{"id":"https://openalex.org/W8879306","doi":"https://doi.org/10.1023/a:1015901731275","title":"An Unexpected pH Effect on the Stability of Moexipril Lyophilized Powder","display_name":"An Unexpected pH Effect on the Stability of Moexipril Lyophilized Powder","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W8879306","doi":"https://doi.org/10.1023/a:1015901731275","mag":"8879306","pmid":"https://pubmed.ncbi.nlm.nih.gov/2594691"},"language":"en","primary_location":{"id":"doi:10.1023/a:1015901731275","doi":"https://doi.org/10.1023/a:1015901731275","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015901731275","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065686845","display_name":"Robert G. Strickley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert G. Strickley","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California 94304","Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California 94304","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080433554","display_name":"Gary C. Visor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary C. Visor","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113548424","display_name":"Li-Hwa Lin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Hwa Lin","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112232615","display_name":"Leo Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Gu","raw_affiliation_strings":["Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto, California, 94304","institution_ids":[]},{"raw_affiliation_string":"Institute of Pharmaceutical Sciences, Syntex Research, Palo Alto,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4690,"currency":"USD","value_usd":4690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.00148957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"11","first_page":"971","last_page":"975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Physical Organic Chemistry and Reaction Kinetics","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/moexipril","display_name":"moexipril","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lyophilized-powder","display_name":"lyophilized powder","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ph-dependence","display_name":"pH dependence","score":0.7009999752044678},{"id":"https://openalex.org/keywords/drug-stability","display_name":"drug stability","score":0.8939999938011169},{"id":"https://openalex.org/keywords/diketopiperazines","display_name":"diketopiperazines","score":0.8740000128746033},{"id":"https://openalex.org/keywords/ester-hydrolysis","display_name":"ester hydrolysis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cyclization","display_name":"cyclization","score":0.777999997138977},{"id":"https://openalex.org/keywords/alkaline-hydrolysis","display_name":"alkaline hydrolysis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tetrahedral-intermediate","display_name":"tetrahedral intermediate","score":0.8960000276565552},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.8029999732971191},{"id":"https://openalex.org/keywords/parenteral-formulations","display_name":"parenteral formulations","score":0.5400000214576721},{"id":"https://openalex.org/keywords/degradation-kinetics","display_name":"degradation kinetics","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8773638010025024},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.8050565719604492},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.8023003339767456},{"id":"https://openalex.org/C84199377","wikidata":"https://www.wikidata.org/wiki/Q723912","display_name":"Freeze-drying","level":2,"score":0.601301372051239},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5873910188674927},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.5598604679107666},{"id":"https://openalex.org/C186399102","wikidata":"https://www.wikidata.org/wiki/Q903517","display_name":"Chemical stability","level":2,"score":0.5041185617446899},{"id":"https://openalex.org/C192604958","wikidata":"https://www.wikidata.org/wiki/Q7706517","display_name":"Tetrahedral carbonyl addition compound","level":4,"score":0.4511609673500061},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4483722448348999},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.43940505385398865},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2502061426639557},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2106657326221466},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005612","descriptor_name":"Freeze Drying","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1015901731275","doi":"https://doi.org/10.1023/a:1015901731275","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1015901731275","pdf_url":null,"source":{"id":"https://openalex.org/S103865650","display_name":"Pharmaceutical Research","issn_l":"0724-8741","issn":["0724-8741","1573-904X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:2594691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2594691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1608525014","https://openalex.org/W1996399663","https://openalex.org/W2014766536","https://openalex.org/W2064929830","https://openalex.org/W2068673527","https://openalex.org/W2400374018","https://openalex.org/W2400832183","https://openalex.org/W4256032733","https://openalex.org/W4299429175"],"related_works":["https://openalex.org/W2409427772","https://openalex.org/W2413558251","https://openalex.org/W1494970407","https://openalex.org/W2080842528","https://openalex.org/W3169729399","https://openalex.org/W2800554253","https://openalex.org/W253025674","https://openalex.org/W2933011777","https://openalex.org/W2425169707","https://openalex.org/W2339395225"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}