{"id":"https://openalex.org/W8811481","doi":null,"title":"The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies.","display_name":"The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies.","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W8811481","mag":"8811481","pmid":"https://pubmed.ncbi.nlm.nih.gov/14763161"},"language":"en","primary_location":{"id":"pmid:14763161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14763161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in clinical and experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023848359","display_name":"Mich\u00e8le Milella","orcid":"https://orcid.org/0000-0002-3826-5237","observed_orcids":["https://orcid.org/0000-0002-3826-5237"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Milella","raw_affiliation_strings":["Division of Medical Oncology A, Regina Elena Cancer Institute, Via Elio Chianesi, n. 53, 00144, Rome, Italy. milella@ifo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology A, Regina Elena Cancer Institute, Via Elio Chianesi, n. 53, 00144, Rome, Italy. milella@ifo.it","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016607292","display_name":"Steven Mitchell Kornblau","orcid":"https://orcid.org/0000-0002-5990-9548","observed_orcids":["https://orcid.org/0000-0002-5990-9548"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M Kornblau","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079262854","display_name":"Michael Andreeff","orcid":"https://orcid.org/0000-0002-1144-1958","observed_orcids":["https://orcid.org/0000-0002-1144-1958"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Andreeff","raw_affiliation_strings":["University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7543,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.631309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"7","issue":"2","first_page":"160","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.46480000019073486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.1736000031232834,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mapk-inhibitors","display_name":"MAPK inhibitors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.972000002861023},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.871999979019165},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.699999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6595649123191833},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6088859438896179},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5715071558952332},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5407540798187256},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5305585861206055},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5297673344612122},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5023260116577148},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.492591917514801},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.47155213356018066},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4539756774902344},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4309215247631073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42547911405563354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39287036657333374},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3783334791660309},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13773825764656067},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.12286955118179321},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11267924308776855}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14763161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14763161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reviews in clinical and experimental hematology","raw_type":"Journal Article"},{"id":"mag:8811481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14763161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1402313056","display_name":"SPORE University of Texas M. D. Anderson Cancer Center-Leukemia","funder_award_id":"P50CA100632","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3774884214","display_name":"THE THERAPY OF AML","funder_award_id":"P01CA055164","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8974040806","display_name":"Anti-Leukemic Activity of the Novel Triterpeniod CDDO","funder_award_id":"R01CA089346","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1851916730","https://openalex.org/W1964504295","https://openalex.org/W1965178122","https://openalex.org/W1967690033","https://openalex.org/W1971769637","https://openalex.org/W1983738115","https://openalex.org/W1994852716","https://openalex.org/W1997015425","https://openalex.org/W2000180576","https://openalex.org/W2012628897","https://openalex.org/W2012876288","https://openalex.org/W2026161109","https://openalex.org/W2038427185","https://openalex.org/W2042901811","https://openalex.org/W2046426871","https://openalex.org/W2057266526","https://openalex.org/W2063936096","https://openalex.org/W2066815321","https://openalex.org/W2069462374","https://openalex.org/W2070332421","https://openalex.org/W2070939689","https://openalex.org/W2077090527","https://openalex.org/W2085987092","https://openalex.org/W2092084335","https://openalex.org/W2093833279","https://openalex.org/W2103220740","https://openalex.org/W2128977393","https://openalex.org/W2412441683"],"related_works":["https://openalex.org/W2015183783","https://openalex.org/W2122051507","https://openalex.org/W2008726956","https://openalex.org/W7006000616","https://openalex.org/W2045455421","https://openalex.org/W2070988789","https://openalex.org/W2008516674","https://openalex.org/W2040997306","https://openalex.org/W1967229252","https://openalex.org/W1986603272"],"abstract_inverted_index":{"Important":[0],"insights":[1],"into":[2,96],"the":[3,22,34,46,93],"cellular":[4],"and":[5,12,28,77,90,144,157],"molecular":[6],"biology":[7],"of":[8,13,36,48,138,140,173,176],"cancer":[9,155],"in":[10,16,21,33,45,60,111,125,149,181],"general":[11],"hematologic":[14,65,126],"malignancies":[15],"particular":[17],"have":[18],"been":[19],"gained":[20,95],"past":[23],"two":[24],"decades.":[25],"The":[26,84,100,128,169],"genes,":[27],"their":[29],"protein":[30,130],"products,":[31],"involved":[32],"transformation":[35],"cells":[37,50,156],"from":[38],"normal":[39],"to":[40,51,88],"neoplastic,":[41],"as":[42,44,109,122,151,153],"well":[43,152],"progression":[47],"neoplastic":[49],"a":[52,135],"more":[53],"aggressive,":[54],"therapy-resistant":[55],"phenotype,":[56],"are":[57,81],"being":[58],"elucidated":[59],"great":[61],"detail.":[62],"However,":[63],"most":[64],"malignancies,":[66],"particularly":[67],"adult":[68],"acute":[69],"leukemias,":[70],"remain":[71],"associated":[72],"with":[73,183,188],"high":[74],"mortality":[75],"rates":[76],"new":[78],"therapeutic":[79,98,123,203],"approaches":[80],"urgently":[82],"needed.":[83],"challenge":[85],"is":[86,134],"therefore":[87],"carefully":[89],"efficiently":[91],"translate":[92],"information":[94],"effective":[97],"strategies.":[99],"clinical":[101],"success":[102],"achieved":[103],"by":[104,163],"tyrosine":[105],"kinase":[106,131],"inhibitors,":[107,178],"such":[108],"ST1571":[110],"chronic":[112],"myelogenous":[113],"leukemia,":[114],"has":[115],"stimulated":[116],"interest":[117],"for":[118],"kinase-based":[119],"signaling":[120],"pathways":[121,148],"targets":[124],"malignancies.":[127],"mitogen-activated":[129],"(MAPK)":[132],"pathway":[133],"common":[136],"point":[137],"convergence":[139],"many":[141],"different":[142],"mitogenic":[143],"anti-apoptotic":[145],"signal":[146],"transduction":[147],"hematopoietic,":[150],"epithelial,":[154],"can":[158],"now":[159],"be":[160],"clinically":[161],"targeted":[162],"highly":[164],"selective":[165],"small":[166,185],"molecule":[167],"inhibitors.":[168],"mounting":[170],"preclinical":[171],"evidence":[172],"anti-leukemic":[174],"activity":[175],"MAPK":[177,195],"alone":[179],"or":[180,187],"combination":[182],"pro-apoptotic":[184],"molecules":[186],"conventional":[189],"chemotherapeutic":[190],"agents":[191],"provides":[192],"rationale":[193],"that":[194],"inhibition-based":[196],"treatment":[197],"strategies":[198],"could":[199],"soon":[200],"enrich":[201],"our":[202],"armamentarium":[204],"against":[205],"human":[206],"leukemias.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
