{"id":"https://openalex.org/W88336485","doi":null,"title":"The development of an experimental model of subretinal neovascularization in disciform macular degeneration.","display_name":"The development of an experimental model of subretinal neovascularization in disciform macular degeneration.","publication_year":1979,"publication_date":"1979-01-01","ids":{"openalex":"https://openalex.org/W88336485","mag":"88336485","pmid":"https://pubmed.ncbi.nlm.nih.gov/94717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1311723"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:268207","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1311723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1311723","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111437901","display_name":"Stephen J. Ryan","orcid":"https://orcid.org/0000-0003-0963-255X","observed_orcids":["https://orcid.org/0000-0003-0963-255X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S J Ryan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111437901"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0798,"has_fulltext":false,"cited_by_count":212,"citation_normalized_percentile":{"value":0.95550813,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"77","issue":null,"first_page":"707","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subretinal-neovascularization","display_name":"subretinal neovascularization","score":0.9890000224113464},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.921999990940094},{"id":"https://openalex.org/keywords/primate-retina","display_name":"primate retina","score":0.6930000185966492},{"id":"https://openalex.org/keywords/laser-induced-retinal-damage","display_name":"laser-induced retinal injury","score":0.6029999852180481},{"id":"https://openalex.org/keywords/retinal-ischemia","display_name":"retinal ischemia","score":0.7879999876022339},{"id":"https://openalex.org/keywords/retinal-hemorrhage","display_name":"retinal hemorrhage","score":0.8930000066757202},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6560972929000854},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5667190551757812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4592125415802002},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.4465310275554657},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4414571225643158},{"id":"https://openalex.org/C2908861002","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Age-related maculopathy","level":5,"score":0.4326934814453125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37706321477890015},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.30353885889053345},{"id":"https://openalex.org/C2781116099","wikidata":"https://www.wikidata.org/wiki/Q3842207","display_name":"Maculopathy","level":4,"score":0.20733597874641418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15796315670013428},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.1563636064529419},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14939984679222107},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008251","descriptor_name":"Macaca","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012166","descriptor_name":"Retinal Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012166","descriptor_name":"Retinal Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:268207","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1311723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1311723","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1311723","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},{"id":"pmid:94717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/94717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Ophthalmological Society","raw_type":"Journal Article"},{"id":"mag:88336485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/94717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:268207","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1311723","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W54912843","https://openalex.org/W138665102","https://openalex.org/W144251549","https://openalex.org/W347019129","https://openalex.org/W1526711176","https://openalex.org/W1574480121","https://openalex.org/W1970874529","https://openalex.org/W1971567149","https://openalex.org/W1974579373","https://openalex.org/W1979618884","https://openalex.org/W1981828982","https://openalex.org/W1989411194","https://openalex.org/W2004814816","https://openalex.org/W2008652833","https://openalex.org/W2020874631","https://openalex.org/W2021486322","https://openalex.org/W2021636549","https://openalex.org/W2023001893","https://openalex.org/W2036453841","https://openalex.org/W2042719287","https://openalex.org/W2043492615","https://openalex.org/W2044404986","https://openalex.org/W2045381604","https://openalex.org/W2046638324","https://openalex.org/W2049814431","https://openalex.org/W2051425117","https://openalex.org/W2052324050","https://openalex.org/W2052989629","https://openalex.org/W2057180636","https://openalex.org/W2062868796","https://openalex.org/W2065598798","https://openalex.org/W2067399747","https://openalex.org/W2071158957","https://openalex.org/W2087308395","https://openalex.org/W2092238390","https://openalex.org/W2095172847","https://openalex.org/W2100027759","https://openalex.org/W2112894112","https://openalex.org/W2136014129","https://openalex.org/W2164159773","https://openalex.org/W2394563692","https://openalex.org/W2404536128","https://openalex.org/W2406561165","https://openalex.org/W2411209509","https://openalex.org/W2415443223","https://openalex.org/W2416435405","https://openalex.org/W2418271299","https://openalex.org/W2418732679","https://openalex.org/W2418988346","https://openalex.org/W2419216672","https://openalex.org/W2419652733","https://openalex.org/W2424904317","https://openalex.org/W2434311641","https://openalex.org/W2461092795","https://openalex.org/W2778080704","https://openalex.org/W3125041688"],"related_works":["https://openalex.org/W52004244","https://openalex.org/W2021846668","https://openalex.org/W1975107877","https://openalex.org/W2088498912","https://openalex.org/W776431081","https://openalex.org/W207480519","https://openalex.org/W2564728775","https://openalex.org/W2441951530","https://openalex.org/W2076924186","https://openalex.org/W1974328526"],"abstract_inverted_index":{"A":[0],"reproducible":[1],"model":[2,42,105],"of":[3,16,25,53,67,97,114,138,150],"subretinal":[4,26,151],"neovascularization":[5,27],"has":[6,75],"been":[7,32,62],"developed,":[8],"an":[9],"important":[10,144],"first":[11],"step":[12],"in":[13,28,133,145],"the":[14,29,51,54,65,68,79,91,103,112,115,128,136,139,146],"study":[15],"disciform":[17,69,82,116],"macular":[18],"degeneration.":[19],"The":[20,95],"methodology":[21],"and":[22,34,36,47,58,131,148],"clinical":[23],"description":[24],"primate":[30],"have":[31,61],"provided":[33],"histopathologic":[35],"electron":[37],"microscopic":[38],"correlations":[39],"included.":[40],"This":[41],"provides":[43],"a":[44],"most":[45],"promising":[46],"useful":[48],"mechanism":[49],"for":[50,64],"evaluation":[52],"many":[55,108],"different":[56,109],"factors":[57,143],"hypotheses":[59],"that":[60,85],"proposed":[63],"genesis":[66],"response.":[70],"In":[71],"humans,":[72],"it":[73],"probably":[74],"more":[76],"relevance":[77],"to":[78,90,101,125,135],"traumatically":[80],"induced":[81],"process,":[83],"particularly":[84],"after":[86],"laser":[87],"therapy,":[88],"than":[89],"senile":[92],"degenerative":[93],"process.":[94],"purpose":[96],"this":[98],"investigation":[99],"is":[100],"develop":[102],"animal":[104],"by":[106],"which":[107],"theories":[110],"regarding":[111],"pathogenesis":[113],"response":[117],"can":[118],"be":[119],"tested.":[120],"These":[121],"initial":[122],"studies":[123],"relate":[124],"ischemia,":[126],"hemorrhage,":[127],"inflammatory":[129],"response,":[130],"position":[132],"relation":[134],"center":[137],"vascular-free":[140],"zone":[141],"as":[142],"development":[147],"evolution":[149],"neovascularization.":[152]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
