{"id":"https://openalex.org/W879985352","doi":null,"title":"Interactions of tizanidine with CYP1A2 enzyme inhibitors : Studies in vitro and in humans","display_name":"Interactions of tizanidine with CYP1A2 enzyme inhibitors : Studies in vitro and in humans","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W879985352","mag":"879985352"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.413.8822","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.413.8822","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/granfors/interact.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/22855","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036114614","display_name":"Marika T. Granfors","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marika T. Granfors","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036114614"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.05635739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tizanidine","display_name":"tizanidine","score":1.0},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9520000219345093},{"id":"https://openalex.org/keywords/enzyme-inhibitors","display_name":"enzyme inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8809999823570251},{"id":"https://openalex.org/keywords/in-vitro-studies","display_name":"in vitro studies","score":0.5189999938011169},{"id":"https://openalex.org/keywords/human-pharmacokinetics","display_name":"human pharmacokinetics","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C2779761043","wikidata":"https://www.wikidata.org/wiki/Q423538","display_name":"Tizanidine","level":3,"score":0.8082062005996704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4943232536315918},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4885459840297699},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48518258333206177},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.47045624256134033},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45542874932289124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.361754834651947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34243857860565186},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.1717710793018341},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.07371851801872253},{"id":"https://openalex.org/C2779012798","wikidata":"https://www.wikidata.org/wiki/Q117060","display_name":"Spasticity","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.413.8822","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.413.8822","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/granfors/interact.pdf","raw_type":"text"},{"id":"pmh:oai:helda.helsinki.fi:10138/22855","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22855","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},{"id":"mag:879985352","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/handle/10138/22855","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/22855","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/22855","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Doctoral dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":211,"referenced_works":["https://openalex.org/W5737406","https://openalex.org/W47128283","https://openalex.org/W67488111","https://openalex.org/W152943885","https://openalex.org/W155747404","https://openalex.org/W1498584605","https://openalex.org/W1503960915","https://openalex.org/W1510377592","https://openalex.org/W1510544978","https://openalex.org/W1550505631","https://openalex.org/W1558276030","https://openalex.org/W1578896110","https://openalex.org/W1582299489","https://openalex.org/W1588458157","https://openalex.org/W1734451748","https://openalex.org/W1746765074","https://openalex.org/W1765706822","https://openalex.org/W1780070459","https://openalex.org/W1829225133","https://openalex.org/W1872557352","https://openalex.org/W1875488666","https://openalex.org/W1877107710","https://openalex.org/W1882430758","https://openalex.org/W1924733673","https://openalex.org/W1925963538","https://openalex.org/W1927445476","https://openalex.org/W1940970798","https://openalex.org/W1944123947","https://openalex.org/W1956507658","https://openalex.org/W1963608458","https://openalex.org/W1966141246","https://openalex.org/W1967089707","https://openalex.org/W1968130270","https://openalex.org/W1968135674","https://openalex.org/W1969652902","https://openalex.org/W1971457180","https://openalex.org/W1972317353","https://openalex.org/W1972764254","https://openalex.org/W1972930816","https://openalex.org/W1975253874","https://openalex.org/W1975741786","https://openalex.org/W1976463815","https://openalex.org/W1978988947","https://openalex.org/W1979610724","https://openalex.org/W1979615955","https://openalex.org/W1981200399","https://openalex.org/W1982128407","https://openalex.org/W1982290436","https://openalex.org/W1982556979","https://openalex.org/W1984085801","https://openalex.org/W1985300130","https://openalex.org/W1986838867","https://openalex.org/W1987506409","https://openalex.org/W1988989289","https://openalex.org/W1989280559","https://openalex.org/W1990085736","https://openalex.org/W1990898136","https://openalex.org/W1990904235","https://openalex.org/W1990912030","https://openalex.org/W1992568187","https://openalex.org/W1992790914","https://openalex.org/W1994334380","https://openalex.org/W1994728875","https://openalex.org/W1995998293","https://openalex.org/W1996485240","https://openalex.org/W1997195932","https://openalex.org/W1997287652","https://openalex.org/W2000339309","https://openalex.org/W2001307099","https://openalex.org/W2002121467","https://openalex.org/W2003197532","https://openalex.org/W2003237988","https://openalex.org/W2004173390","https://openalex.org/W2005353283","https://openalex.org/W2007983159","https://openalex.org/W2008637373","https://openalex.org/W2009280534","https://openalex.org/W2009309230","https://openalex.org/W2009386434","https://openalex.org/W2011616982","https://openalex.org/W2011772637","https://openalex.org/W2013294274","https://openalex.org/W2014147727","https://openalex.org/W2016420931","https://openalex.org/W2016914036","https://openalex.org/W2017098712","https://openalex.org/W2017762816","https://openalex.org/W2021615594","https://openalex.org/W2021943540","https://openalex.org/W2022597534","https://openalex.org/W2023061643","https://openalex.org/W2023451301","https://openalex.org/W2023580320","https://openalex.org/W2024675404","https://openalex.org/W2025502084","https://openalex.org/W2025857581","https://openalex.org/W2027167584","https://openalex.org/W2028987665","https://openalex.org/W2030021013","https://openalex.org/W2030371954","https://openalex.org/W2030772752","https://openalex.org/W2032943580","https://openalex.org/W2032967171","https://openalex.org/W2035091931","https://openalex.org/W2035555993","https://openalex.org/W2036488991","https://openalex.org/W2036910356","https://openalex.org/W2039090622","https://openalex.org/W2044681042","https://openalex.org/W2045548240","https://openalex.org/W2045654730","https://openalex.org/W2048282464","https://openalex.org/W2049480378","https://openalex.org/W2050937868","https://openalex.org/W2050979701","https://openalex.org/W2053481602","https://openalex.org/W2053596799","https://openalex.org/W2054023900","https://openalex.org/W2054040800","https://openalex.org/W2055025618","https://openalex.org/W2055735784","https://openalex.org/W2056770708","https://openalex.org/W2058530997","https://openalex.org/W2059247032","https://openalex.org/W2059293500","https://openalex.org/W2061152607","https://openalex.org/W2061376955","https://openalex.org/W2063128948","https://openalex.org/W2063458512","https://openalex.org/W2064302284","https://openalex.org/W2065344270","https://openalex.org/W2065382947","https://openalex.org/W2065490103","https://openalex.org/W2065921364","https://openalex.org/W2066312456","https://openalex.org/W2066978864","https://openalex.org/W2068493131","https://openalex.org/W2068523715","https://openalex.org/W2068885497","https://openalex.org/W2071418888","https://openalex.org/W2073232204","https://openalex.org/W2074209497","https://openalex.org/W2076025389","https://openalex.org/W2076449998","https://openalex.org/W2079057400","https://openalex.org/W2080382785","https://openalex.org/W2081019523","https://openalex.org/W2082453607","https://openalex.org/W2082999918","https://openalex.org/W2083650072","https://openalex.org/W2084686194","https://openalex.org/W2085321487","https://openalex.org/W2088342692","https://openalex.org/W2089983178","https://openalex.org/W2090055066","https://openalex.org/W2090628258","https://openalex.org/W2090632754","https://openalex.org/W2092521092","https://openalex.org/W2092661856","https://openalex.org/W2093584791","https://openalex.org/W2093704573","https://openalex.org/W2093930484","https://openalex.org/W2094208265","https://openalex.org/W2095106622","https://openalex.org/W2097502628","https://openalex.org/W2099660182","https://openalex.org/W2100744461","https://openalex.org/W2101089910","https://openalex.org/W2105902511","https://openalex.org/W2106443841","https://openalex.org/W2107125008","https://openalex.org/W2110931244","https://openalex.org/W2111731642","https://openalex.org/W2114089215","https://openalex.org/W2114312904","https://openalex.org/W2116570511","https://openalex.org/W2117628306","https://openalex.org/W2119329077","https://openalex.org/W2121914901","https://openalex.org/W2126556545","https://openalex.org/W2127288395","https://openalex.org/W2133105878","https://openalex.org/W2133837027","https://openalex.org/W2136904160","https://openalex.org/W2140023920","https://openalex.org/W2141364356","https://openalex.org/W2145694963","https://openalex.org/W2150263445","https://openalex.org/W2153246785","https://openalex.org/W2155268095","https://openalex.org/W2158607621","https://openalex.org/W2163636261","https://openalex.org/W2163711771","https://openalex.org/W2165995063","https://openalex.org/W2169290209","https://openalex.org/W2169723565","https://openalex.org/W2169922352","https://openalex.org/W2170494490","https://openalex.org/W2224940091","https://openalex.org/W2258654931","https://openalex.org/W2279936106","https://openalex.org/W2322389699","https://openalex.org/W2329526205","https://openalex.org/W2344405022","https://openalex.org/W2368359507","https://openalex.org/W2401475829","https://openalex.org/W2411936418","https://openalex.org/W2498406708","https://openalex.org/W2599076204","https://openalex.org/W2993379710","https://openalex.org/W4294309380"],"related_works":["https://openalex.org/W124396676","https://openalex.org/W3149241892","https://openalex.org/W4304757188","https://openalex.org/W1605114492","https://openalex.org/W7067258688","https://openalex.org/W2040757997","https://openalex.org/W3194576617","https://openalex.org/W2747547070","https://openalex.org/W1997815372","https://openalex.org/W2502760294"],"abstract_inverted_index":{"To":[0],"be":[1],"presented,":[2],"with":[3],"the":[4,7,11,19],"permission":[5],"of":[6,10,13,24],"Medical":[8],"Faculty":[9],"University":[12],"Helsinki,":[14,26],"for":[15],"public":[16],"examination":[17],"in":[18],"small":[20],"lecture":[21],"hall":[22],"2":[23],"Biomedicum":[25]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
