{"id":"https://openalex.org/W8891593","doi":null,"title":"Insulin therapy at onset of type 2 diabetes mellitus--a new concept.","display_name":"Insulin therapy at onset of type 2 diabetes mellitus--a new concept.","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W8891593","mag":"8891593","pmid":"https://pubmed.ncbi.nlm.nih.gov/21818993"},"language":"en","primary_location":{"id":"pmid:21818993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21818993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112950744","display_name":"B K Sahay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]},{"id":"https://openalex.org/I99557698","display_name":"Osmania Medical College","ror":"https://ror.org/00hr54p22","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I99557698"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"B K Sahay","raw_affiliation_strings":["Department of Medicine, Osmania Medical College, 6-3-852/A, Ameerpet, Hyderabad 500016, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Osmania Medical College, 6-3-852/A, Ameerpet, Hyderabad 500016, India","institution_ids":["https://openalex.org/I8975392","https://openalex.org/I99557698"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112950744"],"corresponding_institution_ids":["https://openalex.org/I8975392","https://openalex.org/I99557698"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00116226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59 Suppl","issue":null,"first_page":"13","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8560000061988831},{"id":"https://openalex.org/keywords/insulin-dose-reduction","display_name":"insulin dose reduction","score":0.6520000100135803},{"id":"https://openalex.org/keywords/oral-antidiabetic-drugs","display_name":"oral antidiabetic drugs","score":0.8299999833106995},{"id":"https://openalex.org/keywords/diet-and-exercise","display_name":"diet and exercise","score":0.6389999985694885},{"id":"https://openalex.org/keywords/beta-cell-preservation","display_name":"beta-cell preservation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.9580000042915344},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9528260827064514},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.815581202507019},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.699256181716919},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6598002314567566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5821496248245239},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5499984622001648},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.5078826546669006},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.5069742202758789},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.44731175899505615},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4451165795326233},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.22796961665153503},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.13005730509757996}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055104","descriptor_name":"Infusions, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21818993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21818993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of the Association of Physicians of India","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W22189248","https://openalex.org/W1482038879","https://openalex.org/W1967005515","https://openalex.org/W1979946833","https://openalex.org/W1983099475","https://openalex.org/W1989604753","https://openalex.org/W2030718654","https://openalex.org/W2050826499","https://openalex.org/W2063392732","https://openalex.org/W2090582239","https://openalex.org/W2091978165","https://openalex.org/W2094434238","https://openalex.org/W2113922470","https://openalex.org/W2159851358","https://openalex.org/W2171294019","https://openalex.org/W2769264260","https://openalex.org/W3198570063"],"related_works":["https://openalex.org/W2394693673","https://openalex.org/W2009756430","https://openalex.org/W2324981201","https://openalex.org/W2085212793","https://openalex.org/W2565050773","https://openalex.org/W2105413962","https://openalex.org/W2417227099","https://openalex.org/W2970316592","https://openalex.org/W2110173826","https://openalex.org/W2994891966"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"insulin":[3,30,66,144,151,218],"therapy":[4,152,219],"was":[5,17,56,72],"initiated":[6],"at":[7,153,220],"onset":[8,154,222],"of":[9,43,65,80,83,96,105,116,118,141,194,223,229],"disease":[10],"in":[11,58],"patients":[12,210],"whose":[13],"fasting":[14],"blood":[15],"glucose":[16],"more":[18],"than":[19],"250":[20],"mg/dl.":[21],"All":[22],"enrolled":[23],"subjects":[24,45],"were":[25,85,102],"treated":[26],"with":[27,87,127,135,211],"human":[28],"premixed":[29],"(30/70)":[31],"administered":[32],"subcutaneously":[33],"twice":[34],"daily":[35],"before":[36,39],"breakfast":[37],"and":[38,89,129,139,168,173],"dinner.":[40],"A":[41],"total":[42],"113":[44],"entered":[46],"the":[47,50,161,189,192,221],"study":[48],"fulfilling":[49],"inclusion":[51],"criteria.":[52],"Good":[53],"glycaemic":[54],"control":[55,71,126],"achieved":[57,73],"a":[59,227],"few":[60],"days.":[61],"The":[62],"dosage":[63],"requirement":[64],"came":[67],"down":[68],"gradually":[69],"after":[70],"as":[74],"manifest":[75],"by":[76],"hypoglycaemia--leading":[77],"to":[78,108,145,158,177],"withdrawal":[79],"insulin.":[81],"Some":[82],"them":[84,142],"managed":[86],"diet":[88,128],"exercise":[90,130],"alone.":[91],"Others":[92],"required":[93],"small":[94],"doses":[95],"oral":[97,136],"antidiabetic":[98],"agents":[99,138],"(OAD).":[100],"There":[101],"no":[103],"cases":[104,111,122],"secondary":[106],"failure":[107],"OADs.":[109],"Ten":[110],"are":[112,123],"on":[113,133],"average":[114],"duration":[115],"follow-up":[117],"10":[119],"years.":[120],"Two":[121],"under":[124],"good":[125],"alone,":[131],"seven":[132],"treatment":[134],"hypoglycemic":[137],"one":[140],"requiring":[143],"maintain":[146],"HbAlc":[147],"below":[148],"7%.":[149],"Thus":[150],"provides":[155,184],"an":[156],"opportunity":[157],"correct":[159],"all":[160,209],"underlying":[162],"pathogenic":[163],"mechanisms,":[164],"i.e.,":[165],"glucotoxicity,":[166],"lipotoxicity":[167],"prevents":[169],"beta":[170,178,195,202],"cell":[171,179,196,203],"apoptosis":[172],"suppresses":[174],"inflammation,":[175],"leading":[176],"protection.":[180],"Such":[181],"timely":[182],"intervention":[183],"long":[185],"term":[186],"benefits,":[187],"laying":[188],"foundation":[190],"for":[191,226],"concept":[193],"preservation":[197],"rather":[198],"that":[199,208],"only":[200],"replacing":[201],"function.":[204],"Hence":[205],"we":[206],"propose":[207],"type":[212],"2":[213],"diabetes":[214,225],"should":[215],"be":[216],"offered":[217],"their":[224],"period":[228],"2-4":[230],"weeks.":[231]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}