{"id":"https://openalex.org/W88778322","doi":null,"title":"Synthesis of complement components (C3, C2, B and C1-inhibitor) and lysozyme by human monocytes and macrophages.","display_name":"Synthesis of complement components (C3, C2, B and C1-inhibitor) and lysozyme by human monocytes and macrophages.","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W88778322","mag":"88778322","pmid":"https://pubmed.ncbi.nlm.nih.gov/3638367"},"language":"en","primary_location":{"id":"pmid:3638367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3638367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012250913","display_name":"David Francis Lappin","orcid":"https://orcid.org/0000-0002-6094-4973","observed_orcids":["https://orcid.org/0000-0002-6094-4973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Lappin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003918794","display_name":"Hamilton Ad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A D Hamilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049131690","display_name":"Lindsay J. Morrison","orcid":"https://orcid.org/0000-0002-7400-5248","observed_orcids":["https://orcid.org/0000-0002-7400-5248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Morrison","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Aref","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Aref","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111966993","display_name":"Keith Whaley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Whaley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8613,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.70792962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"3","first_page":"101","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-proteins","display_name":"complement proteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/c2","display_name":"C2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/factor-b","display_name":"factor B","score":0.9639999866485596},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lysozyme","display_name":"lysozyme","score":0.996999979019165},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/synovial-fluid","display_name":"synovial fluid","score":0.9739999771118164},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.4690000116825104},{"id":"https://openalex.org/keywords/secretion-kinetics","display_name":"secretion kinetics","score":0.4429999887943268},{"id":"https://openalex.org/keywords/immune-complexes","display_name":"immune complexes","score":0.8149999976158142},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.5709999799728394},{"id":"https://openalex.org/keywords/oxidative-inactivation","display_name":"oxidative inactivation","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C2776966407","wikidata":"https://www.wikidata.org/wiki/Q24779410","display_name":"Lysozyme","level":2,"score":0.9660364389419556},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.8478816747665405},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.49548280239105225},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4537390470504761},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4186936616897583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39165860414505005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3760288655757904},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32603147625923157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.305213987827301},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1504998505115509}],"mesh":[{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003175","descriptor_name":"Complement C2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004792","descriptor_name":"Enzyme Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011415","descriptor_name":"Complement Factor B","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3638367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3638367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:87345","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/87345/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"mag:88778322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3638367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2148862244","https://openalex.org/W2395567961","https://openalex.org/W2054501475","https://openalex.org/W2408204569","https://openalex.org/W2055843283","https://openalex.org/W2262859325","https://openalex.org/W1541942464","https://openalex.org/W2046450825","https://openalex.org/W2412908983","https://openalex.org/W7100495381"],"abstract_inverted_index":{"The":[0],"synthesis":[1,99,110],"of":[2,23,29,62,87,100,111,133,159,178,206,217,224,236,266],"C3,":[3],"C2,":[4,65,112,253],"factor":[5],"B":[6,66,113,208],"(B)":[7],"C1-inhibitor":[8,68,103],"and":[9,16,49,67,96,102,114,143,197],"lysozyme":[10,48,101,134],"has":[11],"been":[12],"studied":[13],"in":[14,33,54,84,124,141,152,169],"monocytes":[15,142],"macrophages":[17],"isolated":[18],"from":[19],"the":[20,39,59,73,85,106,121,130,164,179,203,215,248,263],"synovial":[21],"fluids":[22],"patients":[24],"with":[25,230,244,251],"rheumatoid":[26],"arthritis.":[27],"Concentrations":[28],"all":[30,78,148],"5":[31,79,221],"proteins":[32,80],"culture":[34,56,107],"supernatants":[35,57,86],"were":[36,69,155,167,191],"measured":[37],"by":[38,193,199,262],"sandwich":[40],"ELISA":[41],"technique.":[42],"Kinetic":[43],"studies":[44,127],"showed":[45,128],"that":[46,129,160,212,223,257],"only":[47],"C3":[50,115],"could":[51,81],"be":[52,82,118],"detected":[53,83],"monocyte":[55,95,153,207,218,231,258],"on":[58,90],"first":[60],"day":[61,91,123],"culture,":[63],"whereas":[64,109],"not":[70,189],"present":[71],"until":[72],"third":[74],"day.":[75],"In":[76,93],"contrast":[77],"macrophage":[88,97],"cultures":[89,98,154],"1.":[92],"both":[94],"continued":[104],"throughout":[105],"period,":[108],"appeared":[116],"to":[117,211],"reduced":[119,198],"after":[120],"fifth":[122],"culture.":[125],"Quantitative":[126],"secretion":[131],"rates":[132,146,166,184],"(4,700":[135],"X":[136],"10(3)":[137],"molecules/cell/hr)":[138],"was":[139,209,220],"similar":[140,210],"macrophages.":[144],"Synthesis":[145],"for":[147,161,181,185,213,247],"4":[149],"complement":[150,186],"components":[151],"less":[156,175],"than":[157,176],"0.2%":[158],"lysozyme.":[162,182],"Although":[163,202],"synthetic":[165],"higher":[168],"macrophages,":[170],"even":[171],"then":[172],"they":[173],"constituted":[174],"2%":[177],"rate":[180],"Synthetic":[183],"components,":[187],"but":[188],"lysozyme,":[190],"increased":[192],"BSA-anti-BSA":[194],"antigen-antibody":[195],"complexes":[196],"serum-treated":[200],"complexes.":[201],"functional":[204],"activity":[205,216],"serum,":[214],"C2":[219,232,259],"times":[222],"serum":[225,252],"C2.":[226],"As":[227],"C42":[228],"formed":[229,250],"had":[233],"a":[234],"half-life":[235],"13.5":[237],"min":[238,246],"at":[239],"30":[240],"degrees":[241],"C,":[242],"compared":[243],"4.5":[245],"enzyme":[249],"it":[254],"is":[255,260],"probable":[256],"oxidized":[261],"oxygen":[264],"products":[265],"these":[267],"cells.":[268]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
