{"id":"https://openalex.org/W88636110","doi":null,"title":"Nystatin LF (Aronex/Abbott).","display_name":"Nystatin LF (Aronex/Abbott).","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W88636110","mag":"88636110","pmid":"https://pubmed.ncbi.nlm.nih.gov/11566004"},"language":"en","primary_location":{"id":"pmid:11566004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11566004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001721475","display_name":"S. Ar\u0131kan","orcid":"https://orcid.org/0000-0001-7987-9078","observed_orcids":["https://orcid.org/0000-0001-7987-9078"]},"institutions":[{"id":"https://openalex.org/I66514158","display_name":"Hacettepe University","ror":"https://ror.org/04kwvgz42","country_code":"TR","type":"education","lineage":["https://openalex.org/I66514158"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"S Arikan","raw_affiliation_strings":["Hacettepe University Medical School, Department of Microbiology and Clinical Microbiology, Ankara, Turkey. sarikan@metu.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hacettepe University Medical School, Department of Microbiology and Clinical Microbiology, Ankara, Turkey. sarikan@metu.edu.tr","institution_ids":["https://openalex.org/I66514158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039260055","display_name":"John H. Rex","orcid":"https://orcid.org/0000-0003-3265-5872","observed_orcids":["https://orcid.org/0000-0003-3265-5872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Rex","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.982,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.74379158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2","issue":"4","first_page":"488","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nystatin","display_name":"nystatin","score":0.9319999814033508},{"id":"https://openalex.org/keywords/liposomal-formulation","display_name":"liposomal formulation","score":0.796999990940094},{"id":"https://openalex.org/keywords/systemic-antifungal-therapy","display_name":"systemic antifungal therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.8180000185966492},{"id":"https://openalex.org/keywords/candida","display_name":"Candida","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polyene-antibiotics","display_name":"polyene antibiotics","score":0.7200000286102295},{"id":"https://openalex.org/keywords/ergosterol-binding","display_name":"ergosterol binding","score":0.8650000095367432},{"id":"https://openalex.org/keywords/filamentous-fungi","display_name":"filamentous fungi","score":0.6970000267028809},{"id":"https://openalex.org/keywords/amphotericin-b-resistance","display_name":"amphotericin B resistance","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cryptococcal-meningitis","display_name":"cryptococcal meningitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-approval","display_name":"drug approval","score":0.5699999928474426},{"id":"https://openalex.org/keywords/drug-commercialization","display_name":"drug commercialization","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2777762789","wikidata":"https://www.wikidata.org/wiki/Q251005","display_name":"Nystatin","level":3,"score":0.939396858215332},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.7124704122543335},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.608824610710144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5508313179016113},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.48158979415893555},{"id":"https://openalex.org/C2777910421","wikidata":"https://www.wikidata.org/wiki/Q143263","display_name":"Ergosterol","level":2,"score":0.4652799963951111},{"id":"https://openalex.org/C3019493264","wikidata":"https://www.wikidata.org/wiki/Q1470140","display_name":"Cryptococcal meningitis","level":4,"score":0.4360197186470032},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4055793285369873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3606462776660919},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34775882959365845},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.2526913285255432},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.24607375264167786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23263108730316162},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22729375958442688},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.15258842706680298},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009761","descriptor_name":"Nystatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009761","descriptor_name":"Nystatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009761","descriptor_name":"Nystatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11566004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11566004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"mag:88636110","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11566004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2358203135","https://openalex.org/W2106244685","https://openalex.org/W2111532512","https://openalex.org/W7155552618","https://openalex.org/W2108757973","https://openalex.org/W2124339021","https://openalex.org/W2435577523","https://openalex.org/W7163917917","https://openalex.org/W2396230079","https://openalex.org/W4210957942"],"abstract_inverted_index":{"Nystatin":[0,60],"LF":[1,137,318],"(Nyotran)":[2],"is":[3,36,61,67,74,115],"a":[4,23,37,44,50,118,277,306],"liposomal,":[5],"intravenous":[6],"nystatin":[7,35,136,317],"formulation":[8],"under":[9,13],"development":[10],"by":[11,153],"Aronex,":[12,239],"license":[14],"from":[15,174],"the":[16,53,58,151,154,175,190,210,219,226,229,255,265,313],"MD":[17],"Anderson":[18],"Cancer":[19],"Research":[20],"Center,":[21],"as":[22,72],"systemic":[24,258],"antifungal":[25,64,92],"agent":[26],"against":[27,94,126],"strains":[28],"including":[29,100],"Aspergillus":[30],"and":[31,55,77,105,144,169,212,286,298],"Candida.":[32],"Like":[33],"amphotericin,":[34],"polyene":[38],"derivative":[39],"that":[40,166,188],"binds":[41],"to":[42,69,103,122,146,164,196,263,291,316],"ergosterol,":[43],"fungal":[45,259],"cell":[46],"membrane":[47,54],"component,":[48],"creating":[49],"pore":[51],"in":[52,90,138,140,150,161,181,225,228,248,270],"thus":[56],"killing":[57],"cell.":[59],"an":[62,148,162,222,246],"established":[63],"agent,":[65],"but":[66],"restricted":[68],"topical":[70],"use":[71],"it":[73],"ineffective":[75],"orally":[76],"severely":[78],"toxic":[79],"when":[80],"administered":[81],"iv":[82],"[187583],":[83],"[187589].":[84],"It":[85],"has":[86],"demonstrated":[87],"good,":[88],"broad":[89],"vitro":[91],"activity":[93],"clinically":[95],"relevant":[96],"filamentous":[97],"fungi":[98,101],"[319465],":[99],"resistant":[102],"fluconazole":[104],"amphotericin":[106],"B":[107],"products":[108],"[264505],":[109],"[2869821,":[110],"[287790],":[111],"1289522].":[112],"The":[113,200],"company":[114,220],"also":[116],"conducting":[117],"phase":[119,176],"III":[120,177],"trial":[121,180],"evaluate":[123],"its":[124,167,182],"efficacy":[125],"cryptococcal":[127,178],"meningitis":[128,179],"[305531],":[129],"[334156].":[130],"Aronex":[131,261,289,304],"filed":[132,245],"for":[133,252,254,284,312],"approval":[134,251],"of":[135,156,232,257],"Spain":[139,249,285],"December":[141,237],"1997":[142],"[272986]":[143],"expected":[145],"file":[147],"NDA":[149,223],"US":[152,168,227],"end":[155],"1999":[157],"1311208],":[158],"[342003].":[159],"However,":[160],"effort":[163],"ensure":[165],"European":[170,272],"filings":[171,269],"contained":[172],"data":[173,192,208],"entirety,":[183],"Aronex's":[184],"marketing":[185],"partner":[186],"requested":[187],"all":[189],"70-day":[191],"be":[193],"gathered":[194],"prior":[195],"unblinding":[197],"this":[198],"study.":[199],"filing":[201,224,266],"had":[202],"initially":[203],"been":[204],"based":[205],"on":[206],"interim":[207],"at":[209],"14-":[211],"21-day":[213],"endpoint":[214],"1344887].":[215],"In":[216,236,275,301],"September":[217],"2000,":[218],"anticipated":[221],"fourth":[230],"quarter":[231],"2001":[233],"1382861],":[234],"1387947].":[235],"1997,":[238,276],"together":[240],"with":[241,267,282,288,309],"Grupo":[242],"Ferrer":[243,283],"Internacional,":[244],"MAA":[247],"seeking":[250],"Nyotran":[253],"treatment":[256],"infections.":[260],"intended":[262],"follow":[264],"additional":[268],"other":[271,293],"countries":[273],"1272986].":[274],"commercialization":[278],"agreement":[279],"was":[280],"signed":[281,305],"Portugal,":[287],"intending":[290],"form":[292],"such":[294],"partnerships":[295],"throughout":[296],"Europe":[297],"Asia":[299],"1248346].":[300],"November":[302],"1998,":[303],"licensing":[307],"collaboration":[308],"Abbott":[310],"Laboratories":[311],"worldwide":[314],"rights":[315],"[305531].":[319]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
