{"id":"https://openalex.org/W887416461","doi":null,"title":"The role of epigenetics in the rat mammary gland","display_name":"The role of epigenetics in the rat mammary gland","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W887416461","mag":"887416461"},"language":"en","primary_location":{"id":"pmh:oai:www.uleth.ca:10133/2492","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/2492","pdf_url":"http://hdl.handle.net/10133/2492","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10133/2492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081732635","display_name":"Kristy R. Kutanzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kristy Kutanzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081732635"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.996999979019165},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.9860000014305115},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5770000219345093},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":1.0},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mammary-gland-morphology","display_name":"mammary gland morphology","score":0.7450000047683716},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.7495009899139404},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6830153465270996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4733060896396637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37182068824768066},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36664819717407227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33370399475097656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16617318987846375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1443437933921814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0808214545249939},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07804843783378601}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.uleth.ca:10133/2492","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/2492","pdf_url":"http://hdl.handle.net/10133/2492","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:887416461","doi":null,"is_oa":false,"landing_page_url":"https://opus.uleth.ca/handle/10133/2492","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.uleth.ca:10133/2492","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/2492","pdf_url":"http://hdl.handle.net/10133/2492","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310768","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320321767","display_name":"Alberta Heritage Foundation for Medical Research","ror":"https://ror.org/0160cpw27"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W887416461.pdf","grobid_xml":"https://content.openalex.org/works/W887416461.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W3352122","https://openalex.org/W57050976","https://openalex.org/W121553317","https://openalex.org/W199710795","https://openalex.org/W1484293540","https://openalex.org/W1510691762","https://openalex.org/W1528035347","https://openalex.org/W1534905912","https://openalex.org/W1572706730","https://openalex.org/W1573746641","https://openalex.org/W1588170891","https://openalex.org/W1658127082","https://openalex.org/W1695354622","https://openalex.org/W1718766467","https://openalex.org/W1790354865","https://openalex.org/W1961026612","https://openalex.org/W1965262464","https://openalex.org/W1967234838","https://openalex.org/W1967764533","https://openalex.org/W1969414262","https://openalex.org/W1969510021","https://openalex.org/W1969848599","https://openalex.org/W1973298558","https://openalex.org/W1976420723","https://openalex.org/W1976626368","https://openalex.org/W1982025877","https://openalex.org/W1983507742","https://openalex.org/W1983725267","https://openalex.org/W1986991630","https://openalex.org/W1987017438","https://openalex.org/W1994664175","https://openalex.org/W1995643652","https://openalex.org/W1995929656","https://openalex.org/W1998871307","https://openalex.org/W1998941814","https://openalex.org/W2000692665","https://openalex.org/W2003726111","https://openalex.org/W2004172747","https://openalex.org/W2005602719","https://openalex.org/W2006764433","https://openalex.org/W2007684630","https://openalex.org/W2009772542","https://openalex.org/W2012463372","https://openalex.org/W2012963160","https://openalex.org/W2013074747","https://openalex.org/W2013521944","https://openalex.org/W2015950242","https://openalex.org/W2016058489","https://openalex.org/W2017583063","https://openalex.org/W2017976437","https://openalex.org/W2024855079","https://openalex.org/W2027799644","https://openalex.org/W2029197798","https://openalex.org/W2029868343","https://openalex.org/W2030170923","https://openalex.org/W2032029477","https://openalex.org/W2033150108","https://openalex.org/W2034018110","https://openalex.org/W2035779163","https://openalex.org/W2038904430","https://openalex.org/W2039154485","https://openalex.org/W2039687299","https://openalex.org/W2041623568","https://openalex.org/W2042601043","https://openalex.org/W2042998069","https://openalex.org/W2043033879","https://openalex.org/W2044323425","https://openalex.org/W2047491571","https://openalex.org/W2048797704","https://openalex.org/W2049662309","https://openalex.org/W2050014799","https://openalex.org/W2051972371","https://openalex.org/W2053935424","https://openalex.org/W2055824301","https://openalex.org/W2056163313","https://openalex.org/W2059587308","https://openalex.org/W2060300649","https://openalex.org/W2060638147","https://openalex.org/W2062421371","https://openalex.org/W2065751798","https://openalex.org/W2067846146","https://openalex.org/W2070135121","https://openalex.org/W2070766068","https://openalex.org/W2075367202","https://openalex.org/W2075520328","https://openalex.org/W2077489154","https://openalex.org/W2084680588","https://openalex.org/W2084811734","https://openalex.org/W2091381826","https://openalex.org/W2091658754","https://openalex.org/W2094979409","https://openalex.org/W2098473439","https://openalex.org/W2099805059","https://openalex.org/W2100285894","https://openalex.org/W2100648255","https://openalex.org/W2102836067","https://openalex.org/W2106080156","https://openalex.org/W2115028635","https://openalex.org/W2117889142","https://openalex.org/W2118147457","https://openalex.org/W2118284394","https://openalex.org/W2119931482","https://openalex.org/W2121155074","https://openalex.org/W2121417064","https://openalex.org/W2123927456","https://openalex.org/W2126490808","https://openalex.org/W2131845534","https://openalex.org/W2134715491","https://openalex.org/W2136693855","https://openalex.org/W2142508010","https://openalex.org/W2143972162","https://openalex.org/W2151028908","https://openalex.org/W2165172234","https://openalex.org/W2166666592","https://openalex.org/W2167463243","https://openalex.org/W2168251468","https://openalex.org/W2171366906","https://openalex.org/W2198753295","https://openalex.org/W2313869316","https://openalex.org/W2321358810","https://openalex.org/W2328946792","https://openalex.org/W2398817223","https://openalex.org/W2404847142","https://openalex.org/W2414734562","https://openalex.org/W2415390444"],"related_works":["https://openalex.org/W2105621153","https://openalex.org/W2703974921","https://openalex.org/W2007201884","https://openalex.org/W2381845415","https://openalex.org/W2097416376","https://openalex.org/W1487062847","https://openalex.org/W2797990408","https://openalex.org/W7144547720","https://openalex.org/W2019605401","https://openalex.org/W3155280215"],"abstract_inverted_index":{"Epigenetics":[0],"plays":[1],"an":[2,80],"important":[3],"role":[4],"in":[5,10,77,97,110,127],"carcinogenesis":[6],"with":[7,112],"heritable":[8],"changes":[9,39],"DNA":[11],"methylation":[12],"and":[13,22,33,46,91],"histone":[14],"modifications":[15,122],"intricately":[16],"linked":[17],"to":[18,105,123,142],"the":[19,56,67,87,103,124,128],"initiation,":[20],"promotion,":[21],"progression":[23],"of":[24,31,59,70,89],"cancer.":[25],"Evidence":[26],"shows":[27],"that":[28,102],"a":[29],"number":[30],"chemical":[32],"physical":[34],"agents":[35],"can":[36,138],"induce":[37],"epigenetic":[38,57,81],"during":[40],"carcinogenesis.":[41],"Two":[42],"such":[43],"agents,":[44],"estrogen":[45,90],"ionizing":[47,92],"radiation,":[48,113],"are":[49],"generally":[50],"recognized":[51],"as":[52],"being":[53],"carcinogenic.":[54],"Yet":[55],"repercussions":[58],"these":[60,71,135],"carcinogens":[61,72],"remain":[62],"relatively":[63],"unknown.":[64],"More":[65],"importantly,":[66],"combined":[68],"effect":[69,88],"has":[73],"never":[74],"been":[75],"addressed":[76],"vivo":[78],"from":[79,134],"standpoint.":[82],"Therefore,":[83],"we":[84],"focused":[85],"on":[86],"radiation":[93],"applied":[94],"separately":[95],"or":[96,109],"conjunction.":[98],"We":[99],"have":[100],"found":[101],"exposure":[104],"estrogen,":[106],"either":[107],"alone":[108],"combination":[111],"induced":[114],"pronounced":[115],"morphological":[116],"alterations,":[117],"which":[118],"was":[119],"paralleled":[120],"by":[121],"epigenomic":[125],"landscape":[126],"mammary":[129],"gland.":[130],"The":[131],"results":[132],"obtained":[133],"rodent":[136],"models":[137],"potentially":[139],"be":[140],"extrapolated":[141],"humans.":[143]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}