{"id":"https://openalex.org/W8794497","doi":"https://doi.org/10.1182/blood.v90.6.2217","title":"CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity","display_name":"CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity","publication_year":1997,"publication_date":"1997-09-15","ids":{"openalex":"https://openalex.org/W8794497","doi":"https://doi.org/10.1182/blood.v90.6.2217","mag":"8794497","pmid":"https://pubmed.ncbi.nlm.nih.gov/9310473"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v90.6.2217","doi":"https://doi.org/10.1182/blood.v90.6.2217","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v90.6.2217","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069362146","display_name":"Rudolf Schmits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799511838","display_name":"Wellesley Institute","ror":"https://ror.org/006nw5s10","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2799511838"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Rudolf Schmits","raw_affiliation_strings":["From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; 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the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]},{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"The Center for Blood Research, Inc, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2799511838"]},{"raw_affiliation_string":"the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015461235","display_name":"Arsen Zakarian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799511838","display_name":"Wellesley Institute","ror":"https://ror.org/006nw5s10","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2799511838"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Arsen Zakarian","raw_affiliation_strings":["From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]},{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"The Center for Blood Research, Inc, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2799511838"]},{"raw_affiliation_string":"the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054812831","display_name":"John J. 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Simard","raw_affiliation_strings":["From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]},{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"The Center for Blood Research, Inc, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2799511838"]},{"raw_affiliation_string":"the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060222946","display_name":"Pamela S. 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Paige","raw_affiliation_strings":["From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","The Center for Blood Research, Inc, Boston, MA","The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","the Amgen Corporation, Thousand Oaks, CA","the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada; the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; the Cancer Biology Research Program, Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada; The Wellesley Hospital Research Institute, Toronto, Ontario, Canada; The Center for Blood Research, Inc, Boston, MA; and the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]},{"raw_affiliation_string":"From the Amgen Institute, Ontario Cancer Institute, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"The Center for Blood Research, Inc, Boston, MA","institution_ids":[]},{"raw_affiliation_string":"The Wellesley Hospital Research Institute, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2799511838"]},{"raw_affiliation_string":"the Amgen Corporation, Thousand Oaks, CA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"the Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111800442","display_name":"Jos\u00e9 Carlos Gutierrez\u2010Ramos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]},{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2799511838","display_name":"Wellesley Institute","ror":"https://ror.org/006nw5s10","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I2799511838"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Jose C. 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