{"id":"https://openalex.org/W88148161","doi":null,"title":"Modulation of the activity of a key metabolic regulator small heterodimer partner by post-translational modifications","display_name":"Modulation of the activity of a key metabolic regulator small heterodimer partner by post-translational modifications","publication_year":2011,"publication_date":"2011-05-25","ids":{"openalex":"https://openalex.org/W88148161","mag":"88148161"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/24491","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/24491","pdf_url":"http://hdl.handle.net/2142/24491","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2142/24491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053047025","display_name":"Deepthi Kanamaluru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Deepthi Kanamaluru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5053047025"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00799327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-heterodimer-partner","display_name":"small heterodimer partner","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nr0b2","display_name":"NR0B2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8220000267028809},{"id":"https://openalex.org/keywords/protein-arginine-methylation","display_name":"arginine methylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cyp7a1","display_name":"CYP7A1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hepatic-cholesterol-metabolism","display_name":"hepatic cholesterol metabolism","score":0.5789999961853027},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.7793465852737427},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.5899251699447632},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5080695152282715},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4924250543117523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4612414240837097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3252967596054077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3161125183105469},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.253900945186615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18443048000335693},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.15552103519439697},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1455409824848175},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/24491","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/24491","pdf_url":"http://hdl.handle.net/2142/24491","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:88148161","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/bitstream/2142/24491/1/Kanamaluru_Deepthi.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/24491","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/24491","pdf_url":"http://hdl.handle.net/2142/24491","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W88148161.pdf","grobid_xml":"https://content.openalex.org/works/W88148161.grobid-xml"},"referenced_works_count":169,"referenced_works":["https://openalex.org/W1486536093","https://openalex.org/W1596796792","https://openalex.org/W1603482072","https://openalex.org/W1908388533","https://openalex.org/W1913383562","https://openalex.org/W1919133853","https://openalex.org/W1963587340","https://openalex.org/W1963839839","https://openalex.org/W1964940783","https://openalex.org/W1965796890","https://openalex.org/W1966922165","https://openalex.org/W1967575685","https://openalex.org/W1968021983","https://openalex.org/W1970316586","https://openalex.org/W1970383445","https://openalex.org/W1970740746","https://openalex.org/W1972378799","https://openalex.org/W1974993651","https://openalex.org/W1976621716","https://openalex.org/W1977865817","https://openalex.org/W1980804977","https://openalex.org/W1982059385","https://openalex.org/W1983620925","https://openalex.org/W1984028142","https://openalex.org/W1986619463","https://openalex.org/W1988941353","https://openalex.org/W1989076356","https://openalex.org/W1990047596","https://openalex.org/W1990065094","https://openalex.org/W1990819179","https://openalex.org/W1991633055","https://openalex.org/W1992439813","https://openalex.org/W1993909796","https://openalex.org/W1993970282","https://openalex.org/W1995754186","https://openalex.org/W1999645000","https://openalex.org/W2001761213","https://openalex.org/W2007172615","https://openalex.org/W2008165628","https://openalex.org/W2012294080","https://openalex.org/W2016211755","https://openalex.org/W2016495202","https://openalex.org/W2017149825","https://openalex.org/W2017386677","https://openalex.org/W2022114839","https://openalex.org/W2022142840","https://openalex.org/W2024057198","https://openalex.org/W2024937228","https://openalex.org/W2029725115","https://openalex.org/W2030637684","https://openalex.org/W2033948748","https://openalex.org/W2036639220","https://openalex.org/W2039630136","https://openalex.org/W2039999119","https://openalex.org/W2040669411","https://openalex.org/W2041012357","https://openalex.org/W2041451676","https://openalex.org/W2044059688","https://openalex.org/W2045938951","https://openalex.org/W2045958351","https://openalex.org/W2046934643","https://openalex.org/W2048328091","https://openalex.org/W2049655058","https://openalex.org/W2050394535","https://openalex.org/W2051140928","https://openalex.org/W2053581007","https://openalex.org/W2053946842","https://openalex.org/W2056739383","https://openalex.org/W2056907128","https://openalex.org/W2058677848","https://openalex.org/W2059675893","https://openalex.org/W2060802613","https://openalex.org/W2062412540","https://openalex.org/W2064023914","https://openalex.org/W2064966728","https://openalex.org/W2065051999","https://openalex.org/W2067123261","https://openalex.org/W2067785496","https://openalex.org/W2068458442","https://openalex.org/W2069054898","https://openalex.org/W2070428103","https://openalex.org/W2072423494","https://openalex.org/W2074545460","https://openalex.org/W2074624862","https://openalex.org/W2075934772","https://openalex.org/W2076142854","https://openalex.org/W2076524169","https://openalex.org/W2077483301","https://openalex.org/W2078197564","https://openalex.org/W2078810890","https://openalex.org/W2079080809","https://openalex.org/W2080485991","https://openalex.org/W2080578796","https://openalex.org/W2081028309","https://openalex.org/W2081963123","https://openalex.org/W2083193359","https://openalex.org/W2085483520","https://openalex.org/W2086111237","https://openalex.org/W2086298115","https://openalex.org/W2089176660","https://openalex.org/W2089286600","https://openalex.org/W2091709423","https://openalex.org/W2092809155","https://openalex.org/W2096418655","https://openalex.org/W2097155763","https://openalex.org/W2101842666","https://openalex.org/W2104209061","https://openalex.org/W2104726963","https://openalex.org/W2106293232","https://openalex.org/W2106515170","https://openalex.org/W2107011114","https://openalex.org/W2112441454","https://openalex.org/W2112632255","https://openalex.org/W2113456624","https://openalex.org/W2116780939","https://openalex.org/W2116903203","https://openalex.org/W2120383034","https://openalex.org/W2120419639","https://openalex.org/W2121953752","https://openalex.org/W2122057254","https://openalex.org/W2124775971","https://openalex.org/W2128693672","https://openalex.org/W2129695504","https://openalex.org/W2130209773","https://openalex.org/W2130420663","https://openalex.org/W2131144673","https://openalex.org/W2131443627","https://openalex.org/W2131566044","https://openalex.org/W2132379232","https://openalex.org/W2132516072","https://openalex.org/W2134155634","https://openalex.org/W2134282794","https://openalex.org/W2134567873","https://openalex.org/W2135007868","https://openalex.org/W2138440003","https://openalex.org/W2139002144","https://openalex.org/W2139667823","https://openalex.org/W2141707814","https://openalex.org/W2142427646","https://openalex.org/W2143658931","https://openalex.org/W2147638334","https://openalex.org/W2148217900","https://openalex.org/W2148672071","https://openalex.org/W2149403715","https://openalex.org/W2150441292","https://openalex.org/W2151741487","https://openalex.org/W2153289239","https://openalex.org/W2153813367","https://openalex.org/W2155096309","https://openalex.org/W2156371750","https://openalex.org/W2157038552","https://openalex.org/W2157776545","https://openalex.org/W2157826971","https://openalex.org/W2159202225","https://openalex.org/W2159955141","https://openalex.org/W2161256943","https://openalex.org/W2163505613","https://openalex.org/W2165877587","https://openalex.org/W2167075350","https://openalex.org/W2167372953","https://openalex.org/W2167886636","https://openalex.org/W2171398834","https://openalex.org/W2171892411","https://openalex.org/W2172132693","https://openalex.org/W2172256092","https://openalex.org/W2176815171","https://openalex.org/W2186528910","https://openalex.org/W2278119399","https://openalex.org/W2324938557"],"related_works":["https://openalex.org/W2055911345","https://openalex.org/W2101842666","https://openalex.org/W2284210706","https://openalex.org/W2056427946","https://openalex.org/W1824181430","https://openalex.org/W4250713640","https://openalex.org/W1990819179","https://openalex.org/W1970383445","https://openalex.org/W4225412787","https://openalex.org/W7061395498"],"abstract_inverted_index":{"Small":[0],"Heterodimer":[1],"Partner":[2],"(SHP,":[3],"NR0B2),":[4],"a":[5,18,24,42,103,138,162,407,534,569,622,655,678,691],"member":[6],"of":[7,62,74,77,96,115,125,154,159,184,210,229,283,291,298,315,329,361,409,426,437,449,456,475,500,506,526,538,546,556,564,641,646,696,709,726],"the":[8,110,123,144,172,182,189,204,211,289,321,326,342,369,377,383,387,391,446,453,466,471,476,483,539,578,647,697],"nuclear":[9,173,194],"receptor":[10,15,176,200],"superfamily,":[11],"is":[12,82,86,102,143,224,274,293,318,374,397,432,482,587,607,630],"an":[13,730],"orphan":[14],"that":[16,264,271,288,351,376,424,491,555,585,599,621],"lacks":[17],"DNA":[19,34],"binding":[20,27,35],"domain":[21],"but":[22,531],"contains":[23],"putative":[25],"ligand":[26],"domain.":[28],"SHP":[29,186,223,272,292,299,330,332,343,412,427,435,487,509,529,567,586,606,633,669,687,710,720,727],"forms":[30],"non-functional":[31],"heterodimers":[32],"with":[33,188,354,489,617,661,701],"transcriptional":[36,43],"factors":[37],"and,":[38],"thereby,":[39],"functions":[40,61],"as":[41,261,406,744],"corepressor":[44],"in":[45,88,92,149,161,238,307,341,348,411,510,514,533,543,551,568,600,632,686],"diverse":[46],"biological":[47,90],"processes,":[48],"including":[49,368],"cellular":[50],"metabolism,":[51],"cell":[52],"proliferation,":[53],"apoptosis,":[54],"and":[55,66,117,127,146,207,219,235,251,357,439,465,496,520,524,548,562,627,636,650,663,672,689,748],"sexual":[56],"maturation.":[57],"Of":[58],"these":[59,362],"reported":[60,258,347,363,698],"SHP,":[63],"maintaining":[64],"cholesterol":[65,78,98,108,116,126,218],"bile":[67,80,100,118,128,155,169,174,220,242,254,277,310,517,549,592,613],"acid":[68,170,175,221,231,243,518,593,614],"levels":[69,124,153,545],"by":[70,276,295,302,324,389,414,430,503,566,577,589,684,711],"negative":[71],"feedback":[72,163],"regulation":[73],"hepatic":[75,97,190,193,233],"conversion":[76],"to":[79,106,131,167,216,226,240,259,309,319,380,394,470,479,554,574,602,716,733,738],"acids":[81,101,119,129,156,255,550],"well":[83],"established.":[84],"Cholesterol":[85,135],"essential":[87],"many":[89],"activities":[91],"mammalian":[93],"cells.":[94],"Conversion":[95],"into":[99],"major":[104],"pathway":[105,624],"eliminate":[107],"from":[109],"body.":[111],"However,":[112],"excess":[113],"amounts":[114],"are":[120,352],"pathogenic.":[121],"Therefore,":[122],"need":[130],"be":[132,717,729],"tightly":[133],"regulated.":[134],"7\u03b1-hydroxylase":[136],"(CYP7A1),":[137],"liver":[139,199,512,552],"specific":[140],"P450":[141],"enzyme,":[142],"first":[145],"rate-limiting":[147],"enzyme":[148],"this":[150,316],"process.":[151],"Increased":[152],"repress":[157],"transcription":[158,183,209],"CYP7A1":[160,205,212,472],"manner.":[164,536],"In":[165,214,335],"response":[166,239,308],"elevated":[168,241,544],"levels,":[171,222],"Farnesoid":[177],"X":[178],"Receptor":[179],"(FXR)":[180],"increases":[181],"SHP.":[185,504,559,642],"interacts":[187],"DNA-binding":[191],"activators,":[192],"factor-4\u03b1":[195],"(HNF-":[196],"4\u03b1)":[197],"or":[198],"homologue-1":[201],"(LRH-1)":[202],"on":[203],"promoter,":[206],"represses":[208],"gene.":[213],"addition":[215,601],"regulating":[217],"known":[225,375],"mediate":[227],"inhibition":[228,282,436,499],"fatty":[230],"synthesis,":[232],"lipogenesis,":[234],"glucose":[236],"production":[237],"levels.":[244],"Posttranslational":[245],"modifications":[246,725],"profoundly":[247],"regulate":[248],"protein":[249,303],"stability":[250,273],"activity.":[252,334,722],"Recently,":[253],"have":[256,345,583],"been":[257,346],"function":[260],"signaling":[262,623,714],"molecules":[263],"activate":[265],"kinase":[266,618,713],"pathways.":[267],"We":[268,285],"recently":[269],"found":[270],"increased":[275,294],"acid-activated":[278],"ERK-mediated":[279],"phosphorylation":[280,648,671,708],"through":[281],"ubiquitination.":[284],"now":[286],"show":[287],"activity":[290,421],"post-translational":[296,327,724],"methylation":[297,410,425,603,640,651,683],"at":[300,428,604,610],"Arg-57":[301,429,477,527,682],"arginine":[304,639],"methyltransferase":[305,463],"5":[306,418],"acids.":[311],"The":[312,643],"overall":[313],"aim":[314],"study":[317,676,704],"delineate":[320],"molecular":[322,384,447],"mechanism":[323,388,448,693],"which":[325,390],"modification":[328],"regulates":[331,638],"functional":[333,721],"recent":[336],"years,":[337],"several":[338],"naturally-occurring":[339],"mutations":[340,364,378,392],"gene":[344,501,522],"human":[349,741],"subjects":[350],"associated":[353],"mild":[355],"obesity":[356],"diabetes.":[358],"About":[359],"30%":[360],"were":[365],"Arg":[366,404,673],"mutations,":[367],"R57W":[370,540,579,699],"mutation.":[371],"Though":[372],"it":[373],"lead":[379,393],"metabolic":[381,395,745],"disorders,":[382],"basis":[385],"underlying":[386],"disease":[396],"unknown.":[398],"By":[399],"mass":[400,596],"spectrometry,":[401],"we":[402,492],"identified":[403],"57":[405],"site":[408,478],"catalyzed":[413],"Protein":[415],"Arginine":[416],"Methyltransferase":[417],"(PRMT5).":[419],"Functional":[420],"assays":[422],"showed":[423,445,620],"PRMT5":[431,590,685],"important":[433,718],"for":[434,681,694,719],"LRH1":[438],"HNF-4\u03b1":[440],"transactivation.":[441],"Our":[442,581],"lab":[443],"previously":[444,494],"SHP-mediated":[450],"repression":[451,576],"involving":[452,625],"coordinate":[454],"recruitment":[455,563],"chromatin":[457],"modifying":[458],"repressive":[459],"cofactors,":[460],"mSin3A/HDAC1,":[461],"NCoR1/HDAC3,":[462],"G9a,":[464],"Swi/Snf-Brm":[467],"remodeling":[468],"complex,":[469],"promoter.":[473],"Mutation":[474],"Trp":[480],"(R57W":[481],"naturallyoccurring":[484],"mutant)":[485],"decreased":[486,515],"interaction":[488,561],"corepressors":[490,565],"had":[493],"identified,":[495],"severely":[497],"impaired":[498],"expression":[502],"Overexpression":[505,537],"wild":[507,557],"type":[508,558],"mouse":[511],"resulted":[513,542],"lipogenic,":[516],"synthetic":[519],"gluconeogenic":[521],"expression,":[523],"mutation":[525,700],"blocked":[528],"function,":[530,688],"remarkably":[532],"gene-selective":[535,575],"mutant":[541],"triglycerides":[547],"compared":[553],"Differential":[560],"promoter-specific":[570],"manner":[571],"may":[572,728],"contribute":[573],"mutant.":[580],"studies":[582],"shown":[584],"methylated":[588],"after":[591,612],"treatment.":[594,615],"Tandem":[595],"spectrometry":[597],"revealed":[598],"Arg-57,":[605],"also":[608,637,705],"phosphorylated":[609],"Thr-55":[611,707],"Studies":[616,660],"inhibitors":[619],"PI3K":[626],"PKC":[628],"\u03b6":[629],"involved":[631],"Thr":[634,670],"phosphorylation,":[635],"close":[644],"proximity":[645],"(Thr-55)":[649],"(Arg-57)":[652],"sites":[653],"suggested":[654],"possible":[656,692],"interplay":[657],"between":[658,668],"them.":[659],"phosphorylation-":[662],"methylation-defective":[664],"mutants":[665],"demonstrated":[666],"crosstalk":[667],"methylation.":[674],"This":[675,703],"demonstrates":[677],"critical":[679],"role":[680],"suggests":[690],"association":[695],"obesity.":[702],"reveals":[706],"upstream":[712],"pathways":[715],"Targeting":[723],"effective":[731],"strategy":[732],"develop":[734],"new":[735],"therapeutic":[736],"agents":[737],"treat":[739],"SHP-related":[740],"diseases,":[742],"such":[743],"syndrome,":[746],"cancer,":[747],"infertility.":[749]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
