{"id":"https://openalex.org/W88659276","doi":null,"title":"The role of sphingosine 1-phosphate in immunity and sepsis.","display_name":"The role of sphingosine 1-phosphate in immunity and sepsis.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W88659276","mag":"88659276","pmid":"https://pubmed.ncbi.nlm.nih.gov/23885318","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3714198"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2713982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3714198","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3714198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046920761","display_name":"Markus H. Gr\u00e4ler","orcid":"https://orcid.org/0000-0001-6650-7849","observed_orcids":["https://orcid.org/0000-0001-6650-7849"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus H Gr\u00e4ler","raw_affiliation_strings":["Molecular Cancer Research Centre, Charit\u00e9 University Medical School Augustenburger Platz 1, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Cancer Research Centre, Charit\u00e9 University Medical School Augustenburger Platz 1, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046920761"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":0.5249,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.57610407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"1","issue":"2","first_page":"90","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/s1p-receptors","display_name":"S1P receptors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/sphingosine-kinase","display_name":"sphingosine kinase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.4959999918937683},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8539999723434448},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/lymphocyte-trafficking","display_name":"lymphocyte migration","score":0.8539999723434448},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.8880000114440918},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7379999756813049},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7032338976860046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6236509084701538},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.5952933430671692},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.587151288986206},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.5370907187461853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.525963306427002},{"id":"https://openalex.org/C2776549689","wikidata":"https://www.wikidata.org/wiki/Q24782485","display_name":"Sphingosine-1-phosphate receptor","level":5,"score":0.4349178075790405},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4183223247528076},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.41244927048683167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41050541400909424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39157724380493164},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2868309020996094},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13843756914138794}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2713982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3714198","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23885318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23885318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical and experimental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3714198","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3714198/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Clin Exp Immunol","raw_type":"Text"},{"id":"mag:2741450333","doi":null,"is_oa":false,"landing_page_url":"http://www.ajcei.us/files/ajcei1206001.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:88659276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23885318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2713982","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3714198","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W52199435","https://openalex.org/W1519007189","https://openalex.org/W1654241956","https://openalex.org/W1824031276","https://openalex.org/W1926790978","https://openalex.org/W1964409906","https://openalex.org/W1967802627","https://openalex.org/W1972668725","https://openalex.org/W1973573934","https://openalex.org/W1977905350","https://openalex.org/W1978707192","https://openalex.org/W1978893911","https://openalex.org/W1981802180","https://openalex.org/W1983092575","https://openalex.org/W1983241545","https://openalex.org/W1984708466","https://openalex.org/W1988204787","https://openalex.org/W1989607865","https://openalex.org/W1991115604","https://openalex.org/W1992495544","https://openalex.org/W1992974015","https://openalex.org/W1997327044","https://openalex.org/W2004313280","https://openalex.org/W2004880863","https://openalex.org/W2005650624","https://openalex.org/W2006683926","https://openalex.org/W2006717761","https://openalex.org/W2006985918","https://openalex.org/W2007541166","https://openalex.org/W2007949618","https://openalex.org/W2009021880","https://openalex.org/W2010372340","https://openalex.org/W2012591726","https://openalex.org/W2017689420","https://openalex.org/W2018350020","https://openalex.org/W2019209482","https://openalex.org/W2028191845","https://openalex.org/W2036071939","https://openalex.org/W2037155515","https://openalex.org/W2041356495","https://openalex.org/W2054892756","https://openalex.org/W2055010521","https://openalex.org/W2056247033","https://openalex.org/W2056401895","https://openalex.org/W2058353078","https://openalex.org/W2064577392","https://openalex.org/W2066717022","https://openalex.org/W2067822704","https://openalex.org/W2070570719","https://openalex.org/W2074548375","https://openalex.org/W2075621166","https://openalex.org/W2076738925","https://openalex.org/W2079042391","https://openalex.org/W2081615703","https://openalex.org/W2087314408","https://openalex.org/W2089751595","https://openalex.org/W2102239923","https://openalex.org/W2102478723","https://openalex.org/W2103477671","https://openalex.org/W2107000889","https://openalex.org/W2108813293","https://openalex.org/W2111134333","https://openalex.org/W2112580223","https://openalex.org/W2112642980","https://openalex.org/W2119536609","https://openalex.org/W2130392812","https://openalex.org/W2132228454","https://openalex.org/W2132579946","https://openalex.org/W2134299879","https://openalex.org/W2135109495","https://openalex.org/W2135746117","https://openalex.org/W2139749434","https://openalex.org/W2141812010","https://openalex.org/W2144526937","https://openalex.org/W2144640866","https://openalex.org/W2145985395","https://openalex.org/W2146170189","https://openalex.org/W2147329531","https://openalex.org/W2147760936","https://openalex.org/W2149902537","https://openalex.org/W2151535044","https://openalex.org/W2152730481","https://openalex.org/W2153849149","https://openalex.org/W2154089780","https://openalex.org/W2155245449","https://openalex.org/W2156445027","https://openalex.org/W2156726966","https://openalex.org/W2156921663","https://openalex.org/W2157082259","https://openalex.org/W2157586986","https://openalex.org/W2161804483","https://openalex.org/W2162838509","https://openalex.org/W2164250102","https://openalex.org/W2164422031","https://openalex.org/W2166036680","https://openalex.org/W2167403404","https://openalex.org/W2168285948","https://openalex.org/W2169521192","https://openalex.org/W2312556605","https://openalex.org/W2439579683"],"related_works":["https://openalex.org/W2741450333","https://openalex.org/W2135109495","https://openalex.org/W2076738925","https://openalex.org/W7015011811","https://openalex.org/W4392235871","https://openalex.org/W2054892756","https://openalex.org/W1967802627","https://openalex.org/W7024930696","https://openalex.org/W2465983866","https://openalex.org/W2790123740"],"abstract_inverted_index":{"Sphingosine":[0],"1-phosphate":[1],"(S1P)":[2],"is":[3],"a":[4,38],"lipid":[5],"metabolite":[6],"with":[7,148],"intra-":[8],"and":[9,32,48,76,83,87,92,162,178,181],"extracellular":[10,28],"signalling":[11,36,98,120,144],"properties.":[12],"It":[13],"activates":[14],"five":[15],"G":[16],"protein-coupled":[17],"cell":[18,106],"surface":[19],"receptors":[20],"designated":[21],"S1P-receptors":[22],"type":[23,46],"1-5":[24],"(S1P1-5)":[25],"that":[26,116],"transmit":[27],"signals":[29],"into":[30],"cells,":[31,75],"it":[33],"modulates":[34],"intracellular":[35],"as":[37,171],"cofactor.":[39],"The":[40],"analysis":[41],"of":[42,68,96,155,165],"sphingosine":[43],"kinases":[44],"(SphK)":[45],"1":[47],"2,":[49],"the":[50,66,89,149,153,156],"key":[51],"enzymes":[52],"for":[53,65,132,145],"S1P":[54,79,143,166],"production,":[55],"in":[56,103],"different":[57,69,157],"infection":[58],"models":[59],"point":[60],"to":[61,127,141,175],"an":[62],"important":[63],"role":[64],"activation":[67,107],"immune":[70,105,110,146,177],"cells":[71],"like":[72],"macrophages,":[73],"mast":[74],"dendritic":[77],"cells.":[78],"additionally":[80],"influences":[81],"local":[82,104,161],"systemic":[84,109,163],"lymphocyte":[85],"circulation":[86],"positioning,":[88],"vascular":[90],"tone,":[91],"blood":[93],"pressure.":[94],"Modulation":[95],"S1P-mediated":[97,119],"pathways":[99,121],"therefore":[100],"results":[101],"either":[102],"or":[108,112],"suppression,":[111],"both.":[113],"Pharmacological":[114],"approaches":[115],"modulate":[117,142],"certain":[118],"while":[122],"leaving":[123],"others":[124],"untouched":[125],"appear":[126],"be":[128],"promising":[129],"new":[130],"avenues":[131],"next":[133],"generation":[134],"pharmaceuticals.":[135],"This":[136],"review":[137],"summarizes":[138],"current":[139],"strategies":[140],"intervention":[147],"clear":[150],"focus":[151],"on":[152,167],"specificity":[154],"principles":[158],"applied.":[159],"Known":[160],"effects":[164],"immunity":[168],"are":[169],"discussed":[170],"potential":[172],"pharmaceutical":[173],"targets":[174],"combat":[176],"autoimmune":[179],"diseases":[180],"sepsis.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
