{"id":"https://openalex.org/W889889289","doi":null,"title":"5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.","display_name":"5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W889889289","mag":"889889289","pmid":"https://pubmed.ncbi.nlm.nih.gov/11220492"},"language":"en","primary_location":{"id":"pmid:11220492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11220492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076244652","display_name":"Katrin Pruus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56085075","display_name":"University of Tartu","ror":"https://ror.org/03z77qz90","country_code":"EE","type":"education","lineage":["https://openalex.org/I56085075"]}],"countries":["EE"],"is_corresponding":false,"raw_author_name":"K Pruus","raw_affiliation_strings":["Department of Pharmacology, University of Tartu, Estonia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Tartu, Estonia","institution_ids":["https://openalex.org/I56085075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011094782","display_name":"Tatjana Skrebuhhova-Malmros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Skrebuhhova-Malmros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080280736","display_name":"Ruth Rudissaar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rudissaar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013785297","display_name":"Vallo Matto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Matto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111590809","display_name":"Lembit Allikmets","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Allikmets","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2328,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.43124789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"51","issue":"4 Pt 2","first_page":"833","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonist","display_name":"5-HT1A receptor agonist","score":0.9710000157356262},{"id":"https://openalex.org/keywords/buspirone","display_name":"buspirone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gepirone","display_name":"gepirone","score":1.0},{"id":"https://openalex.org/keywords/8-oh-dpat","display_name":"8-OH-DPAT","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.9309999942779541},{"id":"https://openalex.org/keywords/way-100635","display_name":"WAY-100635","score":0.8830000162124634},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.906000018119812},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5289999842643738},{"id":"https://openalex.org/keywords/exploratory-behavior","display_name":"exploratory behavior","score":0.8600000143051147},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.7680000066757202},{"id":"https://openalex.org/keywords/stereotyped-behavior","display_name":"stereotypy","score":0.859000027179718},{"id":"https://openalex.org/keywords/antiaggressive-effects","display_name":"antiaggressive effects","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2777287423","wikidata":"https://www.wikidata.org/wiki/Q412194","display_name":"Buspirone","level":4,"score":0.9549483060836792},{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.8944429755210876},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6988942623138428},{"id":"https://openalex.org/C2781093953","wikidata":"https://www.wikidata.org/wiki/Q21115043","display_name":"5-HT1A receptor","level":5,"score":0.6929884552955627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6654782891273499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.626875102519989},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.5398776531219482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5379934906959534},{"id":"https://openalex.org/C2776238416","wikidata":"https://www.wikidata.org/wiki/Q4644282","display_name":"8-OH-DPAT","level":5,"score":0.5284065008163452},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4484069347381592},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36004042625427246},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3037981688976288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2824071943759918}],"mesh":[{"descriptor_ui":"D000374","descriptor_name":"Aggression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002065","descriptor_name":"Buspirone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013239","descriptor_name":"Stereotyped Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017371","descriptor_name":"8-Hydroxy-2-(di-n-propylamino)tetralin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11220492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11220492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},{"id":"mag:889889289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11220492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2005446177","https://openalex.org/W2149196397","https://openalex.org/W1006641771","https://openalex.org/W2168380862","https://openalex.org/W2397882606","https://openalex.org/W2028084064","https://openalex.org/W2420385928","https://openalex.org/W39124337","https://openalex.org/W1996187894","https://openalex.org/W2080408352"],"abstract_inverted_index":{"We":[0],"have":[1],"studied":[2],"the":[3,36,60,69,111,132,139,147,154,157,167,188],"effects":[4],"of":[5,48,84,114,156,171],"acute":[6],"serotonin":[7],"(5-HT)":[8],"5-HT1A":[9,97,105],"receptor":[10,98,106],"agonist":[11],"buspirone":[12,85,119],"(0.5,":[13],"1.0,":[14],"2.5":[15,49],"and":[16,22,26,30,50,62,88,122,135,173],"5.0":[17,51],"mg/kg,":[18,24,32],"s.c.),":[19,25],"gepirone":[20,55,89,123],"(5.0":[21],"10":[23],"8-OH-DPAT":[27,63],"(0.1,":[28],"0.25,":[29],"0.5":[31],"i.p.)":[33],"treatment":[34],"on":[35,131],"apomorphine-induced":[37,158],"aggressive":[38,65,159],"behaviour":[39,66,113,137,160],"in":[40,46,68,78,138,153,161],"adult":[41,162],"male":[42,163],"Wistar":[43,164],"rats.":[44,141,165],"Buspirone":[45],"doses":[47],"mg/kg":[52],"completely":[53],"blocked,":[54],"(10":[56,90,124],"mg/kg)":[57,74,87,91,121,125],"significantly":[58],"attenuated":[59],"aggressiveness,":[61],"abolished":[64],"only":[67,127],"lowest":[70],"dose":[71],"used":[72],"(0.1":[73],"which":[75],"effect":[76,83,130,170],"disappeared":[77],"higher":[79],"doses.":[80],"The":[81],"antiaggressive":[82,169],"(2.5":[86,120],"was":[92],"not":[93],"reversed":[94],"by":[95,182],"a":[96,128,175],"antagonist":[99],"WAY":[100],"100635":[101],"(0.3":[102],"mg/kg).":[103],"All":[104],"agonists":[107],"tested":[108],"dose-dependently":[109],"decreased":[110],"exploratory":[112],"experimentally":[115],"naive":[116],"rats,":[117],"while":[118],"had":[126],"weak":[129],"locomotor":[133],"activity":[134],"stereotyped":[136],"apomorphine-pre-sensitised":[140],"In":[142],"conclusion,":[143],"our":[144],"experiments":[145],"demonstrate":[146],"5-HTIA":[148],"receptors":[149],"may":[150],"be":[151,180],"involved":[152],"mediation":[155],"However,":[166],"prominent":[168],"buspirone,":[172],"to":[174,179],"lesser":[176],"extent--gepirone,":[177],"seems":[178],"mediated":[181],"some":[183],"other":[184],"mechanisms,":[185],"evidently":[186],"via":[187],"dopamine":[189],"D2":[190],"receptors.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}