{"id":"https://openalex.org/W88192686","doi":null,"title":"Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study.","display_name":"Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study.","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W88192686","mag":"88192686","pmid":"https://pubmed.ncbi.nlm.nih.gov/19032827"},"language":"en","primary_location":{"id":"pmid:19032827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19032827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075666258","display_name":"Mikel S\u00e1nchez","orcid":"https://orcid.org/0000-0001-9992-6927","observed_orcids":["https://orcid.org/0000-0001-9992-6927"]},"institutions":[{"id":"https://openalex.org/I4210121780","display_name":"Unidad de Cirug\u00eda Artrosc\u00f3pica","ror":"https://ror.org/02v01cg08","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210121780"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M S\u00e1nchez","raw_affiliation_strings":["Unidad de Cirugia Artrosc\u00f3pica \"Mikel Sanchez\", Vitoria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Cirugia Artrosc\u00f3pica \"Mikel Sanchez\", Vitoria, Spain","institution_ids":["https://openalex.org/I4210121780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003483976","display_name":"Eduardo Anitua","orcid":"https://orcid.org/0000-0002-8386-5303","observed_orcids":["https://orcid.org/0000-0002-8386-5303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Anitua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019114344","display_name":"Juan Azofra","orcid":"https://orcid.org/0000-0002-6864-9258","observed_orcids":["https://orcid.org/0000-0002-6864-9258"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Azofra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102955896","display_name":"Jos\u00e9 Javier Aguirre","orcid":"https://orcid.org/0000-0001-9946-7521","observed_orcids":["https://orcid.org/0000-0001-9946-7521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Aguirre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070217909","display_name":"Isabel And\u0131\u0301a","orcid":"https://orcid.org/0000-0003-0607-4767","observed_orcids":["https://orcid.org/0000-0003-0607-4767","https://orcid.org/0000-0002-7218-2902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Andia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.47,"has_fulltext":false,"cited_by_count":340,"citation_normalized_percentile":{"value":0.99462366,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"26","issue":"5","first_page":"910","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/platelet-rich-growth-factor","display_name":"platelet-rich growth factor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/autologous-platelet-concentrate","display_name":"autologous platelet concentrate","score":0.6930000185966492},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.7879999876022339},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pdgf-ab","display_name":"PDGF-AB","score":0.8519999980926514},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.8410000205039978},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6019999980926514},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.8629999756813049},{"id":"https://openalex.org/keywords/womac","display_name":"WOMAC","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9595396518707275},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.6905572414398193},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6633672118186951},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5597981810569763},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5161412954330444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47172918915748596},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.44703590869903564},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4405383765697479},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4262467324733734},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39287036657333374},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1344483196735382},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007270","descriptor_name":"Injections, Intra-Articular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020370","descriptor_name":"Osteoarthritis, Knee","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D053657","descriptor_name":"Platelet-Rich Plasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055675","descriptor_name":"Viscosupplements","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19032827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19032827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:88192686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19032827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2208152782","https://openalex.org/W4407677882","https://openalex.org/W2761873219","https://openalex.org/W3039162358","https://openalex.org/W2894738078","https://openalex.org/W2103674593","https://openalex.org/W2139382287","https://openalex.org/W2951473150","https://openalex.org/W4391695256","https://openalex.org/W7169518702"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"obtain":[2],"preliminary":[3,188],"information":[4],"about":[5,203],"the":[6,78,104,125,131,137,146,156,204],"effectiveness":[7],"of":[8,11,42,77,175,206],"intra-articular":[9],"injections":[10,66],"an":[12,59],"autologous":[13,213],"preparation":[14],"rich":[15],"in":[16,28,53,155,173,194],"growth":[17,44],"factors":[18,45],"(PRGF)":[19],"for":[20,124,130,136,215],"knee":[21],"OA":[22,76],"treatment":[23,36,109,147,171],"to":[24,82,108,145,191],"be":[25,192],"explored":[26],"further":[27],"future":[29],"studies.":[30],"METHODS:":[31],"We":[32,56],"have":[33,57],"characterized":[34],"PRGF":[35,132,207],"by":[37,121],"platelet":[38],"count":[39],"and":[40,50,88,110,134,160,180,208],"concentration":[41],"relevant":[43],"(TGF-Beta1,":[46],"PDGF-AB,":[47],"VEGF-A;":[48],"HGF":[49],"IGF-I)":[51],"involved":[52],"healing":[54],"mechanisms.":[55],"performed":[58],"observational":[60],"retrospective":[61],"cohort":[62],"study":[63],"using":[64,103],"hyaluronan":[65,138],"as":[67],"a":[68,195],"control.":[69],"Each":[70],"group":[71,133],"included":[72],"30":[73],"patients":[74],"with":[75,170],"knee,":[79],"matched":[80],"according":[81],"age,":[83],"sex,":[84],"body":[85],"mass":[86],"index":[87],"radiographic":[89],"severity.":[90],"Both":[91],"treatments":[92,214],"were":[93,166],"based":[94],"on":[95,212],"three":[96],"weekly":[97],"injections.":[98],"Clinical":[99],"outcome":[100],"was":[101,142],"examined":[102],"WOMAC":[105,162],"questionnaires":[106],"prior":[107],"at":[111,163],"5":[112,123,164],"weeks":[113,165],"after":[114],"treatment.":[115],"RESULTS:":[116],"The":[117,140,152],"observed":[118],"success":[119],"rates":[120],"week":[122],"pain":[126],"subscale":[127,159],"reached":[128],"33.4%":[129],"10%":[135],"group.":[139],"difference":[141],"attributed":[143],"exclusively":[144],"modality,":[148],"p":[149,177,181],"=":[150,178,182],"0.004.":[151],"percent":[153],"reductions":[154],"physical":[157],"function":[158],"overall":[161],"also":[167],"associated":[168],"solely":[169],"modality":[172],"favour":[174],"PRGF,":[176],"0.043":[179],"0.010":[183],"respectively.":[184],"CONCLUSIONS:":[185],"Although":[186],"these":[187],"results":[189],"need":[190],"evaluated":[193],"randomized":[196],"clinical":[197],"trial,":[198],"they":[199],"provide":[200],"useful":[201],"infomration":[202],"safety":[205],"open":[209],"new":[210],"perspectives":[211],"joint":[216],"diseases.":[217]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":32}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
