseases,":[25],"however":[26],"this":[27,102,111,253],"is":[28,81,104,196],"hampered":[29],"by":[30,110,230,235,279],"membrane":[33,47,64,117,272],"barrier":[34,48],"entry":[37],"hydrophilic":[39],"macromolecules.":[40],"A":[41],"possible":[42],"strategy":[43],"overcome":[45],"was":[49,136,192],"proposed":[50],"after":[51],"discovery":[53],"basic":[55],"peptidic":[56],"sequences":[57],"with":[58,134,140,166,200,214,238,262,268],"ability":[59],"pass":[61,114],"trough":[62],"in":[65,138],"non-toxic":[67],"and":[68,84,118,152,170,175,180,201,256],"non-immunogenic":[69],"manner.":[70],"These":[71],"peptides":[72,78],"are":[73],"commonly":[74],"designated":[75],"as":[76,124,247],"cell-penetrating":[77],"(CPPs).":[79],"Pep-1":[80],"CPP":[83],"been":[86],"successfully":[87],"used":[88,109,158,184],"introduce":[90,128],"several":[91],"macromolecules":[92],"biologically":[93],"active":[94],"cultured":[96],"cells.":[97,131],"main":[99],"goal":[100],"thesis":[103],"clarify":[106],"mechanism":[108,233],"peptide":[112],"through":[115],"confirm":[120],"if":[121],"its":[122],"efficiency":[123],"carrier":[126],"interaction":[133],"membranes":[135,286],"followed":[137],"vitro":[139],"model":[141],"membranes:":[142],"large":[143],"unilamellar":[144,150],"vesicles;":[145],"planar":[146],"lipid":[147],"membranes,":[148],"giant":[149],"vesicles":[151],"supported":[153],"bilayers.":[154],"HeLa":[155],"cells":[156],"were":[157,183],"follow":[160],"translocation":[162],"pep-1":[164,195,228,255],"associated":[165],"protein.":[168],"Fluorescence":[169],"UV-Vis":[171],"spectroscopy":[172],"methodologies,":[173],"CD":[174],"ATR-FTIR":[176],"spectroscopy,":[177],"electrophysiological":[178],"measurements":[179],"fluorescence":[181],"microscopy":[182],"carry":[186],"on":[187],"experimental":[189],"work.":[190],"It":[191],"shown":[193],"that":[194,217,227],"able":[197],"interact":[199],"destabilize":[203],"lipidic":[205],"bilayers":[206],"without":[207],"evidence":[208],"pore":[210],"formation":[211],"at":[212],"variance":[213],"other":[215,257],"CPPs":[216,258],"use":[218,243],"an":[219,248],"endosomal":[220,245],"pathway.":[221,250],"Although":[222],"all":[223],"evidences":[225,240],"show":[226],"translocates":[229],"physically-mediated":[232],"promoted":[234],"transmembrane":[236],"no":[239],"routes":[246],"alternative":[249],"Differences":[251],"between":[252],"particular":[254],"can":[259],"be":[260,277],"related":[261],"affinity":[264,270,284],"membrane.":[266],"Peptides":[267],"higher":[269],"have":[273],"more":[274],"propensities":[275],"internalized":[278],"non-endocytic":[281],"mechanism.":[282],"Lower":[283],"favours":[287],"endocytic":[288],"uptake.":[289]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
