{"id":"https://openalex.org/W88754738","doi":null,"title":"Autoimmune Liver Diseases in Canterbury, New Zealand","display_name":"Autoimmune Liver Diseases in Canterbury, New Zealand","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W88754738","mag":"88754738"},"language":"fi","primary_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396881610001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Autoimmune-Liver-Diseases--in-Canterbury/9926480122201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396881600001891/13397302400001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396881600001891/13397302400001891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025833832","display_name":"Jing Hieng Ngu","orcid":"https://orcid.org/0000-0001-6479-1305","observed_orcids":["https://orcid.org/0000-0001-6479-1305"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jing Hieng Ngu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6479-1305","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025833832"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-liver-disease","display_name":"autoimmune liver disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8209999799728394},{"id":"https://openalex.org/keywords/incidence-and-prevalence","display_name":"incidence and prevalence","score":0.7200000286102295},{"id":"https://openalex.org/keywords/age-at-presentation","display_name":"age at presentation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4699999988079071},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cancer-incidence","display_name":"cancer incidence","score":0.6869999766349792},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.8709999918937683},{"id":"https://openalex.org/keywords/environmental-risk-factors","display_name":"environmental risk factors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/canterbury-new-zealand","display_name":"Canterbury, New Zealand","score":0.7329999804496765},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.47492796182632446},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42670509219169617},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38665488362312317},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.32086536288261414},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.12079951167106628}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:alma.64OTAGO_INST:11396881610001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Autoimmune-Liver-Diseases--in-Canterbury/9926480122201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396881600001891/13397302400001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},{"id":"pmh:oai:ourarchive.otago.ac.nz:10523/4312","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10523/4312","pdf_url":"http://hdl.handle.net/10523/4312","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:88754738","doi":null,"is_oa":false,"landing_page_url":"https://ourarchive.otago.ac.nz/bitstream/handle/10523/4312/NguJingH2013PhD.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:alma.64OTAGO_INST:11396881610001891","doi":null,"is_oa":true,"landing_page_url":"https://ourarchive.otago.ac.nz/esploro/outputs/doctoral/Autoimmune-Liver-Diseases--in-Canterbury/9926480122201891","pdf_url":"https://ourarchive.otago.ac.nz/view/delivery/64OTAGO_INST/12396881600001891/13397302400001891","source":{"id":"https://openalex.org/S4306402094","display_name":"Otago University Research Archive (University of Otago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80281795","host_organization_name":"University of Otago","host_organization_lineage":["https://openalex.org/I80281795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320794","display_name":"Canterbury Medical Research Foundation","ror":"https://ror.org/01kr2nz80"},{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W88754738.pdf","grobid_xml":"https://content.openalex.org/works/W88754738.grobid-xml"},"referenced_works_count":271,"referenced_works":["https://openalex.org/W42330504","https://openalex.org/W53993344","https://openalex.org/W79267123","https://openalex.org/W125686439","https://openalex.org/W134126914","https://openalex.org/W170368146","https://openalex.org/W178783021","https://openalex.org/W796875701","https://openalex.org/W1487018400","https://openalex.org/W1489190893","https://openalex.org/W1498948971","https://openalex.org/W1515200381","https://openalex.org/W1528851147","https://openalex.org/W1559754759","https://openalex.org/W1567681575","https://openalex.org/W1568085300","https://openalex.org/W1585286042","https://openalex.org/W1596357345","https://openalex.org/W1613711713","https://openalex.org/W1667685265","https://openalex.org/W1741808808","https://openalex.org/W1776760292","https://openalex.org/W1823704086","https://openalex.org/W1847841744","https://openalex.org/W1858773867","https://openalex.org/W1868512026","https://openalex.org/W1874022447","https://openalex.org/W1964662152","https://openalex.org/W1965275763","https://openalex.org/W1965478670","https://openalex.org/W1966632314","https://openalex.org/W1967176155","https://openalex.org/W1968538527","https://openalex.org/W1968791123","https://openalex.org/W1970088990","https://openalex.org/W1970204534","https://openalex.org/W1970897053","https://openalex.org/W1971928794","https://openalex.org/W1971999794","https://openalex.org/W1972079733","https://openalex.org/W1972897452","https://openalex.org/W1973130325","https://openalex.org/W1973805540","https://openalex.org/W1973987160","https://openalex.org/W1974276656","https://openalex.org/W1975698040","https://openalex.org/W1976139167","https://openalex.org/W1977878136","https://openalex.org/W1978073003","https://openalex.org/W1978346927","https://openalex.org/W1978618138","https://openalex.org/W1980089776","https://openalex.org/W1980426222","https://openalex.org/W1980608423","https://openalex.org/W1982654844","https://openalex.org/W1983024232","https://openalex.org/W1984065159","https://openalex.org/W1984136449","https://openalex.org/W1984419953","https://openalex.org/W1985049522","https://openalex.org/W1985748383","https://openalex.org/W1988139487","https://openalex.org/W1989254363","https://openalex.org/W1991110217","https://openalex.org/W1991417155","https://openalex.org/W1992563553","https://openalex.org/W1993095463","https://openalex.org/W1993958712","https://openalex.org/W1994497077","https://openalex.org/W1994968614","https://openalex.org/W1996463505","https://openalex.org/W1996679935","https://openalex.org/W1997433199","https://openalex.org/W1998918218","https://openalex.org/W1999938910","https://openalex.org/W2000959749","https://openalex.org/W2003122301","https://openalex.org/W2004188199","https://openalex.org/W2005343899","https://openalex.org/W2006412887","https://openalex.org/W2006493179","https://openalex.org/W2006703854","https://openalex.org/W2007242843","https://openalex.org/W2007545033","https://openalex.org/W2009693986","https://openalex.org/W2010615538","https://openalex.org/W2011412954","https://openalex.org/W2013668795","https://openalex.org/W2013803788","https://openalex.org/W2013920381","https://openalex.org/W2014806082","https://openalex.org/W2015172755","https://openalex.org/W2015624008","https://openalex.org/W2017419353","https://openalex.org/W2018309229","https://openalex.org/W2020117090","https://openalex.org/W2020380988","https://openalex.org/W2021512776","https://openalex.org/W2022408681","https://openalex.org/W2022970011","https://openalex.org/W2023097957","https://openalex.org/W2023192639","https://openalex.org/W2023250530","https://openalex.org/W2024645140","https://openalex.org/W2025630596","https://openalex.org/W2025784736","https://openalex.org/W2025785243","https://openalex.org/W2026102665","https://openalex.org/W2026781960","https://openalex.org/W2027232557","https://openalex.org/W2027785103","https://openalex.org/W2028629698","https://openalex.org/W2030447006","https://openalex.org/W2030512720","https://openalex.org/W2030973449","https://openalex.org/W2031679296","https://openalex.org/W2031993658","https://openalex.org/W2032883447","https://openalex.org/W2033199669","https://openalex.org/W2033885823","https://openalex.org/W2034354903","https://openalex.org/W2035094814","https://openalex.org/W2035146122","https://openalex.org/W2037296823","https://openalex.org/W2037316682","https://openalex.org/W2038417476","https://openalex.org/W2039049566","https://openalex.org/W2039757916","https://openalex.org/W2041113577","https://openalex.org/W2043107413","https://openalex.org/W2043474597","https://openalex.org/W2044037509","https://openalex.org/W2044509959","https://openalex.org/W2046064650","https://openalex.org/W2047837181","https://openalex.org/W2048473231","https://openalex.org/W2048772604","https://openalex.org/W2048997301","https://openalex.org/W2049098221","https://openalex.org/W2049473215","https://openalex.org/W2051004952","https://openalex.org/W2051304757","https://openalex.org/W2051833434","https://openalex.org/W2055054205","https://openalex.org/W2055202209","https://openalex.org/W2056295525","https://openalex.org/W2056322204","https://openalex.org/W2058957121","https://openalex.org/W2060255259","https://openalex.org/W2060314227","https://openalex.org/W2061144228","https://openalex.org/W2063975050","https://openalex.org/W2064095927","https://openalex.org/W2064099588","https://openalex.org/W2064578976","https://openalex.org/W2065082654","https://openalex.org/W2065396078","https://openalex.org/W2065637841","https://openalex.org/W2066396710","https://openalex.org/W2066937122","https://openalex.org/W2067610680","https://openalex.org/W2068146271","https://openalex.org/W2069027651","https://openalex.org/W2069999737","https://openalex.org/W2070114714","https://openalex.org/W2071180822","https://openalex.org/W2071307059","https://openalex.org/W2071394537","https://openalex.org/W2072478361","https://openalex.org/W2074294333","https://openalex.org/W2074358609","https://openalex.org/W2075774005","https://openalex.org/W2076165862","https://openalex.org/W2076436750","https://openalex.org/W2079292662","https://openalex.org/W2079853302","https://openalex.org/W2080304201","https://openalex.org/W2080820626","https://openalex.org/W2081285332","https://openalex.org/W2083171998","https://openalex.org/W2087797638","https://openalex.org/W2088182443","https://openalex.org/W2088633095","https://openalex.org/W2089121737","https://openalex.org/W2090645357","https://openalex.org/W2090702738","https://openalex.org/W2091218470","https://openalex.org/W2091336182","https://openalex.org/W2093977733","https://openalex.org/W2094464340","https://openalex.org/W2095262005","https://openalex.org/W2100706559","https://openalex.org/W2101201834","https://openalex.org/W2102495280","https://openalex.org/W2103288048","https://openalex.org/W2107494830","https://openalex.org/W2108326867","https://openalex.org/W2109758313","https://openalex.org/W2110630938","https://openalex.org/W2111285312","https://openalex.org/W2111543635","https://openalex.org/W2112146874","https://openalex.org/W2113126568","https://openalex.org/W2115476346","https://openalex.org/W2118094114","https://openalex.org/W2118422146","https://openalex.org/W2119967316","https://openalex.org/W2120215326","https://openalex.org/W2120698555","https://openalex.org/W2122422943","https://openalex.org/W2125532560","https://openalex.org/W2125763073","https://openalex.org/W2126655686","https://openalex.org/W2128610579","https://openalex.org/W2130419605","https://openalex.org/W2131096427","https://openalex.org/W2131940945","https://openalex.org/W2132244235","https://openalex.org/W2132675308","https://openalex.org/W2132884071","https://openalex.org/W2134613519","https://openalex.org/W2140038579","https://openalex.org/W2140206473","https://openalex.org/W2141885003","https://openalex.org/W2142235629","https://openalex.org/W2146066637","https://openalex.org/W2146831240","https://openalex.org/W2147413263","https://openalex.org/W2148082560","https://openalex.org/W2148095358","https://openalex.org/W2148149018","https://openalex.org/W2148772323","https://openalex.org/W2149363036","https://openalex.org/W2149834061","https://openalex.org/W2149890837","https://openalex.org/W2151805825","https://openalex.org/W2152059260","https://openalex.org/W2153108466","https://openalex.org/W2153418603","https://openalex.org/W2156554590","https://openalex.org/W2159434940","https://openalex.org/W2160126419","https://openalex.org/W2161458396","https://openalex.org/W2161526676","https://openalex.org/W2162762029","https://openalex.org/W2163369593","https://openalex.org/W2163392923","https://openalex.org/W2166497420","https://openalex.org/W2166653283","https://openalex.org/W2168599228","https://openalex.org/W2170705556","https://openalex.org/W2181903556","https://openalex.org/W2226025462","https://openalex.org/W2268357984","https://openalex.org/W2290078664","https://openalex.org/W2316970164","https://openalex.org/W2331216044","https://openalex.org/W2338200925","https://openalex.org/W2340620765","https://openalex.org/W2403262403","https://openalex.org/W2408624074","https://openalex.org/W2411143195","https://openalex.org/W2414153038","https://openalex.org/W2468010477","https://openalex.org/W2519667383","https://openalex.org/W2735656006","https://openalex.org/W3140593116","https://openalex.org/W3143281063","https://openalex.org/W3152200344","https://openalex.org/W3152299393","https://openalex.org/W4297752219"],"related_works":["https://openalex.org/W7008808836","https://openalex.org/W3033183753","https://openalex.org/W2072478361","https://openalex.org/W2118422146","https://openalex.org/W1498948971","https://openalex.org/W2196324096","https://openalex.org/W3182225677","https://openalex.org/W3096878102","https://openalex.org/W2406437112","https://openalex.org/W4402723038"],"abstract_inverted_index":{"Autoimmune":[0],"hepatitis":[1,295],"(AIH),":[2],"primary":[3,8],"sclerosing":[4],"cholangitis":[5],"(PSC)":[6],"and":[7,31,76,83,97,125,129,164,181,331,343,371,397,411,419,427,430,481,536,593,626,648,669],"biliary":[9],"cirrhosis":[10,617],"(PBC)":[11],"are":[12,67,133,144,190,325,414,484,490,545,603],"progressive":[13],"autoimmune":[14,41,148],"liver":[15,22,29,346,387,608,614],"diseases":[16,149],"(AiLD)":[17],"that":[18,37,107,142,151,210,236,279,323,351,443,474,488,493],"can":[19],"lead":[20],"to":[21,43,146,207,234,244,321,336,377,386,464,499,632,662],"cirrhosis,":[23],"hepatic":[24,410,428],"failure,":[25],"the":[26,46,72,111,135,185,208,229,245,249,258,271,297,318,361,378,391,398,440,461,466,475,529,550,569,575,630,663],"need":[27,399],"for":[28,223,345,368,400,404,439,528,613],"transplantation":[30],"death.":[32],"Although":[33,422],"it":[34],"is":[35,39,159,168,228,317,353,373,384,432,448,458,505,513,523,564,620],"believed":[36],"there":[38,211,324],"an":[40,423,524],"basis":[42],"their":[44],"pathogenesis,":[45],"precise":[47],"aetiologies":[48],"of":[49,55,114,119,127,166,187,191,200,219,248,254,260,268,274,294,364,393,408,468,477,531,553,558,571,577,582,597,607,645,655,666],"AiLD":[50,56,66],"remain":[51],"unknown.":[52],"The":[53,116,123,162,366,381,455,556],"epidemiology":[54],"has":[57,308,437],"remained":[58],"poorly":[59],"defined,":[60],"as":[61,101,103,290,340],"population-based":[62,80,112,231,643],"epidemiological":[63,157],"data":[64],"concerning":[65],"scarce.":[68],"This":[69,139,227,276,316],"thesis":[70],"details":[71],"descriptive":[73,642],"epidemiology,":[74],"survival":[75],"cancer":[77,446],"incidence":[78,124,163],"in":[79,86,110,131,155,171,178,225,240,270,287,296,360,417,452,470,503,511,538,560,574,650,671],"AIH,":[81,369,532,646],"PBC,":[82],"PSC":[84,130,301,313,329,372,420,426,647],"cohorts":[85,113,644],"Canterbury.":[87,651],"In":[88],"addition,":[89],"this":[90,120,203,435,636,656],"work":[91,121,204,436,657],"also":[92,449,459],"investigates":[93],"genetic":[94,196],"risk":[95,99,221,447,467,476,526],"loci":[96],"environmental":[98,572],"factors,":[100],"well":[102,433],"identifies":[104],"prognostic":[105],"factors":[106,548,573],"determine":[108],"outcomes":[109],"AIH.":[115,554,578],"major":[117,357],"findings":[118,349,654],"are:\\n\\n1.":[122],"prevalence":[126,165,557],"AIH":[128,232,237,280,418,471,502,559],"Canterbury":[132,172,379,504],"among":[134],"highest":[136],"reported":[137],"worldwide.":[138],"could":[140],"mean":[141],"Cantabrians":[143],"predisposed":[145],"inflammatory":[147,304],"and/or":[150],"case":[152],"recruitment":[153],"methodology":[154],"these":[156,201,405,453,489,667],"studies":[158,176],"thorough.":[160],"\\n\\n2.":[161],"PBC":[167,224,370,649],"surprisingly":[169],"low":[170,565,587],"when":[173],"compared":[174,376],"with":[175,194,198,263,303,330,334,508,515,542,623],"performed":[177],"northern":[179,182],"Europe":[180],"America.":[183],"As":[184],"majority":[186],"our":[188],"population":[189],"Anglo-Celtic":[192],"background":[193,197],"shared":[195],"some":[199],"countries,":[202],"provided":[205],"support":[206],"hypothesis":[209],"may":[212],"be":[213,283,496],"a":[214,220,264,291,309,356,539],"protective":[215,547],"effect":[216],"or":[217,600,611],"lack":[218],"factor":[222,359,527],"Canterbury.\\n\\n3.":[226],"first":[230,319,441,561],"study":[233,320,457,463],"confirm":[235],"presents":[238],"predominantly":[239],"older":[241,298],"women,":[242],"contrary":[243],"classical":[246],"description":[247],"disease.":[250],"Nearly":[251],"three":[252],"quarters":[253],"patients":[255],"presented":[256,640],"after":[257],"age":[259,267,299,594],"40":[261],"years":[262,599],"single":[265],"peak":[266],"presentation":[269,596],"sixth":[272],"decade":[273],"life.":[275],"finding":[277],"indicates":[278],"should":[281,494],"therefore":[282],"considered":[284],"more":[285,516],"frequently":[286],"clinical":[288],"practice":[289],"treatable":[292],"cause":[293],"group.\\n\\n4.":[300],"associated":[302,507,514,622],"bowel":[305],"disease":[306,362,518],"(IBD)":[307],"worse":[310],"outcome":[311],"than":[312],"without":[314,332],"IBD.":[315],"show":[322],"striking":[326],"differences":[327],"between":[328,425],"IBD":[333,352],"regard":[335],"serious":[337],"complications":[338],"such":[339],"cancer,":[341],"death":[342,610],"requirement":[344,612],"transplantation.":[347,615],"These":[348],"demonstrate":[350],"at":[354,566,584,591,595,618],"least":[355],"modifying":[358],"manifestation":[363],"PSC.\\n\\n5.":[365],"mortality":[367,383],"significantly":[374,415,450,485],"increased":[375,416,451],"population.":[380],"excess":[382],"due":[385],"related":[388,609],"death,":[389],"indicating":[390],"inadequacy":[392],"current":[394,456,664],"management":[395,674],"strategies,":[396],"new":[401],"effective":[402],"treatments":[403],"conditions.\\n\\n6.":[406],"Risks":[407],"both":[409],"extra-hepatic":[412],"malignancy":[413,429,469],"patients.":[421,454],"association":[424],"CRC":[431],"established,":[434],"demonstrated":[438],"time":[442],"non-melanoma":[444],"skin":[445,479],"only":[460],"second":[462],"examine":[465],"patients,":[472],"demonstrating":[473],"hepatobiliary,":[478],"(non-melanoma)":[480],"haematological":[482],"cancers":[483],"raised,":[486],"confirming":[487],"real":[491],"risks":[492],"not":[495,621,628],"ignored.\\n\\n7.":[497],"Susceptibility":[498],"type":[500],"1":[501],"independently":[506],"HLA-DRB1*0301.":[509],"Polymorphism":[510],"FAS":[512],"aggressive":[517],"phenotypes.":[519],"\\n\\n8.":[520],"Antibiotic":[521],"use":[522],"independent":[525,546,605],"development":[530,552],"whereas":[533],"alcohol":[534],"consumption":[535],"living":[537],"childhood":[540],"home":[541],"wood":[543],"heating":[544],"against":[549],"later":[551],"\\n\\n9.":[555],"degree":[562],"relatives":[563],"0.2%,":[567],"emphasising":[568],"importance":[570],"aetiology":[576],"\\n\\n10.":[579],"Incomplete":[580],"normalisation":[581],"ALT":[583],"6":[585],"months,":[586],"serum":[588],"albumin":[589],"concentration":[590],"diagnosis":[592,619],"\u226420":[598],">60":[601],"years,":[602],"significant":[604],"predictors":[606],"Histological":[616],"poor":[624],"prognosis":[625],"did":[627],"influence":[629],"response":[631],"initial":[633],"immunosuppressive":[634],"treatment.\\n\\nIn":[635],"thesis,":[637],"we":[638],"have":[639],"detailed":[641],"Several":[652],"novel":[653],"will":[658],"make":[659],"important":[660],"contributions":[661],"understanding":[665],"conditions":[668],"aid":[670],"devising":[672],"better":[673],"strategies.":[675]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}