{"id":"https://openalex.org/W87824809","doi":null,"title":"Monitoring of serum vancomycin concentrations in pediatric patients with normal renal function.","display_name":"Monitoring of serum vancomycin concentrations in pediatric patients with normal renal function.","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W87824809","mag":"87824809","pmid":"https://pubmed.ncbi.nlm.nih.gov/21133000"},"language":"en","primary_location":{"id":"pmid:21133000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21133000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Iranica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/427bd007362c44a1910c67eab04b6ffe","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109986507","display_name":"Ghamar Taj Khotaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ghamar Taj Khotaei","raw_affiliation_strings":["Department of Infectious Disease, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ghamartaj_k@yahoo.com","Department of Infectious Disease, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Ghamartaj_k@yahoo.com","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]},{"raw_affiliation_string":"Department of Infectious Disease, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110276883","display_name":"Sara Jam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928389","display_name":"Iranian Research Center for HIV/AIDS","ror":"https://ror.org/04d9kk613","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sara Jam","raw_affiliation_strings":["Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran,, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran,, Iran","institution_ids":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051105938","display_name":"SeyedAhmad SeyedAlinaghi","orcid":"https://orcid.org/0000-0003-3210-7905","observed_orcids":["https://orcid.org/0000-0003-3210-7905"]},"institutions":[{"id":"https://openalex.org/I4403928389","display_name":"Iranian Research Center for HIV/AIDS","ror":"https://ror.org/04d9kk613","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"SeyedAhmad SeyedAlinaghi","raw_affiliation_strings":["Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran,, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran,, Iran","institution_ids":["https://openalex.org/I4403928389","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033548752","display_name":"Fatemeh Motamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Motamed","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110494599","display_name":"Farideh Nejat","orcid":"https://orcid.org/0000-0002-4095-404X","observed_orcids":["https://orcid.org/0000-0002-4095-404X"]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farideh Nejat","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067103522","display_name":"Mohammad Taghi","orcid":"https://orcid.org/0000-0002-8466-0887","observed_orcids":["https://orcid.org/0000-0002-8466-0887"]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Taghi","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110577210","display_name":"Mohammad Taghi Haghi-Ashtiani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Haghi Ashtiani","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012173440","display_name":"Mina Izadyar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112675","display_name":"Children's Medical Center","ror":"https://ror.org/01v27vf29","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I4210112675"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mina Izadyar","raw_affiliation_strings":["Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Children\u2019s Medical Center, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210112675","https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2188,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57904042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"48","issue":"2","first_page":"91","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.9319999814033508},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.722000002861023},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.9629999995231628},{"id":"https://openalex.org/keywords/normal-renal-function","display_name":"normal renal function","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vancomycin-pharmacokinetics","display_name":"vancomycin pharmacokinetics","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.7979999780654907},{"id":"https://openalex.org/keywords/glycopeptide-antibiotics","display_name":"glycopeptides","score":0.7039999961853027},{"id":"https://openalex.org/keywords/peak-and-trough-concentrations","display_name":"peak and trough concentrations","score":0.578000009059906},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9666666388511658},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.9395514726638794},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.6293171048164368},{"id":"https://openalex.org/C2993561819","wikidata":"https://www.wikidata.org/wiki/Q5097977","display_name":"Pediatric cancer","level":3,"score":0.59324711561203},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5930077433586121},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5123487710952759},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.4926186203956604},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4882838726043701},{"id":"https://openalex.org/C2909355912","wikidata":"https://www.wikidata.org/wiki/Q15756717","display_name":"Pediatric Infectious Disease","level":2,"score":0.4525061547756195},{"id":"https://openalex.org/C2780642338","wikidata":"https://www.wikidata.org/wiki/Q7632042","display_name":"Subspecialty","level":2,"score":0.4405973553657532},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4184204936027527},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41097649931907654},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3948807716369629},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3406344950199127},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.16173598170280457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11138132214546204},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:21133000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21133000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Iranica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:427bd007362c44a1910c67eab04b6ffe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/427bd007362c44a1910c67eab04b6ffe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Iranica, Vol 48, Iss 2 (2010)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:56860360b9b14a9daf14e0cc2ace0c7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/56860360b9b14a9daf14e0cc2ace0c7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Iranica, Vol 48, Iss 2, Pp 91-94 (2010)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:427bd007362c44a1910c67eab04b6ffe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/427bd007362c44a1910c67eab04b6ffe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Iranica, Vol 48, Iss 2 (2010)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W143290930","https://openalex.org/W1965822140","https://openalex.org/W1988426427","https://openalex.org/W2005523935","https://openalex.org/W2012442465","https://openalex.org/W2022407518","https://openalex.org/W2027232785","https://openalex.org/W2056026648","https://openalex.org/W2135419491","https://openalex.org/W2155626541","https://openalex.org/W2408080064","https://openalex.org/W2484973713","https://openalex.org/W4254007224","https://openalex.org/W7122626928"],"related_works":["https://openalex.org/W1997442261","https://openalex.org/W2089537215","https://openalex.org/W1965637784","https://openalex.org/W2738262183","https://openalex.org/W2031231143","https://openalex.org/W3137423626","https://openalex.org/W2081672036","https://openalex.org/W2097088603","https://openalex.org/W2389571949","https://openalex.org/W3148595453"],"abstract_inverted_index":{"Vancomycin":[0],"is":[1,204],"a":[2,3,213],"glycopeptide":[4],"antibiotic":[5],"with":[6,15,103,125,136,161,212],"bacetiocidal":[7],"effects":[8],"on":[9],"gram":[10],"positive":[11],"bacteria":[12],"by":[13],"interfering":[14],"cell":[16],"wall":[17],"synthesis.":[18],"The":[19,60],"necessity":[20],"for":[21,38,65,101,138,153,206],"monitoring":[22,47,199],"of":[23,36,72,155,186,193,200,216],"serum":[24],"vancomycin":[25,84,137,194,201],"concentrations":[26,203],"(SVCs)":[27],"has":[28],"been":[29],"recently":[30],"noticed":[31],"at":[32,85],"many":[33],"institutions":[34],"because":[35],"concerns":[37],"its":[39],"nephrotoxicity.":[40],"We":[41],"aimed":[42],"to":[43,54,75,131,183,190],"describe":[44],"the":[45,76,114,184,198,207],"SVCs":[46,146,164],"in":[48,51,89,148,195],"pediatric":[49],"patients,":[50,197],"an":[52,149],"effort":[53],"determine":[55],"subtherapeutic":[56],"or":[57,78],"toxic":[58],"levels.":[59],"medical":[61],"records":[62],"were":[63,134,147,174],"reviewed":[64],"all":[66],"patients":[67,124,156],"older":[68],"than":[69,167,176],"60":[70],"days":[71],"age":[73],"admitted":[74],"general":[77],"subspecialty":[79],"services":[80],"who":[81],"received":[82],"intravenous":[83],"Children's":[86],"Medical":[87],"Hospital":[88],"Tehran,":[90],"Iran":[91],"between":[92,128],"July":[93],"2003":[94],"and":[95,118,122,171],"December":[96],"2005.":[97],"Because":[98],"pharmacokinetic":[99],"parameters":[100],"children":[102,119,142,160],"cancer":[104,121],"may":[105],"be":[106],"different,":[107],"this":[108,187],"group":[109],"was":[110,165],"evaluated":[111],"separately.":[112],"During":[113],"study,":[115],"167":[116],"infants":[117],"without":[120,143],"42":[123],"cancer;":[126],"aged":[127],"3":[129],"months":[130],"17.5":[132],"years":[133],"treated":[135],"various":[139],"infections.":[140],"In":[141,180],"cancer,":[144,162],"peak":[145,163],"adequate":[150],"therapeutic":[151,209],"range":[152],"93%":[154],"(8-55":[157],"microg/ml).":[158],"For":[159],"lower":[166,175],"10":[168],"microg/ml":[169,178],"(10%),":[170],"trough":[172],"values":[173],"5":[177],"(21%).":[179],"conclusion,":[181],"according":[182],"results":[185],"research,":[188],"due":[189],"different":[191],"pharmacokinetics":[192],"cancerous":[196],"plasma":[202],"necessary":[205],"best":[208],"antibacterial":[210],"activities":[211],"fewer":[214],"occurrence":[215],"serious":[217],"adverse":[218],"effects.":[219]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}