{"id":"https://openalex.org/W88462709","doi":null,"title":"Integrated brain restoration after ischemic stroke--medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity.","display_name":"Integrated brain restoration after ischemic stroke--medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W88462709","mag":"88462709","pmid":"https://pubmed.ncbi.nlm.nih.gov/19364191"},"language":"en","primary_location":{"id":"pmid:19364191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19364191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037159321","display_name":"Parris M. Kidd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Parris M Kidd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5037159321"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6466,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.91766205,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"14","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.489300012588501,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.828000009059906},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9710000157356262},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/krill-oil","display_name":"krill oil","score":0.9160000085830688},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.9350000023841858},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9900000095367432},{"id":"https://openalex.org/keywords/citicoline","display_name":"citicoline","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glycerophosphocholine","display_name":"glycerophosphocholine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8059999942779541},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.9129999876022339},{"id":"https://openalex.org/keywords/constraint-induced-movement-therapy","display_name":"constraint-induced movement therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.6110000014305115},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.5960000157356262},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.43700000643730164},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7437936663627625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6949486136436462},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5237810015678406},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4133349359035492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3326251208782196},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3218587040901184},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006710","descriptor_name":"Homocysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006931","descriptor_name":"Hyperbaric Oxygenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055502","descriptor_name":"Secondary Prevention","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19364191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19364191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},{"id":"mag:88462709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19364191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W90081202","https://openalex.org/W92189825","https://openalex.org/W1502914454","https://openalex.org/W1505870579","https://openalex.org/W1530028553","https://openalex.org/W1571571888","https://openalex.org/W1584244513","https://openalex.org/W1594425991","https://openalex.org/W1598662907","https://openalex.org/W1601668898","https://openalex.org/W1761884844","https://openalex.org/W1812391321","https://openalex.org/W1876366465","https://openalex.org/W1922087192","https://openalex.org/W1944960365","https://openalex.org/W1964349082","https://openalex.org/W1964619726","https://openalex.org/W1966295032","https://openalex.org/W1970674339","https://openalex.org/W1970901436","https://openalex.org/W1973838857","https://openalex.org/W1974964904","https://openalex.org/W1978905283","https://openalex.org/W1981990510","https://openalex.org/W1988828372","https://openalex.org/W1989560466","https://openalex.org/W1990914057","https://openalex.org/W1996233154","https://openalex.org/W1997319250","https://openalex.org/W2001230542","https://openalex.org/W2003240030","https://openalex.org/W2004303128","https://openalex.org/W2004973724","https://openalex.org/W2005001826","https://openalex.org/W2005769855","https://openalex.org/W2008253859","https://openalex.org/W2009201453","https://openalex.org/W2012071630","https://openalex.org/W2013594085","https://openalex.org/W2014225342","https://openalex.org/W2015397316","https://openalex.org/W2015693274","https://openalex.org/W2016656772","https://openalex.org/W2019995128","https://openalex.org/W2030751631","https://openalex.org/W2038159245","https://openalex.org/W2040200937","https://openalex.org/W2041953494","https://openalex.org/W2042251060","https://openalex.org/W2049511772","https://openalex.org/W2049732165","https://openalex.org/W2054423368","https://openalex.org/W2058221604","https://openalex.org/W2067316897","https://openalex.org/W2067856703","https://openalex.org/W2073249703","https://openalex.org/W2075580713","https://openalex.org/W2076024248","https://openalex.org/W2078362009","https://openalex.org/W2080638375","https://openalex.org/W2082649626","https://openalex.org/W2085105457","https://openalex.org/W2085771291","https://openalex.org/W2085878408","https://openalex.org/W2087461651","https://openalex.org/W2088299611","https://openalex.org/W2089981980","https://openalex.org/W2091083724","https://openalex.org/W2091842118","https://openalex.org/W2094544368","https://openalex.org/W2095257528","https://openalex.org/W2095440041","https://openalex.org/W2096807144","https://openalex.org/W2097871484","https://openalex.org/W2098464209","https://openalex.org/W2100216350","https://openalex.org/W2100254792","https://openalex.org/W2102512891","https://openalex.org/W2103822801","https://openalex.org/W2103864988","https://openalex.org/W2106013282","https://openalex.org/W2107261727","https://openalex.org/W2109544293","https://openalex.org/W2113478294","https://openalex.org/W2115227919","https://openalex.org/W2118399987","https://openalex.org/W2122965222","https://openalex.org/W2126273843","https://openalex.org/W2126607005","https://openalex.org/W2127882504","https://openalex.org/W2131123981","https://openalex.org/W2132468224","https://openalex.org/W2132780908","https://openalex.org/W2135293213","https://openalex.org/W2137539662","https://openalex.org/W2138411396","https://openalex.org/W2142765644","https://openalex.org/W2146631984","https://openalex.org/W2146942249","https://openalex.org/W2147261497","https://openalex.org/W2150352511","https://openalex.org/W2151381233","https://openalex.org/W2151899671","https://openalex.org/W2152601266","https://openalex.org/W2155196554","https://openalex.org/W2155945484","https://openalex.org/W2157170329","https://openalex.org/W2160173921","https://openalex.org/W2162914074","https://openalex.org/W2168272960","https://openalex.org/W2181566246","https://openalex.org/W2183626530","https://openalex.org/W2184470307","https://openalex.org/W2206245038","https://openalex.org/W2240758399","https://openalex.org/W2292308933","https://openalex.org/W2317172136","https://openalex.org/W2339089483","https://openalex.org/W2342150662","https://openalex.org/W2491061016","https://openalex.org/W2594075545","https://openalex.org/W2798844093","https://openalex.org/W2984648219","https://openalex.org/W3197474295","https://openalex.org/W3205926832"],"related_works":["https://openalex.org/W2069438897","https://openalex.org/W2090322437","https://openalex.org/W3041089335","https://openalex.org/W2054945824","https://openalex.org/W89625151","https://openalex.org/W2028721709","https://openalex.org/W2056630458","https://openalex.org/W2087482566","https://openalex.org/W4211138103","https://openalex.org/W1990281869"],"abstract_inverted_index":{"Brain":[0,237],"injury":[1,22,175],"from":[2],"ischemic":[3,174,235],"stroke":[4,88,115,187],"can":[5,170,182,245],"be":[6],"devastating,":[7],"but":[8],"full":[9],"brain":[10,167,232,242],"restoration":[11,162,233,243],"is":[12,17,65,110,144],"feasible.":[13],"Time":[14],"until":[15],"treatment":[16],"critical;":[18],"rapid":[19],"rate":[20],"of":[21,34,114],"progression,":[23],"logistical":[24],"and":[25,30,43,46,58,67,72,81,96,117,122,146,189,202,218,226],"personnel":[26],"constraints":[27],"on":[28],"neurological":[29],"cardiovascular":[31],"assessment,":[32],"limitations":[33],"recombinant":[35],"tissue":[36],"plasminogen":[37],"activator":[38],"(rtPA)":[39],"for":[40,130,139,160,193],"thrombolysis,":[41],"anticoagulation":[42],"antiplatelet":[44],"interventions,":[45],"neuroprotection":[47],"all":[48],"affect":[49],"outcome.":[50],"Promising":[51],"acute":[52,140],"neuroprotectant":[53],"measures":[54],"include":[55],"albumin,":[56],"magnesium,":[57],"hypothermia.":[59],"Long-term":[60],"hyperbaric":[61],"oxygen":[62],"therapy":[63,224],"(HBOT)":[64],"safe":[66],"holds":[68],"great":[69],"promise.":[70],"Eicosanoid":[71],"cytokine":[73],"down-regulation":[74],"by":[75],"omega-3":[76],"nutrients":[77],"docosahexaenoic":[78],"acid":[79,83,121],"(DHA)":[80],"eicosapentaenoic":[82],"(EPA)":[84],"may":[85,127],"help":[86],"quench":[87],"inflammation.":[89],"C-reactive":[90],"protein":[91],"(CRP),":[92],"an":[93,173],"inflammatory":[94],"biomarker":[95],"stroke-recurrence":[97],"predictor,":[98],"responds":[99,118],"favorably":[100],"to":[101,119,172,185],"krill":[102],"oil":[103],"(a":[104],"phospholipid-DHA/EPA-astaxanthin":[105],"complex).":[106],"High":[107],"homocysteine":[108],"(Hcy)":[109],"a":[111],"proven":[112],"predictor":[113],"recurrence":[116,129],"folic":[120],"vitamin":[123],"B12.":[124],"Vitamin":[125],"E":[126],"lower":[128],"individuals":[131],"experiencing":[132],"high":[133],"oxidative":[134],"stress.":[135],"Citicoline":[136],"shows":[137],"promise":[138,159,209],"neuroprotection.":[141],"Glycerophosphocholine":[142],"(GPC)":[143],"neuroprotective":[145],"supports":[147],"neuroplasticity":[148],"via":[149],"nerve":[150],"growth":[151,198],"factor":[152,205],"(NGF)":[153],"receptors.":[154],"Stem":[155],"cells":[156,169,179],"have":[157,207],"shown":[158,208],"neuronal":[161],"in":[163,210],"randomized":[164],"trials.":[165],"Endogenous":[166],"stem":[168,178],"migrate":[171,183],"zone;":[176],"exogenous":[177],"once":[180],"transplanted":[181],"(home)":[184],"the":[186,240],"lesion":[188],"provide":[190],"trophic":[191],"support":[192,231],"cortical":[194],"neuroplasticity.":[195],"The":[196],"hematopoietic":[197],"factors":[199],"erythropoietin":[200],"(EPO)":[201],"granulocyte-colony":[203],"stimulating":[204],"(G-CSF)":[206],"preliminary":[211],"trials,":[212],"with":[213],"manageable":[214],"adverse":[215],"effects.":[216],"Physical":[217],"mental":[219],"exercises,":[220],"including":[221],"constraint-induced":[222],"movement":[223],"(CIMT)":[225],"interactive":[227],"learning":[228],"aids,":[229],"further":[230],"following":[234,247],"stroke.":[236,248],"plasticity":[238],"underpins":[239],"function-driven":[241],"that":[244],"occur":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
