{"id":"https://openalex.org/W883248379","doi":null,"title":"Reactive Oxygen Species and P2X7 receptors are critical for Alu RNA induced RPE degeneration caused by NLRP3 inflammasome","display_name":"Reactive Oxygen Species and P2X7 receptors are critical for Alu RNA induced RPE degeneration caused by NLRP3 inflammasome","publication_year":2012,"publication_date":"2012-03-26","ids":{"openalex":"https://openalex.org/W883248379","mag":"883248379"},"language":"en","primary_location":{"id":"mag:883248379","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2360189","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056157883","display_name":"Nagaraj Kerur","orcid":"https://orcid.org/0000-0001-5040-2129","observed_orcids":["https://orcid.org/0000-0001-5040-2129"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nagaraj Kerur","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0001-5040-2129","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063112023","display_name":"Valeria Tarallo","orcid":"https://orcid.org/0000-0002-6920-4402","observed_orcids":["https://orcid.org/0000-0002-6920-4402"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Tarallo","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0002-6920-4402","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074250826","display_name":"Yoshio Hirano","orcid":"https://orcid.org/0000-0002-9173-0839","observed_orcids":["https://orcid.org/0000-0002-9173-0839"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshio Hirano","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0002-9173-0839","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041538742","display_name":"Bradley D. Gelfand","orcid":"https://orcid.org/0000-0003-4619-9409","observed_orcids":["https://orcid.org/0000-0003-4619-9409"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley D. Gelfand","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0003-4619-9409","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071474327","display_name":"Sami Dridi","orcid":"https://orcid.org/0000-0002-6441-2560","observed_orcids":["https://orcid.org/0000-0002-6441-2560"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami Dridi","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0002-6441-2560","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070085596","display_name":"Benjamin J. Fowler","orcid":"https://orcid.org/0000-0001-8995-4131","observed_orcids":["https://orcid.org/0000-0001-8995-4131"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Fowler","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0001-8995-4131","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018076822","display_name":"Sasha Bogdanovich","orcid":"https://orcid.org/0009-0001-1338-0415","observed_orcids":["https://orcid.org/0009-0001-1338-0415","https://orcid.org/0000-0003-4514-7893"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sasha Bogdanovich","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0003-4514-7893","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068278401","display_name":"Judit Baffi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judit Baffi","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079068166","display_name":"Mark Ellsworth Kleinman","orcid":"https://orcid.org/0000-0001-8557-7949","observed_orcids":["https://orcid.org/0000-0001-8557-7949"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Kleinman","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0001-8557-7949","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086654368","display_name":"Jayakrishna Ambati","orcid":"https://orcid.org/0000-0003-1622-6365","observed_orcids":["https://orcid.org/0000-0003-1622-6365"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayakrishna Ambati","raw_affiliation_strings":["Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky"],"raw_orcid":"https://orcid.org/0000-0003-1622-6365","affiliations":[{"raw_affiliation_string":"Ophthalmology & Visual Sciences, University of Kentucky, Lexington, Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07648791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"14","first_page":"6491","last_page":"6491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.4708999991416931,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.16859999299049377,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.08009999990463257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9580000042915344},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alu-rna","display_name":"Alu RNA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium-degeneration","display_name":"retinal pigment epithelium degeneration","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.8645864129066467},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6974964141845703},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6024124622344971},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4871315658092499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4703806936740875},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.42161738872528076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2720802426338196},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14511024951934814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08331269025802612}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:883248379","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2360189","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1964074574","https://openalex.org/W2048889430","https://openalex.org/W939962394","https://openalex.org/W2914003938","https://openalex.org/W2017399556","https://openalex.org/W3212302452","https://openalex.org/W911009299","https://openalex.org/W264102726","https://openalex.org/W856988094","https://openalex.org/W1603663548"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}