{"id":"https://openalex.org/W88839128","doi":null,"title":"Novel mechanisms involved with lipid metabolism in adipose tissue of dairy cows","display_name":"Novel mechanisms involved with lipid metabolism in adipose tissue of dairy cows","publication_year":2013,"publication_date":"2013-03-12","ids":{"openalex":"https://openalex.org/W88839128","mag":"88839128"},"language":"en","primary_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-4092","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4092&context=etd","pdf_url":"https://lib.dr.iastate.edu/etd/13085","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lib.dr.iastate.edu/etd/13085","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016602213","display_name":"Dawn A. Koltes","orcid":"https://orcid.org/0000-0003-4481-7672","observed_orcids":["https://orcid.org/0000-0003-4481-7672"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dawn Koltes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4481-7672","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5016602213"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00920305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10098","display_name":"Ruminant Nutrition and Digestive Physiology","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dairy-cows","display_name":"dairy cattle","score":0.9869999885559082},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lipid-droplet-proteins","display_name":"lipid droplet proteins","score":0.8790000081062317},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.6460000276565552},{"id":"https://openalex.org/keywords/angptl4","display_name":"ANGPTL4","score":0.796999990940094},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hormone-sensitive-lipase","display_name":"hormone-sensitive lipase","score":0.902999997138977},{"id":"https://openalex.org/keywords/perilipin","display_name":"perilipin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/adipose-triglyceride-lipase","display_name":"adipose triglyceride lipase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.843999981880188},{"id":"https://openalex.org/keywords/feed-restriction","display_name":"feed restriction","score":0.6439999938011169},{"id":"https://openalex.org/keywords/transition-period","display_name":"transition period","score":0.7699999809265137},{"id":"https://openalex.org/keywords/early-lactation","display_name":"early lactation","score":0.8130000233650208},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.7799999713897705},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mrna-levels","display_name":"mRNA levels","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7527744174003601},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.7031168341636658},{"id":"https://openalex.org/C2776977481","wikidata":"https://www.wikidata.org/wiki/Q2915","display_name":"Dairy cattle","level":2,"score":0.5405821204185486},{"id":"https://openalex.org/C3020171069","wikidata":"https://www.wikidata.org/wiki/Q909729","display_name":"Milk fat","level":3,"score":0.41900402307510376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4010741710662842},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3627055287361145},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.36269715428352356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28481024503707886},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.222523033618927},{"id":"https://openalex.org/C2778717857","wikidata":"https://www.wikidata.org/wiki/Q818405","display_name":"Linseed oil","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:lib.dr.iastate.edu:etd-4092","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4092&context=etd","pdf_url":"https://lib.dr.iastate.edu/etd/13085","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/27274","doi":null,"is_oa":false,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/27274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"archive/lib.dr.iastate.edu/etd/13085/Koltes_iastate_0097E_13400.pdf|||Fri Jan 14 19:43:50 UTC 2022","raw_type":"dissertation"},{"id":"mag:88839128","doi":null,"is_oa":false,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4092&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4306497848","display_name":"2013 Midwest Meeting (March 11-13, 2013)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"2013 Midwest Meeting (March 11-13, 2013)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:lib.dr.iastate.edu:etd-4092","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=4092&context=etd","pdf_url":"https://lib.dr.iastate.edu/etd/13085","source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W88839128.pdf","grobid_xml":"https://content.openalex.org/works/W88839128.grobid-xml"},"referenced_works_count":196,"referenced_works":["https://openalex.org/W140273776","https://openalex.org/W141475044","https://openalex.org/W151495263","https://openalex.org/W206712987","https://openalex.org/W1512875938","https://openalex.org/W1577577364","https://openalex.org/W1587875569","https://openalex.org/W1588704793","https://openalex.org/W1593931056","https://openalex.org/W1801851319","https://openalex.org/W1836046792","https://openalex.org/W1877484538","https://openalex.org/W1886303132","https://openalex.org/W1963862057","https://openalex.org/W1966705420","https://openalex.org/W1966723744","https://openalex.org/W1966744895","https://openalex.org/W1967130466","https://openalex.org/W1967285554","https://openalex.org/W1967383993","https://openalex.org/W1967901031","https://openalex.org/W1967968809","https://openalex.org/W1969240042","https://openalex.org/W1971452427","https://openalex.org/W1973228456","https://openalex.org/W1974975509","https://openalex.org/W1980937260","https://openalex.org/W1980986040","https://openalex.org/W1983656087","https://openalex.org/W1984191109","https://openalex.org/W1984595457","https://openalex.org/W1985877839","https://openalex.org/W1985990006","https://openalex.org/W1986718149","https://openalex.org/W1987849310","https://openalex.org/W1987893244","https://openalex.org/W1988012917","https://openalex.org/W1993951911","https://openalex.org/W1996713062","https://openalex.org/W1997978122","https://openalex.org/W2000449344","https://openalex.org/W2000661379","https://openalex.org/W2001727439","https://openalex.org/W2003946092","https://openalex.org/W2003993308","https://openalex.org/W2004304269","https://openalex.org/W2008768221","https://openalex.org/W2010029728","https://openalex.org/W2010165664","https://openalex.org/W2010349799","https://openalex.org/W2010406049","https://openalex.org/W2010463960","https://openalex.org/W2013715040","https://openalex.org/W2014053671","https://openalex.org/W2014093920","https://openalex.org/W2014154105","https://openalex.org/W2015437105","https://openalex.org/W2015812049","https://openalex.org/W2017258167","https://openalex.org/W2017650269","https://openalex.org/W2019203626","https://openalex.org/W2020389453","https://openalex.org/W2021710604","https://openalex.org/W2022050193","https://openalex.org/W2022069296","https://openalex.org/W2024398370","https://openalex.org/W2024619707","https://openalex.org/W2024629474","https://openalex.org/W2024760591","https://openalex.org/W2027492954","https://openalex.org/W2028464807","https://openalex.org/W2029330484","https://openalex.org/W2029483110","https://openalex.org/W2030026929","https://openalex.org/W2031502981","https://openalex.org/W2031605578","https://openalex.org/W2033766516","https://openalex.org/W2035216298","https://openalex.org/W2036384710","https://openalex.org/W2036625848","https://openalex.org/W2038080641","https://openalex.org/W2038228231","https://openalex.org/W2039956544","https://openalex.org/W2041335773","https://openalex.org/W2042074642","https://openalex.org/W2043273076","https://openalex.org/W2044985063","https://openalex.org/W2045938248","https://openalex.org/W2046333439","https://openalex.org/W2046961412","https://openalex.org/W2048857485","https://openalex.org/W2049965571","https://openalex.org/W2051051060","https://openalex.org/W2051271590","https://openalex.org/W2051548651","https://openalex.org/W2052809558","https://openalex.org/W2053392026","https://openalex.org/W2053948748","https://openalex.org/W2055443182","https://openalex.org/W2055713506","https://openalex.org/W2056422600","https://openalex.org/W2058366781","https://openalex.org/W2058668243","https://openalex.org/W2059069942","https://openalex.org/W2060682066","https://openalex.org/W2063651749","https://openalex.org/W2065697164","https://openalex.org/W2066836273","https://openalex.org/W2067285807","https://openalex.org/W2067348038","https://openalex.org/W2069425890","https://openalex.org/W2074872905","https://openalex.org/W2080092593","https://openalex.org/W2080649034","https://openalex.org/W2083107893","https://openalex.org/W2085397396","https://openalex.org/W2085672416","https://openalex.org/W2085840332","https://openalex.org/W2086933999","https://openalex.org/W2088251798","https://openalex.org/W2090590787","https://openalex.org/W2090946848","https://openalex.org/W2091318169","https://openalex.org/W2091759162","https://openalex.org/W2094026745","https://openalex.org/W2094466940","https://openalex.org/W2094744133","https://openalex.org/W2095150151","https://openalex.org/W2095718954","https://openalex.org/W2096519088","https://openalex.org/W2097040991","https://openalex.org/W2098674392","https://openalex.org/W2099540110","https://openalex.org/W2100341223","https://openalex.org/W2101048587","https://openalex.org/W2101225272","https://openalex.org/W2101543956","https://openalex.org/W2102428962","https://openalex.org/W2102979083","https://openalex.org/W2104890139","https://openalex.org/W2106330478","https://openalex.org/W2106442657","https://openalex.org/W2107117895","https://openalex.org/W2107277218","https://openalex.org/W2108439743","https://openalex.org/W2108629423","https://openalex.org/W2110079579","https://openalex.org/W2110839026","https://openalex.org/W2111528176","https://openalex.org/W2112220590","https://openalex.org/W2113317108","https://openalex.org/W2114095434","https://openalex.org/W2114592628","https://openalex.org/W2120094861","https://openalex.org/W2121542172","https://openalex.org/W2125510262","https://openalex.org/W2127054137","https://openalex.org/W2129606778","https://openalex.org/W2131256997","https://openalex.org/W2134614230","https://openalex.org/W2134812217","https://openalex.org/W2134886125","https://openalex.org/W2135030836","https://openalex.org/W2137313239","https://openalex.org/W2142354708","https://openalex.org/W2142394429","https://openalex.org/W2142822629","https://openalex.org/W2145334525","https://openalex.org/W2147360459","https://openalex.org/W2148847764","https://openalex.org/W2149703192","https://openalex.org/W2151065725","https://openalex.org/W2152489369","https://openalex.org/W2155722642","https://openalex.org/W2157340523","https://openalex.org/W2157367451","https://openalex.org/W2157509649","https://openalex.org/W2159346623","https://openalex.org/W2160106482","https://openalex.org/W2160610888","https://openalex.org/W2162789070","https://openalex.org/W2162896364","https://openalex.org/W2163261192","https://openalex.org/W2163456856","https://openalex.org/W2165178639","https://openalex.org/W2171034553","https://openalex.org/W2171509914","https://openalex.org/W2171830022","https://openalex.org/W2237233581","https://openalex.org/W2293412032","https://openalex.org/W2338303598","https://openalex.org/W2344350115","https://openalex.org/W2396136059","https://openalex.org/W2411811001","https://openalex.org/W2417371456","https://openalex.org/W2468031161"],"related_works":["https://openalex.org/W17032491","https://openalex.org/W2622909367","https://openalex.org/W2101225272","https://openalex.org/W2576642818","https://openalex.org/W2277798920","https://openalex.org/W2004099179","https://openalex.org/W1534058116","https://openalex.org/W2074619173","https://openalex.org/W2018692163","https://openalex.org/W2044985063"],"abstract_inverted_index":{"Proper":[0],"lipid":[1,25,39,65,105,150,219,234],"metabolism":[2,26,220],"is":[3,19],"essential":[4],"to":[5,50,117,232],"the":[6,14,22,34,44,70,142,175,203,228],"maintenance":[7],"of":[8,24,36,46,56,80,123,137,163,167,177,192,206,218,230],"milk":[9],"production":[10],"and":[11,38,64,73,98,128,160,165,208],"fitness":[12],"in":[13,27,30,53,146,221],"modern":[15],"dairy":[16,31,222],"cow.":[17],"Little":[18],"known":[20],"about":[21],"regulation":[23,191,205],"adipose":[28,108,138],"tissue":[29,109],"cattle,":[32],"including":[33],"roles":[35],"adipokines":[37,57],"droplet":[40,66],"associated":[41,67],"proteins.":[42],"Therefore,":[43,103,181],"objectives":[45],"this":[47,212],"study":[48],"were":[49,172],"characterized":[51],"changes":[52],"transcript":[54],"abundances":[55,79],"during":[58,83,93,110,131,152],"three":[59],"different":[60],"energy":[61,112],"altering":[62],"models,":[63],"proteins":[68],"throughout":[69],"transition":[71],"period":[72],"with":[74,174],"leptin":[75,81,155,182],"induced":[76,156],"lipolysis.":[77],"Transcript":[78],"decreased":[82],"feed":[84,96],"restriction,":[85,97],"while":[86],"angiopoietin":[87],"like":[88],"protein":[89,135,161,185],"4":[90],"(ANGPTL4)":[91],"increased":[92,130,183],"early":[94,132,153],"lactation,":[95,133,154],"following":[99],"growth":[100],"hormone":[101,124],"administration.":[102],"reduced":[104],"uptake":[106],"by":[107,194],"declining":[111],"balance":[113],"may":[114,225],"be":[115],"due":[116],"ANGPTL4":[118],"inhibiting":[119],"lipoprotein":[120],"lipase.":[121],"Phosphorylation":[122],"sensitive":[125],"lipase":[126,140],"(HSL)":[127],"perilipin":[129],"but":[134],"abundance":[136,162,186],"triglyceride":[139],"(ATGL),":[141],"rate":[143],"limiting":[144],"step":[145],"lipolysis,":[147],"decreased.":[148],"Unlike":[149],"catabolism":[151],"lipolysis":[157],"was":[158],"mild,":[159],"ATGL":[164,184,193],"phosphorylation":[166],"STAT3":[168,179,195],"increased.":[169],"These":[170],"responses":[171],"attenuated":[173],"addition":[176],"a":[178,197],"inhibitor.":[180],"through":[187],"STAT3.":[188],"This":[189],"novel":[190,216],"demonstrates":[196],"potential":[198],"mechanism":[199],"that":[200],"allows":[201],"for":[202,227],"differential":[204],"HSL":[207],"ATGL.":[209],"In":[210],"conclusion,":[211],"research":[213],"identified":[214],"two":[215],"mechanisms":[217],"cattle":[223],"which":[224],"allow":[226],"development":[229],"strategies":[231],"optimize":[233],"metabolism.":[235]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}