{"id":"https://openalex.org/W8894131","doi":null,"title":"Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings.","display_name":"Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W8894131","mag":"8894131","pmid":"https://pubmed.ncbi.nlm.nih.gov/8737630"},"language":"en","primary_location":{"id":"pmid:8737630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8737630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029010078","display_name":"Markus Unkauf","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Unkauf","raw_affiliation_strings":["Zyma GmbH, Medizin und Entwicklung, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zyma GmbH, Medizin und Entwicklung, Munich, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024784587","display_name":"Dieter Rehn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Rehn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Klinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Klinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608849","display_name":"Stephan de la Motte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S de la Motte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073549408","display_name":"Kenneth F. Grossmann","orcid":"https://orcid.org/0000-0002-8523-7407","observed_orcids":["https://orcid.org/0000-0002-8523-7407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Grossmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4158,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.61829536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"46","issue":"5","first_page":"478","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11453","display_name":"Diagnosis and Treatment of Venous Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-venous-insufficiency","display_name":"chronic venous insufficiency","score":0.9440000057220459},{"id":"https://openalex.org/keywords/compression-stockings","display_name":"compression stockings","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lower-extremity-edema","display_name":"lower limb edema","score":0.7950000166893005},{"id":"https://openalex.org/keywords/venoruton","display_name":"Venoruton","score":0.8420000076293945},{"id":"https://openalex.org/keywords/leg-volume","display_name":"leg volume","score":0.7080000042915344},{"id":"https://openalex.org/keywords/venous-symptoms","display_name":"venous symptoms","score":0.5040000081062317},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/placebo-controlled-comparison","display_name":"placebo comparison","score":0.503000020980835},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.43700000643730164},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.6600000262260437},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.6100000143051147},{"id":"https://openalex.org/keywords/water-displacement-measurement","display_name":"water displacement measurement","score":0.4659999907016754},{"id":"https://openalex.org/keywords/visual-analog-scale","display_name":"visual analogue scale","score":0.6840000152587891},{"id":"https://openalex.org/keywords/chronic-venous-disease","display_name":"chronic venous disease","score":0.39500001072883606},{"id":"https://openalex.org/keywords/venous-insufficiency","display_name":"venous insufficiency","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8881979584693909},{"id":"https://openalex.org/C2778890739","wikidata":"https://www.wikidata.org/wiki/Q745049","display_name":"Compression stockings","level":3,"score":0.8142998218536377},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7787127494812012},{"id":"https://openalex.org/C2776106345","wikidata":"https://www.wikidata.org/wiki/Q1088042","display_name":"Chronic venous insufficiency","level":2,"score":0.7560378909111023},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4705534279346466},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.44426265358924866},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4009953737258911},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001458","descriptor_name":"Bandages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006896","descriptor_name":"Hydroxyethylrutoside","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006896","descriptor_name":"Hydroxyethylrutoside","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006896","descriptor_name":"Hydroxyethylrutoside","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014689","descriptor_name":"Venous Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8737630","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8737630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arzneimittel-Forschung","raw_type":"Clinical Trial"},{"id":"mag:8894131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8737630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082141158","https://openalex.org/W2463246982","https://openalex.org/W2419040879","https://openalex.org/W123878060","https://openalex.org/W2129397054","https://openalex.org/W2071934419","https://openalex.org/W1486729502","https://openalex.org/W2396170159","https://openalex.org/W2801810146","https://openalex.org/W69397169"],"abstract_inverted_index":{"The":[0,76,216,271,337],"aim":[1],"of":[2,13,43,56,85,113,123,135,232,238,242,253,274,283,328,344],"this":[3,66,126],"study":[4,71,78,338],"was":[5,285],"to":[6,34,40,119,154,228,263,278,316,325,365],"investigate,":[7],"if":[8],"the":[9,10,41,147,220,223,239,246,257,296,312,341],"combined":[11,258,342],"treatment":[12,18,36,74,94,259,284,349,367],"compression":[14,35,109,115,345,366],"stockings":[15,124,129,143,289,300,346],"and":[16,47,50,83,141,169,188,207,212,290,292,301,347],"drug":[17,348],"with":[19,28,60,72,260,318,350],"oxerutins":[20,156,261,351],"(O-(beta-hydroxyethyl)-rutosides,":[21],"Venoruton)":[22],"provides":[23],"additional":[24],"benefit":[25],"for":[26,80,146,256,266,288,295,322],"patients":[27,59,105,297],"chronic":[29,361],"venous":[30,362],"insufficiency":[31,363],"(CVI)":[32],"compared":[33,262,277,315,364],"alone.":[37,368],"Oxerutins":[38,306],"belong":[39],"group":[42],"oedema":[44,244,358],"protective":[45,52],"agents":[46],"possess":[48],"anti-exudative":[49],"membrane":[51],"activity.":[53],"A":[54],"total":[55],"133":[57],"female":[58],"CVI":[61],"grade":[62],"II":[63],"participated":[64],"in":[65,125,249,311,355],"double-blind,":[67],"randomised,":[68],"multi-centre,":[69],"parallel-group":[70],"two":[73],"groups.":[75],"whole":[77],"lasted":[79],"19":[81],"weeks,":[82],"consisted":[84,112],"a":[86,98,107,179,190,210,250,308],"one":[87,133],"week":[88,134,191,198,226,229,323,326],"placebo":[89,180,267,302],"run-in":[90,181],"phase,":[91,95],"12":[92,203,281,324],"weeks":[93,100,204,282],"followed":[96],"by":[97],"6":[99],"treatment-free":[101,214],"follow-up":[102,313],"period.":[103],"All":[104],"received":[106,299],"basis":[108],"therapy":[110,343],"that":[111,340],"standard":[114,136],"stockings.":[116],"In":[117],"order":[118],"standardise":[120],"initial":[121],"fitting":[122],"multi-centre":[127],"setting,":[128],"were":[130,144,152,176],"fitted":[131],"after":[132,209,280],"diuretics":[137],"starting":[138],"at":[139,183,196,200],"baseline":[140,197,224,279],"then":[142],"worn":[145],"following":[148],"11":[149],"weeks.":[150],"Patients":[151],"randomised":[153],"receive":[155],"(2":[157],"x":[158],"500":[159],"mg":[160],"daily)":[161],"or":[162],"matching":[163],"placebo.":[164],"Leg":[165],"volumes":[166],"(water":[167],"displacement)":[168],"associated":[170],"subjective":[171],"symptoms":[172],"(visula":[173],"analogue":[174],"scale)":[175],"measured":[177],"during":[178,245],"period":[182],"enrolment":[184],"(week":[185,193],"-":[186,194],"1)":[187],"half":[189],"later":[192],"1/2),":[195],"0),":[199],"4,":[201],"8,":[202],"on":[205],"treatment,":[206],"again":[208],"3-":[211],"6-weeks":[213],"follow-up.":[215],"primary":[217],"efficacy":[218],"criterion,":[219],"area":[221],"under":[222],"from":[225,360],"0":[227],"18":[230,327],"(AUB0-18)":[231],"leg":[233,243,275,357],"volume":[234,276],"changes,":[235],"as":[236],"measurement":[237],"global":[240],"change":[241,273],"study,":[247],"resulted":[248],"superior":[251,354],"reduction":[252],"-5589":[254],"ml.d":[255,265,330,333],"-2101":[264],"(p":[268,303,334],"=":[269],"0.012).":[270],"mean":[272,319],"-63.9":[286],"ml":[287,294],"oxerutins,":[291],"-32.9":[293],"who":[298],"<":[304,335],"0.05).":[305],"showed":[307],"prolonged":[309],"effect":[310],"phase":[314],"placebo,":[317],"AUB":[320],"values":[321],"-1769":[329],"versus":[331],"-133":[332],"0.01).":[336],"demonstrated":[339],"is":[352],"significantly":[353],"reducing":[356],"resulting":[359]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}